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The map label for this gene is dapA [H]

Identifier: 116327665

GI number: 116327665

Start: 1057726

End: 1058610

Strand: Direct

Name: dapA [H]

Synonym: LBL_0911

Alternate gene names: 116327665

Gene position: 1057726-1058610 (Clockwise)

Preceding gene: 116327663

Following gene: 116327666

Centisome position: 29.26

GC content: 46.1

Gene sequence:

>885_bases
ATGTTCCAGGGCGTTTATACGGCGATCATTACACCATTCAAAAACGATAAAATTGACTACGACAGCTATAACAAACTACT
GGAAAAACAAATCAAGGCGGGAGTGAACGGAGTTGTGCCTTGTGGAACAACGGGAGAATCACCGACCCTTTCCCATACCG
AACACGCGGAATTAATCCGGGAAACCGTCAAGGCCGTACAAGGAAAAATCCAAGTCGTGGCCGGAACCGGTTCCAATTCC
ACCCGGGAGGCGATTGAACTTACCGAAGCCGCATGCAAGGACAGCGTGGACGGGATACTATCCGTAAATCCATATTACAA
TAAGCCGACACAAGAAGGACTTTTTCAACATTTCCAAGCCGTTGCCGAACATTCTTCCGTGCCCGTAATGCTCTACAATA
TACCAGGCAGAACCTCTATAAATCTACAACCGGAAACCGTTTTTCGTTTAAGCGAAATCAAACGGATTCGATCGATGAAG
GAAGCGACGGGAGATCTGGGACAGATGGGAAAATTGATTTCTCTGGTAGGAAATAAAATGACCGTACTTTCCGGAGACGA
TAATCTAACGCTTCCTTTACTTGCCATCGGCGGAGTAGGGGTGGTTTCCGTCGTATCGAATCTCTTTCCAAAAGCGATGG
TGGAGATGGTGAAATACTTTCAGGATGGAAGGGTTATCGAAGCCAGAAAAATACATTACGATTTTATAGAAGCCTTTGCG
CTTGCGTTTATGGAAACCAATCCGATACCGATCAAGGCGGCAATGTCTTGGTTCGGTCACTGCGAACCGGAGATACGGCT
GCCTTTGACCCGACTTTCCCAAAATGAAACAAGCGTAAAATTCAAAAAGGCGCTCGAAGTACTGAAAGAAAAAGGATACG
AGTGA

Upstream 100 bases:

>100_bases
TTTCACTAGCGATCCAGCCTAGAAGGAAGAAGTCTCACTGCAATCAGAAATCGAAACGATTTTGATTGCCAAATCAAGTA
GAAAGAAAGAATCTAACCTT

Downstream 100 bases:

>100_bases
GAATGTCCGATTCCAAGTATCAGATTGCACTGATTGGAGGTTCTGGAAGAATGGGACGCGCCATCATCACGGTACTTTCT
TCCTCCAGCAAATCTACGCT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MFQGVYTAIITPFKNDKIDYDSYNKLLEKQIKAGVNGVVPCGTTGESPTLSHTEHAELIRETVKAVQGKIQVVAGTGSNS
TREAIELTEAACKDSVDGILSVNPYYNKPTQEGLFQHFQAVAEHSSVPVMLYNIPGRTSINLQPETVFRLSEIKRIRSMK
EATGDLGQMGKLISLVGNKMTVLSGDDNLTLPLLAIGGVGVVSVVSNLFPKAMVEMVKYFQDGRVIEARKIHYDFIEAFA
LAFMETNPIPIKAAMSWFGHCEPEIRLPLTRLSQNETSVKFKKALEVLKEKGYE

Sequences:

>Translated_294_residues
MFQGVYTAIITPFKNDKIDYDSYNKLLEKQIKAGVNGVVPCGTTGESPTLSHTEHAELIRETVKAVQGKIQVVAGTGSNS
TREAIELTEAACKDSVDGILSVNPYYNKPTQEGLFQHFQAVAEHSSVPVMLYNIPGRTSINLQPETVFRLSEIKRIRSMK
EATGDLGQMGKLISLVGNKMTVLSGDDNLTLPLLAIGGVGVVSVVSNLFPKAMVEMVKYFQDGRVIEARKIHYDFIEAFA
LAFMETNPIPIKAAMSWFGHCEPEIRLPLTRLSQNETSVKFKKALEVLKEKGYE
>Mature_294_residues
MFQGVYTAIITPFKNDKIDYDSYNKLLEKQIKAGVNGVVPCGTTGESPTLSHTEHAELIRETVKAVQGKIQVVAGTGSNS
TREAIELTEAACKDSVDGILSVNPYYNKPTQEGLFQHFQAVAEHSSVPVMLYNIPGRTSINLQPETVFRLSEIKRIRSMK
EATGDLGQMGKLISLVGNKMTVLSGDDNLTLPLLAIGGVGVVSVVSNLFPKAMVEMVKYFQDGRVIEARKIHYDFIEAFA
LAFMETNPIPIKAAMSWFGHCEPEIRLPLTRLSQNETSVKFKKALEVLKEKGYE

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=278, Percent_Identity=28.7769784172662, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI13540533, Length=227, Percent_Identity=27.3127753303965, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788823, Length=277, Percent_Identity=41.8772563176895, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1786463, Length=242, Percent_Identity=31.8181818181818, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI87082415, Length=275, Percent_Identity=29.4545454545455, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789620, Length=233, Percent_Identity=25.7510729613734, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32429; Mature: 32429

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQGVYTAIITPFKNDKIDYDSYNKLLEKQIKAGVNGVVPCGTTGESPTLSHTEHAELIR
CCCCEEEHEECCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHH
ETVKAVQGKIQVVAGTGSNSTREAIELTEAACKDSVDGILSVNPYYNKPTQEGLFQHFQA
HHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHH
VAEHSSVPVMLYNIPGRTSINLQPETVFRLSEIKRIRSMKEATGDLGQMGKLISLVGNKM
HHHCCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCE
TVLSGDDNLTLPLLAIGGVGVVSVVSNLFPKAMVEMVKYFQDGRVIEARKIHYDFIEAFA
EEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
LAFMETNPIPIKAAMSWFGHCEPEIRLPLTRLSQNETSVKFKKALEVLKEKGYE
HHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFQGVYTAIITPFKNDKIDYDSYNKLLEKQIKAGVNGVVPCGTTGESPTLSHTEHAELIR
CCCCEEEHEECCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHH
ETVKAVQGKIQVVAGTGSNSTREAIELTEAACKDSVDGILSVNPYYNKPTQEGLFQHFQA
HHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHH
VAEHSSVPVMLYNIPGRTSINLQPETVFRLSEIKRIRSMKEATGDLGQMGKLISLVGNKM
HHHCCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCE
TVLSGDDNLTLPLLAIGGVGVVSVVSNLFPKAMVEMVKYFQDGRVIEARKIHYDFIEAFA
EEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
LAFMETNPIPIKAAMSWFGHCEPEIRLPLTRLSQNETSVKFKKALEVLKEKGYE
HHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA