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The map label for this gene is tetA [H]

Identifier: 116327635

GI number: 116327635

Start: 1014506

End: 1015732

Strand: Direct

Name: tetA [H]

Synonym: LBL_0870

Alternate gene names: 116327635

Gene position: 1014506-1015732 (Clockwise)

Preceding gene: 116327632

Following gene: 116327636

Centisome position: 28.07

GC content: 44.99

Gene sequence:

>1227_bases
TTGGTTGGATTTATGAATCCCCAACGTCCTGCCGCCTTAGGCTTTATTTTTATAACTGTTCTCATTGACGTGATAGGTTT
CGGAGTTATCATCCCCGTTTTGCCGAAGCTCATTCAGGAATTAACTCACGGATCTTTGAGCGACGTCGCTTGGTACGGCG
GTCTCTTGATGTTCGCTTATTCATTCGTTCAGTTTATCAGTGCGCCATTTGTTGGAGGATTGAGCGACCGATATGGGAGA
AGGCCTATTTTACTCGCGTCTCTGTTTGGTTTTACGTTGGATTATTTATTTTTAGCGTTTGCACCTTCCATTTTTTGGTT
GTTTGTCGGAAGAGTTGTATCGGGTATAATGGGAGCAAGTTTTACGACAGGTTATGCCTACATTGCGGATATCAGCCCTC
CCGAAAAGAGAGCACAGAATTTCGGGATTCTCGGAGCTGCGTTCGGACTGGGATTTATCATCGGGCCCGTGATTGGAGGT
TCCCTTGGACAATTCGGTTCTAGAGCGCCCTTTTTAGCCGCGGCCGCTCTTACGTTGGTAAATTGGTTGTTCGGATTTTT
TGTCCTTCCGGAGTCATTGACCGACGAAAATCGAAGGAAGTTCGAATGGAAAAAAGCGAATCCGATAGATTCGCTTATCA
ATTTAAAACGTTATCCGATGATTGTCGGTTTAATAATTGCATTTTTTCTAATAAATACTGCCGCGCATGCTGTTCAAGGA
ACCTGGAATTATTATACGATGGAAAAATTTCAATGGAACGAGGCGATGATAGGTTATTCGCTCGGGGTCGTTGGACTTGT
TTATGCGGTTACGCAAGGAGGGCTGATTAGGATCATTCTTCCTGTGTTGGGACAGAATCGGAGTATCTATCTAGGTTTGG
CTTTGAGCGCGCTCGGATACGCGTTATTCGCTATTGCGACACAAAGTTGGATGATGTTTGTATTTTTAATACCTTATTGT
TTGGGAGGGATCGCGATGCCTCCACTCCAGGGAATCATGTCCTCTCAGGTCCCCCCAAGAGAACAAGGGGAATTGCAAGG
AGCACTCACGAGTTTAATGAGCGTTACCGCTATCGTTGAACCGATTTTGATGACGGGATTATTTTCTTATTTTACAGCCA
GGGAAACTCCGATCTATTCTCCGGAAGCTCCACTTTGGATGGGAACGATATTGACTGCGGCGAGCCTCTGGATTTCCGTG
GGTTCTTTAAGGAAACATCATTCTTAA

Upstream 100 bases:

>100_bases
GATTTGATTCTGAATATCTTTCAAATATGAAGATTTAATGAAATCACTGTGGAATTACTTAAGGGGTTATTTTTTGATTG
CCAAGAGGTTTATTATTTGT

Downstream 100 bases:

>100_bases
ATAATAAAAGAGGAATATTCGAGGATCTTGATGACTTTCTACAAGTTATTACTCGGACGTATGAAAAGAATACTACAGTA
AGAGCCGGTCTCAAAACTGT

Product: permease

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MVGFMNPQRPAALGFIFITVLIDVIGFGVIIPVLPKLIQELTHGSLSDVAWYGGLLMFAYSFVQFISAPFVGGLSDRYGR
RPILLASLFGFTLDYLFLAFAPSIFWLFVGRVVSGIMGASFTTGYAYIADISPPEKRAQNFGILGAAFGLGFIIGPVIGG
SLGQFGSRAPFLAAAALTLVNWLFGFFVLPESLTDENRRKFEWKKANPIDSLINLKRYPMIVGLIIAFFLINTAAHAVQG
TWNYYTMEKFQWNEAMIGYSLGVVGLVYAVTQGGLIRIILPVLGQNRSIYLGLALSALGYALFAIATQSWMMFVFLIPYC
LGGIAMPPLQGIMSSQVPPREQGELQGALTSLMSVTAIVEPILMTGLFSYFTARETPIYSPEAPLWMGTILTAASLWISV
GSLRKHHS

Sequences:

>Translated_408_residues
MVGFMNPQRPAALGFIFITVLIDVIGFGVIIPVLPKLIQELTHGSLSDVAWYGGLLMFAYSFVQFISAPFVGGLSDRYGR
RPILLASLFGFTLDYLFLAFAPSIFWLFVGRVVSGIMGASFTTGYAYIADISPPEKRAQNFGILGAAFGLGFIIGPVIGG
SLGQFGSRAPFLAAAALTLVNWLFGFFVLPESLTDENRRKFEWKKANPIDSLINLKRYPMIVGLIIAFFLINTAAHAVQG
TWNYYTMEKFQWNEAMIGYSLGVVGLVYAVTQGGLIRIILPVLGQNRSIYLGLALSALGYALFAIATQSWMMFVFLIPYC
LGGIAMPPLQGIMSSQVPPREQGELQGALTSLMSVTAIVEPILMTGLFSYFTARETPIYSPEAPLWMGTILTAASLWISV
GSLRKHHS
>Mature_408_residues
MVGFMNPQRPAALGFIFITVLIDVIGFGVIIPVLPKLIQELTHGSLSDVAWYGGLLMFAYSFVQFISAPFVGGLSDRYGR
RPILLASLFGFTLDYLFLAFAPSIFWLFVGRVVSGIMGASFTTGYAYIADISPPEKRAQNFGILGAAFGLGFIIGPVIGG
SLGQFGSRAPFLAAAALTLVNWLFGFFVLPESLTDENRRKFEWKKANPIDSLINLKRYPMIVGLIIAFFLINTAAHAVQG
TWNYYTMEKFQWNEAMIGYSLGVVGLVYAVTQGGLIRIILPVLGQNRSIYLGLALSALGYALFAIATQSWMMFVFLIPYC
LGGIAMPPLQGIMSSQVPPREQGELQGALTSLMSVTAIVEPILMTGLFSYFTARETPIYSPEAPLWMGTILTAASLWISV
GSLRKHHS

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=334, Percent_Identity=24.8502994011976, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI94721311, Length=332, Percent_Identity=25.6024096385542, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI225703104, Length=248, Percent_Identity=29.8387096774194, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI225703102, Length=248, Percent_Identity=29.8387096774194, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI217416366, Length=150, Percent_Identity=32, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI166064062, Length=301, Percent_Identity=27.906976744186, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI166064060, Length=301, Percent_Identity=27.906976744186, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71996331, Length=380, Percent_Identity=22.6315789473684, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17551570, Length=345, Percent_Identity=24.9275362318841, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357569, Length=306, Percent_Identity=26.4705882352941, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI161080926, Length=306, Percent_Identity=26.4705882352941, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI161080924, Length=306, Percent_Identity=26.4705882352941, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24656463, Length=306, Percent_Identity=26.4705882352941, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24656468, Length=306, Percent_Identity=26.4705882352941, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI221513297, Length=360, Percent_Identity=25.8333333333333, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17738085, Length=157, Percent_Identity=38.8535031847134, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24667557, Length=161, Percent_Identity=30.4347826086957, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24667561, Length=182, Percent_Identity=28.021978021978, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24652013, Length=322, Percent_Identity=27.3291925465839, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI62471713, Length=157, Percent_Identity=34.3949044585987, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI62471717, Length=157, Percent_Identity=34.3949044585987, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI62471715, Length=157, Percent_Identity=34.3949044585987, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24652011, Length=357, Percent_Identity=24.3697478991597, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44541; Mature: 44541

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]