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The map label for this gene is mtnA

Identifier: 116327766

GI number: 116327766

Start: 1195726

End: 1196814

Strand: Reverse

Name: mtnA

Synonym: LBL_1024

Alternate gene names: 116327766

Gene position: 1196814-1195726 (Counterclockwise)

Preceding gene: 116327769

Following gene: 116327761

Centisome position: 33.11

GC content: 45.27

Gene sequence:

>1089_bases
ATGCAGGAATCAGGATTAAAACCTATTCTTTGGACAAACAAAGAATTGATCCTTTTGGATCAAAGAGTCCTGCCCGGAAC
CACGTCCTATTTGAAGGCAAAAACATTGGAAGATTGTATTTTTGCAATTCGGGAAATGGTTGTTCGGGGGGCTCCCGCAA
TTGCAATTACCGGCGCCTTCGGAATCGCATTGTATTTAAACGGCCTATCCTCCCAACCGACCTTCTCCCAACTCAAAACA
AAACTCGATGAACTTTTAGAATCCAGACCGACCGCAGTCAACCTTAGACTTGTGATAGAAGAATTCTTTTCCCGTTTTCC
GGAAGCGGATTATTCCTCCGCTAATTTAGAAAAGATGCAAAAAAGCGCGGAAGAATTTGCGCTCTTTATGCTCGAAGAAG
ATTTAGAGAATAATTTAACCCTTTCTAAAAACGCTCTTTCACTCTTTCCCAAATCTCCTTCTTCCTTGAATATCATCACT
CACTGTAACACGGGCGCACTCGCCACCGCAGGACACGGGACTGCGTTAGGCGTTATACGATCTCTCCGAGACGCGGGACA
TTCTCTCACTGTTTTTGCGGACGAAACCAGACCTTATCTTCAAGGAGCTCGTTTAACCGCCTGGGAATTGAAAGAGGAAG
GAATTCCGTCATATCTTATCACGGACAATATGGCCGGTTGGGTGATGTCTTCCAGAAAGATTCACGCGGTCATCGTAGGC
GCGGATCGTATTGCTTCCAACGGGGACACTGCCAATAAAATCGGAACGTATCCCTTAGCCATCATCGCCAAACACCACGG
AGTTCCTTTCTACGTGGCCGCAACCTCTAAAAGTATGGATTTTAGAATTCCCGACGGAAGTCACATTCCTATCGAAATGA
GAAAAGAAAATGAAGTCACTTCGTTCGGATTTTTGAAGGATGCCACAGGAAAACCTTTGTTAAACGAAGGTGTGCTTGCT
CCCAACGGAATCAAAGCCCTCAATCCTTCCTTCGATGTGACACCCGCCTCTCTCATTTCGGGAATTATCACCGAAAGAGG
AATCATCTCTCCCGTAACGGAAGAAAATCTCAGAAAGACTTTCTCATAA

Upstream 100 bases:

>100_bases
GGGTTTCCTACATTCTCCGGGAGTAAGGAGAATGATTTTTCAATCACATTCTTTAAATCGAAAAATCGGACCTCAACCTT
TAGAGTCGGGAAGAAAAAAA

Downstream 100 bases:

>100_bases
AATCCGACAACGACGGACAGATATATTAGAAAGGCAACTTGGGGAGAAACTCTGATTCAAATGCTTTCCTTTTTCGAGAA
ATTTTCGTAGAACTACTTTA

Product: translation initiation factor 2B

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MQESGLKPILWTNKELILLDQRVLPGTTSYLKAKTLEDCIFAIREMVVRGAPAIAITGAFGIALYLNGLSSQPTFSQLKT
KLDELLESRPTAVNLRLVIEEFFSRFPEADYSSANLEKMQKSAEEFALFMLEEDLENNLTLSKNALSLFPKSPSSLNIIT
HCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELKEEGIPSYLITDNMAGWVMSSRKIHAVIVG
ADRIASNGDTANKIGTYPLAIIAKHHGVPFYVAATSKSMDFRIPDGSHIPIEMRKENEVTSFGFLKDATGKPLLNEGVLA
PNGIKALNPSFDVTPASLISGIITERGIISPVTEENLRKTFS

Sequences:

>Translated_362_residues
MQESGLKPILWTNKELILLDQRVLPGTTSYLKAKTLEDCIFAIREMVVRGAPAIAITGAFGIALYLNGLSSQPTFSQLKT
KLDELLESRPTAVNLRLVIEEFFSRFPEADYSSANLEKMQKSAEEFALFMLEEDLENNLTLSKNALSLFPKSPSSLNIIT
HCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELKEEGIPSYLITDNMAGWVMSSRKIHAVIVG
ADRIASNGDTANKIGTYPLAIIAKHHGVPFYVAATSKSMDFRIPDGSHIPIEMRKENEVTSFGFLKDATGKPLLNEGVLA
PNGIKALNPSFDVTPASLISGIITERGIISPVTEENLRKTFS
>Mature_362_residues
MQESGLKPILWTNKELILLDQRVLPGTTSYLKAKTLEDCIFAIREMVVRGAPAIAITGAFGIALYLNGLSSQPTFSQLKT
KLDELLESRPTAVNLRLVIEEFFSRFPEADYSSANLEKMQKSAEEFALFMLEEDLENNLTLSKNALSLFPKSPSSLNIIT
HCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELKEEGIPSYLITDNMAGWVMSSRKIHAVIVG
ADRIASNGDTANKIGTYPLAIIAKHHGVPFYVAATSKSMDFRIPDGSHIPIEMRKENEVTSFGFLKDATGKPLLNEGVLA
PNGIKALNPSFDVTPASLISGIITERGIISPVTEENLRKTFS

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=367, Percent_Identity=43.0517711171662, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI23943880, Length=362, Percent_Identity=37.0165745856354, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI4503503, Length=256, Percent_Identity=27.34375, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI78000156, Length=282, Percent_Identity=23.0496453900709, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI78000158, Length=282, Percent_Identity=23.0496453900709, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI187607323, Length=282, Percent_Identity=23.0496453900709, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=340, Percent_Identity=39.1176470588235, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17557123, Length=300, Percent_Identity=27, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325375, Length=391, Percent_Identity=37.3401534526854, Blast_Score=215, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6322878, Length=291, Percent_Identity=27.1477663230241, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357667, Length=361, Percent_Identity=43.213296398892, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24651647, Length=361, Percent_Identity=43.213296398892, Blast_Score=283, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_LEPBJ (Q04RD6)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_801292.1
- ProteinModelPortal:   Q04RD6
- SMR:   Q04RD6
- STRING:   Q04RD6
- GeneID:   4410916
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_2026
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- PhylomeDB:   Q04RD6
- ProtClustDB:   CLSK574624
- BioCyc:   LBOR355277:LBJ_2026-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 39466; Mature: 39466

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: ACT_SITE 242-242 BINDING 89-89 BINDING 201-201

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQESGLKPILWTNKELILLDQRVLPGTTSYLKAKTLEDCIFAIREMVVRGAPAIAITGAF
CCCCCCCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHH
GIALYLNGLSSQPTFSQLKTKLDELLESRPTAVNLRLVIEEFFSRFPEADYSSANLEKMQ
EEEHEEECCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCHHHHHH
KSAEEFALFMLEEDLENNLTLSKNALSLFPKSPSSLNIITHCNTGALATAGHGTALGVIR
HHHHHHHHHHHHHHHCCCCEEECCHHEECCCCCCCEEEEEECCCCCEEECCCCHHHHHHH
SLRDAGHSLTVFADETRPYLQGARLTAWELKEEGIPSYLITDNMAGWVMSSRKIHAVIVG
HHHHCCCEEEEEECCCCHHHCCCCEEEEEHHHCCCCCEEEECCCCHHEECCCEEEEEEEE
ADRIASNGDTANKIGTYPLAIIAKHHGVPFYVAATSKSMDFRIPDGSHIPIEMRKENEVT
CHHHCCCCCCCHHCCCCEEEEEEECCCCEEEEEECCCCCEEECCCCCCCCEEECCCCCCC
SFGFLKDATGKPLLNEGVLAPNGIKALNPSFDVTPASLISGIITERGIISPVTEENLRKT
CCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHH
FS
CC
>Mature Secondary Structure
MQESGLKPILWTNKELILLDQRVLPGTTSYLKAKTLEDCIFAIREMVVRGAPAIAITGAF
CCCCCCCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHH
GIALYLNGLSSQPTFSQLKTKLDELLESRPTAVNLRLVIEEFFSRFPEADYSSANLEKMQ
EEEHEEECCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCHHHHHH
KSAEEFALFMLEEDLENNLTLSKNALSLFPKSPSSLNIITHCNTGALATAGHGTALGVIR
HHHHHHHHHHHHHHHCCCCEEECCHHEECCCCCCCEEEEEECCCCCEEECCCCHHHHHHH
SLRDAGHSLTVFADETRPYLQGARLTAWELKEEGIPSYLITDNMAGWVMSSRKIHAVIVG
HHHHCCCEEEEEECCCCHHHCCCCEEEEEHHHCCCCCEEEECCCCHHEECCCEEEEEEEE
ADRIASNGDTANKIGTYPLAIIAKHHGVPFYVAATSKSMDFRIPDGSHIPIEMRKENEVT
CHHHCCCCCCCHHCCCCEEEEEEECCCCEEEEEECCCCCEEECCCCCCCCEEECCCCCCC
SFGFLKDATGKPLLNEGVLAPNGIKALNPSFDVTPASLISGIITERGIISPVTEENLRKT
CCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHH
FS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA