Click here to switch to the map view.

The map label for this gene is fabG2 [H]

Identifier: 115352648

GI number: 115352648

Start: 2860199

End: 2860957

Strand: Direct

Name: fabG2 [H]

Synonym: Bamb_2597

Alternate gene names: 115352648

Gene position: 2860199-2860957 (Clockwise)

Preceding gene: 115352647

Following gene: 115352651

Centisome position: 80.42

GC content: 70.49

Gene sequence:

>759_bases
ATGGAGATTCGCGGCAACGTCTTTCTGATCACGGGCGGCGCATCGGGCCTCGGCGCCGGCACGGCGCGCATGCTCGCGCA
GGCCGGCGGCAAGGTCGTGCTCGCCGACCTGAACGAGGCGGCCGGCACGGCGCTCGCGAGCGAACTGGGTGGCATATTCG
TGCGCTGCGACGTGTCGAGCGAGGCCGATGCGCAGGCAGCTGTGGACGCCGCGACGCGCGCGGGCACGCTGCGCGGCCTC
GTGAACTGCGCGGGCATCGCGCCTGCCGCGAAAACCGTCGGCAAGGACGGCGCGCATCCGCTCGACGTGTTCGCGAAGAC
GATCAACGTGAACCTGGTCGGCACCTTCAACATGATCCGGCTCGCGGCCGCCGCGATGGCCGCGACTACGCCGAACGACG
GCGGCGAGCGCGGCGTGATCGTCAGCACCGCATCGGTCGCCGCCTACGACGGCCAGATCGGCCAGGCCGCGTACGCGGCG
TCAAAGTCCGGCGTCGCGGGCATGACGCTGCCGATCGCGCGCGACCTCGCGCGCCAGGGCATCCGCGTGATGACGATCGC
GCCGGGGCTGTTCGAGACGCCGATGCTGCTCGGCATGCCGAAGGACGTGCAGGACGCGCTCGGCGCGATGGTGCCGTTCC
CGCCGCGGCTCGGCAAACCGGACGAATACGCGATGCTGGTGCGCCAGATCGTCGAGAACCCGATGCTCAACGGCGAAGTG
ATCCGCCTCGACGGCGCGATCCGGATGCAGCCGAAATAA

Upstream 100 bases:

>100_bases
ATGCGCACGAGCGTGCCGGTCGCTCCTGCGCCCCCGCGGCGCCTCGTACAATCGATCGGACGCAGGTGCCGACCGGCATC
GGACCAACAAGGAGGCAGTG

Downstream 100 bases:

>100_bases
ATGCAAACAACTGCAAACAAAAACGCCCGCAATGCGGGCGTTTTGTTGTTCAAGGCTCTCGACGCCGGGCCGCGCCAGCG
GCTCAGTCCTCGTCGTCGCG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MEIRGNVFLITGGASGLGAGTARMLAQAGGKVVLADLNEAAGTALASELGGIFVRCDVSSEADAQAAVDAATRAGTLRGL
VNCAGIAPAAKTVGKDGAHPLDVFAKTINVNLVGTFNMIRLAAAAMAATTPNDGGERGVIVSTASVAAYDGQIGQAAYAA
SKSGVAGMTLPIARDLARQGIRVMTIAPGLFETPMLLGMPKDVQDALGAMVPFPPRLGKPDEYAMLVRQIVENPMLNGEV
IRLDGAIRMQPK

Sequences:

>Translated_252_residues
MEIRGNVFLITGGASGLGAGTARMLAQAGGKVVLADLNEAAGTALASELGGIFVRCDVSSEADAQAAVDAATRAGTLRGL
VNCAGIAPAAKTVGKDGAHPLDVFAKTINVNLVGTFNMIRLAAAAMAATTPNDGGERGVIVSTASVAAYDGQIGQAAYAA
SKSGVAGMTLPIARDLARQGIRVMTIAPGLFETPMLLGMPKDVQDALGAMVPFPPRLGKPDEYAMLVRQIVENPMLNGEV
IRLDGAIRMQPK
>Mature_252_residues
MEIRGNVFLITGGASGLGAGTARMLAQAGGKVVLADLNEAAGTALASELGGIFVRCDVSSEADAQAAVDAATRAGTLRGL
VNCAGIAPAAKTVGKDGAHPLDVFAKTINVNLVGTFNMIRLAAAAMAATTPNDGGERGVIVSTASVAAYDGQIGQAAYAA
SKSGVAGMTLPIARDLARQGIRVMTIAPGLFETPMLLGMPKDVQDALGAMVPFPPRLGKPDEYAMLVRQIVENPMLNGEV
IRLDGAIRMQPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=57.2549019607843, Blast_Score=268, Evalue=3e-72,
Organism=Homo sapiens, GI83715985, Length=254, Percent_Identity=53.9370078740158, Blast_Score=244, Evalue=7e-65,
Organism=Homo sapiens, GI15277342, Length=240, Percent_Identity=34.1666666666667, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=31.2, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI31542939, Length=265, Percent_Identity=27.5471698113208, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI59889578, Length=194, Percent_Identity=30.4123711340206, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI224922801, Length=192, Percent_Identity=31.25, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI32483357, Length=230, Percent_Identity=29.5652173913043, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=31.3725490196078, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI87082100, Length=239, Percent_Identity=31.3807531380753, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787905, Length=235, Percent_Identity=31.063829787234, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082160, Length=204, Percent_Identity=30.8823529411765, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=31.7269076305221, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789208, Length=255, Percent_Identity=29.8039215686275, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=249, Percent_Identity=50.6024096385542, Blast_Score=239, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17555706, Length=223, Percent_Identity=36.322869955157, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=31.7460317460317, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=265, Percent_Identity=28.6792452830189, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=204, Percent_Identity=30.3921568627451, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=241, Percent_Identity=26.5560165975104, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=207, Percent_Identity=32.3671497584541, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=206, Percent_Identity=28.1553398058252, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=204, Percent_Identity=30.3921568627451, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320089, Length=201, Percent_Identity=28.3582089552239, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=59.0551181102362, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24639444, Length=256, Percent_Identity=33.59375, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21357041, Length=202, Percent_Identity=31.6831683168317, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571526, Length=232, Percent_Identity=30.6034482758621, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24644339, Length=229, Percent_Identity=30.1310043668122, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI23397609, Length=241, Percent_Identity=29.4605809128631, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25657; Mature: 25657

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRGNVFLITGGASGLGAGTARMLAQAGGKVVLADLNEAAGTALASELGGIFVRCDVSS
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCC
EADAQAAVDAATRAGTLRGLVNCAGIAPAAKTVGKDGAHPLDVFAKTINVNLVGTFNMIR
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHEEEEEEEEEHHHHHH
LAAAAMAATTPNDGGERGVIVSTASVAAYDGQIGQAAYAASKSGVAGMTLPIARDLARQG
HHHHHHHHCCCCCCCCCEEEEEECEEEEECCCCCHHHHHHCCCCCCCEEHHHHHHHHHCC
IRVMTIAPGLFETPMLLGMPKDVQDALGAMVPFPPRLGKPDEYAMLVRQIVENPMLNGEV
CEEEEECCCHHHCCHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
IRLDGAIRMQPK
EEECCEEEECCC
>Mature Secondary Structure
MEIRGNVFLITGGASGLGAGTARMLAQAGGKVVLADLNEAAGTALASELGGIFVRCDVSS
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCC
EADAQAAVDAATRAGTLRGLVNCAGIAPAAKTVGKDGAHPLDVFAKTINVNLVGTFNMIR
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHEEEEEEEEEHHHHHH
LAAAAMAATTPNDGGERGVIVSTASVAAYDGQIGQAAYAASKSGVAGMTLPIARDLARQG
HHHHHHHHCCCCCCCCCEEEEEECEEEEECCCCCHHHHHHCCCCCCCEEHHHHHHHHHCC
IRVMTIAPGLFETPMLLGMPKDVQDALGAMVPFPPRLGKPDEYAMLVRQIVENPMLNGEV
CEEEEECCCHHHCCHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
IRLDGAIRMQPK
EEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]