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The map label for this gene is gcp

Identifier: 116327804

GI number: 116327804

Start: 1253277

End: 1254293

Strand: Reverse

Name: gcp

Synonym: LBL_1068

Alternate gene names: 116327804

Gene position: 1254293-1253277 (Counterclockwise)

Preceding gene: 116327805

Following gene: 116327803

Centisome position: 34.7

GC content: 45.03

Gene sequence:

>1017_bases
ATGATCGGAATGGGAATCGAAACCAGTTGCGACGAAACCTCCATCGGAATCATACGCGACGGGAAAGAATTACTCAGCCT
CGGAATTTTCAGCCAGATTGATTTACACAAACCTTACGGAGGGATTGTGCCGGAGATTGCGTCACGCGCTCATTTGGAAA
AAATCAATCTTCTTTTGGAAGAAACGATGGAAGAGGCAAAGATTCGATTCGAGGATCTTTCTTACGTCGCAGTTACTTCT
TCTCCCGGTTTGACCGGGTCCTTGATGGTCGGGGCGCAGATGGCACGTTGTATAAATATGGTTTATGAAACCCCGATTCT
ACCGGTTTGTCATCTGCAGTCTCACTTTGCGGTGTTACACCTTGAGGGAGTTCCCACAGAATTTCCGGTTTTAGGGTTAC
TACTTTCCGGGGGAAATTCCGCCGTTTATATCCTACAAGAATTCGGTAGGATGGAACTCGTAGGAGATACGATGGATGAT
GCTTTAGGAGAAGCCTTTGATAAGGTTGCGGGTCTTTTGGATCTTCCTTATCCTGGCGGACCTCATATCGAGGCGAAAGC
GAATGAATACATTCCGACTCCCGATGAAAAACCGATTCTTCCTCTTTTATTGCGAAATCTGCCTCAGGGAGAGGTATCTT
TTTCTTTCAGCGGGTTAAAAACGGCGGTGATGGTCTTACTGGAAAAACAGAAGGAAGTTTCCAAGGAACAAATCTGCTGG
AATTTTCAAAACTCCGCTTTCGATTTGGTGGAAAGAAATCTGAAACGAGCGGTGGCAAAAACCGGGATTCGTAAAGTTTT
TGCGGCGGGAGGAGTGTTGGCAAATACAACTCTCCAGAAACGATTGGAGGTTTGGGCGGGTAAAAATTCCGTGGAACTTT
TTACTCCCAAGAAAAAAATTTATTGTACCGATAATGGTGCAATGGTAGCTTCACTGGGATACCATTTGTTCCGGAAAGGT
TACAAAAAAGGCGTCGATTTTACGGTCAATCCATCCAGACAGGAGATTTTTTCATGA

Upstream 100 bases:

>100_bases
GGACAGAATGTGATTCCGGATTTGGAACTTGATCCGCAACTTCGTAAGGCGATCGAAATTCTCAGTATTCCCAAAGACGG
AGAAAAAAAATCTTAACTTC

Downstream 100 bases:

>100_bases
AACTCAAACTTAGTTGGGTTCCGAATACTCTTACACTCGGAAATCTCACAATGGGGTTCAGCGCGATGCTCGTAGCATCA
GAAGCGGGATCCAGGGGCGC

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MIGMGIETSCDETSIGIIRDGKELLSLGIFSQIDLHKPYGGIVPEIASRAHLEKINLLLEETMEEAKIRFEDLSYVAVTS
SPGLTGSLMVGAQMARCINMVYETPILPVCHLQSHFAVLHLEGVPTEFPVLGLLLSGGNSAVYILQEFGRMELVGDTMDD
ALGEAFDKVAGLLDLPYPGGPHIEAKANEYIPTPDEKPILPLLLRNLPQGEVSFSFSGLKTAVMVLLEKQKEVSKEQICW
NFQNSAFDLVERNLKRAVAKTGIRKVFAAGGVLANTTLQKRLEVWAGKNSVELFTPKKKIYCTDNGAMVASLGYHLFRKG
YKKGVDFTVNPSRQEIFS

Sequences:

>Translated_338_residues
MIGMGIETSCDETSIGIIRDGKELLSLGIFSQIDLHKPYGGIVPEIASRAHLEKINLLLEETMEEAKIRFEDLSYVAVTS
SPGLTGSLMVGAQMARCINMVYETPILPVCHLQSHFAVLHLEGVPTEFPVLGLLLSGGNSAVYILQEFGRMELVGDTMDD
ALGEAFDKVAGLLDLPYPGGPHIEAKANEYIPTPDEKPILPLLLRNLPQGEVSFSFSGLKTAVMVLLEKQKEVSKEQICW
NFQNSAFDLVERNLKRAVAKTGIRKVFAAGGVLANTTLQKRLEVWAGKNSVELFTPKKKIYCTDNGAMVASLGYHLFRKG
YKKGVDFTVNPSRQEIFS
>Mature_338_residues
MIGMGIETSCDETSIGIIRDGKELLSLGIFSQIDLHKPYGGIVPEIASRAHLEKINLLLEETMEEAKIRFEDLSYVAVTS
SPGLTGSLMVGAQMARCINMVYETPILPVCHLQSHFAVLHLEGVPTEFPVLGLLLSGGNSAVYILQEFGRMELVGDTMDD
ALGEAFDKVAGLLDLPYPGGPHIEAKANEYIPTPDEKPILPLLLRNLPQGEVSFSFSGLKTAVMVLLEKQKEVSKEQICW
NFQNSAFDLVERNLKRAVAKTGIRKVFAAGGVLANTTLQKRLEVWAGKNSVELFTPKKKIYCTDNGAMVASLGYHLFRKG
YKKGVDFTVNPSRQEIFS

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=348, Percent_Identity=30.4597701149425, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI8923380, Length=326, Percent_Identity=28.2208588957055, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1789445, Length=330, Percent_Identity=38.7878787878788, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71995670, Length=345, Percent_Identity=28.4057971014493, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17557464, Length=326, Percent_Identity=27.3006134969325, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320099, Length=360, Percent_Identity=26.9444444444444, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322891, Length=353, Percent_Identity=23.7960339943343, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI20129063, Length=340, Percent_Identity=32.9411764705882, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21357207, Length=341, Percent_Identity=29.6187683284457, Blast_Score=138, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_LEPBJ (Q04RH4)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_801254.1
- STRING:   Q04RH4
- GeneID:   4411396
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_1982
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   LBOR355277:LBJ_1982-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37120; Mature: 37120

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGMGIETSCDETSIGIIRDGKELLSLGIFSQIDLHKPYGGIVPEIASRAHLEKINLLLE
CCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ETMEEAKIRFEDLSYVAVTSSPGLTGSLMVGAQMARCINMVYETPILPVCHLQSHFAVLH
HHHHHHHEEHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEE
LEGVPTEFPVLGLLLSGGNSAVYILQEFGRMELVGDTMDDALGEAFDKVAGLLDLPYPGG
ECCCCCCCCEEEEEEECCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHEECCCCCC
PHIEAKANEYIPTPDEKPILPLLLRNLPQGEVSFSFSGLKTAVMVLLEKQKEVSKEQICW
CCEECCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHEE
NFQNSAFDLVERNLKRAVAKTGIRKVFAAGGVLANTTLQKRLEVWAGKNSVELFTPKKKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCEE
YCTDNGAMVASLGYHLFRKGYKKGVDFTVNPSRQEIFS
EECCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHCC
>Mature Secondary Structure
MIGMGIETSCDETSIGIIRDGKELLSLGIFSQIDLHKPYGGIVPEIASRAHLEKINLLLE
CCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ETMEEAKIRFEDLSYVAVTSSPGLTGSLMVGAQMARCINMVYETPILPVCHLQSHFAVLH
HHHHHHHEEHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEE
LEGVPTEFPVLGLLLSGGNSAVYILQEFGRMELVGDTMDDALGEAFDKVAGLLDLPYPGG
ECCCCCCCCEEEEEEECCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHEECCCCCC
PHIEAKANEYIPTPDEKPILPLLLRNLPQGEVSFSFSGLKTAVMVLLEKQKEVSKEQICW
CCEECCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHEE
NFQNSAFDLVERNLKRAVAKTGIRKVFAAGGVLANTTLQKRLEVWAGKNSVELFTPKKKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCEE
YCTDNGAMVASLGYHLFRKGYKKGVDFTVNPSRQEIFS
EECCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA