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The map label for this gene is fmt

Identifier: 116328326

GI number: 116328326

Start: 1941305

End: 1942252

Strand: Reverse

Name: fmt

Synonym: LBL_1663

Alternate gene names: 116328326

Gene position: 1942252-1941305 (Counterclockwise)

Preceding gene: 116328327

Following gene: 116328325

Centisome position: 53.74

GC content: 43.35

Gene sequence:

>948_bases
ATGAAAATCGGATACTTTGGAACTCCAGAACATTCCGCAAAACTTTTAAAAGCTCTGATCGATTCTACACTTGCTGAAGT
TTTGTTTGTCGTCACCAATCCTGATCGTCCGAAAGGAAGGAATAAAAAAACCGAAGCCGGTCCGGTAAAAAAAACCGCGC
TTGAACATCATATTCCCGTATTTCAATACGAATCTATTAAAAGGGAAAAAGAAAAAGCCCTTTCTGACTTCGGCTCTTTT
CCTGCGGATCTCTATGTGGTCTTCGCCTATGGATCCATTCTTCCCAAGGAAGTATATGAGTGTCCGCCTTTGTCTTCCAT
CAACTTGCACGGATCTTTGTTGCCGGATCTGCGTGGAGCTTCCCCCGTTCAAACCGCACTTTGGAAAGGTTACAGCGCAT
CCGGGATCACGATTCAATACATCGGGGAGAAAATGGACGAAGGTGATATTCTTTTATCCCAGAAGATCGACATCATCCCG
GAGGATAATACGGAAACCTTGATGAATAAAATCACAGATGCAGGAACCGAATCGATTCTTCGATTATTGAAGGCATATGA
TGGAAAACCGTTTCCTGCCATTCCTCAAAATCACGCTAAAGCGACGTATTGCGGAAAAATCAAATCGGAAGATAGAATTT
TAGATTGGTCTCTCGGGGCGGAGGAACTGCACAATCGAATCCGAGCCTTATACCCAGATGCGATTGCAACAACTCGGTTT
CGCGAAAAAAGAATAGGCATTTTAAAAACAAAGCTCTCTTCTTTGTCTATCGAATCGAATCCGGAACCTGGCAAGTTGAA
ACGGTTGGACAAAAAAGGCCTTCTTACGCAGTGTGGTGATGGTAGATTTCTGGAAATTCTCGAATTACAACCGGAAAATA
AAAACAGGATGTCTGCATCCGATTTTCTCAACGGTTTCAGAATCCAGGAAGGGGAAACATTCGGGTGA

Upstream 100 bases:

>100_bases
GGCGATTGGAGGGAAATTTTTAAAAAAGAAGTTCGTCCTCTGAAACTTTCGAAAAAAGTGTATTTAGAAATTGATTTCGA
TCCTTTGGATCTGGTGTAAC

Downstream 100 bases:

>100_bases
ATCAGGAACAAATCAAAGAAAAGTATCTTCCGATCGGAGGTTACATCTTATTCTTAGCGGTCGGTCTCCTTTTATTTTTT
AGCGCGGCTTTCCTAATCGT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MKIGYFGTPEHSAKLLKALIDSTLAEVLFVVTNPDRPKGRNKKTEAGPVKKTALEHHIPVFQYESIKREKEKALSDFGSF
PADLYVVFAYGSILPKEVYECPPLSSINLHGSLLPDLRGASPVQTALWKGYSASGITIQYIGEKMDEGDILLSQKIDIIP
EDNTETLMNKITDAGTESILRLLKAYDGKPFPAIPQNHAKATYCGKIKSEDRILDWSLGAEELHNRIRALYPDAIATTRF
REKRIGILKTKLSSLSIESNPEPGKLKRLDKKGLLTQCGDGRFLEILELQPENKNRMSASDFLNGFRIQEGETFG

Sequences:

>Translated_315_residues
MKIGYFGTPEHSAKLLKALIDSTLAEVLFVVTNPDRPKGRNKKTEAGPVKKTALEHHIPVFQYESIKREKEKALSDFGSF
PADLYVVFAYGSILPKEVYECPPLSSINLHGSLLPDLRGASPVQTALWKGYSASGITIQYIGEKMDEGDILLSQKIDIIP
EDNTETLMNKITDAGTESILRLLKAYDGKPFPAIPQNHAKATYCGKIKSEDRILDWSLGAEELHNRIRALYPDAIATTRF
REKRIGILKTKLSSLSIESNPEPGKLKRLDKKGLLTQCGDGRFLEILELQPENKNRMSASDFLNGFRIQEGETFG
>Mature_315_residues
MKIGYFGTPEHSAKLLKALIDSTLAEVLFVVTNPDRPKGRNKKTEAGPVKKTALEHHIPVFQYESIKREKEKALSDFGSF
PADLYVVFAYGSILPKEVYECPPLSSINLHGSLLPDLRGASPVQTALWKGYSASGITIQYIGEKMDEGDILLSQKIDIIP
EDNTETLMNKITDAGTESILRLLKAYDGKPFPAIPQNHAKATYCGKIKSEDRILDWSLGAEELHNRIRALYPDAIATTRF
REKRIGILKTKLSSLSIESNPEPGKLKRLDKKGLLTQCGDGRFLEILELQPENKNRMSASDFLNGFRIQEGETFG

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=291, Percent_Identity=29.553264604811, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI238814322, Length=290, Percent_Identity=29.6551724137931, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI164663775, Length=322, Percent_Identity=25.4658385093168, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1789683, Length=308, Percent_Identity=38.6363636363636, Blast_Score=199, Evalue=1e-52,
Organism=Escherichia coli, GI1788589, Length=314, Percent_Identity=26.1146496815287, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI133930964, Length=305, Percent_Identity=25.5737704918033, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550868, Length=309, Percent_Identity=31.7152103559871, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28571984, Length=227, Percent_Identity=33.920704845815, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24585660, Length=319, Percent_Identity=27.5862068965517, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_LEPBJ (Q04SV8)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_800770.1
- ProteinModelPortal:   Q04SV8
- SMR:   Q04SV8
- STRING:   Q04SV8
- GeneID:   4411535
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_1439
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- PhylomeDB:   Q04SV8
- ProtClustDB:   CLSK574385
- BioCyc:   LBOR355277:LBJ_1439-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 35107; Mature: 35107

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGYFGTPEHSAKLLKALIDSTLAEVLFVVTNPDRPKGRNKKTEAGPVKKTALEHHIPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCC
FQYESIKREKEKALSDFGSFPADLYVVFAYGSILPKEVYECPPLSSINLHGSLLPDLRGA
HHHHHHHHHHHHHHHHHCCCCHHHEEEEHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCC
SPVQTALWKGYSASGITIQYIGEKMDEGDILLSQKIDIIPEDNTETLMNKITDAGTESIL
CHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCHHHHH
RLLKAYDGKPFPAIPQNHAKATYCGKIKSEDRILDWSLGAEELHNRIRALYPDAIATTRF
HHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHH
REKRIGILKTKLSSLSIESNPEPGKLKRLDKKGLLTQCGDGRFLEILELQPENKNRMSAS
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEECCCCCEEEEEEECCCCCCCCCHH
DFLNGFRIQEGETFG
HHHCCCEECCCCCCC
>Mature Secondary Structure
MKIGYFGTPEHSAKLLKALIDSTLAEVLFVVTNPDRPKGRNKKTEAGPVKKTALEHHIPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCC
FQYESIKREKEKALSDFGSFPADLYVVFAYGSILPKEVYECPPLSSINLHGSLLPDLRGA
HHHHHHHHHHHHHHHHHCCCCHHHEEEEHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCC
SPVQTALWKGYSASGITIQYIGEKMDEGDILLSQKIDIIPEDNTETLMNKITDAGTESIL
CHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCHHHHH
RLLKAYDGKPFPAIPQNHAKATYCGKIKSEDRILDWSLGAEELHNRIRALYPDAIATTRF
HHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHH
REKRIGILKTKLSSLSIESNPEPGKLKRLDKKGLLTQCGDGRFLEILELQPENKNRMSAS
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEECCCCCEEEEEEECCCCCCCCCHH
DFLNGFRIQEGETFG
HHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA