Click here to switch to the map view.

The map label for this gene is thrB [H]

Identifier: 116328108

GI number: 116328108

Start: 1639500

End: 1640465

Strand: Direct

Name: thrB [H]

Synonym: LBL_1406

Alternate gene names: 116328108

Gene position: 1639500-1640465 (Clockwise)

Preceding gene: 116328106

Following gene: 116328111

Centisome position: 45.36

GC content: 41.1

Gene sequence:

>966_bases
ATGCCTTCGATTCGACAATATTCCATTCGCGTTCCGGGAACCTCGGCCAATTTAGGGTCGGGTTTTGATCTTTTTGGTCT
TGCGTTTCGAGTCTACAACCGATTTCAATTTCAATTCATTCCCGAAAGGGGATTTAAAACCTCTGTAAAGGGGATGGAGA
CTCTTCCTTTCGATCCCGATGAAGATCTTGTTCTATTTTCGTACCAATCCTATTTTAGAAGATTTTTACCTGGTGTTGAA
CCGCGTCCGTATTCCCTACTTATGGATCTCGAACTTCCGATAAAAGGAGGGCTCGGTTCTAGTGCGAGTGCGGCCGTAGC
CGGAGTCTGTGCCGCGAGATTTGCACATCAGAATTTTTATTCTATGATTCCTCTCCCTAAGGAAAACGAATTTCTGTTTC
ATCTCGGGCAGATCGAAGGGCATCCGGATAATACGATTCCTGCTTATTTGGGCGGTTTTGTATTTGCCTATTTCAATGGA
AACCGTTTGGAATATGTTAAAAAGAAATTTCCAAAGAAGATACGTTGTTTTTTGATCGTACCGAATTTGGAAACTTCCAC
GCATCAATCTAGAAAAACTCTCCCCGGTTCTTATTCCACCGAGGACGTAATTTTTAATATGGGCCGCATCGCTACATGGA
TGGAATTTTTGGATTCGGGTAAAATTTCTCTTTTGAAACTTGCTTTGGAAGATCGAATTCATACACCGTATCGAATGCAC
TCCGGGTTTGAATTAAACCCACTTTTGGCCGAGATAAGTAAGAATTTAATCGGACATTCTCTTTCTGGAAGTGGTCCTTC
CGTTCTTTTATTTTCCGAGAGAAACAAAGCGATTCGGATAGAAAAAATTCTCAAAGAAAAGGTCGCCGAGTTCGTTCAAA
AAACTCATTTCGATTGCCAGCTTCTTTCCTTAAAAGTGGAGGAGGATGGAATTTTGGAATCCTGGAAGAATATTCAAATT
TTATAA

Upstream 100 bases:

>100_bases
TCTGGATTCTGGAAAACGAAAATCAAATGACGATTTGATTCGGAGAGAAATTGTGGTCGTAGTTTTTTACGATCGTTTTG
TTGATCTACTTTCATTTTTT

Downstream 100 bases:

>100_bases
TGTTTATAAGTATGTCAAATCTACTTCTAAAAAAAGAACGAACTAAAAATCAATTACACGACGTCTGAAAAATTCTACGT
TTCCATTTCGTACTGTCCTT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MPSIRQYSIRVPGTSANLGSGFDLFGLAFRVYNRFQFQFIPERGFKTSVKGMETLPFDPDEDLVLFSYQSYFRRFLPGVE
PRPYSLLMDLELPIKGGLGSSASAAVAGVCAARFAHQNFYSMIPLPKENEFLFHLGQIEGHPDNTIPAYLGGFVFAYFNG
NRLEYVKKKFPKKIRCFLIVPNLETSTHQSRKTLPGSYSTEDVIFNMGRIATWMEFLDSGKISLLKLALEDRIHTPYRMH
SGFELNPLLAEISKNLIGHSLSGSGPSVLLFSERNKAIRIEKILKEKVAEFVQKTHFDCQLLSLKVEEDGILESWKNIQI
L

Sequences:

>Translated_321_residues
MPSIRQYSIRVPGTSANLGSGFDLFGLAFRVYNRFQFQFIPERGFKTSVKGMETLPFDPDEDLVLFSYQSYFRRFLPGVE
PRPYSLLMDLELPIKGGLGSSASAAVAGVCAARFAHQNFYSMIPLPKENEFLFHLGQIEGHPDNTIPAYLGGFVFAYFNG
NRLEYVKKKFPKKIRCFLIVPNLETSTHQSRKTLPGSYSTEDVIFNMGRIATWMEFLDSGKISLLKLALEDRIHTPYRMH
SGFELNPLLAEISKNLIGHSLSGSGPSVLLFSERNKAIRIEKILKEKVAEFVQKTHFDCQLLSLKVEEDGILESWKNIQI
L
>Mature_320_residues
PSIRQYSIRVPGTSANLGSGFDLFGLAFRVYNRFQFQFIPERGFKTSVKGMETLPFDPDEDLVLFSYQSYFRRFLPGVEP
RPYSLLMDLELPIKGGLGSSASAAVAGVCAARFAHQNFYSMIPLPKENEFLFHLGQIEGHPDNTIPAYLGGFVFAYFNGN
RLEYVKKKFPKKIRCFLIVPNLETSTHQSRKTLPGSYSTEDVIFNMGRIATWMEFLDSGKISLLKLALEDRIHTPYRMHS
GFELNPLLAEISKNLIGHSLSGSGPSVLLFSERNKAIRIEKILKEKVAEFVQKTHFDCQLLSLKVEEDGILESWKNIQIL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=313, Percent_Identity=24.6006389776358, Blast_Score=85, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321814, Length=361, Percent_Identity=26.3157894736842, Blast_Score=116, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 36406; Mature: 36274

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSIRQYSIRVPGTSANLGSGFDLFGLAFRVYNRFQFQFIPERGFKTSVKGMETLPFDPD
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCC
EDLVLFSYQSYFRRFLPGVEPRPYSLLMDLELPIKGGLGSSASAAVAGVCAARFAHQNFY
CCEEEEHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHH
SMIPLPKENEFLFHLGQIEGHPDNTIPAYLGGFVFAYFNGNRLEYVKKKFPKKIRCFLIV
HCCCCCCCCCEEEEEECCCCCCCCCHHHHHCCEEEEEECCCCHHHHHHHCCCEEEEEEEE
PNLETSTHQSRKTLPGSYSTEDVIFNMGRIATWMEFLDSGKISLLKLALEDRIHTPYRMH
CCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHEEHHHHCCCCEECC
SGFELNPLLAEISKNLIGHSLSGSGPSVLLFSERNKAIRIEKILKEKVAEFVQKTHFDCQ
CCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCEE
LLSLKVEEDGILESWKNIQIL
EEEEEECCCCHHHCCCCEECC
>Mature Secondary Structure 
PSIRQYSIRVPGTSANLGSGFDLFGLAFRVYNRFQFQFIPERGFKTSVKGMETLPFDPD
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCC
EDLVLFSYQSYFRRFLPGVEPRPYSLLMDLELPIKGGLGSSASAAVAGVCAARFAHQNFY
CCEEEEHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHH
SMIPLPKENEFLFHLGQIEGHPDNTIPAYLGGFVFAYFNGNRLEYVKKKFPKKIRCFLIV
HCCCCCCCCCEEEEEECCCCCCCCCHHHHHCCEEEEEECCCCHHHHHHHCCCEEEEEEEE
PNLETSTHQSRKTLPGSYSTEDVIFNMGRIATWMEFLDSGKISLLKLALEDRIHTPYRMH
CCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHEEHHHHCCCCEECC
SGFELNPLLAEISKNLIGHSLSGSGPSVLLFSERNKAIRIEKILKEKVAEFVQKTHFDCQ
CCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCEE
LLSLKVEEDGILESWKNIQIL
EEEEEECCCCHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA