The gene/protein map for NC_008508 is currently unavailable.
Definition Leptospira borgpetersenii serovar Hardjo-bovis L550 chromosome 1, complete sequence.
Accession NC_008508
Length 3,614,446

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The map label for this gene is ppiB-1 [H]

Identifier: 116328554

GI number: 116328554

Start: 2230043

End: 2230501

Strand: Direct

Name: ppiB-1 [H]

Synonym: LBL_1909

Alternate gene names: 116328554

Gene position: 2230043-2230501 (Clockwise)

Preceding gene: 116328550

Following gene: 116328556

Centisome position: 61.7

GC content: 38.78

Gene sequence:

>459_bases
ATGTCAACCGCAGTATTTAAAACAAATTTTGGAGACTTTTCAGTTTATCTGGATCAGGAAAGAGCCCCGATTACAGTCGG
CAATTTTATCAAATTGGCAAAAGACGGATTTTACGATGGTCTTACATTTCATAGGATCATCAAAAATTTTATGATTCAAG
GAGGTTGTCCGGTTGGAAATGGGACAGGTGGGCCGGGTTATAAGATCCAAGACGAGTTTCATAAAGATCTGAAGAATGAA
AAATACACACTTTCCATGGCAAATGCAGGGCCGAATACGGGCGGATCTCAGTTTTTTATTAATGTACGCAATAACTTCTA
TTTGGATAACCGTCATTCAGTTTTTGGAAAAGTTACACAAGGAATGAACATCGTAGAAACGATTTCGGAGACGGAAACGG
GTTTTCATGATAAACCGACAAAAGCGGTTATCATCGAAAGGATCACTGTTTCCGAATAA

Upstream 100 bases:

>100_bases
CATTTGTGTATTTTTGTTTGTTTTTTACAAGAAATCGTTTTCTGTCTATTTTATGATACCGGAAAATGGAAATAAATTCT
TAAAATAAAAGGAAAGTGAT

Downstream 100 bases:

>100_bases
GAGCCGTCTCAAAACCTTAGGAATGTAAGAGCTATTACAATCTTAAACGACAGGACAAACCTTCAATACGACGGTTTCTG
TGGGAACTCTCACATTCAGA

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase B; Cyclophilin ScCypB; Rotamase B; S-cyclophilin [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MSTAVFKTNFGDFSVYLDQERAPITVGNFIKLAKDGFYDGLTFHRIIKNFMIQGGCPVGNGTGGPGYKIQDEFHKDLKNE
KYTLSMANAGPNTGGSQFFINVRNNFYLDNRHSVFGKVTQGMNIVETISETETGFHDKPTKAVIIERITVSE

Sequences:

>Translated_152_residues
MSTAVFKTNFGDFSVYLDQERAPITVGNFIKLAKDGFYDGLTFHRIIKNFMIQGGCPVGNGTGGPGYKIQDEFHKDLKNE
KYTLSMANAGPNTGGSQFFINVRNNFYLDNRHSVFGKVTQGMNIVETISETETGFHDKPTKAVIIERITVSE
>Mature_151_residues
STAVFKTNFGDFSVYLDQERAPITVGNFIKLAKDGFYDGLTFHRIIKNFMIQGGCPVGNGTGGPGYKIQDEFHKDLKNEK
YTLSMANAGPNTGGSQFFINVRNNFYLDNRHSVFGKVTQGMNIVETISETETGFHDKPTKAVIIERITVSE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=153, Percent_Identity=49.6732026143791, Blast_Score=136, Evalue=8e-33,
Organism=Homo sapiens, GI7706339, Length=144, Percent_Identity=45.1388888888889, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI19557636, Length=134, Percent_Identity=44.0298507462687, Blast_Score=102, Evalue=9e-23,
Organism=Homo sapiens, GI64276486, Length=119, Percent_Identity=42.0168067226891, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI22547212, Length=148, Percent_Identity=43.2432432432432, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI7657473, Length=148, Percent_Identity=43.2432432432432, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI22547215, Length=148, Percent_Identity=43.2432432432432, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI4758950, Length=130, Percent_Identity=48.4615384615385, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI4505991, Length=138, Percent_Identity=43.4782608695652, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI10863927, Length=132, Percent_Identity=47.7272727272727, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI5454154, Length=153, Percent_Identity=39.8692810457516, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI5174637, Length=142, Percent_Identity=41.5492957746479, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI20911035, Length=141, Percent_Identity=37.5886524822695, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI45439316, Length=129, Percent_Identity=41.8604651162791, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI310129267, Length=132, Percent_Identity=45.4545454545455, Blast_Score=83, Evalue=8e-17,
Organism=Homo sapiens, GI310120620, Length=132, Percent_Identity=45.4545454545455, Blast_Score=83, Evalue=8e-17,
Organism=Homo sapiens, GI6631100, Length=108, Percent_Identity=45.3703703703704, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI256017253, Length=125, Percent_Identity=45.6, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI221139811, Length=125, Percent_Identity=45.6, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI256017251, Length=125, Percent_Identity=45.6, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI303305009, Length=125, Percent_Identity=42.4, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI310110104, Length=132, Percent_Identity=44.6969696969697, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI4826932, Length=113, Percent_Identity=46.9026548672566, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI5031987, Length=126, Percent_Identity=43.6507936507937, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI169163387, Length=95, Percent_Identity=51.5789473684211, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI42560244, Length=112, Percent_Identity=41.9642857142857, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI169164185, Length=95, Percent_Identity=51.5789473684211, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI169163623, Length=95, Percent_Identity=51.5789473684211, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI178057341, Length=126, Percent_Identity=44.4444444444444, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI209417936, Length=126, Percent_Identity=44.4444444444444, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI30102944, Length=126, Percent_Identity=44.4444444444444, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI219842199, Length=126, Percent_Identity=44.4444444444444, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI310127646, Length=132, Percent_Identity=41.6666666666667, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI310114371, Length=132, Percent_Identity=41.6666666666667, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI310119221, Length=132, Percent_Identity=41.6666666666667, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI310132444, Length=131, Percent_Identity=39.6946564885496, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI310113152, Length=131, Percent_Identity=39.6946564885496, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI150418007, Length=150, Percent_Identity=35.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310114540, Length=118, Percent_Identity=40.6779661016949, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310127745, Length=118, Percent_Identity=40.6779661016949, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310119290, Length=118, Percent_Identity=40.6779661016949, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI169214050, Length=95, Percent_Identity=44.2105263157895, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI239751853, Length=121, Percent_Identity=38.0165289256198, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI113428306, Length=121, Percent_Identity=38.0165289256198, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789763, Length=152, Percent_Identity=36.8421052631579, Blast_Score=98, Evalue=2e-22,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=38.5093167701863, Blast_Score=96, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17539496, Length=152, Percent_Identity=43.421052631579, Blast_Score=123, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17506311, Length=153, Percent_Identity=44.4444444444444, Blast_Score=122, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17532641, Length=149, Percent_Identity=42.9530201342282, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17552780, Length=142, Percent_Identity=44.3661971830986, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71997782, Length=121, Percent_Identity=42.9752066115703, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17506307, Length=130, Percent_Identity=48.4615384615385, Blast_Score=99, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17551284, Length=114, Percent_Identity=50.8771929824561, Blast_Score=96, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17551282, Length=114, Percent_Identity=50.8771929824561, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71980594, Length=152, Percent_Identity=34.8684210526316, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17559074, Length=149, Percent_Identity=41.6107382550336, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=130, Percent_Identity=38.4615384615385, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532643, Length=148, Percent_Identity=40.5405405405405, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539498, Length=131, Percent_Identity=43.5114503816794, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17566266, Length=102, Percent_Identity=49.0196078431373, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI32563659, Length=160, Percent_Identity=33.125, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17552782, Length=112, Percent_Identity=45.5357142857143, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17565860, Length=113, Percent_Identity=50.4424778761062, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17552784, Length=160, Percent_Identity=35.625, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323562, Length=151, Percent_Identity=43.7086092715232, Blast_Score=94, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320359, Length=140, Percent_Identity=45, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321848, Length=136, Percent_Identity=43.3823529411765, Blast_Score=85, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320510, Length=133, Percent_Identity=44.3609022556391, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323246, Length=155, Percent_Identity=38.7096774193548, Blast_Score=79, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322492, Length=191, Percent_Identity=32.4607329842932, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17986117, Length=151, Percent_Identity=42.3841059602649, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI19922376, Length=147, Percent_Identity=41.4965986394558, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19922912, Length=152, Percent_Identity=47.3684210526316, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI20130249, Length=142, Percent_Identity=45.7746478873239, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21357249, Length=152, Percent_Identity=34.8684210526316, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24664125, Length=144, Percent_Identity=44.4444444444444, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21357783, Length=144, Percent_Identity=44.4444444444444, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI45549139, Length=143, Percent_Identity=41.958041958042, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24650807, Length=139, Percent_Identity=38.1294964028777, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136360, Length=135, Percent_Identity=37.037037037037, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17647301, Length=142, Percent_Identity=39.4366197183099, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586038, Length=157, Percent_Identity=38.2165605095541, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24652460, Length=132, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21355677, Length=162, Percent_Identity=29.6296296296296, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16912; Mature: 16781

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MSTAVFKTNFGDFSVYLDQERAPITVGNFIKLAKDGFYDGLTFHRIIKNFMIQGGCPVGN
CCCEEEEECCCCEEEEEECCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
GTGGPGYKIQDEFHKDLKNEKYTLSMANAGPNTGGSQFFINVRNNFYLDNRHSVFGKVTQ
CCCCCCCEECHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCEEECCCHHHHHHHHC
GMNIVETISETETGFHDKPTKAVIIERITVSE
CCHHHHHHHHHCCCCCCCCCEEEEEEEEECCC
>Mature Secondary Structure 
STAVFKTNFGDFSVYLDQERAPITVGNFIKLAKDGFYDGLTFHRIIKNFMIQGGCPVGN
CCEEEEECCCCEEEEEECCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
GTGGPGYKIQDEFHKDLKNEKYTLSMANAGPNTGGSQFFINVRNNFYLDNRHSVFGKVTQ
CCCCCCCEECHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCEEECCCHHHHHHHHC
GMNIVETISETETGFHDKPTKAVIIERITVSE
CCHHHHHHHHHCCCCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9025285 [H]