| Definition | Leptospira borgpetersenii serovar Hardjo-bovis L550 chromosome 1, complete sequence. |
|---|---|
| Accession | NC_008508 |
| Length | 3,614,446 |
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The map label for this gene is leuS
Identifier: 116327373
GI number: 116327373
Start: 632578
End: 635172
Strand: Reverse
Name: leuS
Synonym: LBL_0571
Alternate gene names: 116327373
Gene position: 635172-632578 (Counterclockwise)
Preceding gene: 116327380
Following gene: 116327372
Centisome position: 17.57
GC content: 44.28
Gene sequence:
>2595_bases ATGCAATATCCGTTTCAAGAAGTAGAATCTTTTTGGCAAAAATTCTGGGAAGAAAATAAAAGCTTTCAAACAAACATTCG GTCTTCTAAACCCAAATTCTACTGCCTGGACATGTTTCCTTACCCTTCCGGAGCAGGACTTCATGTGGGTCATCCGGAAG GCTACACGGCAACCGACATTCTTTCTCGATTCAAAAGAATGAAAGGTTTCGAAGTTCTGCATCCTATGGGTTGGGATGCT TTCGGACTTCCTGCAGAACGTTATGCAATGCAAACCGGGATCCATCCGGCAATCACCACAAAAAACAATATCGATAATTT TCGTCGTCAGATACAGATGATCGGTCTTTCTTACGACTGGTCCCGGGAATTATCCACGACGGATCCGGATTATTATAAAT TCACTCAGTGGATTTTTATCCAACTCTACCAATCCTGGTTCAATCCCGAACTTAAAAAAGCGGAATCCATCGAGACTCTC ATTCAAAGATTTTCAAATAAGGGTTCTGCAGACTTAGATTACAAACCGTTTAGTGCACAAGAATGGAAACAATTCTCCCT TGTTGAAAAAGAGAAAATCCTTTCCGATTTCAGATTGGTGTATCAAGCCGAAATTCCCGTAAATTGGTGCGAGGCTTTGG GAACCGTTCTCGCAAACGAAGAAGTGGAAGAATGGATCGACAAGGGTTACGAAGTCGTCCGTAAACCGATGCGTCAGTAT ATGATGAGAATCACCGCCTACGCGGATCGGCTTTTGGAAGACCTCAAACTCGTTCAATGGCCTTCTTCCACTTTAGAGAT GCAAAAGAACTGGATCGGCAAAAGTGAAGGCCTTGAAATCACATTTCCGTTTAAAAAACCGCTGAAAAGCGGTTCAGATG GAATTCGAATTTTTACCACAAGGCCCGATACGATCTTCGGAGTGACTTATATGGTCGTAGCTCCCGAACATCCGATCGTT TCCGAAATCACAACTCCCGAGCAAAAGCAAAAAGTGGAAGAATATCAAAAGGTTTCTTCCCTAAAAAGCGATCTGGATCG TATGGAACTCACCAAGGAAAAAACCGGGGTCTTTACGGGATCGTTTGTTCTCAATCCCGCCAACCCTTCGAAAGAAATTC CGATTTGGATCAGCGACTACGTATTGTACGGATACGGAACGGGGGCGATCATGGCGGTTCCTGCGCATGATCAACGCGAC TACGAGTTCGCTAAAACGTTCGGATTAGAAATTCTTCCCGTCATCGAAGGTGAGATCACAGATGTAGCCTTTGATTCTAA AACTTCGATTTGTATCCACTCGTCTTCTTCCGAAATTTCCATCGACGGACTCGATTACTCTTCCGCTTCATCCAAAATCA TCTCTTGGGCGGAATCCAAAAGAATCGGAAAGAAAAAAACCCAGTTTAAACTTAGAGACTGGCTCTTTGCAAGACAAAGG TATTGGGGAGAACCTATCCCCCTAGTTCATTATCCGTCCGGAATCACAAAACCGATTCCCGAATCGGAACTCCCGTTAGA ACTTCCTCCTAATTTAGAAGAGTTTAAACCTTCCGGCACGGGAGAATCCCCTCTTGCTCTGGCCAAAGAATGGTTGCAGT ACAAAGATCCGGAAACGGGGGAAATCGGAACAAGAGAAACGAACACGATGCCCCAATGGGCGGGTTCGTGTTGGTATTAC CTACGTTATATCGATCCGAAAAACGGAAAACTTTTTTGCGATCCGGATTTGGAAAAGAAATGGATGCCTGTCGATCTTTA CGTAGGTGGCGCCGAACACGCGGTATTACATCTTCTTTATTCAAGATTCTGGCATAAATTTTTATACGATATCGGAGTGG TCTCGACTCAGGAACCGTTTGCCAAACTGATTCACCAAGGTTTGATTCTCGGAGAGGACAAACGCAAGATGTCCAAGTCT CTCGGCAACGTAATCAACCCGGACGACGTCATCCGAAAATACGGAGCGGATAGTCTCAGACTTTTTGAAATGTTTATGGG TCCGCTCGAAATGGTAAAACCCTGGAGTACGAGAGGTGTGGAAGGTGTATTCCGTTTTTTGAATAGAGTTTGGAGGCTTT TTCATACGGGAGAGGGAGAATCATTTCGTTTGGACGAAATCGAACCGACTACCGAAGAACTCAAAATTCTTCACAAGACG ATTCAAAAAGTCGGGGAAGACATTCCGAACTTTTCCTTCAACACCGCGATTTCGCAATTGATGATTTTCGTGAACGAGTT CACTCCTTCGGATCGAAGGCCGAAAGAAGTTTTAGAAACATTCATCCTCCTTTTGGCTCCGTTTGCCCCACATATAGCGG AAGAACTCTGGAAGCGTTCCGGCAACAACAAATCCCTTTCGACCGAAAAATTTCCGGAAGCCGATCCGCAATATCTCGTC GAATCGGAGATTTTAATCGTAGTTCAAGTCAACGGCAAATTAAGAGACGAATTCAAAGCTCCGAAAGACGTTTCCGAAGC GGATGCGATTTCCATTGCTAAAAACCTGGATAAAATCAAAGGGATTTTAGACGGTAAAACGATCCGGAAAGAAATCTACG TCCCGGGGAAGTTAATCAACTTAGTGATCGGTTAA
Upstream 100 bases:
>100_bases TCACGCAACTCTACCAATATGATCTTTGTAAATCCTGTTTGAGCAAAACTTTTCAAAGATTGATCAAGGTAATCGACTCC GTAAGAAAGTAAAAACCGAA
Downstream 100 bases:
>100_bases AGTAATAACGATAAATCCATGAATGTTAAGGTTGCTGAATTTTCATTAGAAACTATCTCAAAAATACTTTATCTTTACTT AAAACTCTGATTCCAATCAT
Product: leucyl-tRNA synthetase
Products: NA
Alternate protein names: Leucine--tRNA ligase; LeuRS
Number of amino acids: Translated: 864; Mature: 864
Protein sequence:
>864_residues MQYPFQEVESFWQKFWEENKSFQTNIRSSKPKFYCLDMFPYPSGAGLHVGHPEGYTATDILSRFKRMKGFEVLHPMGWDA FGLPAERYAMQTGIHPAITTKNNIDNFRRQIQMIGLSYDWSRELSTTDPDYYKFTQWIFIQLYQSWFNPELKKAESIETL IQRFSNKGSADLDYKPFSAQEWKQFSLVEKEKILSDFRLVYQAEIPVNWCEALGTVLANEEVEEWIDKGYEVVRKPMRQY MMRITAYADRLLEDLKLVQWPSSTLEMQKNWIGKSEGLEITFPFKKPLKSGSDGIRIFTTRPDTIFGVTYMVVAPEHPIV SEITTPEQKQKVEEYQKVSSLKSDLDRMELTKEKTGVFTGSFVLNPANPSKEIPIWISDYVLYGYGTGAIMAVPAHDQRD YEFAKTFGLEILPVIEGEITDVAFDSKTSICIHSSSSEISIDGLDYSSASSKIISWAESKRIGKKKTQFKLRDWLFARQR YWGEPIPLVHYPSGITKPIPESELPLELPPNLEEFKPSGTGESPLALAKEWLQYKDPETGEIGTRETNTMPQWAGSCWYY LRYIDPKNGKLFCDPDLEKKWMPVDLYVGGAEHAVLHLLYSRFWHKFLYDIGVVSTQEPFAKLIHQGLILGEDKRKMSKS LGNVINPDDVIRKYGADSLRLFEMFMGPLEMVKPWSTRGVEGVFRFLNRVWRLFHTGEGESFRLDEIEPTTEELKILHKT IQKVGEDIPNFSFNTAISQLMIFVNEFTPSDRRPKEVLETFILLLAPFAPHIAEELWKRSGNNKSLSTEKFPEADPQYLV ESEILIVVQVNGKLRDEFKAPKDVSEADAISIAKNLDKIKGILDGKTIRKEIYVPGKLINLVIG
Sequences:
