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The map label for this gene is arpR [H]

Identifier: 115352708

GI number: 115352708

Start: 2928089

End: 2928730

Strand: Direct

Name: arpR [H]

Synonym: Bamb_2657

Alternate gene names: 115352708

Gene position: 2928089-2928730 (Clockwise)

Preceding gene: 115352704

Following gene: 115352710

Centisome position: 82.33

GC content: 64.64

Gene sequence:

>642_bases
ATGGTCAGACGTACCAAGGAGGAGGCGCTCGAGACGCGCAACCGCATTCTCGATGCCGCCGAGCACGTGTTCTTCGAGAA
GGGCGTGTCGCACACGTCGCTCGCGGACATCGCCCAGCACGCCGGCGTGACGCGCGGCGCGATCTACTGGCATTTCGCGA
ACAAGAGCGAGCTGTTCGATGCGATGTTCGACCGCGTGTTCCTGCCGATCGACGAGCTCAAGCGAATGCCGCACGACGCG
CCCGGCGGCAATCCGCTCGACACGATTCGCAAGATTCTGATCTGGTGCCTGCTCGGCGTGCAGCGCGACTCGCAGTTGCG
ACGCGTGTTCAGCATCCTGTTCATGAAGTGCGAATACGTCGCGGACATGGAGCCGCTGCTGCAGCGCAACCGCGCGGGGA
TGAGCGAGGCGCTGCACGCGATCGATGCCGATCTCGCGGTCGCCGTCCGGCTCAAGCTGCTGCCCGAGCGGCTCGACACA
TGGCGCGCGACGCTGATGCTGCACACGCTCGTCAGCGGTTTCGTGCGCGACATGCTGATGCTGCCCGACGAAATCGACGC
CGAGCAGCATGCGGAAAAACTCGTCGACGGCTGCTTCGACATGCTGCGCTACAGCCCGGCGATGCTGAAGACGGGCGACT
GA

Upstream 100 bases:

>100_bases
TTACGAATTATTTCCAATCGAGAGCATAGCGGCTCCCGGAGACGGCGACGAGGGTTGCAGACCCTATATTCACCTACGAT
CGTTCCATTCAGGCCTGCAC

Downstream 100 bases:

>100_bases
CGGGCGCTCCGCCGACGGCGCGACGTGCGCCGTTTCATCGTCTGCGGCCGGGCGATCCGGCCATGCGCGCGGTAGTCAGC
GCCGCGCCGCCCGAGCGATT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELFDAMFDRVFLPIDELKRMPHDA
PGGNPLDTIRKILIWCLLGVQRDSQLRRVFSILFMKCEYVADMEPLLQRNRAGMSEALHAIDADLAVAVRLKLLPERLDT
WRATLMLHTLVSGFVRDMLMLPDEIDAEQHAEKLVDGCFDMLRYSPAMLKTGD

Sequences:

>Translated_213_residues
MVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELFDAMFDRVFLPIDELKRMPHDA
PGGNPLDTIRKILIWCLLGVQRDSQLRRVFSILFMKCEYVADMEPLLQRNRAGMSEALHAIDADLAVAVRLKLLPERLDT
WRATLMLHTLVSGFVRDMLMLPDEIDAEQHAEKLVDGCFDMLRYSPAMLKTGD
>Mature_213_residues
MVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELFDAMFDRVFLPIDELKRMPHDA
PGGNPLDTIRKILIWCLLGVQRDSQLRRVFSILFMKCEYVADMEPLLQRNRAGMSEALHAIDADLAVAVRLKLLPERLDT
WRATLMLHTLVSGFVRDMLMLPDEIDAEQHAEKLVDGCFDMLRYSPAMLKTGD

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=208, Percent_Identity=37.5, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1789664, Length=212, Percent_Identity=33.0188679245283, Blast_Score=91, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24365; Mature: 24365

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELFD
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
AMFDRVFLPIDELKRMPHDAPGGNPLDTIRKILIWCLLGVQRDSQLRRVFSILFMKCEYV
HHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ADMEPLLQRNRAGMSEALHAIDADLAVAVRLKLLPERLDTWRATLMLHTLVSGFVRDMLM
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPDEIDAEQHAEKLVDGCFDMLRYSPAMLKTGD
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELFD
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
AMFDRVFLPIDELKRMPHDAPGGNPLDTIRKILIWCLLGVQRDSQLRRVFSILFMKCEYV
HHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ADMEPLLQRNRAGMSEALHAIDADLAVAVRLKLLPERLDTWRATLMLHTLVSGFVRDMLM
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPDEIDAEQHAEKLVDGCFDMLRYSPAMLKTGD
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]