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The map label for this gene is hemF [H]

Identifier: 115352385

GI number: 115352385

Start: 2571809

End: 2572729

Strand: Direct

Name: hemF [H]

Synonym: Bamb_2334

Alternate gene names: 115352385

Gene position: 2571809-2572729 (Clockwise)

Preceding gene: 115352384

Following gene: 115352386

Centisome position: 72.31

GC content: 68.19

Gene sequence:

>921_bases
ATGACCGATTCCACCTACGACGTGCCCCGCGTGCGCACGTACCTCCAGGGCCTGCAAGCTCGCATCGCCGACGCGCTCGG
CGCGCTCGACGGCACGCCGCTCGCGACCGACGCATGGCAGCGCGGCCCTGAAGAGCGGCTGCGCGGCGGCGGCTGTACGC
GGATTCTCGAAGGCGGCCGCGTGTTCGAGCGCGCGGGGATCGGTTTTTCCGACGTGGCGGGCGACGCGCTGCCGCCGTCG
GCGAGCGCCGCGCGCCCGCAGCTGGCCGGCCGCGGTTTCGAGGCGCTCGGTGTGTCGCTCGTGCTGCACCCGCGCAACCC
GTACTGCCCGACCGTACACATGAACGTGCGGATGCTGATCGCGACGAAGCCGGGCGAGGCGCCGATCTTCTGGTTCGGCG
GCGGCATGGATCTGACACCGGTTTATCCGTTCGAGGACGACGCGCGGCATTTCCACCAGGTCTGCAAGGACGCGCTCGAT
CCGTTCGGCGCCGAGCTCTACCCGCGCTTCAAGACCTGGTGCGACGAGTATTTCTTCCTGAAGCACCGCAACGAGACGCG
CGGCATCGGCGGGATCTTCTTCGACGATTTCTCCGAGCCCGGATTCGAACGCTCGTTTGAGATGATGCAAAGCGTCGGCG
ACGCGTTCCTGAACGCGTACCTGCCGATCGTCGAGCGCCGTGCCGCGCTGCCGTATGGCGAGCGCGAGCGCGACTTCCAG
GCTTACCGGCGCGGCCGCTACGTCGAATTCAACCTCGTGTTCGACCGCGGCACGCTGTTCGGCCTGCAAAGCGGCGGCCG
GACCGAATCGATCCTGATGTCGATGCCGCCGGTCGCGAACTGGCGCTACAACTGGCAACCCGAGCCGGGTTCGCCGGAAG
CGCGCCTGAGCGAGTTTCTCGTGCCGCGCGACTGGGTCTGA

Upstream 100 bases:

>100_bases
ACCGCCTGCCCGCGCAGGCCCCTCTGCCGGGGTTCGATAGAATGCCCGGCAGTGGCCTTTTTTACGGCCCCCGCTTCGCG
CGGGGGCATCCAGTCCAGAC

Downstream 100 bases:

>100_bases
GCCCGCCGCGCCCCGCCGCCCCAAGAACAGGACACGTTTTTCTGGACACCACCGCCCGCCCCACCCCGCAGCCGCACCCG
CCGTTACGTCGCATCGGCCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTDSTYDVPRVRTYLQGLQARIADALGALDGTPLATDAWQRGPEERLRGGGCTRILEGGRVFERAGIGFSDVAGDALPPS
ASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPIFWFGGGMDLTPVYPFEDDARHFHQVCKDALD
PFGAELYPRFKTWCDEYFFLKHRNETRGIGGIFFDDFSEPGFERSFEMMQSVGDAFLNAYLPIVERRAALPYGERERDFQ
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLSEFLVPRDWV

Sequences:

>Translated_306_residues
MTDSTYDVPRVRTYLQGLQARIADALGALDGTPLATDAWQRGPEERLRGGGCTRILEGGRVFERAGIGFSDVAGDALPPS
ASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPIFWFGGGMDLTPVYPFEDDARHFHQVCKDALD
PFGAELYPRFKTWCDEYFFLKHRNETRGIGGIFFDDFSEPGFERSFEMMQSVGDAFLNAYLPIVERRAALPYGERERDFQ
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLSEFLVPRDWV
>Mature_305_residues
TDSTYDVPRVRTYLQGLQARIADALGALDGTPLATDAWQRGPEERLRGGGCTRILEGGRVFERAGIGFSDVAGDALPPSA
SAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPIFWFGGGMDLTPVYPFEDDARHFHQVCKDALDP
FGAELYPRFKTWCDEYFFLKHRNETRGIGGIFFDDFSEPGFERSFEMMQSVGDAFLNAYLPIVERRAALPYGERERDFQA
YRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLSEFLVPRDWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=45.364238410596, Blast_Score=251, Evalue=5e-67,
Organism=Escherichia coli, GI1788777, Length=300, Percent_Identity=62.3333333333333, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320249, Length=319, Percent_Identity=45.7680250783699, Blast_Score=277, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17864388, Length=312, Percent_Identity=47.7564102564103, Blast_Score=263, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34461; Mature: 34330

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSTYDVPRVRTYLQGLQARIADALGALDGTPLATDAWQRGPEERLRGGGCTRILEGGR
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHCCCCCHHHHCCCC
VFERAGIGFSDVAGDALPPSASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLI
EEHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEECCCCCCCEEEEEEEEEE
ATKPGEAPIFWFGGGMDLTPVYPFEDDARHFHQVCKDALDPFGAELYPRFKTWCDEYFFL
EECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEE
KHRNETRGIGGIFFDDFSEPGFERSFEMMQSVGDAFLNAYLPIVERRAALPYGERERDFQ
EECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLSEFL
HHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCEECCCCCCCCCHHHHHHHC
VPRDWV
CCCCCC
>Mature Secondary Structure 
TDSTYDVPRVRTYLQGLQARIADALGALDGTPLATDAWQRGPEERLRGGGCTRILEGGR
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHCCCCCHHHHCCCC
VFERAGIGFSDVAGDALPPSASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLI
EEHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEECCCCCCCEEEEEEEEEE
ATKPGEAPIFWFGGGMDLTPVYPFEDDARHFHQVCKDALDPFGAELYPRFKTWCDEYFFL
EECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEE
KHRNETRGIGGIFFDDFSEPGFERSFEMMQSVGDAFLNAYLPIVERRAALPYGERERDFQ
EECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLSEFL
HHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCEECCCCCCCCCHHHHHHHC
VPRDWV
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA