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The map label for this gene is rcsC [H]

Identifier: 116327157

GI number: 116327157

Start: 392692

End: 393795

Strand: Reverse

Name: rcsC [H]

Synonym: LBL_0334

Alternate gene names: 116327157

Gene position: 393795-392692 (Counterclockwise)

Preceding gene: 116327160

Following gene: 116327156

Centisome position: 10.9

GC content: 36.14

Gene sequence:

>1104_bases
ATGGAATTGATTCAGGAAGTTTTAAACAACATAGGAGATAAAATCCGTCTCGTGGAATTTATTCCGTATCCTGTGTTGCT
TTCGAGAGTAAAAGGAGATCAATTCCAAACTCTTTATCTGAATCGAAGTTTTCGAGAAATCGTCGGTTATAAAGTTAAGG
AAATCCCCACCATAGAAGATTGGTTTGTTCAAGCTTATCCAGACGAGAATTATAGAGAGAAGGTCAAATTAAATTGGCTG
ACCGAAGTCGACAAAGTAAAAAAAAATGAAAAACATAATATTTTAATGAAGACAAAAATTCGAACCAAATCAAACGGAGA
AAGATGGTTCCACCTACGAAGCACGGAGTTCGGAGAATTAAATGCGTTTGCATTTCAGGATATTCACGATCTTGAAACTT
TGAACTTGGAGCTAATTCGCAGCAATTCCATCAAGTCCCAATTACTCTCTATTCTTGCACACGACTTAAGAACACCTCTA
ATACAGATCATTTCTCTGATTTCTCTGTTTAAAAATGAGGAAATCCCCTCCATCGATCTTCATCAACATCTTTCAAAATT
AAACATTCAAACCCATCTTACGATCGACTTGATCGACAACACGCTGAATTGGGTGAAAACGAACTCTAAAAGTATCGCAG
CGAACAAGATCTTTTTTAATCCGATCCCGATCATGCAGGAAATCACAACCCTTTATAACGATTATATCCGACTTAAATGT
CTTCAAGTTCATCTGGAGTTTGACGAGGATCTAAAAATATTTAGTGATGTGAATATTTTCAAAGTGATTGTTCGTAATTT
ATTCGTAAATGCGCTTAAATTTTCAAATCCCGGTGGAAAGATTTTTCTAAGAGGGATAATTTCTCCGGATTATCAACATA
TTTCAGTAATCGACGAAGGTATAGGAATGTCCGCCGAGGAATTAGAAAAGATTTTTTCCAAAGAATTTTATTCCTCAATC
GGAACTCTCAATGAAAACGGGTCCGGACTCGGAATTAAACTTTGCAGAGATTTCGCTCAGTTAATCGATGCAGAATTTTG
CTTGAAAAGTGAAAAGCACAGAGGAACTTGTGCGAGTTTGATTTTTAAGACGATAAATCGATAG

Upstream 100 bases:

>100_bases
CAGGCTTTGGGTAGATTATAATAATCTTATTTTTAATATAGATGCTTCTATATTAAAAATTTAAAGATATAATTTTGGAT
TAACTTGGGGTTTTAAAAAA

Downstream 100 bases:

>100_bases
TAATTCATTCCAATATTAGTGGATAGCTCTGACCTTGCTCTTTTTTCCCCACACGCGTGGAGTTATGTAGTCGTCCCTAA
AATCAAGTTTACGGAAATCA

Product: sensor protein of a two component response regulator

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MELIQEVLNNIGDKIRLVEFIPYPVLLSRVKGDQFQTLYLNRSFREIVGYKVKEIPTIEDWFVQAYPDENYREKVKLNWL
TEVDKVKKNEKHNILMKTKIRTKSNGERWFHLRSTEFGELNAFAFQDIHDLETLNLELIRSNSIKSQLLSILAHDLRTPL
IQIISLISLFKNEEIPSIDLHQHLSKLNIQTHLTIDLIDNTLNWVKTNSKSIAANKIFFNPIPIMQEITTLYNDYIRLKC
LQVHLEFDEDLKIFSDVNIFKVIVRNLFVNALKFSNPGGKIFLRGIISPDYQHISVIDEGIGMSAEELEKIFSKEFYSSI
GTLNENGSGLGIKLCRDFAQLIDAEFCLKSEKHRGTCASLIFKTINR

Sequences:

>Translated_367_residues
MELIQEVLNNIGDKIRLVEFIPYPVLLSRVKGDQFQTLYLNRSFREIVGYKVKEIPTIEDWFVQAYPDENYREKVKLNWL
TEVDKVKKNEKHNILMKTKIRTKSNGERWFHLRSTEFGELNAFAFQDIHDLETLNLELIRSNSIKSQLLSILAHDLRTPL
IQIISLISLFKNEEIPSIDLHQHLSKLNIQTHLTIDLIDNTLNWVKTNSKSIAANKIFFNPIPIMQEITTLYNDYIRLKC
LQVHLEFDEDLKIFSDVNIFKVIVRNLFVNALKFSNPGGKIFLRGIISPDYQHISVIDEGIGMSAEELEKIFSKEFYSSI
GTLNENGSGLGIKLCRDFAQLIDAEFCLKSEKHRGTCASLIFKTINR
>Mature_367_residues
MELIQEVLNNIGDKIRLVEFIPYPVLLSRVKGDQFQTLYLNRSFREIVGYKVKEIPTIEDWFVQAYPDENYREKVKLNWL
TEVDKVKKNEKHNILMKTKIRTKSNGERWFHLRSTEFGELNAFAFQDIHDLETLNLELIRSNSIKSQLLSILAHDLRTPL
IQIISLISLFKNEEIPSIDLHQHLSKLNIQTHLTIDLIDNTLNWVKTNSKSIAANKIFFNPIPIMQEITTLYNDYIRLKC
LQVHLEFDEDLKIFSDVNIFKVIVRNLFVNALKFSNPGGKIFLRGIISPDYQHISVIDEGIGMSAEELEKIFSKEFYSSI
GTLNENGSGLGIKLCRDFAQLIDAEFCLKSEKHRGTCASLIFKTINR

Specific function: Member of the two-component regulatory system RcsC/RcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with RcsF, RcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=220, Percent_Identity=28.1818181818182, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081816, Length=226, Percent_Identity=22.1238938053097, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=25.1046025104602, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=23.0125523012552, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788393, Length=216, Percent_Identity=20.8333333333333, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42592; Mature: 42592

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIQEVLNNIGDKIRLVEFIPYPVLLSRVKGDQFQTLYLNRSFREIVGYKVKEIPTIED
CHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCEEEEEECCHHHHHHCCHHHCCCCHHH
WFVQAYPDENYREKVKLNWLTEVDKVKKNEKHNILMKTKIRTKSNGERWFHLRSTEFGEL
HHEECCCCCCCHHHEEEHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCC
NAFAFQDIHDLETLNLELIRSNSIKSQLLSILAHDLRTPLIQIISLISLFKNEEIPSIDL
CHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
HQHLSKLNIQTHLTIDLIDNTLNWVKTNSKSIAANKIFFNPIPIMQEITTLYNDYIRLKC
HHHHHHCCCEEEEEEEEHHCCHHHHCCCCCCEEECEEEECCCHHHHHHHHHHHHHHEEEE
LQVHLEFDEDLKIFSDVNIFKVIVRNLFVNALKFSNPGGKIFLRGIISPDYQHISVIDEG
EEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHC
IGMSAEELEKIFSKEFYSSIGTLNENGSGLGIKLCRDFAQLIDAEFCLKSEKHRGTCASL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IFKTINR
HHHHHCC
>Mature Secondary Structure
MELIQEVLNNIGDKIRLVEFIPYPVLLSRVKGDQFQTLYLNRSFREIVGYKVKEIPTIED
CHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCEEEEEECCHHHHHHCCHHHCCCCHHH
WFVQAYPDENYREKVKLNWLTEVDKVKKNEKHNILMKTKIRTKSNGERWFHLRSTEFGEL
HHEECCCCCCCHHHEEEHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCC
NAFAFQDIHDLETLNLELIRSNSIKSQLLSILAHDLRTPLIQIISLISLFKNEEIPSIDL
CHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
HQHLSKLNIQTHLTIDLIDNTLNWVKTNSKSIAANKIFFNPIPIMQEITTLYNDYIRLKC
HHHHHHCCCEEEEEEEEHHCCHHHHCCCCCCEEECEEEECCCHHHHHHHHHHHHHHEEEE
LQVHLEFDEDLKIFSDVNIFKVIVRNLFVNALKFSNPGGKIFLRGIISPDYQHISVIDEG
EEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHC
IGMSAEELEKIFSKEFYSSIGTLNENGSGLGIKLCRDFAQLIDAEFCLKSEKHRGTCASL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IFKTINR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2404948; 8366025; 9097040; 9278503; 11758943; 11309126; 13129944 [H]