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The map label for this gene is hisD [H]

Identifier: 116328535

GI number: 116328535

Start: 2202413

End: 2203693

Strand: Reverse

Name: hisD [H]

Synonym: LBL_1887

Alternate gene names: 116328535

Gene position: 2203693-2202413 (Counterclockwise)

Preceding gene: 116328537

Following gene: 116328534

Centisome position: 60.97

GC content: 46.06

Gene sequence:

>1281_bases
ATGGCAATACAGATTTTACAAGTTGGTTTGAAAAATCGGTCGGTTTTGAACCCGATTTTAGAACGTGCCAGAGAGGATTT
GAGTTCTACTTTGAACCTTGTTAAACCGATTATTGAAGACGTGAAAAATCGAGGGAACATGGCTCTTCGGGAATACACCA
GTAAGTTCGACAATGTCGCTCCGGATTCTTTTGTTTTAGACCTTTCCCGATTCAATCCTAAGATCGATTCGAAATTGGAG
CAGGCCCTGAAGAAAGCGGCGGAGAATATCAAAGCTTTCCATCAGATCCAAATTCCAGAAGATAAAGAAATCATAGTTCA
CGGAAATCGCCTCGGAATTCGCCATACTCCCGTCGAATCGGTTTCCGTTTATGCCCCTGGCGGAAAGGCGTTATATCCTT
CCACAATTTTGATGGGTGTCATTCCCGCTAAACTTGCGGGAGTAAAAAATATTCAAATCGTTACTCCTCCACAACAAGGT
TTTTTGCCGGATGGTCTTATCGCGGCCGCAAAGATTGCCGGTGCGGATCGTGTCATTCTTGCCGGAGGTGCGCAAGGAAT
TGCGGCGGTTTCTTATGGAACTGAAACGATTCCCGCCTCCGAATTTGTAATCGGCCCCGGCAGTAAATTCGTGACCGCTG
CGAAAGTTTTTTTGAGCGGTCAAGGTGTGATCGGTATCGACAGCCCCGCCGGTCCGAGTGAAGTTTTAGTAATTGCGGAC
GATTCCGCAAATCCTATTTGGGTGGCGTCGGATCTTTTATCCCAAGCCGAACATGGGGATGATTCGGTTGCGATCCTTTG
TACGGATTCCTTGTCCTTTGCTGAAAAGGTCCGTGTGGAAGTGGAGAGGGCTCTTTTGGAAAGGCCTAAACGAGGTGAGA
TGAAACGGAAATCCATCGAAGATTACGGAAGAATATTCGTTTTTCCTAATTTAGAAGAATGTTTTGCATTTTCGAATTTG
TTCGCGCCCGAACATTTGGAAATCCAAACGAGGAATTTTAAGGAAGACCTGAAAAGGGTTCGTCACGCGGGTTCCGTATT
TTTGGGAAATTATTCTCCCGTTGCCATGGGTGATTATATCAGCGGGACCAACCATATCCTCCCTACCGCGGGTGCCGCGA
GAATTTATTCTTCTCTCGGAGTTTCCACATTCTTAAAGAAAGTGACATGGCAGGAAGTTTCGAAGGAATCGCTCGAAGAT
CTTTATCCTCACGTCAAGGCCCTTTCCGAATTCGAAGGCCTCGACGAAGAACACGGAACCTCGGTAAAAATTAGAATTTG
A

Upstream 100 bases:

>100_bases
ATAGGCAAGGTGTAAATTGGATGAATTCTCTTCCAGGGCAATTGTTTTTTGGGTAAATTTCAGATGCAGGAACAGTTCTT
TCGGAAATTCTGGTTTTTTG

Downstream 100 bases:

>100_bases
ATATTATGATTATTTGTAGAACTCCAGAAGAGATTTCGGTTCAGGTCCGTAGGTGGAAGGCGGAGGATAAAAAGGTGGGT
TTTGTTCCCACAATGGGTTA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MAIQILQVGLKNRSVLNPILERAREDLSSTLNLVKPIIEDVKNRGNMALREYTSKFDNVAPDSFVLDLSRFNPKIDSKLE
QALKKAAENIKAFHQIQIPEDKEIIVHGNRLGIRHTPVESVSVYAPGGKALYPSTILMGVIPAKLAGVKNIQIVTPPQQG
FLPDGLIAAAKIAGADRVILAGGAQGIAAVSYGTETIPASEFVIGPGSKFVTAAKVFLSGQGVIGIDSPAGPSEVLVIAD
DSANPIWVASDLLSQAEHGDDSVAILCTDSLSFAEKVRVEVERALLERPKRGEMKRKSIEDYGRIFVFPNLEECFAFSNL
FAPEHLEIQTRNFKEDLKRVRHAGSVFLGNYSPVAMGDYISGTNHILPTAGAARIYSSLGVSTFLKKVTWQEVSKESLED
LYPHVKALSEFEGLDEEHGTSVKIRI

Sequences:

>Translated_426_residues
MAIQILQVGLKNRSVLNPILERAREDLSSTLNLVKPIIEDVKNRGNMALREYTSKFDNVAPDSFVLDLSRFNPKIDSKLE
QALKKAAENIKAFHQIQIPEDKEIIVHGNRLGIRHTPVESVSVYAPGGKALYPSTILMGVIPAKLAGVKNIQIVTPPQQG
FLPDGLIAAAKIAGADRVILAGGAQGIAAVSYGTETIPASEFVIGPGSKFVTAAKVFLSGQGVIGIDSPAGPSEVLVIAD
DSANPIWVASDLLSQAEHGDDSVAILCTDSLSFAEKVRVEVERALLERPKRGEMKRKSIEDYGRIFVFPNLEECFAFSNL
FAPEHLEIQTRNFKEDLKRVRHAGSVFLGNYSPVAMGDYISGTNHILPTAGAARIYSSLGVSTFLKKVTWQEVSKESLED
LYPHVKALSEFEGLDEEHGTSVKIRI
>Mature_425_residues
AIQILQVGLKNRSVLNPILERAREDLSSTLNLVKPIIEDVKNRGNMALREYTSKFDNVAPDSFVLDLSRFNPKIDSKLEQ
ALKKAAENIKAFHQIQIPEDKEIIVHGNRLGIRHTPVESVSVYAPGGKALYPSTILMGVIPAKLAGVKNIQIVTPPQQGF
LPDGLIAAAKIAGADRVILAGGAQGIAAVSYGTETIPASEFVIGPGSKFVTAAKVFLSGQGVIGIDSPAGPSEVLVIADD
SANPIWVASDLLSQAEHGDDSVAILCTDSLSFAEKVRVEVERALLERPKRGEMKRKSIEDYGRIFVFPNLEECFAFSNLF
APEHLEIQTRNFKEDLKRVRHAGSVFLGNYSPVAMGDYISGTNHILPTAGAARIYSSLGVSTFLKKVTWQEVSKESLEDL
YPHVKALSEFEGLDEEHGTSVKIRI

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=411, Percent_Identity=43.30900243309, Blast_Score=294, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6319819, Length=420, Percent_Identity=43.5714285714286, Blast_Score=300, Evalue=3e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46324; Mature: 46192

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQILQVGLKNRSVLNPILERAREDLSSTLNLVKPIIEDVKNRGNMALREYTSKFDNVA
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
PDSFVLDLSRFNPKIDSKLEQALKKAAENIKAFHQIQIPEDKEIIVHGNRLGIRHTPVES
CCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCEECCEECCCCC
VSVYAPGGKALYPSTILMGVIPAKLAGVKNIQIVTPPQQGFLPDGLIAAAKIAGADRVIL
EEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEE
AGGAQGIAAVSYGTETIPASEFVIGPGSKFVTAAKVFLSGQGVIGIDSPAGPSEVLVIAD
ECCCCCEEEEECCCCCCCCCCEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEC
DSANPIWVASDLLSQAEHGDDSVAILCTDSLSFAEKVRVEVERALLERPKRGEMKRKSIE
CCCCCEEEHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
DYGRIFVFPNLEECFAFSNLFAPEHLEIQTRNFKEDLKRVRHAGSVFLGNYSPVAMGDYI
CCCCEEEECCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCEEECCCCCEECCCCC
SGTNHILPTAGAARIYSSLGVSTFLKKVTWQEVSKESLEDLYPHVKALSEFEGLDEEHGT
CCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SVKIRI
EEEEEC
>Mature Secondary Structure 
AIQILQVGLKNRSVLNPILERAREDLSSTLNLVKPIIEDVKNRGNMALREYTSKFDNVA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
PDSFVLDLSRFNPKIDSKLEQALKKAAENIKAFHQIQIPEDKEIIVHGNRLGIRHTPVES
CCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCEECCEECCCCC
VSVYAPGGKALYPSTILMGVIPAKLAGVKNIQIVTPPQQGFLPDGLIAAAKIAGADRVIL
EEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEE
AGGAQGIAAVSYGTETIPASEFVIGPGSKFVTAAKVFLSGQGVIGIDSPAGPSEVLVIAD
ECCCCCEEEEECCCCCCCCCCEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEC
DSANPIWVASDLLSQAEHGDDSVAILCTDSLSFAEKVRVEVERALLERPKRGEMKRKSIE
CCCCCEEEHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
DYGRIFVFPNLEECFAFSNLFAPEHLEIQTRNFKEDLKRVRHAGSVFLGNYSPVAMGDYI
CCCCEEEECCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCEEECCCCCEECCCCC
SGTNHILPTAGAARIYSSLGVSTFLKKVTWQEVSKESLEDLYPHVKALSEFEGLDEEHGT
CCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SVKIRI
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA