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The map label for this gene is manC [H]

Identifier: 116328562

GI number: 116328562

Start: 2239837

End: 2240898

Strand: Reverse

Name: manC [H]

Synonym: LBL_1919

Alternate gene names: 116328562

Gene position: 2240898-2239837 (Counterclockwise)

Preceding gene: 116328563

Following gene: 116328561

Centisome position: 62.0

GC content: 40.87

Gene sequence:

>1062_bases
ATGAATCAGGATAAACCGATCGTATTGATTATGGCCGGAGGTAAAGGAGAACGATTCTGGCCTCGTTCCAGAGTATCTAC
TCCGAAACAACTTCAGAAAGTATATTCCAATAAAACTCTCTTGAAAGAAACCTTGGAACGCGCGCTTACGATTACCACGA
TCGATCGTGTTTATATCGGAACCAACGCAAGTCTAAAAAAATCGATCCTGGCTCAGGAAAAAAATTTTCCCGAAAAAAAT
TTCATTATCGAACCGGAAGGTAAAAACACGGCTCCCATCATCGCTCTTGCGTCCTTGTATTTCTGGGAAAAATACGGCGA
TCCTCTGCAGGTCGTATTGTCTGCAGACGCTTGGATTAATCCCGTAAAAGAATTCACAAAAACGATTTTAAATGCGCTGG
AACAGGCGAAAGATCATTTGGTCCTTCTCGGGATTAAGCCGAATCGTCCTGAAGTAGGTTACGGTTATATCGAAGCCGGA
AAATCGATTGATGGTTGTTTTGCGGTAAAGTCGTTTTATGAAAAACCGGACTTAAAGACTGCGCTCAAGTATATCAAAAA
GAAGAATTTTTATTGGAATCCGGGGATTTTTCTTTGGAAGACTTCCATAATATTAGAGGAATTTAAAACGTATTCTCCTA
AAATTATAAACCCTTTGGAAGATCGGTTTCCGTTTAAAAAGGCTGGAGAACTTTCGGCGGCTTTTAAGATCATTCCTTCC
GATCCGGTGGATATCGCGATTATGGAAAAAAGTTCCCGGATCAGAATGGTGGAAGCGAGTTTCGGTTGGGATGATGTGGG
TTCTTGGACTTCTTTGGAAAGAGTGATGTCCGGGGATTCGTTTGGAAACAGACATATGGGTAAGACGATACTTTTTCATA
AATCTTCTGGAAACATCACTCAAACTCGAAAAGAATTTACCGCGATTCTCGGAGTGAAAGATTTGATTGTTGTGGAAGAG
GAAGACGTTCTGTTTATCAGTACGAAGTCGGGAGTCGGTGATATCAAAAGTTTGGTAGCGGAGCTTCGTAAAAATAAAAC
TTTACAAAAGTACACGGAATAG

Upstream 100 bases:

>100_bases
ACGTGGAGGTGATTCTGCTTCCTTCGGAGATGATCTTGGGAGAAATTCCGTCTTCCAAAAAGAAAAAGAACGGCGCAGCG
AAAAAATCCAAAGAGGTAGA

Downstream 100 bases:

>100_bases
TTTTCTGACAGGAAGGAAATCTAAGGAGTTCTTTAATGCCTTCAGGTAAGAAAAGAAAGCGCAGAAAGATCGCTACTCAC
AAAAGAAAGAAAAAGAGAAG

Product: mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MNQDKPIVLIMAGGKGERFWPRSRVSTPKQLQKVYSNKTLLKETLERALTITTIDRVYIGTNASLKKSILAQEKNFPEKN
FIIEPEGKNTAPIIALASLYFWEKYGDPLQVVLSADAWINPVKEFTKTILNALEQAKDHLVLLGIKPNRPEVGYGYIEAG
KSIDGCFAVKSFYEKPDLKTALKYIKKKNFYWNPGIFLWKTSIILEEFKTYSPKIINPLEDRFPFKKAGELSAAFKIIPS
DPVDIAIMEKSSRIRMVEASFGWDDVGSWTSLERVMSGDSFGNRHMGKTILFHKSSGNITQTRKEFTAILGVKDLIVVEE
EDVLFISTKSGVGDIKSLVAELRKNKTLQKYTE

Sequences:

>Translated_353_residues
MNQDKPIVLIMAGGKGERFWPRSRVSTPKQLQKVYSNKTLLKETLERALTITTIDRVYIGTNASLKKSILAQEKNFPEKN
FIIEPEGKNTAPIIALASLYFWEKYGDPLQVVLSADAWINPVKEFTKTILNALEQAKDHLVLLGIKPNRPEVGYGYIEAG
KSIDGCFAVKSFYEKPDLKTALKYIKKKNFYWNPGIFLWKTSIILEEFKTYSPKIINPLEDRFPFKKAGELSAAFKIIPS
DPVDIAIMEKSSRIRMVEASFGWDDVGSWTSLERVMSGDSFGNRHMGKTILFHKSSGNITQTRKEFTAILGVKDLIVVEE
EDVLFISTKSGVGDIKSLVAELRKNKTLQKYTE
>Mature_353_residues
MNQDKPIVLIMAGGKGERFWPRSRVSTPKQLQKVYSNKTLLKETLERALTITTIDRVYIGTNASLKKSILAQEKNFPEKN
FIIEPEGKNTAPIIALASLYFWEKYGDPLQVVLSADAWINPVKEFTKTILNALEQAKDHLVLLGIKPNRPEVGYGYIEAG
KSIDGCFAVKSFYEKPDLKTALKYIKKKNFYWNPGIFLWKTSIILEEFKTYSPKIINPLEDRFPFKKAGELSAAFKIIPS
DPVDIAIMEKSSRIRMVEASFGWDDVGSWTSLERVMSGDSFGNRHMGKTILFHKSSGNITQTRKEFTAILGVKDLIVVEE
EDVLFISTKSGVGDIKSLVAELRKNKTLQKYTE

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group B O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=363, Percent_Identity=35.2617079889807, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 39971; Mature: 39971

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQDKPIVLIMAGGKGERFWPRSRVSTPKQLQKVYSNKTLLKETLERALTITTIDRVYIG
CCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHEEEEEEEEEEEC
TNASLKKSILAQEKNFPEKNFIIEPEGKNTAPIIALASLYFWEKYGDPLQVVLSADAWIN
CCCHHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHH
PVKEFTKTILNALEQAKDHLVLLGIKPNRPEVGYGYIEAGKSIDGCFAVKSFYEKPDLKT
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCHHH
ALKYIKKKNFYWNPGIFLWKTSIILEEFKTYSPKIINPLEDRFPFKKAGELSAAFKIIPS
HHHHHHHCCCEECCCEEEEEHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCEEEEECCC
DPVDIAIMEKSSRIRMVEASFGWDDVGSWTSLERVMSGDSFGNRHMGKTILFHKSSGNIT
CCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCH
QTRKEFTAILGVKDLIVVEEEDVLFISTKSGVGDIKSLVAELRKNKTLQKYTE
HHHHHHHHHHCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MNQDKPIVLIMAGGKGERFWPRSRVSTPKQLQKVYSNKTLLKETLERALTITTIDRVYIG
CCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHEEEEEEEEEEEC
TNASLKKSILAQEKNFPEKNFIIEPEGKNTAPIIALASLYFWEKYGDPLQVVLSADAWIN
CCCHHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHH
PVKEFTKTILNALEQAKDHLVLLGIKPNRPEVGYGYIEAGKSIDGCFAVKSFYEKPDLKT
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCHHH
ALKYIKKKNFYWNPGIFLWKTSIILEEFKTYSPKIINPLEDRFPFKKAGELSAAFKIIPS
HHHHHHHCCCEECCCEEEEEHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCEEEEECCC
DPVDIAIMEKSSRIRMVEASFGWDDVGSWTSLERVMSGDSFGNRHMGKTILFHKSSGNIT
CCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCH
QTRKEFTAILGVKDLIVVEEEDVLFISTKSGVGDIKSLVAELRKNKTLQKYTE
HHHHHHHHHHCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]