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The map label for this gene is panC

Identifier: 116328534

GI number: 116328534

Start: 2201550

End: 2202407

Strand: Reverse

Name: panC

Synonym: LBL_1886

Alternate gene names: 116328534

Gene position: 2202407-2201550 (Counterclockwise)

Preceding gene: 116328535

Following gene: 116328533

Centisome position: 60.93

GC content: 44.29

Gene sequence:

>858_bases
ATGATTATTTGTAGAACTCCAGAAGAGATTTCGGTTCAGGTCCGTAGGTGGAAGGCGGAGGATAAAAAGGTGGGTTTTGT
TCCCACAATGGGTTATCTTCACGAAGGCCACGCAAGTTTGTTCAGGGAATGCCTGTCCAAGGCGGATAAAACCGTAGTTT
CGATTTTCGTGAATCCCGCTCAGTTCAACGATCCAGAAGATTATGCGAAGTATCCGATCAATACGGACGGGGATCTGAAA
ATCTGCGAATCCGGTAAAGTGGATCTTGTTTTTTTGCCCGAAAAGGAAACGATATATCCAGAAGGAATTCCGAATGTCGT
ATTACAAGTTCCTCATTTAATGAGAAATCTTTGTGCGGTTTCCAGGCCGGGCCATTTCGAAGGTGTGCTTCTTGTGATCT
CTAGGCTGTTTCACTTCGTGAAGCCTGATTTTGCGTTTTTTGGTAAAAAAGATTATCAACAATATCTTCTCGTCAAAGAG
TTTTGTAAAATTCTCGCGTTTCCGGTCGAAGTTATTGGCTGTGAAACGATTCGTTCCGATAAAGGATTGGCTCTCAGTTC
CAGAAATTCCCGCCTGAGTGAGGACGAGAAAGAGGAGTCTCTTTTGATCTCCAGAGCCTTGAAACTAGGGGAAGCTCAGA
TTCTTTCCGGAATAAAAGATCCGGTCGTAGTTCGGGATATCATGAAGGACGTTTTGGATTCTTCGCCTAAGATTCGTCTG
GATTACTTGGAAGTTTTGAATGCGGATACTTTAGAGTCTTTGGAGATTTTAGAGGGGAATATCCTTCTTGCAGCCGCCGT
TTTTATCGGGTCCGTGCGTCTGATCGACAATCGAACCTTACGCGTGGCTTCTGTATGA

Upstream 100 bases:

>100_bases
AATCGCTCGAAGATCTTTATCCTCACGTCAAGGCCCTTTCCGAATTCGAAGGCCTCGACGAAGAACACGGAACCTCGGTA
AAAATTAGAATTTGAATATT

Downstream 100 bases:

>100_bases
AAGATCTTCTTCGAATCATAGGAGAAGGATTGTTTGCTCGGTTTGAATTTTCTTTTCCTGCAAAAAAGAACCCTGCTCGA
AAGGTAAAGGCCGCCGCCGC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MIICRTPEEISVQVRRWKAEDKKVGFVPTMGYLHEGHASLFRECLSKADKTVVSIFVNPAQFNDPEDYAKYPINTDGDLK
ICESGKVDLVFLPEKETIYPEGIPNVVLQVPHLMRNLCAVSRPGHFEGVLLVISRLFHFVKPDFAFFGKKDYQQYLLVKE
FCKILAFPVEVIGCETIRSDKGLALSSRNSRLSEDEKEESLLISRALKLGEAQILSGIKDPVVVRDIMKDVLDSSPKIRL
DYLEVLNADTLESLEILEGNILLAAAVFIGSVRLIDNRTLRVASV

Sequences:

>Translated_285_residues
MIICRTPEEISVQVRRWKAEDKKVGFVPTMGYLHEGHASLFRECLSKADKTVVSIFVNPAQFNDPEDYAKYPINTDGDLK
ICESGKVDLVFLPEKETIYPEGIPNVVLQVPHLMRNLCAVSRPGHFEGVLLVISRLFHFVKPDFAFFGKKDYQQYLLVKE
FCKILAFPVEVIGCETIRSDKGLALSSRNSRLSEDEKEESLLISRALKLGEAQILSGIKDPVVVRDIMKDVLDSSPKIRL
DYLEVLNADTLESLEILEGNILLAAAVFIGSVRLIDNRTLRVASV
>Mature_285_residues
MIICRTPEEISVQVRRWKAEDKKVGFVPTMGYLHEGHASLFRECLSKADKTVVSIFVNPAQFNDPEDYAKYPINTDGDLK
ICESGKVDLVFLPEKETIYPEGIPNVVLQVPHLMRNLCAVSRPGHFEGVLLVISRLFHFVKPDFAFFGKKDYQQYLLVKE
FCKILAFPVEVIGCETIRSDKGLALSSRNSRLSEDEKEESLLISRALKLGEAQILSGIKDPVVVRDIMKDVLDSSPKIRL
DYLEVLNADTLESLEILEGNILLAAAVFIGSVRLIDNRTLRVASV

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=291, Percent_Identity=38.1443298969072, Blast_Score=197, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322046, Length=311, Percent_Identity=34.7266881028939, Blast_Score=153, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_LEPBJ (Q04S98)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_800980.1
- ProteinModelPortal:   Q04S98
- SMR:   Q04S98
- STRING:   Q04S98
- GeneID:   4410795
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_1667
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   Q04S98
- ProtClustDB:   PRK00380
- BioCyc:   LBOR355277:LBJ_1667-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32039; Mature: 32039

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 154-154 BINDING 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIICRTPEEISVQVRRWKAEDKKVGFVPTMGYLHEGHASLFRECLSKADKTVVSIFVNPA
CEEECCCHHHHHHHHEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCEEEEEEECCC
QFNDPEDYAKYPINTDGDLKICESGKVDLVFLPEKETIYPEGIPNVVLQVPHLMRNLCAV
CCCCCHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
SRPGHFEGVLLVISRLFHFVKPDFAFFGKKDYQQYLLVKEFCKILAFPVEVIGCETIRSD
CCCCCHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KGLALSSRNSRLSEDEKEESLLISRALKLGEAQILSGIKDPVVVRDIMKDVLDSSPKIRL
CCCEECCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEE
DYLEVLNADTLESLEILEGNILLAAAVFIGSVRLIDNRTLRVASV
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCEEEECCCEEEEECC
>Mature Secondary Structure
MIICRTPEEISVQVRRWKAEDKKVGFVPTMGYLHEGHASLFRECLSKADKTVVSIFVNPA
CEEECCCHHHHHHHHEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCEEEEEEECCC
QFNDPEDYAKYPINTDGDLKICESGKVDLVFLPEKETIYPEGIPNVVLQVPHLMRNLCAV
CCCCCHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
SRPGHFEGVLLVISRLFHFVKPDFAFFGKKDYQQYLLVKEFCKILAFPVEVIGCETIRSD
CCCCCHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KGLALSSRNSRLSEDEKEESLLISRALKLGEAQILSGIKDPVVVRDIMKDVLDSSPKIRL
CCCEECCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEE
DYLEVLNADTLESLEILEGNILLAAAVFIGSVRLIDNRTLRVASV
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCEEEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA