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The map label for this gene is caiA-3 [H]

Identifier: 116328517

GI number: 116328517

Start: 2175203

End: 2176960

Strand: Direct

Name: caiA-3 [H]

Synonym: LBL_1867

Alternate gene names: 116328517

Gene position: 2175203-2176960 (Clockwise)

Preceding gene: 116328516

Following gene: 116328520

Centisome position: 60.18

GC content: 44.6

Gene sequence:

>1758_bases
ATGATCGAGAATAATTACTTTTTAGAAAATCAAGACTTACAGGAAAACTTCCAATCCATCGCAAACTGGAAGGAAATCAT
AGACGGCTTCGAAGGGGATTTTGAGGATCATAAAGAATATCAAAAAACCGGAAAAGAATCCCTGACAATGGCGCCCGGAT
CTTACGAAGATGCATTAGAATATTATAAATCTATTTTAGAATCTGGAGGGGATATCGCGGGCAAACAAATCGCACCACTT
GCAAAGGATATGGATATAGAAGGTCTGAAATATTCTTCCGGAAAGGTCACGTTTCCAAATTCGATGGCCAAAGGAATCAA
CCAAGTCAAAGACGCCGGGATTCTCCCCTATAGCATCGGAAGAAAACATGGAGGACTCGGAATTCCCGCGACCGTTCAAA
CTATGATGATGGAAGTATTTTCCAGAGCGGACGGCTCCTTTGCAATCGCACTCGGATGTCTCAACCTGGCAGAAACCATA
GAGCGTTTCGGTTCCAAAGAAATGGTGAAAGAATACGTTCCTAAAATGGCAAATGGAGAAGTTTTCGGAGCAATGGCTTT
GACCGAACCAAACTACGGATCGGATCTCCCGAATCTTCAAACCAAAGCGGTAAAAGACGAAAACGGAGTCTGGAGACTCA
CAGGCACCAAACGTTTCATCACGCACGGTTGCGGGTTCGGAGATATTCCTGCGGTAATTTTAACTCTTGCAAGAACCGGA
ACTCCCACGAGCGGAGCCCGCGGTCTTTCCTTCTTCTTGGTAAAAAGCTCCGACGTTTTTATCGCAGGAATCGAAAAGAA
AATGGGGCTTCACTGTTCTCCGACTTGCGAAGTAGTTTATGAAAACTCTCCCGGAATTCTTATCGGAGAAGAAGGTTACG
GTTTGATTCGTTATTCCATGGCGATGATGAACGGTGCAAGACTTTCGATCGCCGCTCAAGCGATGGGAATCGCTACGGCG
GCTTATATGGAAGCGAAAAAATACGCTTCCGAAAGAGAACAGTTCGGAAAAACGATCCAAAATATCCCCGCCGTTCGTAG
AATGCTTTCCTGTATGGATCGCGAAATCGCGGGAATGAGAGCCGTTCTGCTGGAAGCGTCCCGTTCCATCGACCTTTATC
ACTGGAAGTCGGAAAGAATGAAGGAAAAAGGTATCGACGAACGTGATATCAAAAAAGATGAAACGATTCGTAAATGGGAA
AAACTGGCGAACCTTTTTACTCCATTATCGAAGTATTATATTACAGAAGCCGCAAATAAGATCGCATACGACGGCCTTCA
GATCCACGGAGGAGCGGGATTTACCTACGACTACGACATTTCCAGAATCTACAGAGACGTGAGAATCACAAACATCTACG
AAGGAACAACACAACTCCAAATCGTAGCGGCCATTGGTGGGATCGTATCCGGCATGTCTGCAAAGGGACATTTACGCCAG
TATTTCGAAGAAGAATTCTCCAAAATCAGTGTTTCCTCTTTGTTAAACGAAAACAAAGAGACTCTTGAAAAAATCGTAGA
ATCCTATTCCGCTATCGAAAATTCCTCCACAAGGGACGAGGTCGCTTTCGAGGTGGTCCAGTCCACTGCGCGGGTTTTAA
TCGGATTCCTTCTAGAAAGAGGCGCTTCAAGACTAAAAGGAGAAGCCAAAGAAAAAAAGGGAATTCTCGCCAAAGAATAC
AACTTGGAATCCAAGGCAATCCTTCTCTCCAATCGTATTACAATTGAGAATCGCCAATCTCAATTGACATACGCCTAA

Upstream 100 bases:

>100_bases
CGTCCGATAAAAAGAATTTCGATTTCCATAAGCACAACGCAAACCCTGAGTGGTAAAGAAACTAAAACGCATTGGAACAA
AAGTTTATAAAGGATTTAAA

Downstream 100 bases:

>100_bases
ACTCAAAAATTACACGAACATGCGGGTCTCCTTACCAATTTCAACGTTATATCGCTTATTGGTAAGGAGTATTGCGAGTT
GCGAATCACTGTCTTACGTT

Product: Acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MIENNYFLENQDLQENFQSIANWKEIIDGFEGDFEDHKEYQKTGKESLTMAPGSYEDALEYYKSILESGGDIAGKQIAPL
AKDMDIEGLKYSSGKVTFPNSMAKGINQVKDAGILPYSIGRKHGGLGIPATVQTMMMEVFSRADGSFAIALGCLNLAETI
ERFGSKEMVKEYVPKMANGEVFGAMALTEPNYGSDLPNLQTKAVKDENGVWRLTGTKRFITHGCGFGDIPAVILTLARTG
TPTSGARGLSFFLVKSSDVFIAGIEKKMGLHCSPTCEVVYENSPGILIGEEGYGLIRYSMAMMNGARLSIAAQAMGIATA
AYMEAKKYASEREQFGKTIQNIPAVRRMLSCMDREIAGMRAVLLEASRSIDLYHWKSERMKEKGIDERDIKKDETIRKWE
KLANLFTPLSKYYITEAANKIAYDGLQIHGGAGFTYDYDISRIYRDVRITNIYEGTTQLQIVAAIGGIVSGMSAKGHLRQ
YFEEEFSKISVSSLLNENKETLEKIVESYSAIENSSTRDEVAFEVVQSTARVLIGFLLERGASRLKGEAKEKKGILAKEY
NLESKAILLSNRITIENRQSQLTYA

Sequences:

>Translated_585_residues
MIENNYFLENQDLQENFQSIANWKEIIDGFEGDFEDHKEYQKTGKESLTMAPGSYEDALEYYKSILESGGDIAGKQIAPL
AKDMDIEGLKYSSGKVTFPNSMAKGINQVKDAGILPYSIGRKHGGLGIPATVQTMMMEVFSRADGSFAIALGCLNLAETI
ERFGSKEMVKEYVPKMANGEVFGAMALTEPNYGSDLPNLQTKAVKDENGVWRLTGTKRFITHGCGFGDIPAVILTLARTG
TPTSGARGLSFFLVKSSDVFIAGIEKKMGLHCSPTCEVVYENSPGILIGEEGYGLIRYSMAMMNGARLSIAAQAMGIATA
AYMEAKKYASEREQFGKTIQNIPAVRRMLSCMDREIAGMRAVLLEASRSIDLYHWKSERMKEKGIDERDIKKDETIRKWE
KLANLFTPLSKYYITEAANKIAYDGLQIHGGAGFTYDYDISRIYRDVRITNIYEGTTQLQIVAAIGGIVSGMSAKGHLRQ
YFEEEFSKISVSSLLNENKETLEKIVESYSAIENSSTRDEVAFEVVQSTARVLIGFLLERGASRLKGEAKEKKGILAKEY
NLESKAILLSNRITIENRQSQLTYA
>Mature_585_residues
MIENNYFLENQDLQENFQSIANWKEIIDGFEGDFEDHKEYQKTGKESLTMAPGSYEDALEYYKSILESGGDIAGKQIAPL
AKDMDIEGLKYSSGKVTFPNSMAKGINQVKDAGILPYSIGRKHGGLGIPATVQTMMMEVFSRADGSFAIALGCLNLAETI
ERFGSKEMVKEYVPKMANGEVFGAMALTEPNYGSDLPNLQTKAVKDENGVWRLTGTKRFITHGCGFGDIPAVILTLARTG
TPTSGARGLSFFLVKSSDVFIAGIEKKMGLHCSPTCEVVYENSPGILIGEEGYGLIRYSMAMMNGARLSIAAQAMGIATA
AYMEAKKYASEREQFGKTIQNIPAVRRMLSCMDREIAGMRAVLLEASRSIDLYHWKSERMKEKGIDERDIKKDETIRKWE
KLANLFTPLSKYYITEAANKIAYDGLQIHGGAGFTYDYDISRIYRDVRITNIYEGTTQLQIVAAIGGIVSGMSAKGHLRQ
YFEEEFSKISVSSLLNENKETLEKIVESYSAIENSSTRDEVAFEVVQSTARVLIGFLLERGASRLKGEAKEKKGILAKEY
NLESKAILLSNRITIENRQSQLTYA

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=355, Percent_Identity=30.7042253521127, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI4557233, Length=417, Percent_Identity=28.7769784172662, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI4501859, Length=397, Percent_Identity=27.9596977329975, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI4557235, Length=376, Percent_Identity=29.2553191489362, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI76496475, Length=376, Percent_Identity=29.2553191489362, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI21361497, Length=400, Percent_Identity=26.25, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI7656849, Length=424, Percent_Identity=26.1792452830189, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI226958412, Length=363, Percent_Identity=26.7217630853994, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI226958414, Length=363, Percent_Identity=26.7217630853994, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI4557231, Length=420, Percent_Identity=26.9047619047619, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI187960098, Length=420, Percent_Identity=26.9047619047619, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=25.1322751322751, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI7669494, Length=358, Percent_Identity=25.1396648044693, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=30.3664921465969, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1786223, Length=363, Percent_Identity=24.7933884297521, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87082384, Length=281, Percent_Identity=27.4021352313167, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=418, Percent_Identity=26.0765550239234, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17538396, Length=399, Percent_Identity=28.0701754385965, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17506239, Length=393, Percent_Identity=25.1908396946565, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17534899, Length=366, Percent_Identity=28.1420765027322, Blast_Score=115, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17569725, Length=371, Percent_Identity=29.1105121293801, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71985184, Length=436, Percent_Identity=25.6880733944954, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17533517, Length=403, Percent_Identity=24.8138957816377, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17570075, Length=365, Percent_Identity=27.1232876712329, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI86563383, Length=444, Percent_Identity=26.8018018018018, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=444, Percent_Identity=26.8018018018018, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71990804, Length=270, Percent_Identity=27.4074074074074, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17534353, Length=322, Percent_Identity=24.8447204968944, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71982178, Length=288, Percent_Identity=27.4305555555556, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI32563615, Length=234, Percent_Identity=25.6410256410256, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71985192, Length=219, Percent_Identity=30.1369863013699, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551932, Length=313, Percent_Identity=25.5591054313099, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17505929, Length=305, Percent_Identity=24.2622950819672, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666513, Length=406, Percent_Identity=30.0492610837438, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21356377, Length=417, Percent_Identity=28.2973621103118, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646207, Length=409, Percent_Identity=26.4058679706601, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=30.3430079155673, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21355753, Length=396, Percent_Identity=26.2626262626263, Blast_Score=119, Evalue=9e-27,
Organism=Drosophila melanogaster, GI281363737, Length=379, Percent_Identity=27.1767810026385, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=25.9067357512953, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 64877; Mature: 64877

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIENNYFLENQDLQENFQSIANWKEIIDGFEGDFEDHKEYQKTGKESLTMAPGSYEDALE
CCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEECCCCHHHHHH
YYKSILESGGDIAGKQIAPLAKDMDIEGLKYSSGKVTFPNSMAKGINQVKDAGILPYSIG
HHHHHHHCCCCCCCCHHCCHHHCCCCCCEEECCCCEECCHHHHHHHHHHHHCCCCCHHHC
RKHGGLGIPATVQTMMMEVFSRADGSFAIALGCLNLAETIERFGSKEMVKEYVPKMANGE
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCC
VFGAMALTEPNYGSDLPNLQTKAVKDENGVWRLTGTKRFITHGCGFGDIPAVILTLARTG
EEEEEEECCCCCCCCCCCCCHHHEECCCCEEEEECCHHHHHCCCCCCCHHHHHHHHHHCC
TPTSGARGLSFFLVKSSDVFIAGIEKKMGLHCSPTCEVVYENSPGILIGEEGYGLIRYSM
CCCCCCCCEEEEEEECCCEEEEECHHHCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHH
AMMNGARLSIAAQAMGIATAAYMEAKKYASEREQFGKTIQNIPAVRRMLSCMDREIAGMR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVLLEASRSIDLYHWKSERMKEKGIDERDIKKDETIRKWEKLANLFTPLSKYYITEAANK
HHHHHHCCCCEEEECHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYDGLQIHGGAGFTYDYDISRIYRDVRITNIYEGTTQLQIVAAIGGIVSGMSAKGHLRQ
HEECCEEEECCCCCEEECHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHH
YFEEEFSKISVSSLLNENKETLEKIVESYSAIENSSTRDEVAFEVVQSTARVLIGFLLER
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GASRLKGEAKEKKGILAKEYNLESKAILLSNRITIENRQSQLTYA
HHHHHCCCHHHHCCCEEECCCCCCCEEEEECCEEEECCCCCCCCC
>Mature Secondary Structure
MIENNYFLENQDLQENFQSIANWKEIIDGFEGDFEDHKEYQKTGKESLTMAPGSYEDALE
CCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEECCCCHHHHHH
YYKSILESGGDIAGKQIAPLAKDMDIEGLKYSSGKVTFPNSMAKGINQVKDAGILPYSIG
HHHHHHHCCCCCCCCHHCCHHHCCCCCCEEECCCCEECCHHHHHHHHHHHHCCCCCHHHC
RKHGGLGIPATVQTMMMEVFSRADGSFAIALGCLNLAETIERFGSKEMVKEYVPKMANGE
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCC
VFGAMALTEPNYGSDLPNLQTKAVKDENGVWRLTGTKRFITHGCGFGDIPAVILTLARTG
EEEEEEECCCCCCCCCCCCCHHHEECCCCEEEEECCHHHHHCCCCCCCHHHHHHHHHHCC
TPTSGARGLSFFLVKSSDVFIAGIEKKMGLHCSPTCEVVYENSPGILIGEEGYGLIRYSM
CCCCCCCCEEEEEEECCCEEEEECHHHCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHH
AMMNGARLSIAAQAMGIATAAYMEAKKYASEREQFGKTIQNIPAVRRMLSCMDREIAGMR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVLLEASRSIDLYHWKSERMKEKGIDERDIKKDETIRKWEKLANLFTPLSKYYITEAANK
HHHHHHCCCCEEEECHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYDGLQIHGGAGFTYDYDISRIYRDVRITNIYEGTTQLQIVAAIGGIVSGMSAKGHLRQ
HEECCEEEECCCCCEEECHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHH
YFEEEFSKISVSSLLNENKETLEKIVESYSAIENSSTRDEVAFEVVQSTARVLIGFLLER
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GASRLKGEAKEKKGILAKEYNLESKAILLSNRITIENRQSQLTYA
HHHHHCCCHHHHCCCEEECCCCCCCEEEEECCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]