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The map label for this gene is neuB-1

Identifier: 116327846

GI number: 116327846

Start: 1323695

End: 1324693

Strand: Reverse

Name: neuB-1

Synonym: LBL_1124

Alternate gene names: NA

Gene position: 1324693-1323695 (Counterclockwise)

Preceding gene: 116327847

Following gene: 116327845

Centisome position: 36.65

GC content: 43.94

Gene sequence:

>999_bases
ATGACCTTTCTAAAAAAATTTTCAATCGCATCCGAACTATACGTTGGCTCCGAATCCCCTCCAATCGTCGTCGCAGAAAT
CGGGTTGAATCACAACAACGACGAAGAGATCGGCAAAAAAACGATCGCCGCCGCAAAAAAGGCCGGGGCACAAGTCGTAA
AATTTCAATCTTATGTTACGGAAGAATTTATCGACGTCCACAATCCGGACGCGAAGATTCTCGTGGATATATTCAAAAAA
TATGAATTATCCGAAACAATGCATAGGAAATTTCAAAAAACCGCAGAAGACGAAGGCCTGTTTTTTTTTTCCACCCCTCT
TTGTGTCAATTCTTTGCATCTTCTTTTAAGTCTTAAAGTTCCCGCGATCAAGATTGCAAGCGGAGATATAACCAACAAAA
CCCTTCTTTTAGAAACCGCAAAATCGAAACTTCCGGTGATTCTCTCCTCGGGTGCCGCGGATTTTTTCGAAGTGAATCGG
GCAATCTCATTCTTAGAAAAAGAAGGAACGGACAAACTCTGTCTTTTACACTGCGTTTCTCTTTATCCAACGCCTCCGGA
AAAGGCGAACCTCAAGGTGGTAGAAACATTCAAAAACCTTTATCCGTTTCCGGTGGGTTTTTCGGATCATACCATCGGAA
ATATCGCCGCCTCGATCGCCGTTTCCTTAGGAGCGTGTATGATCGAAAAACATTTCACACTGGATCGGAATCTGGACGGA
CCGGATCACGGAATTTCCGCAAATCCGGAAGAACTAAAAACGGTTTGTGAAAACGCTCTTATCGCTTGGAAAATGAAAGG
AAACGGAGAAAAAAAACCTTGGCCGGAAGAAATAAGCGGAAGGTTTTTCGGCAGAAGATCTTTGTATGCAGATGCAAACG
GTTCGCCGATCGCTCTCCGACCGGATCTAACTCAAAAAACCGGAACGTATTTAGATTCCTGGGAAATCGAAAAAACAAAC
GGACTCGAATCGGAGCCGGGCAAACCCTTCCATGTCTAA

Upstream 100 bases:

>100_bases
AATATACCATCGGAAAGCGAAATCATTTTGGAACTTAAGTTACGAGTTAATGAGCCGAAATCTTATATATCCCCCAAAGA
ATAAAAGTACGAAGTAAAAC

Downstream 100 bases:

>100_bases
TATTTTTAAATTACAAAATTCGATTATAATTTTCGGATTTTCGATCTTTTTCACTTTCACTTCCATAATCGGGACTCCGA
TCTCATACGGGAATCTCGGC

Product: N-acetyl neuraminic (sialic) acid synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTFLKKFSIASELYVGSESPPIVVAEIGLNHNNDEEIGKKTIAAAKKAGAQVVKFQSYVTEEFIDVHNPDAKILVDIFKK
YELSETMHRKFQKTAEDEGLFFFSTPLCVNSLHLLLSLKVPAIKIASGDITNKTLLLETAKSKLPVILSSGAADFFEVNR
AISFLEKEGTDKLCLLHCVSLYPTPPEKANLKVVETFKNLYPFPVGFSDHTIGNIAASIAVSLGACMIEKHFTLDRNLDG
PDHGISANPEELKTVCENALIAWKMKGNGEKKPWPEEISGRFFGRRSLYADANGSPIALRPDLTQKTGTYLDSWEIEKTN
GLESEPGKPFHV

Sequences:

>Translated_332_residues
MTFLKKFSIASELYVGSESPPIVVAEIGLNHNNDEEIGKKTIAAAKKAGAQVVKFQSYVTEEFIDVHNPDAKILVDIFKK
YELSETMHRKFQKTAEDEGLFFFSTPLCVNSLHLLLSLKVPAIKIASGDITNKTLLLETAKSKLPVILSSGAADFFEVNR
AISFLEKEGTDKLCLLHCVSLYPTPPEKANLKVVETFKNLYPFPVGFSDHTIGNIAASIAVSLGACMIEKHFTLDRNLDG
PDHGISANPEELKTVCENALIAWKMKGNGEKKPWPEEISGRFFGRRSLYADANGSPIALRPDLTQKTGTYLDSWEIEKTN
GLESEPGKPFHV
>Mature_331_residues
TFLKKFSIASELYVGSESPPIVVAEIGLNHNNDEEIGKKTIAAAKKAGAQVVKFQSYVTEEFIDVHNPDAKILVDIFKKY
ELSETMHRKFQKTAEDEGLFFFSTPLCVNSLHLLLSLKVPAIKIASGDITNKTLLLETAKSKLPVILSSGAADFFEVNRA
ISFLEKEGTDKLCLLHCVSLYPTPPEKANLKVVETFKNLYPFPVGFSDHTIGNIAASIAVSLGACMIEKHFTLDRNLDGP
DHGISANPEELKTVCENALIAWKMKGNGEKKPWPEEISGRFFGRRSLYADANGSPIALRPDLTQKTGTYLDSWEIEKTNG
LESEPGKPFHV

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=277, Percent_Identity=31.7689530685921, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21357081, Length=280, Percent_Identity=33.9285714285714, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 36659; Mature: 36528

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLKKFSIASELYVGSESPPIVVAEIGLNHNNDEEIGKKTIAAAKKAGAQVVKFQSYVT
CCHHHHHHHHHHEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
EEFIDVHNPDAKILVDIFKKYELSETMHRKFQKTAEDEGLFFFSTPLCVNSLHLLLSLKV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHEEEECC
PAIKIASGDITNKTLLLETAKSKLPVILSSGAADFFEVNRAISFLEKEGTDKLCLLHCVS
CEEEEECCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LYPTPPEKANLKVVETFKNLYPFPVGFSDHTIGNIAASIAVSLGACMIEKHFTLDRNLDG
HCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PDHGISANPEELKTVCENALIAWKMKGNGEKKPWPEEISGRFFGRRSLYADANGSPIALR
CCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHCCCCCCCEEEEECCCCCEEEEC
PDLTQKTGTYLDSWEIEKTNGLESEPGKPFHV
CCCCHHCCCCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TFLKKFSIASELYVGSESPPIVVAEIGLNHNNDEEIGKKTIAAAKKAGAQVVKFQSYVT
CHHHHHHHHHHEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
EEFIDVHNPDAKILVDIFKKYELSETMHRKFQKTAEDEGLFFFSTPLCVNSLHLLLSLKV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHEEEECC
PAIKIASGDITNKTLLLETAKSKLPVILSSGAADFFEVNRAISFLEKEGTDKLCLLHCVS
CEEEEECCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LYPTPPEKANLKVVETFKNLYPFPVGFSDHTIGNIAASIAVSLGACMIEKHFTLDRNLDG
HCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PDHGISANPEELKTVCENALIAWKMKGNGEKKPWPEEISGRFFGRRSLYADANGSPIALR
CCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHCCCCCCCEEEEECCCCCEEEEC
PDLTQKTGTYLDSWEIEKTNGLESEPGKPFHV
CCCCHHCCCCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]