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The map label for this gene is fadE12 [H]

Identifier: 115351620

GI number: 115351620

Start: 1734227

End: 1735393

Strand: Direct

Name: fadE12 [H]

Synonym: Bamb_1567

Alternate gene names: 115351620

Gene position: 1734227-1735393 (Clockwise)

Preceding gene: 115351619

Following gene: 115351621

Centisome position: 48.76

GC content: 68.72

Gene sequence:

>1167_bases
ATGCAGTTCGACCTGACCGACGACCAGCGCGCGATCGAAAGCGCGATCGAGAAAATCTGCGAACGCTTCGGCGACGACTA
CTGGCTCGAACGCGATCGCGCGGGCGGGTTTCCGTCCGACTTTCACGCGGCGCTCGCCGAGGCCGGCTGGCTCGGCATCG
CGATGGACCCGGCCCACGGCGGCGCCGGCCTCGGGATGACCGAGGCCGCGCTGATGATGCGCACGATCAGCGCGTCGGGC
GCCGGCCTGTCGGGTGCCTCGGCCGTCCACATGAACATCTTCGGGCTGAACCCGGTGCAGGTGTTCGGCAACGACGCGCA
GAAGGCGCGCTTCCTGCCGCCGCTGATCGCCGGGCGCGACAAGGCCTGCTTCGCGGTGACCGAGCCCGACGCGGGCCTCG
ACACGACGCACCTGAGCACGCAGGCACGCCGCGATGGCGACCACTACGTGCTGAGCGGGCGCAAGATCTGGATCTCGACC
GCGCAGGTCGCGAACAAGATGCTGATCATCGCGCGCACGACGCCGCTCGACGCGGTCGCGAAGCCGACCGACGGGCTCAG
CCTGTTCTACACCGACCTCGACCGGTCGCGCGTCGAGGTGCGCGAGATCGAGAAGATGGGCCGCAAGGCCGTCGATTCGA
ACATGCTGTTCATCGACAACCTGCGCGTGCCGCGCGACGACCTGATCGGCAACGAGGGCGACGGCTTCCGTTATCTGCTG
CACGGGCTGAATCCCGAGCGGATCCTGATCGCCGCCGAGGCGATCGGCCTCGGGCAGGCCGCGCTGCGGCGCGCGACGCA
GTATGCGTGCGAGCGCGTCGTGTTCGGCCGGCCGATCGGGCAGAACCAGTCGATCCAGCATCCGCTCGCGCAGGCGTGGA
TGCAGCTCGAGGCCGCGTGGCTGATGGTGATGAAGGCCGCGACGCGCTACGACGCGGGGCAGTCGTGCGGGGCGGAGGCG
AACGCCGCGAAGTACCTCGGCGCGGAAGCCGCGTTCGAGGCGTGCCAGACGGCGATCGCGACGCACGGCGGGATGGGCTA
TGCGAAGGAATACCATGTCGAGCGCTACCTGCGCGAGTGTATGATTCCGAGGCTCGCGCCCGTGAGCCCGCAACTGATCC
TCTGCTACATCGCGGAGAAGGTGCTCGGGCTGCCGAAGTCGTACTGA

Upstream 100 bases:

>100_bases
CCATCCCGCAAACGGACGCTTTTCGACGCCAAGCGCTGGCTCCATCCGGCGTGTTGCTGAGAGCGGCGCGGCCGCTCGCC
TATTTCCAGGAGTGCAATCC

Downstream 100 bases:

>100_bases
CCGTACCGACCCGGCGGCCCGCCCGGCGCGCGGCTTCCCGTTCCGAATCAAGCGCTCGACATGGACGTCAAACTCGTTGC
CCGCACGCTCGACCTGTTCG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MQFDLTDDQRAIESAIEKICERFGDDYWLERDRAGGFPSDFHAALAEAGWLGIAMDPAHGGAGLGMTEAALMMRTISASG
AGLSGASAVHMNIFGLNPVQVFGNDAQKARFLPPLIAGRDKACFAVTEPDAGLDTTHLSTQARRDGDHYVLSGRKIWIST
AQVANKMLIIARTTPLDAVAKPTDGLSLFYTDLDRSRVEVREIEKMGRKAVDSNMLFIDNLRVPRDDLIGNEGDGFRYLL
HGLNPERILIAAEAIGLGQAALRRATQYACERVVFGRPIGQNQSIQHPLAQAWMQLEAAWLMVMKAATRYDAGQSCGAEA
NAAKYLGAEAAFEACQTAIATHGGMGYAKEYHVERYLRECMIPRLAPVSPQLILCYIAEKVLGLPKSY

Sequences:

>Translated_388_residues
MQFDLTDDQRAIESAIEKICERFGDDYWLERDRAGGFPSDFHAALAEAGWLGIAMDPAHGGAGLGMTEAALMMRTISASG
AGLSGASAVHMNIFGLNPVQVFGNDAQKARFLPPLIAGRDKACFAVTEPDAGLDTTHLSTQARRDGDHYVLSGRKIWIST
AQVANKMLIIARTTPLDAVAKPTDGLSLFYTDLDRSRVEVREIEKMGRKAVDSNMLFIDNLRVPRDDLIGNEGDGFRYLL
HGLNPERILIAAEAIGLGQAALRRATQYACERVVFGRPIGQNQSIQHPLAQAWMQLEAAWLMVMKAATRYDAGQSCGAEA
NAAKYLGAEAAFEACQTAIATHGGMGYAKEYHVERYLRECMIPRLAPVSPQLILCYIAEKVLGLPKSY
>Mature_388_residues
MQFDLTDDQRAIESAIEKICERFGDDYWLERDRAGGFPSDFHAALAEAGWLGIAMDPAHGGAGLGMTEAALMMRTISASG
AGLSGASAVHMNIFGLNPVQVFGNDAQKARFLPPLIAGRDKACFAVTEPDAGLDTTHLSTQARRDGDHYVLSGRKIWIST
AQVANKMLIIARTTPLDAVAKPTDGLSLFYTDLDRSRVEVREIEKMGRKAVDSNMLFIDNLRVPRDDLIGNEGDGFRYLL
HGLNPERILIAAEAIGLGQAALRRATQYACERVVFGRPIGQNQSIQHPLAQAWMQLEAAWLMVMKAATRYDAGQSCGAEA
NAAKYLGAEAAFEACQTAIATHGGMGYAKEYHVERYLRECMIPRLAPVSPQLILCYIAEKVLGLPKSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=30.1587301587302, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4557231, Length=373, Percent_Identity=28.1501340482574, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI187960098, Length=373, Percent_Identity=28.1501340482574, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI226958412, Length=359, Percent_Identity=28.9693593314763, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI4557233, Length=355, Percent_Identity=32.9577464788732, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI226958414, Length=322, Percent_Identity=29.8136645962733, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI21361497, Length=357, Percent_Identity=28.5714285714286, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI7656849, Length=365, Percent_Identity=29.041095890411, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI76496475, Length=339, Percent_Identity=30.6784660766962, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI4557235, Length=339, Percent_Identity=30.6784660766962, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI4501857, Length=327, Percent_Identity=28.7461773700306, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=24.9307479224377, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4503943, Length=361, Percent_Identity=24.9307479224377, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI38505218, Length=294, Percent_Identity=27.2108843537415, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI48976061, Length=324, Percent_Identity=25.6172839506173, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI211971008, Length=324, Percent_Identity=25.6172839506173, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=28.0927835051546, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=27.34375, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87081702, Length=309, Percent_Identity=24.5954692556634, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082384, Length=272, Percent_Identity=26.8382352941176, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71985184, Length=384, Percent_Identity=30.7291666666667, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=29.4573643410853, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17569725, Length=388, Percent_Identity=28.6082474226804, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=29.287598944591, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=27.2486772486773, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17538396, Length=360, Percent_Identity=27.7777777777778, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=29.144385026738, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=318, Percent_Identity=29.874213836478, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71990804, Length=283, Percent_Identity=30.7420494699647, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17533517, Length=353, Percent_Identity=26.3456090651558, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17534353, Length=361, Percent_Identity=25.7617728531856, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17551932, Length=354, Percent_Identity=25.7062146892655, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17505929, Length=330, Percent_Identity=27.8787878787879, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=28.3898305084746, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=27.007299270073, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=27.5720164609054, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562446, Length=251, Percent_Identity=27.8884462151394, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17531913, Length=161, Percent_Identity=27.3291925465839, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=32.3607427055703, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21356377, Length=379, Percent_Identity=31.9261213720317, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281363737, Length=381, Percent_Identity=30.4461942257218, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=31.1827956989247, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24660351, Length=371, Percent_Identity=29.1105121293801, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21355753, Length=320, Percent_Identity=30, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19920834, Length=363, Percent_Identity=25.8953168044077, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42308; Mature: 42308

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFDLTDDQRAIESAIEKICERFGDDYWLERDRAGGFPSDFHAALAEAGWLGIAMDPAHG
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCC
GAGLGMTEAALMMRTISASGAGLSGASAVHMNIFGLNPVQVFGNDAQKARFLPPLIAGRD
CCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHCCCCCHHHHHCCCHHHCCCC
KACFAVTEPDAGLDTTHLSTQARRDGDHYVLSGRKIWISTAQVANKMLIIARTTPLDAVA
CEEEEEECCCCCCCCHHCCHHHHCCCCEEEEECCEEEEEHHHHHCEEEEEEECCCCHHHC
KPTDGLSLFYTDLDRSRVEVREIEKMGRKAVDSNMLFIDNLRVPRDDLIGNEGDGFRYLL
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCCHHHHH
HGLNPERILIAAEAIGLGQAALRRATQYACERVVFGRPIGQNQSIQHPLAQAWMQLEAAW
HCCCCCEEEEEECHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LMVMKAATRYDAGQSCGAEANAAKYLGAEAAFEACQTAIATHGGMGYAKEYHVERYLREC
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MIPRLAPVSPQLILCYIAEKVLGLPKSY
CCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQFDLTDDQRAIESAIEKICERFGDDYWLERDRAGGFPSDFHAALAEAGWLGIAMDPAHG
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCC
GAGLGMTEAALMMRTISASGAGLSGASAVHMNIFGLNPVQVFGNDAQKARFLPPLIAGRD
CCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHCCCCCHHHHHCCCHHHCCCC
KACFAVTEPDAGLDTTHLSTQARRDGDHYVLSGRKIWISTAQVANKMLIIARTTPLDAVA
CEEEEEECCCCCCCCHHCCHHHHCCCCEEEEECCEEEEEHHHHHCEEEEEEECCCCHHHC
KPTDGLSLFYTDLDRSRVEVREIEKMGRKAVDSNMLFIDNLRVPRDDLIGNEGDGFRYLL
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCCHHHHH
HGLNPERILIAAEAIGLGQAALRRATQYACERVVFGRPIGQNQSIQHPLAQAWMQLEAAW
HCCCCCEEEEEECHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LMVMKAATRYDAGQSCGAEANAAKYLGAEAAFEACQTAIATHGGMGYAKEYHVERYLREC
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MIPRLAPVSPQLILCYIAEKVLGLPKSY
CCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]