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The map label for this gene is glpK-1 [H]

Identifier: 116328096

GI number: 116328096

Start: 1624605

End: 1626095

Strand: Direct

Name: glpK-1 [H]

Synonym: LBL_1393

Alternate gene names: 116328096

Gene position: 1624605-1626095 (Clockwise)

Preceding gene: 116328095

Following gene: 116328103

Centisome position: 44.95

GC content: 43.26

Gene sequence:

>1491_bases
ATGAGCGATTATATCATTGGGATTGATGCTGGAACCACTGGGATTCGAATTTTTTGTTTTAACAGATCCGGGAACGTGAT
TTCGAGTTCCTATTCCGAATTCAAACAATACTATCCGAAATCGGGTTGGGTGGAACATGACGCGGAAGAGATCTGGGCAA
AAACTGAAAAACTGATCATCAAAGCGATTCGTAATGGAAAATTAAGTCCTTCTAAGGCCGTCGCGATCGGAATCACAAAT
CAAAGAGAAACCACCGTCTTGTTCGATAAGGATACGGGCAAGCCGGTTTATAATGCAATTGTATGGCAATGTAGGAGAAC
CGCCGGAATTTGTAAGGATCTAAAGTCGAAAGGTTTGGAGCCGCTTTTCCGTAAAAAAACGGGGCTCGTTTTGGACGCAT
ACTTCAGCGGAACAAAAATTCAATGGATTCTGGAAAATGTGAAAGGTGTGAAAGCGAGAGCCGAGAAGGGAAAAATACTT
TTTGGAACCGTCGATACGTATTTGCTCCACCGGTTGACCAATGGAAAATCGCATAAAACCGATCATACGAATGCTAGTAG
GACACTAGTCTACAATATAGAAAAGAAGGAATGGGACAAGGAATTGACTCAGATTCTTGGAATTCCGGATTCTATTCTTC
CCGAAGCGCATAACTCTAGTTCTCTTTTCGGAAGAACGGAGAAGGTGAAAGGACTTCTGGACGGAATTCCGATTTCTTCT
CTCGTTGGAGATCAGCAGGGAGCCTTATTCGGTCAACTCTGCACGGAACCGGGGGAAGCGAAAAATACCTACGGAACCGG
ATGTTTTCTTTTGTTTAACACTGGAAATAATTTTCAGATTTCAAGAAACAATCTCCTTACAACTCTTGGGTGTGGTCCGG
AAGGAAAGACGGTTTATTGTTTGGAAGGTTCCGTTTTTATCGGAGGCGCCGTCGTTCAATTTTTGAGAGACAACCTTAAG
TTTTTCAAAGAGTCCAAGATTTCCGAAAAATTCGCTTCCTCCGTTAAGAAGGAAGATGAAATTATATTTGTTCCCGCATT
CACTGGATTAGGTGCTCCTTACTGGGATATGAATGCAAGAGGTGCGATTTTGGGTCTAACGAGAGATACAACTCCGGAAC
AAATTACGAAAGCCGCGTTGAAATCGATTGCACTTCAATCTTATGAACTGGTGGAAGCGATGGAGAACGATACCGGCTCA
AAGCTAAAAGTCCTCAAAGTGGATGGGGGCGCCACCGGAAACTCCTGGCTGATGCAGTATCAATCCGATGTGTTAGGAAA
ACGCGTAATTCGTCCTTCGAATGTAGATACGACCGTATTGGGTGCGGCTTTTTTAGCCGGGCTTGAAAGAGGATTTTTTC
CCTCTGTTGCGGATCTGAAAAAGAAAATCAAAGTAAATAAAGAGTTTTTCCCTCAGATGAAAGTGGCACAGAGAGAAAGG
GAAATTCAGATTTGGAAGGATTCCGTACGAAGAATCCGCACCGATCAATAA

Upstream 100 bases:

>100_bases
GCACAACCGGCTTGAAATCATCATGGCCTACGAAGGCCTGGAACTAGAAGTATAACTCTAATATTGAGATTCGGATTCAA
AACTTTTGGGAGAATCTTTC

Downstream 100 bases:

>100_bases
TCGAATCCTAATAAACAGAATTCGAATGTCTTTTTTTCTAAAGTAATTCCCGCTCCACATAGAATTCGAAATTCAGGAAA
AAAAGGAATTTCAAGGATTC

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MSDYIIGIDAGTTGIRIFCFNRSGNVISSSYSEFKQYYPKSGWVEHDAEEIWAKTEKLIIKAIRNGKLSPSKAVAIGITN
QRETTVLFDKDTGKPVYNAIVWQCRRTAGICKDLKSKGLEPLFRKKTGLVLDAYFSGTKIQWILENVKGVKARAEKGKIL
FGTVDTYLLHRLTNGKSHKTDHTNASRTLVYNIEKKEWDKELTQILGIPDSILPEAHNSSSLFGRTEKVKGLLDGIPISS
LVGDQQGALFGQLCTEPGEAKNTYGTGCFLLFNTGNNFQISRNNLLTTLGCGPEGKTVYCLEGSVFIGGAVVQFLRDNLK
FFKESKISEKFASSVKKEDEIIFVPAFTGLGAPYWDMNARGAILGLTRDTTPEQITKAALKSIALQSYELVEAMENDTGS
KLKVLKVDGGATGNSWLMQYQSDVLGKRVIRPSNVDTTVLGAAFLAGLERGFFPSVADLKKKIKVNKEFFPQMKVAQRER
EIQIWKDSVRRIRTDQ

Sequences:

>Translated_496_residues
MSDYIIGIDAGTTGIRIFCFNRSGNVISSSYSEFKQYYPKSGWVEHDAEEIWAKTEKLIIKAIRNGKLSPSKAVAIGITN
QRETTVLFDKDTGKPVYNAIVWQCRRTAGICKDLKSKGLEPLFRKKTGLVLDAYFSGTKIQWILENVKGVKARAEKGKIL
FGTVDTYLLHRLTNGKSHKTDHTNASRTLVYNIEKKEWDKELTQILGIPDSILPEAHNSSSLFGRTEKVKGLLDGIPISS
LVGDQQGALFGQLCTEPGEAKNTYGTGCFLLFNTGNNFQISRNNLLTTLGCGPEGKTVYCLEGSVFIGGAVVQFLRDNLK
FFKESKISEKFASSVKKEDEIIFVPAFTGLGAPYWDMNARGAILGLTRDTTPEQITKAALKSIALQSYELVEAMENDTGS
KLKVLKVDGGATGNSWLMQYQSDVLGKRVIRPSNVDTTVLGAAFLAGLERGFFPSVADLKKKIKVNKEFFPQMKVAQRER
EIQIWKDSVRRIRTDQ
>Mature_495_residues
SDYIIGIDAGTTGIRIFCFNRSGNVISSSYSEFKQYYPKSGWVEHDAEEIWAKTEKLIIKAIRNGKLSPSKAVAIGITNQ
RETTVLFDKDTGKPVYNAIVWQCRRTAGICKDLKSKGLEPLFRKKTGLVLDAYFSGTKIQWILENVKGVKARAEKGKILF
GTVDTYLLHRLTNGKSHKTDHTNASRTLVYNIEKKEWDKELTQILGIPDSILPEAHNSSSLFGRTEKVKGLLDGIPISSL
VGDQQGALFGQLCTEPGEAKNTYGTGCFLLFNTGNNFQISRNNLLTTLGCGPEGKTVYCLEGSVFIGGAVVQFLRDNLKF
FKESKISEKFASSVKKEDEIIFVPAFTGLGAPYWDMNARGAILGLTRDTTPEQITKAALKSIALQSYELVEAMENDTGSK
LKVLKVDGGATGNSWLMQYQSDVLGKRVIRPSNVDTTVLGAAFLAGLERGFFPSVADLKKKIKVNKEFFPQMKVAQRERE
IQIWKDSVRRIRTDQ

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=497, Percent_Identity=43.8631790744467, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI4504007, Length=497, Percent_Identity=43.8631790744467, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI42794763, Length=501, Percent_Identity=43.9121756487026, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI41393575, Length=495, Percent_Identity=43.4343434343434, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI88196792, Length=506, Percent_Identity=32.6086956521739, Blast_Score=285, Evalue=6e-77,
Organism=Escherichia coli, GI1790361, Length=488, Percent_Identity=51.0245901639344, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1789987, Length=501, Percent_Identity=22.5548902195609, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790005, Length=491, Percent_Identity=22.8105906313646, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1789168, Length=480, Percent_Identity=22.9166666666667, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787789, Length=487, Percent_Identity=22.7926078028747, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535599, Length=498, Percent_Identity=40.1606425702811, Blast_Score=358, Evalue=4e-99,
Organism=Caenorhabditis elegans, GI71986140, Length=515, Percent_Identity=23.8834951456311, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71986147, Length=257, Percent_Identity=29.5719844357977, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321755, Length=544, Percent_Identity=35.4779411764706, Blast_Score=287, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24655555, Length=494, Percent_Identity=38.4615384615385, Blast_Score=351, Evalue=8e-97,
Organism=Drosophila melanogaster, GI24655560, Length=494, Percent_Identity=38.4615384615385, Blast_Score=351, Evalue=8e-97,
Organism=Drosophila melanogaster, GI24655570, Length=494, Percent_Identity=38.4615384615385, Blast_Score=351, Evalue=8e-97,
Organism=Drosophila melanogaster, GI24655574, Length=494, Percent_Identity=38.4615384615385, Blast_Score=351, Evalue=8e-97,
Organism=Drosophila melanogaster, GI24655565, Length=494, Percent_Identity=38.4615384615385, Blast_Score=351, Evalue=8e-97,
Organism=Drosophila melanogaster, GI17864214, Length=507, Percent_Identity=40.2366863905325, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24654573, Length=430, Percent_Identity=42.7906976744186, Blast_Score=334, Evalue=8e-92,
Organism=Drosophila melanogaster, GI19922058, Length=530, Percent_Identity=32.8301886792453, Blast_Score=278, Evalue=8e-75,
Organism=Drosophila melanogaster, GI24652871, Length=489, Percent_Identity=33.9468302658487, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24656367, Length=492, Percent_Identity=28.8617886178862, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI21357867, Length=503, Percent_Identity=29.0258449304175, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24656372, Length=348, Percent_Identity=31.6091954022989, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI45552909, Length=307, Percent_Identity=28.6644951140065, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55074; Mature: 54943

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDYIIGIDAGTTGIRIFCFNRSGNVISSSYSEFKQYYPKSGWVEHDAEEIWAKTEKLII
CCCEEEEEECCCCEEEEEEECCCCCEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
KAIRNGKLSPSKAVAIGITNQRETTVLFDKDTGKPVYNAIVWQCRRTAGICKDLKSKGLE
HHHHCCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PLFRKKTGLVLDAYFSGTKIQWILENVKGVKARAEKGKILFGTVDTYLLHRLTNGKSHKT
HHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCC
DHTNASRTLVYNIEKKEWDKELTQILGIPDSILPEAHNSSSLFGRTEKVKGLLDGIPISS
CCCCCCEEEEEECHHHHHHHHHHHHHCCCHHHCCCCCCCCHHCCCHHHHHHHHCCCCHHH
LVGDQQGALFGQLCTEPGEAKNTYGTGCFLLFNTGNNFQISRNNLLTTLGCGPEGKTVYC
HHCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCCEEEEECCCCCCCEEEE
LEGSVFIGGAVVQFLRDNLKFFKESKISEKFASSVKKEDEIIFVPAFTGLGAPYWDMNAR
ECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCC
GAILGLTRDTTPEQITKAALKSIALQSYELVEAMENDTGSKLKVLKVDGGATGNSWLMQY
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHH
QSDVLGKRVIRPSNVDTTVLGAAFLAGLERGFFPSVADLKKKIKVNKEFFPQMKVAQRER
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCHHHHHHHHH
EIQIWKDSVRRIRTDQ
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDYIIGIDAGTTGIRIFCFNRSGNVISSSYSEFKQYYPKSGWVEHDAEEIWAKTEKLII
CCEEEEEECCCCEEEEEEECCCCCEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
KAIRNGKLSPSKAVAIGITNQRETTVLFDKDTGKPVYNAIVWQCRRTAGICKDLKSKGLE
HHHHCCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PLFRKKTGLVLDAYFSGTKIQWILENVKGVKARAEKGKILFGTVDTYLLHRLTNGKSHKT
HHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCC
DHTNASRTLVYNIEKKEWDKELTQILGIPDSILPEAHNSSSLFGRTEKVKGLLDGIPISS
CCCCCCEEEEEECHHHHHHHHHHHHHCCCHHHCCCCCCCCHHCCCHHHHHHHHCCCCHHH
LVGDQQGALFGQLCTEPGEAKNTYGTGCFLLFNTGNNFQISRNNLLTTLGCGPEGKTVYC
HHCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCCEEEEECCCCCCCEEEE
LEGSVFIGGAVVQFLRDNLKFFKESKISEKFASSVKKEDEIIFVPAFTGLGAPYWDMNAR
ECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCC
GAILGLTRDTTPEQITKAALKSIALQSYELVEAMENDTGSKLKVLKVDGGATGNSWLMQY
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHH
QSDVLGKRVIRPSNVDTTVLGAAFLAGLERGFFPSVADLKKKIKVNKEFFPQMKVAQRER
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCHHHHHHHHH
EIQIWKDSVRRIRTDQ
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA