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The map label for this gene is czcD-2 [H]

Identifier: 116328261

GI number: 116328261

Start: 1862107

End: 1863069

Strand: Reverse

Name: czcD-2 [H]

Synonym: LBL_1589

Alternate gene names: 116328261

Gene position: 1863069-1862107 (Counterclockwise)

Preceding gene: 116328262

Following gene: 116328259

Centisome position: 51.55

GC content: 39.67

Gene sequence:

>963_bases
ATGGATGATTTTTTTCAACTTCATCATGTAGAAAGAAGCCAGGAGAAAGGGCTGAAAAGATCGATCCTGCTAGCGATTTT
AGTCTCTTTTTCCATCTTTCTAGTAGAGTTGTTCGGGGGGATCCAAAGTGGAAGTATCGCCCTTCTTGCCGATGCGGGTC
ATATCATTACAGATGTGATCGCATTGTCCTTATCTCTGATCGCCGTGCTGCTCGCTTCTCAAAAACCGAATCATCGATTT
TCCTTCGGTTATTATCGAATCGAAATACTGACTTCTCTTCTCAATTCGATTTTAATTTTCGGGATTTCGTTTTATATTTT
TTACGAAGCCACGGAAAGATTTCAAAATCAAAAAGAGGTTTTGAGTTTTCCTATGATCTTTTACAGTGTTTCCGGAATCG
TTCTCAATCTAATCAGCGCTTGGATCTTGTTTCGTTTTAGCGCCGAAAACATCAATATCAAATCGGCTTATATTCACGTT
TTAAGCGATCTTCTTTCCACTGCGGGTGTTTTAATCGGTTCCATTTTGATTTATCTTACGAACTGGAACTGGCTTGATCC
TTTGATCAGCATCTTGATTTCGATTTTGATTTTACGTTCCGCTTGGGGAATTTTTCAGGAAAGTATTTCCATTCTCTTGG
AATCTTCGCCTCAAACATTCGAAATTTTGCATATTCTAGAACACATTCGTGAAATCGAAGGAATTCGTCAAATTTTGGAC
TATCATTTTTGGGCGATCACCAGAGGAGTTTACGCTTGTACTTTAAAAGTCTCGGTTGTCGATCTGAAACATACGGAAGG
AGTCATTTTCAATTCCAATCGAATCTTAAAATCAAAATTCGGGATCGATTACATTACCATTCAGTGCGAAACTCCGGCTC
TAATTGAAAAAATCCAAGGGTTACCTCTCGCAGATTCTCGCGGGACCCAGGAACACGGCCATGGACATTTCCACCCACAT
TAA

Upstream 100 bases:

>100_bases
CTCTAGCAGGTTATGGAGAATTCCAACCAATCGTTTCCAACGACACTCCTGAAAATAGGGCTCTCAATCGTAGAGTGGAC
ATTGTAGTCGTTCCACGTTG

Downstream 100 bases:

>100_bases
AATTTATTCACTTAAAGAAACGCCGGTCTCCTACATTTCGAAATAAAACCAAAGCCGATTTTTCCAAGGATCTAAAACAG
AAATATACTTTGAATCCTGA

Product: Co/Zn/Cd efflux system component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MDDFFQLHHVERSQEKGLKRSILLAILVSFSIFLVELFGGIQSGSIALLADAGHIITDVIALSLSLIAVLLASQKPNHRF
SFGYYRIEILTSLLNSILIFGISFYIFYEATERFQNQKEVLSFPMIFYSVSGIVLNLISAWILFRFSAENINIKSAYIHV
LSDLLSTAGVLIGSILIYLTNWNWLDPLISILISILILRSAWGIFQESISILLESSPQTFEILHILEHIREIEGIRQILD
YHFWAITRGVYACTLKVSVVDLKHTEGVIFNSNRILKSKFGIDYITIQCETPALIEKIQGLPLADSRGTQEHGHGHFHPH

Sequences:

>Translated_320_residues
MDDFFQLHHVERSQEKGLKRSILLAILVSFSIFLVELFGGIQSGSIALLADAGHIITDVIALSLSLIAVLLASQKPNHRF
SFGYYRIEILTSLLNSILIFGISFYIFYEATERFQNQKEVLSFPMIFYSVSGIVLNLISAWILFRFSAENINIKSAYIHV
LSDLLSTAGVLIGSILIYLTNWNWLDPLISILISILILRSAWGIFQESISILLESSPQTFEILHILEHIREIEGIRQILD
YHFWAITRGVYACTLKVSVVDLKHTEGVIFNSNRILKSKFGIDYITIQCETPALIEKIQGLPLADSRGTQEHGHGHFHPH
>Mature_320_residues
MDDFFQLHHVERSQEKGLKRSILLAILVSFSIFLVELFGGIQSGSIALLADAGHIITDVIALSLSLIAVLLASQKPNHRF
SFGYYRIEILTSLLNSILIFGISFYIFYEATERFQNQKEVLSFPMIFYSVSGIVLNLISAWILFRFSAENINIKSAYIHV
LSDLLSTAGVLIGSILIYLTNWNWLDPLISILISILILRSAWGIFQESISILLESSPQTFEILHILEHIREIEGIRQILD
YHFWAITRGVYACTLKVSVVDLKHTEGVIFNSNRILKSKFGIDYITIQCETPALIEKIQGLPLADSRGTQEHGHGHFHPH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=328, Percent_Identity=28.3536585365854, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI21359890, Length=307, Percent_Identity=24.1042345276873, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI52352805, Length=295, Percent_Identity=24.0677966101695, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI21361112, Length=318, Percent_Identity=24.5283018867925, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI289803013, Length=309, Percent_Identity=26.537216828479, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI289803009, Length=309, Percent_Identity=26.537216828479, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI289803007, Length=309, Percent_Identity=26.537216828479, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI289803003, Length=309, Percent_Identity=26.537216828479, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI64762489, Length=309, Percent_Identity=26.537216828479, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI14210520, Length=217, Percent_Identity=23.5023041474654, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI222080086, Length=144, Percent_Identity=25.6944444444444, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI40255009, Length=144, Percent_Identity=25.6944444444444, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI52351208, Length=205, Percent_Identity=24.8780487804878, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786966, Length=278, Percent_Identity=36.3309352517986, Blast_Score=153, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI193210990, Length=314, Percent_Identity=25.1592356687898, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17555794, Length=302, Percent_Identity=24.5033112582781, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17555796, Length=300, Percent_Identity=24.6666666666667, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32564488, Length=306, Percent_Identity=27.1241830065359, Blast_Score=117, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6320411, Length=175, Percent_Identity=30.8571428571429, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=125, Percent_Identity=29.6, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324892, Length=148, Percent_Identity=28.3783783783784, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583858, Length=358, Percent_Identity=22.3463687150838, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24585900, Length=140, Percent_Identity=29.2857142857143, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585898, Length=140, Percent_Identity=29.2857142857143, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585896, Length=140, Percent_Identity=29.2857142857143, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921672, Length=140, Percent_Identity=29.2857142857143, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24645863, Length=143, Percent_Identity=27.972027972028, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24584409, Length=135, Percent_Identity=28.1481481481481, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574430, Length=135, Percent_Identity=28.1481481481481, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36214; Mature: 36214

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00511 CRF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDFFQLHHVERSQEKGLKRSILLAILVSFSIFLVELFGGIQSGSIALLADAGHIITDVI
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHH
ALSLSLIAVLLASQKPNHRFSFGYYRIEILTSLLNSILIFGISFYIFYEATERFQNQKEV
HHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LSFPMIFYSVSGIVLNLISAWILFRFSAENINIKSAYIHVLSDLLSTAGVLIGSILIYLT
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NWNWLDPLISILISILILRSAWGIFQESISILLESSPQTFEILHILEHIREIEGIRQILD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
YHFWAITRGVYACTLKVSVVDLKHTEGVIFNSNRILKSKFGIDYITIQCETPALIEKIQG
HHHHHHHHCCEEEEEEEEEEEEECCCCEEECCCCEEHHHCCCEEEEEEECCHHHHHHHCC
LPLADSRGTQEHGHGHFHPH
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDDFFQLHHVERSQEKGLKRSILLAILVSFSIFLVELFGGIQSGSIALLADAGHIITDVI
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHH
ALSLSLIAVLLASQKPNHRFSFGYYRIEILTSLLNSILIFGISFYIFYEATERFQNQKEV
HHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LSFPMIFYSVSGIVLNLISAWILFRFSAENINIKSAYIHVLSDLLSTAGVLIGSILIYLT
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NWNWLDPLISILISILILRSAWGIFQESISILLESSPQTFEILHILEHIREIEGIRQILD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
YHFWAITRGVYACTLKVSVVDLKHTEGVIFNSNRILKSKFGIDYITIQCETPALIEKIQG
HHHHHHHHCCEEEEEEEEEEEEECCCCEEECCCCEEHHHCCCEEEEEEECCHHHHHHHCC
LPLADSRGTQEHGHGHFHPH
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]