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The map label for this gene is hldE [H]

Identifier: 116328340

GI number: 116328340

Start: 1956562

End: 1957575

Strand: Reverse

Name: hldE [H]

Synonym: LBL_1677

Alternate gene names: 116328340

Gene position: 1957575-1956562 (Counterclockwise)

Preceding gene: 116328342

Following gene: 116328339

Centisome position: 54.16

GC content: 41.91

Gene sequence:

>1014_bases
TTGTACTATTTGAATAGAGATCGTTTTCTGACCTCAACCACGCGTCTCAAAGATTTAAAGATCATCGTGATCGGAGATTT
CATTTTGGACGAGTATCTCATCGGAGAAGTGAATCGAATTTCTCCGGAAGCTCCCGTCCCAGTCGTTTGGGTTCGTAAGG
AGAAGATCACATTAGGCGGGGCCGGAAACGTAGTGAAGAACTTATCAAGTTTAGGTGTAAAGTCTATCGTTCTTGGAAGA
GTCGGAAACGATGAAAAAGCGAAAAGTCTTTCTAAACTTCTCATGAATGAGAATACGGATAAAAGCCAAAATTTTCTGAT
CGAATCTGAGGAGATACCGACGATTTTAAAAACAAGGGTGATCGCGGGACACCAGCAAGTTTGTCGAATCGATAAGGAAG
AACTAAAACCGATCAATCAAAAAGAGGAAGAACTGCTACTCGAAGCATTTTTGGAAAGAATCGACTTCGTAGACGCGGTA
ATTCTTTCCGATTATGATAAAGGAACCTTAACACCGAGAATCATCCGGGAAGTATCTAAAATTTGTTCGGATAAAAAAAA
GATCGTGACAGTGGATCCCCAGGTGAGTCATTTTTTTCTGTATCAAGGTGTAAGTATCCTCACTCCGAATCACCACGAAG
CGGGTAGAGCGATCGGAAGAAAATTGGAAAACGATTCCGAAATCTTAAACGCAGCACGGGAAATTTCCGAAAAACTTTCC
TGTTTTTCTTTAATGATCACAAGAGGAGAAAAGGGAATGAGTTTATATCTTTCTTCTCAAAAAGAAATCTATCATATTCC
AACCGCAGCGAGAGAAGTCTTTGACGTAACCGGAGCGGGGGATACGGTCATCAGTGCTTATACAGCCTATTATGCAGCGG
GTCTTAGCGAGTTGGATGCAAGCGTGGTAGCAAACGCTGCGGCGGGAGTTGTAATCGCAAAATTAGGAGCGGAAACCGTG
ACTCCCGAAGAATTAGATCTTTCTTTGCAATCTATGGGAAGTTTTCAAAAGTAA

Upstream 100 bases:

>100_bases
CCGGCAGTGGAAAGATTGGGACAGTAATGATTGACACGGGAAGGCTACTATAACTGCTTAGAGAGAAACCGTAAATCAAA
ATCCCAAGGATCGGTAGAAT

Downstream 100 bases:

>100_bases
AGATGGATTTGAAGACCCGTATTGTTCCTTGGGAAAACGTGGCGATTTTTGCGAACCGAATTCGAGAAAATCGAAGAATT
GTTTTCACCAATGGATGTTT

Product: ADP-heptose synthase, sugar kinase component

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MYYLNRDRFLTSTTRLKDLKIIVIGDFILDEYLIGEVNRISPEAPVPVVWVRKEKITLGGAGNVVKNLSSLGVKSIVLGR
VGNDEKAKSLSKLLMNENTDKSQNFLIESEEIPTILKTRVIAGHQQVCRIDKEELKPINQKEEELLLEAFLERIDFVDAV
ILSDYDKGTLTPRIIREVSKICSDKKKIVTVDPQVSHFFLYQGVSILTPNHHEAGRAIGRKLENDSEILNAAREISEKLS
CFSLMITRGEKGMSLYLSSQKEIYHIPTAAREVFDVTGAGDTVISAYTAYYAAGLSELDASVVANAAAGVVIAKLGAETV
TPEELDLSLQSMGSFQK

