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The map label for this gene is envZ [H]

Identifier: 115351978

GI number: 115351978

Start: 2122178

End: 2123539

Strand: Direct

Name: envZ [H]

Synonym: Bamb_1927

Alternate gene names: 115351978

Gene position: 2122178-2123539 (Clockwise)

Preceding gene: 115351977

Following gene: 115351979

Centisome position: 59.67

GC content: 69.46

Gene sequence:

>1362_bases
ATGCGTATCGACCGGCGCCTCCTGCAGCTCGCGTTCGGCGGGCTGTTCTGGCGCACCTTCCTGCTGATCGCGCTGCTGAT
CTCGGTCAGTCTCGCCGCGTGGTTCCAGAGCTTTCGCGTGATCGAGCGCGAGCCGCGCGCGCAGCGCGTCGCGCTCCAGC
TCGTCGCGATCGTGAAGCTCACGCGCACCGCCCTGCTCTATTCCGATCCCGATTTGCGGCGCGCGCTGCTGCAGGATCTC
GAGAGCAACGAGGGCGTGCGCGTCTACCCGCGCGAAAAAACCGACAAGTTCAAGCTGCAGCCCGACGAATCGCTGAACCG
TCTGATCGAACACGATATCCGCAGCCGGCTCGGCGACGAGACCGTGATCGCGCAGTCGGTCAACGACATCCCTGGCGTGT
GGATCAGCTTCAAGATCGACGACGACGACTACTGGGTCGCGCTCGACCGCGACCAGCTCGACAGCGTCACGGGCCTTCAG
TGGGCGGGCTGGGGCCTGTTCGCGCTCGCGCTGTCGCTGTTCGGCTCCGCGTTCATCACGAGCCTCGTGAACCGGCCGTT
CTCGCGGCTCGCGCTCGCCGCGCGCCAGATCGGCTCGGGCCAGACGCCCGAGCTGCTGCCCGAGCGCGGGATGGGCGTCG
CGGCCGAGACCAACCGCAGCTTCAACCAGATGGTGCGCGACCTCGAACAGCTCGAGGCCGATCGCGCGCTGATGCTCGCG
GGCATCTCGCACGACCTGCGCACGCCGCTCGCGCGGCTGCGGCTCGAGACCGAGATGAGCCCGTCCGACCAGGCGACCAA
GGATGCGATGGTCGACGACATCGAGCAGATGGACCGCATCATCGCCGCCTTCATCGACTACGCGCGCCCGTCCCAGCGCA
AGCCGGAGCCGGTCGACCTGTCGTCGATCGCGCACGAAGTCGCCGCGCGCGTGTCGGGCGAGGACGGCGTCGAGATCCGC
ACGCGGCTTGCGCCGAGCGCCGTGATCGAAGCCGACGAGACCGACATGCGCCGCGTGATCGGCAACCTCGTCGAGAACGC
GCGCAAATACGGCCAGAGCCGGCAGGACGGCGTGTCGCGCATCACGCTCGAGACGCGCGTGACGCATGCGCGGGTCGAGC
TGTCGGTGACCGACGAAGGCCCCGGCATCCCCGAGGATCAGCTGCCGCTCGTGATGCGGCCGTTCTACCGCGTCGACACG
GCGCGCACCAAGGCGGACGGCACGGGGCTCGGGATGGCGATCGTGCTGCGCCTCGTCGGCCGCTACCGCGGCGCACTGCG
CCTGCGCAACCGCAGCCCCGACGCGGGCCTCGAAGTCACGCTCGAATTCCCCGGCGCCGGCAAGGCGCGTGCGACGGCGT
GA

Upstream 100 bases:

>100_bases
CGTTTCATCCAGACTGTCTGGGGCCTCGGCTACGTGTTCATTCCGGACGGCGCCGCCTGATCTTTTTCCTTTCCGGTTTC
GCCTGTCCTCGGCCCGTCCC

Downstream 100 bases:

>100_bases
CGCGTTCGCGCATGCCGCTTGCGCGTCACACTATCGCTGCGGTTGAAAAAAACTATGGGAATCGTTAGTCAAAATCTATT
GAATCGCTTGGTTAATAGTG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPREKTDKFKLQPDESLNRLIEHDIRSRLGDETVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDSVTGLQ
WAGWGLFALALSLFGSAFITSLVNRPFSRLALAARQIGSGQTPELLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPSQRKPEPVDLSSIAHEVAARVSGEDGVEIR
TRLAPSAVIEADETDMRRVIGNLVENARKYGQSRQDGVSRITLETRVTHARVELSVTDEGPGIPEDQLPLVMRPFYRVDT
ARTKADGTGLGMAIVLRLVGRYRGALRLRNRSPDAGLEVTLEFPGAGKARATA

Sequences:

>Translated_453_residues
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPREKTDKFKLQPDESLNRLIEHDIRSRLGDETVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDSVTGLQ
WAGWGLFALALSLFGSAFITSLVNRPFSRLALAARQIGSGQTPELLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPSQRKPEPVDLSSIAHEVAARVSGEDGVEIR
TRLAPSAVIEADETDMRRVIGNLVENARKYGQSRQDGVSRITLETRVTHARVELSVTDEGPGIPEDQLPLVMRPFYRVDT
ARTKADGTGLGMAIVLRLVGRYRGALRLRNRSPDAGLEVTLEFPGAGKARATA
>Mature_453_residues
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPREKTDKFKLQPDESLNRLIEHDIRSRLGDETVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDSVTGLQ
WAGWGLFALALSLFGSAFITSLVNRPFSRLALAARQIGSGQTPELLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPSQRKPEPVDLSSIAHEVAARVSGEDGVEIR
TRLAPSAVIEADETDMRRVIGNLVENARKYGQSRQDGVSRITLETRVTHARVELSVTDEGPGIPEDQLPLVMRPFYRVDT
ARTKADGTGLGMAIVLRLVGRYRGALRLRNRSPDAGLEVTLEFPGAGKARATA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=441, Percent_Identity=32.4263038548753, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1787894, Length=239, Percent_Identity=32.6359832635983, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=28.4671532846715, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788393, Length=282, Percent_Identity=30.4964539007092, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=28.8990825688073, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790551, Length=285, Percent_Identity=27.3684210526316, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=27.8538812785388, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=29.5964125560538, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=26.4227642276423, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082128, Length=322, Percent_Identity=25.1552795031056, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=25.2252252252252, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI48994928, Length=215, Percent_Identity=29.3023255813954, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=218, Percent_Identity=29.3577981651376, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787374, Length=265, Percent_Identity=27.1698113207547, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=28.2700421940928, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790861, Length=281, Percent_Identity=25.6227758007117, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50640; Mature: 50640

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TRTALLYSDPDLRRALLQDLESNEGVRVYPREKTDKFKLQPDESLNRLIEHDIRSRLGDE
HHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHHHCCCH
TVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDSVTGLQWAGWGLFALALSLFGSAFIT
HHHHHHHCCCCCEEEEEEECCCCEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SLVNRPFSRLALAARQIGSGQTPELLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLA
HHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCHHHHHH
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPSQRKPEPVDL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
SSIAHEVAARVSGEDGVEIRTRLAPSAVIEADETDMRRVIGNLVENARKYGQSRQDGVSR
HHHHHHHHHHCCCCCCCEEHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHCCHHE
ITLETRVTHARVELSVTDEGPGIPEDQLPLVMRPFYRVDTARTKADGTGLGMAIVLRLVG
EEEEEEEEEEEEEEEEECCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHH
RYRGALRLRNRSPDAGLEVTLEFPGAGKARATA
HHHHHEEECCCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TRTALLYSDPDLRRALLQDLESNEGVRVYPREKTDKFKLQPDESLNRLIEHDIRSRLGDE
HHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHHHCCCH
TVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDSVTGLQWAGWGLFALALSLFGSAFIT
HHHHHHHCCCCCEEEEEEECCCCEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SLVNRPFSRLALAARQIGSGQTPELLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLA
HHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCHHHHHH
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPSQRKPEPVDL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
SSIAHEVAARVSGEDGVEIRTRLAPSAVIEADETDMRRVIGNLVENARKYGQSRQDGVSR
HHHHHHHHHHCCCCCCCEEHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHCCHHE
ITLETRVTHARVELSVTDEGPGIPEDQLPLVMRPFYRVDTARTKADGTGLGMAIVLRLVG
EEEEEEEEEEEEEEEEECCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHH
RYRGALRLRNRSPDAGLEVTLEFPGAGKARATA
HHHHHEEECCCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]