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The map label for this gene is aceA [H]

Identifier: 115352131

GI number: 115352131

Start: 2282734

End: 2284041

Strand: Direct

Name: aceA [H]

Synonym: Bamb_2080

Alternate gene names: 115352131

Gene position: 2282734-2284041 (Clockwise)

Preceding gene: 115352130

Following gene: 115352134

Centisome position: 64.18

GC content: 64.76

Gene sequence:

>1308_bases
ATGTCGCGACACCAACAGGCGCAGGAACTGCAACAGCAATGGGAAACCGATCCGCGCTGGAAAGGCATCAAGCGCAGCTA
CACCGCTGACGACGTGGTTCGCCTGCGCGGCTCGATCGCCGTCGAGCACACGCTGGCCAAGCGCGGCGCGCAAAAGCTGT
GGAGCCTCATGAACGAAGAGCCGTTCGTCAACGCGCTCGGCGCGCTGACCGGCAACCAGGCAATGCAGCAGGTGAAGGCC
GGTCTCAAGGCGATCTACCTGTCGGGCTGGCAAGTGGCCGGCGACGCGAACGTCGCGGGCGAAATGTACCCGGACCAGTC
GCTGTACCCGGCGAACTCGGTGCCGCTCGTCGTCAAGCGCATCAACAACACGCTGACGCGCGCCGACCAGATCCAGTGGT
CCGAAGGCAAGAACCCGGGCGACGAAGGTTACGTCGACTACTTCGCGCCGATCGTCGCGGATGCGGAAGCCGGCTTCGGC
GGCGTGCTGAACGCGTTCGAGCTGATGAAGGCGATGATCGAGGCAGGCGCATCGGGCGTCCACTTCGAGGACCAGCTTGC
ATCGGTGAAGAAGTGCGGCCACATGGGCGGCAAGGTGCTCGTGCCGACGCGCGAGGCCGTCGCGAAGCTGTCGGCGGCGC
GTCTCGCCGCTGACGTGATGGGCACGCCGACCGTGCTGGTCGCGCGCACCGACGCGGAAGCAGCGGACCTGATCACGTCC
GACATCGACGACAACGACAAGCCGTTCCTGACGGGCGAGCGCACGGTCGAAGGCTTCTTCCGCACGAAGCCGGGCATCGA
GCAGGCGATCTCGCGCGGCCTCGCGTATGCGCCGTACGCCGATCTGGTCTGGTGCGAAACGGGCAAGCCGGATCTCGAGT
ACGCGAAGAAGTTCGCGGAAGCGATCCACAAGCAGTTCCCGGGCAAGATGCTGTCGTACAACTGCTCGCCGTCGTTCAAC
TGGAAGAAGAACCTCGACGACGCGACGATCGCGAAGTTCCAGAAGGAACTGGGCGCGATGGGCTACAAGTTCCAGTTCAT
CACGCTGGCCGGCTTCCATGCGCTGAACTACTCGATGTTCAACCTCGCGCACGGCTATGCCCGCACGCAGATGAGCGCGT
TCGTCGAACTGCAGCAGGCCGAGTTCGCGGCGGCCGACAAGGGCTTCACGGCCGTCAAGCACCAGCGCGAAGTCGGCACC
GGATACTTCGACGCGGTGACGCAGACGGTCGAGCGCGAAGCCTCGACGACCGCGCTGCACGGCTCGACCGAGGACGAACA
GTTCTTCGACGGCAAGAAGGTCGCGTAA

Upstream 100 bases:

>100_bases
AAGACTTCGCGAAACGGCAGCACCCCGCTCCGCTTCGCGAACAGCATCCTCACCGTCCGATTCGACTCATCAGGCAACGC
ACCGTATCAAGGAGCTCATC

Downstream 100 bases:

>100_bases
CGCGCGCAAGCGTCACGCCGATGCCCGCCCGTCACGCGACGGCGCGGCATCGGCGGCACCGAACAAAAATCAGGGAGGAG
ACGGCAGGCGCGCGGTGACC

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSRHQQAQELQQQWETDPRWKGIKRSYTADDVVRLRGSIAVEHTLAKRGAQKLWSLMNEEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDYFAPIVADAEAGFG
GVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLSAARLAADVMGTPTVLVARTDAEAADLITS
DIDDNDKPFLTGERTVEGFFRTKPGIEQAISRGLAYAPYADLVWCETGKPDLEYAKKFAEAIHKQFPGKMLSYNCSPSFN
WKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGT
GYFDAVTQTVEREASTTALHGSTEDEQFFDGKKVA

Sequences:

>Translated_435_residues
MSRHQQAQELQQQWETDPRWKGIKRSYTADDVVRLRGSIAVEHTLAKRGAQKLWSLMNEEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDYFAPIVADAEAGFG
GVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLSAARLAADVMGTPTVLVARTDAEAADLITS
DIDDNDKPFLTGERTVEGFFRTKPGIEQAISRGLAYAPYADLVWCETGKPDLEYAKKFAEAIHKQFPGKMLSYNCSPSFN
WKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGT
GYFDAVTQTVEREASTTALHGSTEDEQFFDGKKVA
>Mature_434_residues
SRHQQAQELQQQWETDPRWKGIKRSYTADDVVRLRGSIAVEHTLAKRGAQKLWSLMNEEPFVNALGALTGNQAMQQVKAG
LKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDYFAPIVADAEAGFGG
VLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLSAARLAADVMGTPTVLVARTDAEAADLITSD
IDDNDKPFLTGERTVEGFFRTKPGIEQAISRGLAYAPYADLVWCETGKPDLEYAKKFAEAIHKQFPGKMLSYNCSPSFNW
KKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGTG
YFDAVTQTVEREASTTALHGSTEDEQFFDGKKVA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=433, Percent_Identity=70.4387990762125, Blast_Score=628, Evalue=0.0,
Organism=Escherichia coli, GI1786525, Length=269, Percent_Identity=26.7657992565056, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71982926, Length=418, Percent_Identity=63.8755980861244, Blast_Score=543, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17561814, Length=418, Percent_Identity=63.8755980861244, Blast_Score=543, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320908, Length=294, Percent_Identity=36.734693877551, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6325263, Length=256, Percent_Identity=35.15625, Blast_Score=149, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 47724; Mature: 47593

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRHQQAQELQQQWETDPRWKGIKRSYTADDVVRLRGSIAVEHTLAKRGAQKLWSLMNEE
CCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKR
CHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
INNTLTRADQIQWSEGKNPGDEGYVDYFAPIVADAEAGFGGVLNAFELMKAMIEAGASGV
HHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
HFEDQLASVKKCGHMGGKVLVPTREAVAKLSAARLAADVMGTPTVLVARTDAEAADLITS
CHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
DIDDNDKPFLTGERTVEGFFRTKPGIEQAISRGLAYAPYADLVWCETGKPDLEYAKKFAE
CCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
AIHKQFPGKMLSYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMF
HHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHH
NLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGTGYFDAVTQTVEREASTTALH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEC
GSTEDEQFFDGKKVA
CCCCCHHHCCCCCCC
>Mature Secondary Structure 
SRHQQAQELQQQWETDPRWKGIKRSYTADDVVRLRGSIAVEHTLAKRGAQKLWSLMNEE
CHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKR
CHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
INNTLTRADQIQWSEGKNPGDEGYVDYFAPIVADAEAGFGGVLNAFELMKAMIEAGASGV
HHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
HFEDQLASVKKCGHMGGKVLVPTREAVAKLSAARLAADVMGTPTVLVARTDAEAADLITS
CHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
DIDDNDKPFLTGERTVEGFFRTKPGIEQAISRGLAYAPYADLVWCETGKPDLEYAKKFAE
CCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
AIHKQFPGKMLSYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMF
HHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHH
NLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGTGYFDAVTQTVEREASTTALH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEC
GSTEDEQFFDGKKVA
CCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]