Sequences:

>Translated_337_residues
MYYLNRDRFLTSTTRLKDLKIIVIGDFILDEYLIGEVNRISPEAPVPVVWVRKEKITLGGAGNVVKNLSSLGVKSIVLGR
VGNDEKAKSLSKLLMNENTDKSQNFLIESEEIPTILKTRVIAGHQQVCRIDKEELKPINQKEEELLLEAFLERIDFVDAV
ILSDYDKGTLTPRIIREVSKICSDKKKIVTVDPQVSHFFLYQGVSILTPNHHEAGRAIGRKLENDSEILNAAREISEKLS
CFSLMITRGEKGMSLYLSSQKEIYHIPTAAREVFDVTGAGDTVISAYTAYYAAGLSELDASVVANAAAGVVIAKLGAETV
TPEELDLSLQSMGSFQK
>Mature_337_residues
MYYLNRDRFLTSTTRLKDLKIIVIGDFILDEYLIGEVNRISPEAPVPVVWVRKEKITLGGAGNVVKNLSSLGVKSIVLGR
VGNDEKAKSLSKLLMNENTDKSQNFLIESEEIPTILKTRVIAGHQQVCRIDKEELKPINQKEEELLLEAFLERIDFVDAV
ILSDYDKGTLTPRIIREVSKICSDKKKIVTVDPQVSHFFLYQGVSILTPNHHEAGRAIGRKLENDSEILNAAREISEKLS
CFSLMITRGEKGMSLYLSSQKEIYHIPTAAREVFDVTGAGDTVISAYTAYYAAGLSELDASVVANAAAGVVIAKLGAETV
TPEELDLSLQSMGSFQK

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=306, Percent_Identity=39.8692810457516, Blast_Score=196, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 37292; Mature: 37292

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYLNRDRFLTSTTRLKDLKIIVIGDFILDEYLIGEVNRISPEAPVPVVWVRKEKITLGG
CCEECCCCEEECCCCCCEEEEEEEEHHHHHHHHHCCHHCCCCCCCCCEEEEEEEEEEECC
AGNVVKNLSSLGVKSIVLGRVGNDEKAKSLSKLLMNENTDKSQNFLIESEEIPTILKTRV
CCHHHHHHHHCCHHHHEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHH
IAGHQQVCRIDKEELKPINQKEEELLLEAFLERIDFVDAVILSDYDKGTLTPRIIREVSK
HHCCHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ICSDKKKIVTVDPQVSHFFLYQGVSILTPNHHEAGRAIGRKLENDSEILNAAREISEKLS
HHCCCCEEEEECCCHHHHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CFSLMITRGEKGMSLYLSSQKEIYHIPTAAREVFDVTGAGDTVISAYTAYYAAGLSELDA
HHHHHHHCCCCCEEEEEECCCEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHH
SVVANAAAGVVIAKLGAETVTPEELDLSLQSMGSFQK
HHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MYYLNRDRFLTSTTRLKDLKIIVIGDFILDEYLIGEVNRISPEAPVPVVWVRKEKITLGG
CCEECCCCEEECCCCCCEEEEEEEEHHHHHHHHHCCHHCCCCCCCCCEEEEEEEEEEECC
AGNVVKNLSSLGVKSIVLGRVGNDEKAKSLSKLLMNENTDKSQNFLIESEEIPTILKTRV
CCHHHHHHHHCCHHHHEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHH
IAGHQQVCRIDKEELKPINQKEEELLLEAFLERIDFVDAVILSDYDKGTLTPRIIREVSK
HHCCHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ICSDKKKIVTVDPQVSHFFLYQGVSILTPNHHEAGRAIGRKLENDSEILNAAREISEKLS
HHCCCCEEEEECCCHHHHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CFSLMITRGEKGMSLYLSSQKEIYHIPTAAREVFDVTGAGDTVISAYTAYYAAGLSELDA
HHHHHHHCCCCCEEEEEECCCEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHH
SVVANAAAGVVIAKLGAETVTPEELDLSLQSMGSFQK
HHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA