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The map label for this gene is caiA-2 [H]

Identifier: 116328457

GI number: 116328457

Start: 2095344

End: 2096474

Strand: Reverse

Name: caiA-2 [H]

Synonym: LBL_1801

Alternate gene names: 116328457

Gene position: 2096474-2095344 (Counterclockwise)

Preceding gene: 116328458

Following gene: 116328456

Centisome position: 58.0

GC content: 42.44

Gene sequence:

>1131_bases
ATGAATAGAATTCTTCAGTTCACGGAAGAGCATGAGACTTTCCGTGCGATGGCGAGAAAGTTTTTTGAGACGGAAGTTGC
TCCGAATCATGAATCTTGGGAAAAAGTAGGGGTTGTTCCGAAGGAAATTTGGAAAAAAGCGGGTGCGAACGGTCTTTTAT
GTCCGGATATTCCCGTGGAATACGGCGGAGCCGGAGCCGATTTTTTGTATAATGTAGTCGTAATTGAGGAATCTTCCCGA
GTTGGAAACAGTGGATTTTTCATTTCTCTACATAACGACGTAATTGCACCTTATGTTTCGACTTACGCGAACGAGGAGCA
AAAAAAACGTTGGTTGCCTGGTTGTGCAACCGGTGACAGTATTCTTGCCATTGCCATGACTGAGCCGGGAGCCGGTTCCG
ATTTGAAAAATATCAGAACTTCCGCTGTTGAAAAAAGCGATCATTACGTAGTAAATGGACAAAAAACCTTCATTTCCAAC
GGACAATTAGCAAATTTAATCATCACGGCTGTTAAACATAATAACGGTACGATGTCTCTTCTTATGGTAGAAGAGGGAAT
GAAAGGTTTTGAAAGAGGAAGAAGATTAGAAAAGATTGGTTTAAAGGCTCAGGATACTTCGGAATTGTATTACAACGACG
TAATCGTTCCAAAGGAAAACTTGATCGGAAAACAAGGCCAAGGTTTTCGTTACCTCATGCAAAAGTTAGCTACGGAGCGA
TTAGTTCTTTCCATCGCAGCCGTAGAAGCAACTGCACTTGTACAAAAAATTACCCTTCAATACATCAAGGAAAGACAGGC
CTTCGGAAAGAAAATCGGAACCTTTCAGAATATCAAATTTAAGATGGCTGAAATGGCGACGGAACTAGAGATGTGCCGTA
CTTTTGTCGATAAGGTTACTCTGGAAACGATAGCCGGAAGATCGAATACCGCAGAAGCTTCGATGGCAAAGTGGTATTCT
ACCGAGATGCAAAAACGTCATACGGATGAATGTTTGCAGTTCTTCGGCGGTTATGGTTACATGATGGAGTATCCGATCGC
TAGAGCGTATTTGGATGCCAGAATCCAAACAATTTATGCGGGGACAACGGAAATTATGAAAGAGATCATAGGTAGAAGCC
TAGGGCTCTGA

Upstream 100 bases:

>100_bases
ATATTCCATTCAGCAGAATGATTTGATCGATTACGTGAAGAAGAATCCTGGCGTTTACATGCGAATGAATACGGTCTATT
CGTAGACGCAGGAGAAATAA

Downstream 100 bases:

>100_bases
AAGAAATTTCTAGCGCTCCCCGTCCAATAAAAATGGGGTAATAATGAATACCTGCCACAATTCAATGATAAGAAAAATTT
TTCCTATCGTATTCCTTTCT

Product: Acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MNRILQFTEEHETFRAMARKFFETEVAPNHESWEKVGVVPKEIWKKAGANGLLCPDIPVEYGGAGADFLYNVVVIEESSR
VGNSGFFISLHNDVIAPYVSTYANEEQKKRWLPGCATGDSILAIAMTEPGAGSDLKNIRTSAVEKSDHYVVNGQKTFISN
GQLANLIITAVKHNNGTMSLLMVEEGMKGFERGRRLEKIGLKAQDTSELYYNDVIVPKENLIGKQGQGFRYLMQKLATER
LVLSIAAVEATALVQKITLQYIKERQAFGKKIGTFQNIKFKMAEMATELEMCRTFVDKVTLETIAGRSNTAEASMAKWYS
TEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYAGTTEIMKEIIGRSLGL

Sequences:

>Translated_376_residues
MNRILQFTEEHETFRAMARKFFETEVAPNHESWEKVGVVPKEIWKKAGANGLLCPDIPVEYGGAGADFLYNVVVIEESSR
VGNSGFFISLHNDVIAPYVSTYANEEQKKRWLPGCATGDSILAIAMTEPGAGSDLKNIRTSAVEKSDHYVVNGQKTFISN
GQLANLIITAVKHNNGTMSLLMVEEGMKGFERGRRLEKIGLKAQDTSELYYNDVIVPKENLIGKQGQGFRYLMQKLATER
LVLSIAAVEATALVQKITLQYIKERQAFGKKIGTFQNIKFKMAEMATELEMCRTFVDKVTLETIAGRSNTAEASMAKWYS
TEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYAGTTEIMKEIIGRSLGL
>Mature_376_residues
MNRILQFTEEHETFRAMARKFFETEVAPNHESWEKVGVVPKEIWKKAGANGLLCPDIPVEYGGAGADFLYNVVVIEESSR
VGNSGFFISLHNDVIAPYVSTYANEEQKKRWLPGCATGDSILAIAMTEPGAGSDLKNIRTSAVEKSDHYVVNGQKTFISN
GQLANLIITAVKHNNGTMSLLMVEEGMKGFERGRRLEKIGLKAQDTSELYYNDVIVPKENLIGKQGQGFRYLMQKLATER
LVLSIAAVEATALVQKITLQYIKERQAFGKKIGTFQNIKFKMAEMATELEMCRTFVDKVTLETIAGRSNTAEASMAKWYS
TEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYAGTTEIMKEIIGRSLGL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=43.8502673796791, Blast_Score=344, Evalue=7e-95,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=34.3915343915344, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=35.9649122807018, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=31.4666666666667, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=31.8181818181818, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=31.9148936170213, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=31.9148936170213, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=29.8666666666667, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI21361497, Length=375, Percent_Identity=31.4666666666667, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI76496475, Length=375, Percent_Identity=29.8666666666667, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI4557235, Length=378, Percent_Identity=29.6296296296296, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4503943, Length=385, Percent_Identity=26.7532467532467, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI7669494, Length=291, Percent_Identity=27.8350515463918, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI211971008, Length=283, Percent_Identity=28.2685512367491, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI48976061, Length=283, Percent_Identity=28.2685512367491, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI38505218, Length=355, Percent_Identity=25.9154929577465, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI87081958, Length=376, Percent_Identity=29.5212765957447, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1786223, Length=377, Percent_Identity=23.8726790450928, Blast_Score=126, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=33.8624338624339, Blast_Score=217, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=385, Percent_Identity=31.4285714285714, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17533517, Length=365, Percent_Identity=33.1506849315069, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=30.952380952381, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17551932, Length=377, Percent_Identity=32.3607427055703, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=30.5263157894737, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=26.8817204301075, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17505929, Length=377, Percent_Identity=31.0344827586207, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=27.2237196765499, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=31.7689530685921, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71985184, Length=359, Percent_Identity=29.8050139275766, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=26.790450928382, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=30.9859154929577, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=26.9090909090909, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32563615, Length=227, Percent_Identity=27.3127753303965, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=25.5230125523013, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17562446, Length=286, Percent_Identity=26.9230769230769, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=25.5681818181818, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=31.9371727748691, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=31.4666666666667, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=32.8912466843501, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=29.7587131367292, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=29.8941798941799, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI281363737, Length=368, Percent_Identity=28.804347826087, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=27.4611398963731, Blast_Score=117, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42146; Mature: 42146

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRILQFTEEHETFRAMARKFFETEVAPNHESWEKVGVVPKEIWKKAGANGLLCPDIPVE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHCCCCCCCCCCCCCC
YGGAGADFLYNVVVIEESSRVGNSGFFISLHNDVIAPYVSTYANEEQKKRWLPGCATGDS
CCCCCHHHEEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCCCC
ILAIAMTEPGAGSDLKNIRTSAVEKSDHYVVNGQKTFISNGQLANLIITAVKHNNGTMSL
EEEEEEECCCCCCHHHHHHHHHHCCCCCEEECCCEEEECCCCEEEEEEEEEECCCCCEEE
LMVEEGMKGFERGRRLEKIGLKAQDTSELYYNDVIVPKENLIGKQGQGFRYLMQKLATER
EEEHHHHHHHHHCCHHHHHCCCCCCCCHHHCCCEECCCHHHCCCCCCCHHHHHHHHHHHH
LVLSIAAVEATALVQKITLQYIKERQAFGKKIGTFQNIKFKMAEMATELEMCRTFVDKVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LETIAGRSNTAEASMAKWYSTEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYA
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GTTEIMKEIIGRSLGL
CHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNRILQFTEEHETFRAMARKFFETEVAPNHESWEKVGVVPKEIWKKAGANGLLCPDIPVE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHCCCCCCCCCCCCCC
YGGAGADFLYNVVVIEESSRVGNSGFFISLHNDVIAPYVSTYANEEQKKRWLPGCATGDS
CCCCCHHHEEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCCCC
ILAIAMTEPGAGSDLKNIRTSAVEKSDHYVVNGQKTFISNGQLANLIITAVKHNNGTMSL
EEEEEEECCCCCCHHHHHHHHHHCCCCCEEECCCEEEECCCCEEEEEEEEEECCCCCEEE
LMVEEGMKGFERGRRLEKIGLKAQDTSELYYNDVIVPKENLIGKQGQGFRYLMQKLATER
EEEHHHHHHHHHCCHHHHHCCCCCCCCHHHCCCEECCCHHHCCCCCCCHHHHHHHHHHHH
LVLSIAAVEATALVQKITLQYIKERQAFGKKIGTFQNIKFKMAEMATELEMCRTFVDKVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LETIAGRSNTAEASMAKWYSTEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYA
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GTTEIMKEIIGRSLGL
CHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]