>Translated_864_residues MQYPFQEVESFWQKFWEENKSFQTNIRSSKPKFYCLDMFPYPSGAGLHVGHPEGYTATDILSRFKRMKGFEVLHPMGWDA FGLPAERYAMQTGIHPAITTKNNIDNFRRQIQMIGLSYDWSRELSTTDPDYYKFTQWIFIQLYQSWFNPELKKAESIETL IQRFSNKGSADLDYKPFSAQEWKQFSLVEKEKILSDFRLVYQAEIPVNWCEALGTVLANEEVEEWIDKGYEVVRKPMRQY MMRITAYADRLLEDLKLVQWPSSTLEMQKNWIGKSEGLEITFPFKKPLKSGSDGIRIFTTRPDTIFGVTYMVVAPEHPIV SEITTPEQKQKVEEYQKVSSLKSDLDRMELTKEKTGVFTGSFVLNPANPSKEIPIWISDYVLYGYGTGAIMAVPAHDQRD YEFAKTFGLEILPVIEGEITDVAFDSKTSICIHSSSSEISIDGLDYSSASSKIISWAESKRIGKKKTQFKLRDWLFARQR YWGEPIPLVHYPSGITKPIPESELPLELPPNLEEFKPSGTGESPLALAKEWLQYKDPETGEIGTRETNTMPQWAGSCWYY LRYIDPKNGKLFCDPDLEKKWMPVDLYVGGAEHAVLHLLYSRFWHKFLYDIGVVSTQEPFAKLIHQGLILGEDKRKMSKS LGNVINPDDVIRKYGADSLRLFEMFMGPLEMVKPWSTRGVEGVFRFLNRVWRLFHTGEGESFRLDEIEPTTEELKILHKT IQKVGEDIPNFSFNTAISQLMIFVNEFTPSDRRPKEVLETFILLLAPFAPHIAEELWKRSGNNKSLSTEKFPEADPQYLV ESEILIVVQVNGKLRDEFKAPKDVSEADAISIAKNLDKIKGILDGKTIRKEIYVPGKLINLVIG >Mature_864_residues MQYPFQEVESFWQKFWEENKSFQTNIRSSKPKFYCLDMFPYPSGAGLHVGHPEGYTATDILSRFKRMKGFEVLHPMGWDA FGLPAERYAMQTGIHPAITTKNNIDNFRRQIQMIGLSYDWSRELSTTDPDYYKFTQWIFIQLYQSWFNPELKKAESIETL IQRFSNKGSADLDYKPFSAQEWKQFSLVEKEKILSDFRLVYQAEIPVNWCEALGTVLANEEVEEWIDKGYEVVRKPMRQY MMRITAYADRLLEDLKLVQWPSSTLEMQKNWIGKSEGLEITFPFKKPLKSGSDGIRIFTTRPDTIFGVTYMVVAPEHPIV SEITTPEQKQKVEEYQKVSSLKSDLDRMELTKEKTGVFTGSFVLNPANPSKEIPIWISDYVLYGYGTGAIMAVPAHDQRD YEFAKTFGLEILPVIEGEITDVAFDSKTSICIHSSSSEISIDGLDYSSASSKIISWAESKRIGKKKTQFKLRDWLFARQR YWGEPIPLVHYPSGITKPIPESELPLELPPNLEEFKPSGTGESPLALAKEWLQYKDPETGEIGTRETNTMPQWAGSCWYY LRYIDPKNGKLFCDPDLEKKWMPVDLYVGGAEHAVLHLLYSRFWHKFLYDIGVVSTQEPFAKLIHQGLILGEDKRKMSKS LGNVINPDDVIRKYGADSLRLFEMFMGPLEMVKPWSTRGVEGVFRFLNRVWRLFHTGEGESFRLDEIEPTTEELKILHKT IQKVGEDIPNFSFNTAISQLMIFVNEFTPSDRRPKEVLETFILLLAPFAPHIAEELWKRSGNNKSLSTEKFPEADPQYLV ESEILIVVQVNGKLRDEFKAPKDVSEADAISIAKNLDKIKGILDGKTIRKEIYVPGKLINLVIG
Specific function: Unknown
COG id: COG0495
COG function: function code J; Leucyl-tRNA synthetase
Gene ontology:
Cell location: Cytoplasm
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family
Homologues:
Organism=Homo sapiens, GI7661872, Length=939, Percent_Identity=31.2034078807242, Blast_Score=415, Evalue=1e-116, Organism=Escherichia coli, GI1786861, Length=931, Percent_Identity=38.1310418904404, Blast_Score=587, Evalue=1e-168, Organism=Caenorhabditis elegans, GI71997510, Length=346, Percent_Identity=29.4797687861272, Blast_Score=148, Evalue=1e-35, Organism=Caenorhabditis elegans, GI71997517, Length=331, Percent_Identity=29.9093655589124, Blast_Score=147, Evalue=2e-35, Organism=Caenorhabditis elegans, GI212645227, Length=317, Percent_Identity=29.0220820189274, Blast_Score=118, Evalue=2e-26, Organism=Saccharomyces cerevisiae, GI6323414, Length=907, Percent_Identity=31.9735391400221, Blast_Score=397, Evalue=1e-111, Organism=Saccharomyces cerevisiae, GI6325217, Length=355, Percent_Identity=25.0704225352113, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI21355409, Length=944, Percent_Identity=29.8728813559322, Blast_Score=359, Evalue=5e-99,
Paralogues:
None
Copy number: 800 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): SYL_LEPBJ (Q04Q48)
Other databases:
- EMBL: CP000350 - RefSeq: YP_801730.1 - ProteinModelPortal: Q04Q48 - SMR: Q04Q48 - STRING: Q04Q48 - GeneID: 4411815 - GenomeReviews: CP000350_GR - KEGG: lbj:LBJ_2541 - eggNOG: COG0495 - HOGENOM: HBG693845 - OMA: ERGNFPV - ProtClustDB: PRK00390 - BioCyc: LBOR355277:LBJ_2541-MONOMER - GO: GO:0005737 - HAMAP: MF_00049_B - InterPro: IPR001412 - InterPro: IPR002300 - InterPro: IPR002302 - InterPro: IPR014729 - InterPro: IPR009080 - InterPro: IPR013155 - InterPro: IPR009008 - Gene3D: G3DSA:3.40.50.620 - PANTHER: PTHR11946:SF7 - PRINTS: PR00985 - TIGRFAMs: TIGR00396
Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1; SSF47323 tRNAsyn_1a_bind; SSF50677 ValRS_IleRS_edit
EC number: =6.1.1.4
Molecular weight: Translated: 99489; Mature: 99489
Theoretical pI: Translated: 5.86; Mature: 5.86
Prosite motif: PS00178 AA_TRNA_LIGASE_I
Important sites: BINDING 639-639
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQYPFQEVESFWQKFWEENKSFQTNIRSSKPKFYCLDMFPYPSGAGLHVGHPEGYTATDI CCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCHHHH LSRFKRMKGFEVLHPMGWDAFGLPAERYAMQTGIHPAITTKNNIDNFRRQIQMIGLSYDW HHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCC SRELSTTDPDYYKFTQWIFIQLYQSWFNPELKKAESIETLIQRFSNKGSADLDYKPFSAQ CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH EWKQFSLVEKEKILSDFRLVYQAEIPVNWCEALGTVLANEEVEEWIDKGYEVVRKPMRQY HHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH MMRITAYADRLLEDLKLVQWPSSTLEMQKNWIGKSEGLEITFPFKKPLKSGSDGIRIFTT HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCCEEEEEE RPDTIFGVTYMVVAPEHPIVSEITTPEQKQKVEEYQKVSSLKSDLDRMELTKEKTGVFTG CCCCEEEEEEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE SFVLNPANPSKEIPIWISDYVLYGYGTGAIMAVPAHDQRDYEFAKTFGLEILPVIEGEIT EEEECCCCCCCCCCEEEECEEEEEECCCEEEEECCCCCCCHHHHHHCCCEEEEECCCCEE DVAFDSKTSICIHSSSSEISIDGLDYSSASSKIISWAESKRIGKKKTQFKLRDWLFARQR EEEECCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH YWGEPIPLVHYPSGITKPIPESELPLELPPNLEEFKPSGTGESPLALAKEWLQYKDPETG HCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCC EIGTRETNTMPQWAGSCWYYLRYIDPKNGKLFCDPDLEKKWMPVDLYVGGAEHAVLHLLY CCCCCCCCCCCHHCCCEEEEEEEEECCCCCEEECCCCCCCCEEEEEEECCHHHHHHHHHH SRFWHKFLYDIGVVSTQEPFAKLIHQGLILGEDKRKMSKSLGNVINPDDVIRKYGADSLR HHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCHHHHHHHHHCCCCCHHHHHHHHCCCHHH LFEMFMGPLEMVKPWSTRGVEGVFRFLNRVWRLFHTGEGESFRLDEIEPTTEELKILHKT HHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHH IQKVGEDIPNFSFNTAISQLMIFVNEFTPSDRRPKEVLETFILLLAPFAPHIAEELWKRS HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCC GNNKSLSTEKFPEADPQYLVESEILIVVQVNGKLRDEFKAPKDVSEADAISIAKNLDKIK CCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHH GILDGKTIRKEIYVPGKLINLVIG HHHCCHHHHHHCCCCHHHHHEECC >Mature Secondary Structure MQYPFQEVESFWQKFWEENKSFQTNIRSSKPKFYCLDMFPYPSGAGLHVGHPEGYTATDI CCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCHHHH LSRFKRMKGFEVLHPMGWDAFGLPAERYAMQTGIHPAITTKNNIDNFRRQIQMIGLSYDW HHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCC SRELSTTDPDYYKFTQWIFIQLYQSWFNPELKKAESIETLIQRFSNKGSADLDYKPFSAQ CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH EWKQFSLVEKEKILSDFRLVYQAEIPVNWCEALGTVLANEEVEEWIDKGYEVVRKPMRQY HHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH MMRITAYADRLLEDLKLVQWPSSTLEMQKNWIGKSEGLEITFPFKKPLKSGSDGIRIFTT HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCCEEEEEE RPDTIFGVTYMVVAPEHPIVSEITTPEQKQKVEEYQKVSSLKSDLDRMELTKEKTGVFTG CCCCEEEEEEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE SFVLNPANPSKEIPIWISDYVLYGYGTGAIMAVPAHDQRDYEFAKTFGLEILPVIEGEIT EEEECCCCCCCCCCEEEECEEEEEECCCEEEEECCCCCCCHHHHHHCCCEEEEECCCCEE DVAFDSKTSICIHSSSSEISIDGLDYSSASSKIISWAESKRIGKKKTQFKLRDWLFARQR EEEECCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH YWGEPIPLVHYPSGITKPIPESELPLELPPNLEEFKPSGTGESPLALAKEWLQYKDPETG HCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCC EIGTRETNTMPQWAGSCWYYLRYIDPKNGKLFCDPDLEKKWMPVDLYVGGAEHAVLHLLY CCCCCCCCCCCHHCCCEEEEEEEEECCCCCEEECCCCCCCCEEEEEEECCHHHHHHHHHH SRFWHKFLYDIGVVSTQEPFAKLIHQGLILGEDKRKMSKSLGNVINPDDVIRKYGADSLR HHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCHHHHHHHHHCCCCCHHHHHHHHCCCHHH LFEMFMGPLEMVKPWSTRGVEGVFRFLNRVWRLFHTGEGESFRLDEIEPTTEELKILHKT HHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHH IQKVGEDIPNFSFNTAISQLMIFVNEFTPSDRRPKEVLETFILLLAPFAPHIAEELWKRS HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCC GNNKSLSTEKFPEADPQYLVESEILIVVQVNGKLRDEFKAPKDVSEADAISIAKNLDKIK CCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHH GILDGKTIRKEIYVPGKLINLVIG HHHCCHHHHHHCCCCHHHHHEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA