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The map label for this gene is nadB [H]

Identifier: 116328570

GI number: 116328570

Start: 2247129

End: 2248727

Strand: Direct

Name: nadB [H]

Synonym: LBL_1927

Alternate gene names: 116328570

Gene position: 2247129-2248727 (Clockwise)

Preceding gene: 116328569

Following gene: 116328578

Centisome position: 62.17

GC content: 45.22

Gene sequence:

>1599_bases
ATGCCCCGTATCAAAACGGACTTCCTAGTCTTAGGGAGCGGAATCACGGGCCTCTTCGCGGCCTTAAAATTAGCTTCCTA
CGGCTCCGTTATCATCATCACAAAAAAATCGGATTATGAGTCCAACACGAATTACGCGCAAGGCGGAATCGCCTCCGTTT
TTGCGGAAGGCGATAAACTTGAGGACCACGTCAGGGACACTCTGGAAGCGGGAGCCTGGCTTTGCGATCCGGCAGCGGTT
CAAATTCTCGTGGAAGAAGGCCCCCCCCTAGTCAAAGAACTACTCGACTACGGGGTTCCGTTTAATTTGGAACCCTCGGG
AAAATTCGATCTTTCCAGAGAAGGTGGGCATGGAAAGAATAGAATCGTCCACGCACACGACAGAACGGGAAGGGAAATCG
AAAAGACCCTTCTAAACGTAGTCAAACAGAATTCAAACATTCGAATATTAGAATATCATACTTTGGTAGATTTAATTACG
CCTCATCAATTAAAACGTAAAGGACTCATCTGCTACGGCGCCTACGTCCTTTCCAATCATACAGGGGAAGTTTTTCCGAT
TTTGGCGAGAGAAACGATTCTTGCGACCGGAGGAGCGGGACAAGTTTACTCTCATACGACCAATCCTAAGATCGCAACCG
GAGACGGTGTCGCTTCCGCATACAGGGCCGGAGCGCTCATCAAAAATATGGAATTTTACCAATTCCATCCGACCGCACTT
TATCACGAAGATGGAAATTCTTTTTTGATTTCCGAAGCAGTTCGAGGAAAAGGTGCGATTCTTTTGAATAAAGATGGAGA
ACCGTTTATGAAACGGTATCATTCGATGGGGGACTTGGCTCCGAGAGACGTGGTAGCAAGAGCTATAGACTCCGAAATGA
AAAAAAGAGGAGAGCCGCATGTTTGGTTGGACGTCACTCATCTTTCTTCCTCTCAGATCAAAGAATCTTTTCCCTCCATT
TACGAGAAATGCAAAGAACTCGGAATTGATATCACTACGGATCGAATACCGGTCGTTCCGGTTGCACACTTTCTTTGCGG
CGGTGTATCTTCCGATTTGGAAGGAAGAACAACAATTCCAAATCTTTCTACAGCGGGCGAAACCGCATGCACGGGAGTTC
ACGGTGGAAATCGTCTTGCGTCTAATAGTCTTCTGGAGTGTCTTGTTTTCTCCAATCGAATCGCCAAAAGAATCGGAAAA
GAAAAGCCGGAATTCACAAAAGCACACGACGAAATCCCTTCTTGGAATAAGGAAGGAATGGTCAATACCGAAGAGTGGGT
TTTAATCTCTCACGATTTAAATGAAATTAAAAATACGATGAGCAACTACGTGGGAATCGTCCGTTCCAATTTACGTTTAG
AACGCGCTAAACGCAGAATGGATCTGATCTACGACGAAGTAAAGGATTATTACAACAGAACAATTATCACCAATCCTTTA
ATCGAACTAAGAAATTTGGTGATTGTAGCGAAACTCATCATTCGTTCCGCGTTGTCCAGAAAAGAAAGCAGAGGGCTTCA
TTTTTCCACAGACTATCCGGAAAACAGAAGTCCTTCCCGTGTCGACACGGAAATCCGCAACGACAAAGTCCGATTTTAA

Upstream 100 bases:

>100_bases
ATCGCGGCTCATAAAAACGATCCCATCAAACCGGACTACCAGCTCATTCGTTCCTTAGATTATATCGAAGCGCTTATTAA
CACACAAAAAAAGAAATAAA

Downstream 100 bases:

>100_bases
GGGAAAAAATATTTTAAATCATTAGAATATTTTACTTTTAGAATGTGTGATTGAAATTGACGAAAAGTTGCTCATCCTCT
CTGGAAACCGCGTAGTCCAT

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MPRIKTDFLVLGSGITGLFAALKLASYGSVIIITKKSDYESNTNYAQGGIASVFAEGDKLEDHVRDTLEAGAWLCDPAAV
QILVEEGPPLVKELLDYGVPFNLEPSGKFDLSREGGHGKNRIVHAHDRTGREIEKTLLNVVKQNSNIRILEYHTLVDLIT
PHQLKRKGLICYGAYVLSNHTGEVFPILARETILATGGAGQVYSHTTNPKIATGDGVASAYRAGALIKNMEFYQFHPTAL
YHEDGNSFLISEAVRGKGAILLNKDGEPFMKRYHSMGDLAPRDVVARAIDSEMKKRGEPHVWLDVTHLSSSQIKESFPSI
YEKCKELGIDITTDRIPVVPVAHFLCGGVSSDLEGRTTIPNLSTAGETACTGVHGGNRLASNSLLECLVFSNRIAKRIGK
EKPEFTKAHDEIPSWNKEGMVNTEEWVLISHDLNEIKNTMSNYVGIVRSNLRLERAKRRMDLIYDEVKDYYNRTIITNPL
IELRNLVIVAKLIIRSALSRKESRGLHFSTDYPENRSPSRVDTEIRNDKVRF

Sequences:

>Translated_532_residues
MPRIKTDFLVLGSGITGLFAALKLASYGSVIIITKKSDYESNTNYAQGGIASVFAEGDKLEDHVRDTLEAGAWLCDPAAV
QILVEEGPPLVKELLDYGVPFNLEPSGKFDLSREGGHGKNRIVHAHDRTGREIEKTLLNVVKQNSNIRILEYHTLVDLIT
PHQLKRKGLICYGAYVLSNHTGEVFPILARETILATGGAGQVYSHTTNPKIATGDGVASAYRAGALIKNMEFYQFHPTAL
YHEDGNSFLISEAVRGKGAILLNKDGEPFMKRYHSMGDLAPRDVVARAIDSEMKKRGEPHVWLDVTHLSSSQIKESFPSI
YEKCKELGIDITTDRIPVVPVAHFLCGGVSSDLEGRTTIPNLSTAGETACTGVHGGNRLASNSLLECLVFSNRIAKRIGK
EKPEFTKAHDEIPSWNKEGMVNTEEWVLISHDLNEIKNTMSNYVGIVRSNLRLERAKRRMDLIYDEVKDYYNRTIITNPL
IELRNLVIVAKLIIRSALSRKESRGLHFSTDYPENRSPSRVDTEIRNDKVRF
>Mature_531_residues
PRIKTDFLVLGSGITGLFAALKLASYGSVIIITKKSDYESNTNYAQGGIASVFAEGDKLEDHVRDTLEAGAWLCDPAAVQ
ILVEEGPPLVKELLDYGVPFNLEPSGKFDLSREGGHGKNRIVHAHDRTGREIEKTLLNVVKQNSNIRILEYHTLVDLITP
HQLKRKGLICYGAYVLSNHTGEVFPILARETILATGGAGQVYSHTTNPKIATGDGVASAYRAGALIKNMEFYQFHPTALY
HEDGNSFLISEAVRGKGAILLNKDGEPFMKRYHSMGDLAPRDVVARAIDSEMKKRGEPHVWLDVTHLSSSQIKESFPSIY
EKCKELGIDITTDRIPVVPVAHFLCGGVSSDLEGRTTIPNLSTAGETACTGVHGGNRLASNSLLECLVFSNRIAKRIGKE
KPEFTKAHDEIPSWNKEGMVNTEEWVLISHDLNEIKNTMSNYVGIVRSNLRLERAKRRMDLIYDEVKDYYNRTIITNPLI
ELRNLVIVAKLIIRSALSRKESRGLHFSTDYPENRSPSRVDTEIRNDKVRF

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=519, Percent_Identity=32.5626204238921, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI1788928, Length=521, Percent_Identity=47.6007677543186, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI1790597, Length=521, Percent_Identity=31.4779270633397, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786942, Length=560, Percent_Identity=32.3214285714286, Blast_Score=214, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17505833, Length=525, Percent_Identity=33.1428571428571, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17550100, Length=530, Percent_Identity=32.8301886792453, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71986328, Length=276, Percent_Identity=31.1594202898551, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322701, Length=524, Percent_Identity=34.3511450381679, Blast_Score=246, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6322416, Length=514, Percent_Identity=33.0739299610895, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6320788, Length=489, Percent_Identity=25.7668711656442, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322511, Length=489, Percent_Identity=25.1533742331288, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17137288, Length=540, Percent_Identity=33.3333333333333, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI24655642, Length=540, Percent_Identity=33.3333333333333, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI24655647, Length=540, Percent_Identity=33.3333333333333, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI24663005, Length=558, Percent_Identity=32.078853046595, Blast_Score=225, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 59211; Mature: 59080

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRIKTDFLVLGSGITGLFAALKLASYGSVIIITKKSDYESNTNYAQGGIASVFAEGDKL
CCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCHH
EDHVRDTLEAGAWLCDPAAVQILVEEGPPLVKELLDYGVPFNLEPSGKFDLSREGGHGKN
HHHHHHHHHCCCEEECHHHEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
RIVHAHDRTGREIEKTLLNVVKQNSNIRILEYHTLVDLITPHQLKRKGLICYGAYVLSNH
CEEECCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCHHHHHCCEEEEEEEEEECC
TGEVFPILARETILATGGAGQVYSHTTNPKIATGDGVASAYRAGALIKNMEFYQFHPTAL
CCCEEEEEECCEEEEECCCCCEEEECCCCCEECCCCHHHHHHHHHHHHCCEEEEECCCEE
YHEDGNSFLISEAVRGKGAILLNKDGEPFMKRYHSMGDLAPRDVVARAIDSEMKKRGEPH
EECCCCEEEEEHHHCCCCEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCE
VWLDVTHLSSSQIKESFPSIYEKCKELGIDITTDRIPVVPVAHFLCGGVSSDLEGRTTIP
EEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCCCCCCCCCCC
NLSTAGETACTGVHGGNRLASNSLLECLVFSNRIAKRIGKEKPEFTKAHDEIPSWNKEGM
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCC
VNTEEWVLISHDLNEIKNTMSNYVGIVRSNLRLERAKRRMDLIYDEVKDYYNRTIITNPL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHH
IELRNLVIVAKLIIRSALSRKESRGLHFSTDYPENRSPSRVDTEIRNDKVRF
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
PRIKTDFLVLGSGITGLFAALKLASYGSVIIITKKSDYESNTNYAQGGIASVFAEGDKL
CCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCHH
EDHVRDTLEAGAWLCDPAAVQILVEEGPPLVKELLDYGVPFNLEPSGKFDLSREGGHGKN
HHHHHHHHHCCCEEECHHHEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
RIVHAHDRTGREIEKTLLNVVKQNSNIRILEYHTLVDLITPHQLKRKGLICYGAYVLSNH
CEEECCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCHHHHHCCEEEEEEEEEECC
TGEVFPILARETILATGGAGQVYSHTTNPKIATGDGVASAYRAGALIKNMEFYQFHPTAL
CCCEEEEEECCEEEEECCCCCEEEECCCCCEECCCCHHHHHHHHHHHHCCEEEEECCCEE
YHEDGNSFLISEAVRGKGAILLNKDGEPFMKRYHSMGDLAPRDVVARAIDSEMKKRGEPH
EECCCCEEEEEHHHCCCCEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCE
VWLDVTHLSSSQIKESFPSIYEKCKELGIDITTDRIPVVPVAHFLCGGVSSDLEGRTTIP
EEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCCCCCCCCCCC
NLSTAGETACTGVHGGNRLASNSLLECLVFSNRIAKRIGKEKPEFTKAHDEIPSWNKEGM
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCC
VNTEEWVLISHDLNEIKNTMSNYVGIVRSNLRLERAKRRMDLIYDEVKDYYNRTIITNPL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHH
IELRNLVIVAKLIIRSALSRKESRGLHFSTDYPENRSPSRVDTEIRNDKVRF
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]