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The map label for this gene is serA [H]

Identifier: 116328383

GI number: 116328383

Start: 2005237

End: 2006460

Strand: Direct

Name: serA [H]

Synonym: LBL_1720

Alternate gene names: 116328383

Gene position: 2005237-2006460 (Clockwise)

Preceding gene: 116328381

Following gene: 116328384

Centisome position: 55.48

GC content: 42.08

Gene sequence:

>1224_bases
ATGATTTCATTTCCAAAAGATAAGATCAATGTTCTCCTTCTCGAAAACGTTCACCAAGACGCATTTGATATGTTCCGGAA
AGACGGCTTTAATGTGCGCCTTCTCTCCGCCGCCTATTCGGAAAAAGAACTTCTGAACGAAATTGAAAGCATACACGTTT
TAGGAATTCGAAGTAAGACCAACGTAACTCCTTCCGTTTTAGAAAAAGCCAAAAGACTTTTGACAATCGGTTGTTTTTGC
ATCGGGACCAACCAGGTAGATCTTTCCGGAGCGGAAAAAAAAGGAATTCCAGTATTCAATGCCCCTTACTCCAACACTCG
TTCCGTGGCAGAACTCGTGATTTCCGAAATCATTATGCTCGCCAGAAGAGTTCCAGATCATATTCGAAACACTCATTCCG
GAATTTGGAACAAAATTTCAAAAAATTGTTTCGAAGTTCGAGGTAAAACGATCGGAATCGTAGGTTACGGTCATATCGGA
AGCCAAGTCTCCGTTCTCGCAGAAGCGATGGGAATGAAAGTCATCTACTACGACGTCCAAACGGTTCTTCCCCTCGGAAA
CGCAACTCCGGTCGAAAGTTATCAGGAACTTTTGAAGAACTCGGATTTCATCACATTCCACGTCCCGGAAACTCCTCAAA
CGATGAATCTCTACGGAAAAAAAGAAATCGAGATCACCAAAAAAGGCGCATACATGATTAACCTTTCCAGAGGAAAAGTT
GTAGATCTGGAAGCACTTGCAGAAGCAATCAAATCCGGTCATATCTCTGGAGCGGGAATAGACGTTTTTCCACAAGAACC
CGAATCCAACAACGATCCGTTTTTAACCCCGATGCAAAATCTGCCTAATGTGATTCTTACGCCGCATATAGGAGGCAGCA
CCGAAGAAGCACAAAAAAACATCGGTTCCGAAGTCGCGAGCAAACTTTTAAAATTCGTAAATAACGGTTCGACTACGTTC
TCGGTAAATTTTCCAAATCTGGAAATCACCCCATTACCGTCCGGTCAGTATAGAATTCTAAACGTTCATAAAAACCAACC
CGGCTTCTTAAAAGACATCAACTCTATGGTTTCTGAAATCGGCGCAAATATCAGCTCCCAAAATTTGGGAACCAGCGCGG
AAATCGGTTATTTATCGATGGTGATCGACAAATCTGTTGGAGACGAACTCAAGGAAAAAATCGAAAAACATCCGTTTTCA
ATTAAAACTCGAATTCTTTATTAG

Upstream 100 bases:

>100_bases
TCGTCTTTGAAGAGCTTTTCTCAAACTAGGATTTTTTCCGTAACAAGCCAAGCAAAATTCAATTTTCAGAGAATCGCATT
CTTGAAATCTTGGTAGGTAA

Downstream 100 bases:

>100_bases
AGTTGTTGAAAAATTAGTTCTCCATTCGTTTCTGTTTCATGAAAACGATTGATTGCAGCAGTTTTGTTAAACTGAACTAT
GAAATTTTTCAACAACTCTA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MISFPKDKINVLLLENVHQDAFDMFRKDGFNVRLLSAAYSEKELLNEIESIHVLGIRSKTNVTPSVLEKAKRLLTIGCFC
IGTNQVDLSGAEKKGIPVFNAPYSNTRSVAELVISEIIMLARRVPDHIRNTHSGIWNKISKNCFEVRGKTIGIVGYGHIG
SQVSVLAEAMGMKVIYYDVQTVLPLGNATPVESYQELLKNSDFITFHVPETPQTMNLYGKKEIEITKKGAYMINLSRGKV
VDLEALAEAIKSGHISGAGIDVFPQEPESNNDPFLTPMQNLPNVILTPHIGGSTEEAQKNIGSEVASKLLKFVNNGSTTF
SVNFPNLEITPLPSGQYRILNVHKNQPGFLKDINSMVSEIGANISSQNLGTSAEIGYLSMVIDKSVGDELKEKIEKHPFS
IKTRILY

Sequences:

>Translated_407_residues
MISFPKDKINVLLLENVHQDAFDMFRKDGFNVRLLSAAYSEKELLNEIESIHVLGIRSKTNVTPSVLEKAKRLLTIGCFC
IGTNQVDLSGAEKKGIPVFNAPYSNTRSVAELVISEIIMLARRVPDHIRNTHSGIWNKISKNCFEVRGKTIGIVGYGHIG
SQVSVLAEAMGMKVIYYDVQTVLPLGNATPVESYQELLKNSDFITFHVPETPQTMNLYGKKEIEITKKGAYMINLSRGKV
VDLEALAEAIKSGHISGAGIDVFPQEPESNNDPFLTPMQNLPNVILTPHIGGSTEEAQKNIGSEVASKLLKFVNNGSTTF
SVNFPNLEITPLPSGQYRILNVHKNQPGFLKDINSMVSEIGANISSQNLGTSAEIGYLSMVIDKSVGDELKEKIEKHPFS
IKTRILY
>Mature_407_residues
MISFPKDKINVLLLENVHQDAFDMFRKDGFNVRLLSAAYSEKELLNEIESIHVLGIRSKTNVTPSVLEKAKRLLTIGCFC
IGTNQVDLSGAEKKGIPVFNAPYSNTRSVAELVISEIIMLARRVPDHIRNTHSGIWNKISKNCFEVRGKTIGIVGYGHIG
SQVSVLAEAMGMKVIYYDVQTVLPLGNATPVESYQELLKNSDFITFHVPETPQTMNLYGKKEIEITKKGAYMINLSRGKV
VDLEALAEAIKSGHISGAGIDVFPQEPESNNDPFLTPMQNLPNVILTPHIGGSTEEAQKNIGSEVASKLLKFVNNGSTTF
SVNFPNLEITPLPSGQYRILNVHKNQPGFLKDINSMVSEIGANISSQNLGTSAEIGYLSMVIDKSVGDELKEKIEKHPFS
IKTRILY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=286, Percent_Identity=36.7132867132867, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI4557497, Length=261, Percent_Identity=30.2681992337165, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI61743967, Length=261, Percent_Identity=30.2681992337165, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI145580578, Length=257, Percent_Identity=30.3501945525292, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI4557499, Length=257, Percent_Identity=30.3501945525292, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI145580575, Length=261, Percent_Identity=30.2681992337165, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI6912396, Length=276, Percent_Identity=31.5217391304348, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1789279, Length=409, Percent_Identity=50.1222493887531, Blast_Score=430, Evalue=1e-121,
Organism=Escherichia coli, GI87082289, Length=260, Percent_Identity=30.7692307692308, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1787645, Length=253, Percent_Identity=30.0395256916996, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788660, Length=274, Percent_Identity=30.6569343065693, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87081824, Length=195, Percent_Identity=28.7179487179487, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=319, Percent_Identity=34.1692789968652, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI25147481, Length=259, Percent_Identity=30.1158301158301, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=418, Percent_Identity=48.3253588516746, Blast_Score=400, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322116, Length=418, Percent_Identity=48.0861244019139, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6324964, Length=251, Percent_Identity=32.6693227091633, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=227, Percent_Identity=28.1938325991189, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324980, Length=193, Percent_Identity=33.6787564766839, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=178, Percent_Identity=30.8988764044944, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=155, Percent_Identity=29.6774193548387, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=318, Percent_Identity=29.2452830188679, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI28574286, Length=278, Percent_Identity=30.5755395683453, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646446, Length=272, Percent_Identity=30.8823529411765, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24646448, Length=272, Percent_Identity=30.8823529411765, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24646452, Length=272, Percent_Identity=30.8823529411765, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24646450, Length=272, Percent_Identity=30.8823529411765, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI62472511, Length=272, Percent_Identity=30.8823529411765, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45551003, Length=304, Percent_Identity=25.6578947368421, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574284, Length=304, Percent_Identity=25.6578947368421, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585514, Length=304, Percent_Identity=25.6578947368421, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28574282, Length=304, Percent_Identity=25.6578947368421, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45552429, Length=304, Percent_Identity=25.6578947368421, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585516, Length=305, Percent_Identity=25.5737704918033, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28571528, Length=276, Percent_Identity=28.2608695652174, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44875; Mature: 44875

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISFPKDKINVLLLENVHQDAFDMFRKDGFNVRLLSAAYSEKELLNEIESIHVLGIRSKT
CCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHEEEEEECCCC
NVTPSVLEKAKRLLTIGCFCIGTNQVDLSGAEKKGIPVFNAPYSNTRSVAELVISEIIML
CCCHHHHHHHHHHHEEEEEEEECCEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHH
ARRVPDHIRNTHSGIWNKISKNCFEVRGKTIGIVGYGHIGSQVSVLAEAMGMKVIYYDVQ
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEEHH
TVLPLGNATPVESYQELLKNSDFITFHVPETPQTMNLYGKKEIEITKKGAYMINLSRGKV
HHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCEECCCCEEEEEEECCEEEEEECCCCE
VDLEALAEAIKSGHISGAGIDVFPQEPESNNDPFLTPMQNLPNVILTPHIGGSTEEAQKN
EEHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCEECCHHHCCCEEEECCCCCCHHHHHHH
IGSEVASKLLKFVNNGSTTFSVNFPNLEITPLPSGQYRILNVHKNQPGFLKDINSMVSEI
HHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHH
GANISSQNLGTSAEIGYLSMVIDKSVGDELKEKIEKHPFSIKTRILY
CCCCCCCCCCCCCCCCHHHEEHHHHCCHHHHHHHHHCCCEEEEEEEC
>Mature Secondary Structure
MISFPKDKINVLLLENVHQDAFDMFRKDGFNVRLLSAAYSEKELLNEIESIHVLGIRSKT
CCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHEEEEEECCCC
NVTPSVLEKAKRLLTIGCFCIGTNQVDLSGAEKKGIPVFNAPYSNTRSVAELVISEIIML
CCCHHHHHHHHHHHEEEEEEEECCEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHH
ARRVPDHIRNTHSGIWNKISKNCFEVRGKTIGIVGYGHIGSQVSVLAEAMGMKVIYYDVQ
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEEHH
TVLPLGNATPVESYQELLKNSDFITFHVPETPQTMNLYGKKEIEITKKGAYMINLSRGKV
HHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCEECCCCEEEEEEECCEEEEEECCCCE
VDLEALAEAIKSGHISGAGIDVFPQEPESNNDPFLTPMQNLPNVILTPHIGGSTEEAQKN
EEHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCEECCHHHCCCEEEECCCCCCHHHHHHH
IGSEVASKLLKFVNNGSTTFSVNFPNLEITPLPSGQYRILNVHKNQPGFLKDINSMVSEI
HHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHH
GANISSQNLGTSAEIGYLSMVIDKSVGDELKEKIEKHPFSIKTRILY
CCCCCCCCCCCCCCCCHHHEEHHHHCCHHHHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]