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The map label for this gene is adk

Identifier: 115352647

GI number: 115352647

Start: 2859359

End: 2860021

Strand: Direct

Name: adk

Synonym: Bamb_2596

Alternate gene names: 115352647

Gene position: 2859359-2860021 (Clockwise)

Preceding gene: 115352646

Following gene: 115352648

Centisome position: 80.4

GC content: 64.56

Gene sequence:

>663_bases
ATGCGTTTGATCCTGTTGGGCGCGCCCGGCGCGGGAAAGGGCACCCAGGCAAACTTCATCAAGGAAAAGTTCGGCATCCC
GCAAATCTCGACGGGCGACATGCTGCGCGCGGCCGTCAAGGCCGGCTCGCCGCTCGGCGTCGAGGCGAAGGGCTACATGG
ACGCCGGCAAGCTCGTGCCGGACGCGCTGATCATCGGCCTCGTGAAGGAGCGCCTGAAGGACGCCGACTGCGCGAACGGC
TACCTGTTCGACGGCTTCCCGCGCACGATCGCGCAGGCTGACGCGATGAAGGACGCCGGCGTCGCGATCGACTACGTGCT
CGAAATCGACGTTCCGTTCTCGGAAATCGTCGAGCGCATGAGCGGCCGCCGCACGCACCCGGCATCGGGCCGCACGTACC
ACGTGAAGTTCAACCCGCCGAAGGTCGAGGGCAAGGACGACGTGACGGGCGAACCGCTGATCCAGCGCGACGACGACAAG
GAAGAAACCGTCAAGAAGCGTCTCGAAGTGTACGAAGCGCAGACCAAGCCGCTGATCACGTACTACGGCGACTGGGCGCA
GCGCGGCGAGGAAAACGGCCTGAAGGCCCCGCAGTATCGCAAGATCTCGGGTCTCGGCACCGTCGACGAAATCCGCGAAC
GTGCGTTTGACGCACTGAAGTAA

Upstream 100 bases:

>100_bases
CGCGTCAGACCGGTCCGCCGCGCGCCAGGCAAGCGCCGCGCACGCTGTCGCCGACACTTTCGCGTCTCGCCATACGAATC
TACATTCTGGAGATATCACC

Downstream 100 bases:

>100_bases
GCACCGCGTCGTGCACCCGCAAGCCGCCCTTTCCGGGCGGTTTTTTTCGTCTGCTCGATCCGCTTCGGCTAACGGGGATG
CGCACGAGCGTGCCGGTCGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGSPLGVEAKGYMDAGKLVPDALIIGLVKERLKDADCANG
YLFDGFPRTIAQADAMKDAGVAIDYVLEIDVPFSEIVERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLEVYEAQTKPLITYYGDWAQRGEENGLKAPQYRKISGLGTVDEIRERAFDALK

Sequences:

>Translated_220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGSPLGVEAKGYMDAGKLVPDALIIGLVKERLKDADCANG
YLFDGFPRTIAQADAMKDAGVAIDYVLEIDVPFSEIVERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLEVYEAQTKPLITYYGDWAQRGEENGLKAPQYRKISGLGTVDEIRERAFDALK
>Mature_220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGSPLGVEAKGYMDAGKLVPDALIIGLVKERLKDADCANG
YLFDGFPRTIAQADAMKDAGVAIDYVLEIDVPFSEIVERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLEVYEAQTKPLITYYGDWAQRGEENGLKAPQYRKISGLGTVDEIRERAFDALK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=202, Percent_Identity=49.5049504950495, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI4502013, Length=202, Percent_Identity=49.5049504950495, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=49.4505494505495, Blast_Score=187, Evalue=5e-48,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=43.956043956044, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=43.956043956044, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=43.956043956044, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=43.956043956044, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI22749187, Length=186, Percent_Identity=29.5698924731183, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI4502011, Length=222, Percent_Identity=29.7297297297297, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI7706497, Length=217, Percent_Identity=30.4147465437788, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI28144899, Length=214, Percent_Identity=25.7009345794392, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI28144897, Length=214, Percent_Identity=25.7009345794392, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=26.6187050359712, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=26.6187050359712, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=66.0377358490566, Blast_Score=275, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=46.7741935483871, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17537943, Length=185, Percent_Identity=37.2972972972973, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=211, Percent_Identity=32.2274881516588, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=223, Percent_Identity=29.5964125560538, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=30.4347826086957, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=194, Percent_Identity=47.4226804123711, Blast_Score=190, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321018, Length=184, Percent_Identity=47.2826086956522, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=30.6010928961749, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=54.3478260869565, Blast_Score=200, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=47.2527472527472, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=47.2527472527472, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24663208, Length=179, Percent_Identity=28.4916201117318, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647141, Length=179, Percent_Identity=28.4916201117318, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=29.8913043478261, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=29.8913043478261, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24157; Mature: 24157

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGSPLGVEAKGYMDAGKLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
DALIIGLVKERLKDADCANGYLFDGFPRTIAQADAMKDAGVAIDYVLEIDVPFSEIVERM
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDKEETVKKRLEVYEAQTKPLIT
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
YYGDWAQRGEENGLKAPQYRKISGLGTVDEIRERAFDALK
EECCHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGSPLGVEAKGYMDAGKLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
DALIIGLVKERLKDADCANGYLFDGFPRTIAQADAMKDAGVAIDYVLEIDVPFSEIVERM
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDKEETVKKRLEVYEAQTKPLIT
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
YYGDWAQRGEENGLKAPQYRKISGLGTVDEIRERAFDALK
EECCHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA