| Definition | Leptospira borgpetersenii serovar Hardjo-bovis L550 chromosome 1, complete sequence. |
|---|---|
| Accession | NC_008508 |
| Length | 3,614,446 |
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The map label for this gene is yvgN [H]
Identifier: 116327018
GI number: 116327018
Start: 221523
End: 222347
Strand: Reverse
Name: yvgN [H]
Synonym: LBL_0189
Alternate gene names: 116327018
Gene position: 222347-221523 (Counterclockwise)
Preceding gene: 116327019
Following gene: 116327016
Centisome position: 6.15
GC content: 37.09
Gene sequence:
>825_bases ATGGAAAATGTATTAAACCAAGCTGTTACACTCAACAATGGACTTTCAATGCCCATCTTAGGACTTGGGGTTTGGAAAAC CCAATCCGGTAATTGCAGGGAAGCAGTCTTAAACGCTTTAGAAGCGGGTTATCGTCATATCGATACCGCAAAAATTTATT CTAATGAAGAAGACGTAGGTAAAGCGATTAAAGAAAGCGGAATTCCAAGAAAAGAGATTTTCATCACTACAAAACTTTGG AATGCGGATCAAGGGTCGGACAAAACAAGAAAAGCTCTTGAAACCAGTCTCAAAAAATTAGGAATCGATCAGGTAGATCT TTATCTCATTCATTTTCCGGTGACTTCCAAAAGGATGGATTCTTGGAAAGAATTAGAAAAAGCGTACCACGATAAACTCT GTAAATCGATCGGGGTCAGTAATTATACGATTACTCATCTTACAGAGTTATTAAAAAATTCTGAAGCCACTCCTACAGTC AATCAAGTGGAATTTCATCCTTTTTTAAACCAGGTCGATCTATTCGAATTTTGTAAAAAGCATAAGATTCAACTCGAAGC TTACAGTCCTCTCGCTCACGGACAAAAAGTCGAAGATCCGAAGATCGCAGAAATTGCAAAAAAATACGGTAAAACACCGG CGCAGATTTTGATCCGTTGGGCAATTGAACAAAAGATTGTGGTGATTCCAAAATCCACAAAAAAAGAAAGAATTGTTGAG AACTCAAAAGTTTTCGATTTTAAAATTTCCGAAGAAGATATGAAAATTCTGAATTCTTTGGATGAAAATTTCAGAACCTG TTGGGATCCTTCTGAAGTCGCTTAG
Upstream 100 bases:
>100_bases TATTCTCTTATTCACGATATTATAGAATTATTGTGATGTTTTTATCTTTAAAAGTTTTGGTTCCGTTTCAGAGTCGTCCT AATATCACGGAAATTCTACG
Downstream 100 bases:
>100_bases GAATCGAAACTTATTTTACATACAAGACCAAAGTTTTCTATTAATGATTCGAAAACTGTATGATGAGTCTATACCAAAAT CTTCGGATACTCCAATCGGA
Product: aldo/keto reductase
Products: NA
Alternate protein names: GR; Methylglyoxal reductase [H]
Number of amino acids: Translated: 274; Mature: 274
Protein sequence:
>274_residues MENVLNQAVTLNNGLSMPILGLGVWKTQSGNCREAVLNALEAGYRHIDTAKIYSNEEDVGKAIKESGIPRKEIFITTKLW NADQGSDKTRKALETSLKKLGIDQVDLYLIHFPVTSKRMDSWKELEKAYHDKLCKSIGVSNYTITHLTELLKNSEATPTV NQVEFHPFLNQVDLFEFCKKHKIQLEAYSPLAHGQKVEDPKIAEIAKKYGKTPAQILIRWAIEQKIVVIPKSTKKERIVE NSKVFDFKISEEDMKILNSLDENFRTCWDPSEVA
Sequences:
>Translated_274_residues MENVLNQAVTLNNGLSMPILGLGVWKTQSGNCREAVLNALEAGYRHIDTAKIYSNEEDVGKAIKESGIPRKEIFITTKLW NADQGSDKTRKALETSLKKLGIDQVDLYLIHFPVTSKRMDSWKELEKAYHDKLCKSIGVSNYTITHLTELLKNSEATPTV NQVEFHPFLNQVDLFEFCKKHKIQLEAYSPLAHGQKVEDPKIAEIAKKYGKTPAQILIRWAIEQKIVVIPKSTKKERIVE NSKVFDFKISEEDMKILNSLDENFRTCWDPSEVA >Mature_274_residues MENVLNQAVTLNNGLSMPILGLGVWKTQSGNCREAVLNALEAGYRHIDTAKIYSNEEDVGKAIKESGIPRKEIFITTKLW NADQGSDKTRKALETSLKKLGIDQVDLYLIHFPVTSKRMDSWKELEKAYHDKLCKSIGVSNYTITHLTELLKNSEATPTV NQVEFHPFLNQVDLFEFCKKHKIQLEAYSPLAHGQKVEDPKIAEIAKKYGKTPAQILIRWAIEQKIVVIPKSTKKERIVE NSKVFDFKISEEDMKILNSLDENFRTCWDPSEVA
Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=293, Percent_Identity=37.8839590443686, Blast_Score=225, Evalue=3e-59, Organism=Homo sapiens, GI5174391, Length=293, Percent_Identity=37.8839590443686, Blast_Score=225, Evalue=3e-59, Organism=Homo sapiens, GI223468663, Length=295, Percent_Identity=40, Blast_Score=215, Evalue=3e-56, Organism=Homo sapiens, GI310109922, Length=280, Percent_Identity=41.0714285714286, Blast_Score=205, Evalue=3e-53, Organism=Homo sapiens, GI310109920, Length=300, Percent_Identity=38.6666666666667, Blast_Score=201, Evalue=4e-52, Organism=Homo sapiens, GI45446745, Length=300, Percent_Identity=38.6666666666667, Blast_Score=201, Evalue=5e-52, Organism=Homo sapiens, GI4503285, Length=300, Percent_Identity=38.6666666666667, Blast_Score=201, Evalue=5e-52, Organism=Homo sapiens, GI5453543, Length=299, Percent_Identity=38.4615384615385, Blast_Score=200, Evalue=1e-51, Organism=Homo sapiens, GI24497585, Length=299, Percent_Identity=38.4615384615385, Blast_Score=199, Evalue=2e-51, Organism=Homo sapiens, GI4502049, Length=295, Percent_Identity=40.6779661016949, Blast_Score=197, Evalue=7e-51, Organism=Homo sapiens, GI24497583, Length=299, Percent_Identity=37.4581939799331, Blast_Score=195, Evalue=5e-50, Organism=Homo sapiens, GI5174695, Length=299, Percent_Identity=37.123745819398, Blast_Score=190, Evalue=1e-48, Organism=Homo sapiens, GI93277124, Length=303, Percent_Identity=34.983498349835, Blast_Score=182, Evalue=2e-46, Organism=Homo sapiens, GI291291012, Length=273, Percent_Identity=37.7289377289377, Blast_Score=178, Evalue=4e-45, Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=36.6906474820144, Blast_Score=168, Evalue=5e-42, Organism=Homo sapiens, GI300116271, Length=284, Percent_Identity=34.8591549295775, Blast_Score=166, Evalue=2e-41, Organism=Homo sapiens, GI310109926, Length=131, Percent_Identity=45.0381679389313, Blast_Score=107, Evalue=8e-24, Organism=Homo sapiens, GI207028673, Length=131, Percent_Identity=45.0381679389313, Blast_Score=107, Evalue=8e-24, Organism=Homo sapiens, GI310109924, Length=155, Percent_Identity=38.0645161290323, Blast_Score=107, Evalue=2e-23, Organism=Escherichia coli, GI87082198, Length=270, Percent_Identity=46.2962962962963, Blast_Score=238, Evalue=3e-64, Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=38.4313725490196, Blast_Score=182, Evalue=2e-47, Organism=Escherichia coli, GI1788081, Length=270, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=7e-25, Organism=Escherichia coli, GI1787674, Length=245, Percent_Identity=24.8979591836735, Blast_Score=65, Evalue=4e-12, Organism=Caenorhabditis elegans, GI71998625, Length=276, Percent_Identity=42.3913043478261, Blast_Score=223, Evalue=8e-59, Organism=Caenorhabditis elegans, GI17537075, Length=300, Percent_Identity=36.6666666666667, Blast_Score=197, Evalue=3e-51, Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=36.734693877551, Blast_Score=197, Evalue=7e-51, Organism=Caenorhabditis elegans, GI17550248, Length=284, Percent_Identity=38.0281690140845, Blast_Score=191, Evalue=3e-49, Organism=Caenorhabditis elegans, GI17552492, Length=278, Percent_Identity=36.6906474820144, Blast_Score=189, Evalue=1e-48, Organism=Caenorhabditis elegans, GI17566692, Length=285, Percent_Identity=37.5438596491228, Blast_Score=187, Evalue=4e-48, Organism=Caenorhabditis elegans, GI17561298, Length=279, Percent_Identity=35.84229390681, Blast_Score=187, Evalue=6e-48, Organism=Caenorhabditis elegans, GI17564128, Length=298, Percent_Identity=36.5771812080537, Blast_Score=184, Evalue=3e-47, Organism=Caenorhabditis elegans, GI17562292, Length=282, Percent_Identity=34.0425531914894, Blast_Score=160, Evalue=5e-40, Organism=Caenorhabditis elegans, GI17537079, Length=297, Percent_Identity=30.3030303030303, Blast_Score=160, Evalue=5e-40, Organism=Caenorhabditis elegans, GI17538386, Length=271, Percent_Identity=32.4723247232472, Blast_Score=146, Evalue=1e-35, Organism=Caenorhabditis elegans, GI17561300, Length=276, Percent_Identity=33.695652173913, Blast_Score=145, Evalue=2e-35, Organism=Caenorhabditis elegans, GI17550246, Length=77, Percent_Identity=45.4545454545455, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6320576, Length=282, Percent_Identity=41.8439716312057, Blast_Score=220, Evalue=2e-58, Organism=Saccharomyces cerevisiae, GI6324694, Length=303, Percent_Identity=38.9438943894389, Blast_Score=209, Evalue=5e-55, Organism=Saccharomyces cerevisiae, GI6321896, Length=311, Percent_Identity=36.0128617363344, Blast_Score=192, Evalue=4e-50, Organism=Saccharomyces cerevisiae, GI6322556, Length=270, Percent_Identity=35.1851851851852, Blast_Score=188, Evalue=7e-49, Organism=Saccharomyces cerevisiae, GI6320079, Length=294, Percent_Identity=36.734693877551, Blast_Score=171, Evalue=1e-43, Organism=Saccharomyces cerevisiae, GI6319625, Length=309, Percent_Identity=36.2459546925566, Blast_Score=168, Evalue=1e-42, Organism=Drosophila melanogaster, GI24663317, Length=288, Percent_Identity=38.8888888888889, Blast_Score=208, Evalue=3e-54, Organism=Drosophila melanogaster, GI24644950, Length=301, Percent_Identity=38.2059800664452, Blast_Score=207, Evalue=7e-54, Organism=Drosophila melanogaster, GI24657054, Length=281, Percent_Identity=40.9252669039146, Blast_Score=204, Evalue=4e-53, Organism=Drosophila melanogaster, GI45553081, Length=293, Percent_Identity=37.2013651877133, Blast_Score=204, Evalue=7e-53, Organism=Drosophila melanogaster, GI20129731, Length=290, Percent_Identity=38.2758620689655, Blast_Score=203, Evalue=1e-52, Organism=Drosophila melanogaster, GI24662789, Length=292, Percent_Identity=35.958904109589, Blast_Score=201, Evalue=5e-52, Organism=Drosophila melanogaster, GI221378297, Length=321, Percent_Identity=35.8255451713396, Blast_Score=199, Evalue=1e-51, Organism=Drosophila melanogaster, GI21356425, Length=290, Percent_Identity=37.9310344827586, Blast_Score=196, Evalue=1e-50, Organism=Drosophila melanogaster, GI24662781, Length=291, Percent_Identity=40.893470790378, Blast_Score=184, Evalue=7e-47, Organism=Drosophila melanogaster, GI24662785, Length=291, Percent_Identity=39.5189003436426, Blast_Score=174, Evalue=5e-44, Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=35.2713178294574, Blast_Score=166, Evalue=2e-41,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.283 [H]
Molecular weight: Translated: 31205; Mature: 31205
Theoretical pI: Translated: 7.98; Mature: 7.98
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.5 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MENVLNQAVTLNNGLSMPILGLGVWKTQSGNCREAVLNALEAGYRHIDTAKIYSNEEDVG CCHHHHHHEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCHHHHH KAIKESGIPRKEIFITTKLWNADQGSDKTRKALETSLKKLGIDQVDLYLIHFPVTSKRMD HHHHHHCCCCHHEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHH SWKELEKAYHDKLCKSIGVSNYTITHLTELLKNSEATPTVNQVEFHPFLNQVDLFEFCKK HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHH HKIQLEAYSPLAHGQKVEDPKIAEIAKKYGKTPAQILIRWAIEQKIVVIPKSTKKERIVE CCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCHHHHHC NSKVFDFKISEEDMKILNSLDENFRTCWDPSEVA CCCEEEEEECHHHHHHHHHHHHHHHCCCCHHCCC >Mature Secondary Structure MENVLNQAVTLNNGLSMPILGLGVWKTQSGNCREAVLNALEAGYRHIDTAKIYSNEEDVG CCHHHHHHEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCHHHHH KAIKESGIPRKEIFITTKLWNADQGSDKTRKALETSLKKLGIDQVDLYLIHFPVTSKRMD HHHHHHCCCCHHEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHH SWKELEKAYHDKLCKSIGVSNYTITHLTELLKNSEATPTVNQVEFHPFLNQVDLFEFCKK HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHH HKIQLEAYSPLAHGQKVEDPKIAEIAKKYGKTPAQILIRWAIEQKIVVIPKSTKKERIVE CCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCHHHHHC NSKVFDFKISEEDMKILNSLDENFRTCWDPSEVA CCCEEEEEECHHHHHHHHHHHHHHHCCCCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9639930; 9384377 [H]