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The map label for this gene is folP-A [H]

Identifier: 115351228

GI number: 115351228

Start: 1285652

End: 1286593

Strand: Direct

Name: folP-A [H]

Synonym: Bamb_1175

Alternate gene names: 115351228

Gene position: 1285652-1286593 (Clockwise)

Preceding gene: 115351227

Following gene: 115351229

Centisome position: 36.15

GC content: 70.59

Gene sequence:

>942_bases
GTGTGGCTTCACACCGGCCCGTTTTGCATTCATCAACGCCTCCCGCCCGTGTCCGATTCCGCTGTTTCCGCGTTCATCCC
CGCGCCGCTCCAGTGCGGCCGCTTCTCGCTGACGTTCGAACGCCCGCTCGTGATGGGCATCCTCAACGCAACCCCCGATT
CGTTTTCCGACGGCGGCCGCTTCCTCGCGCGCGACGATGCATTGCGCCAGGCCGAGCGGATGATCGCCGAAGGCGTCGAC
CTGATCGACATCGGCGGTGAGTCGACGCGTCCCGGCGCGCCGCCCGTGCCGCTCGACGAGGAGCTCGCGCGCGTGATCCC
GCTCGTCGAAGCGCTGCGGCCGCTGAACGTGCCGCTGTCGATCGACACCTACAAGCCGGCCGTGATGCGCGCGGCGCTTG
CGGCCGGCGCCGACCTGATCAACGACATCTGGGGGTTCCGCCAGCCCGGGGCGATCGACGCGGTGCGCGAGGGTAACAGC
GGGCTGTGCGCGATGCACATGCTCGGCGAGCCGCAGACGATGCAGGTCGGCGAGCCCGACTACGGCGACGTCGTGACCGA
CGTTCACGACTTTCTCGCCGCGCGTGCGCAGGCGCTGCGCGACGCGGGCATTGCGCCGGAGCGGATCTGCGTCGATCCGG
GCTTTGGCTTCGGCAAGGCGGTGGTCGACGACAACTACGCGCTGCTGGCCGCCTTGCGGGACACGGCGCCCGCGCGGCCC
GACGGGCGCGCGTATCCGATTCTCGCGGGCATGTCGCGCAAGTCGATGCTCGGCGCGGTGATCGGCGGCAAGCCGCCGAT
GGAACGCGTCGCGGCAAGCGTGGCGGCCGCGTTGTGCGCAGTCGGGCGCGGCGCCGCGATCGTGCGCGTGCACGATGTCG
CGGCGACGGTCGACGCGCTCAAGGTCTGGAATGCCGTGCGCGAAGCCGCGCGGCAACGATAA

Upstream 100 bases:

>100_bases
GACTCGTCGGGTGGTGGCACGACCGCCGAAGTGAAGCCGGCCAACGCGCCGGCGCCTGCTTCGCCGGCCTGAGCGCCGCT
GTAGCACCGTTCACGGGCTG

Downstream 100 bases:

>100_bases
GTCAGAATTCAGAAAGACGAAGGAGGAAGATTCGCCATGGGACGTCGATATTTCGGCACGGACGGCATTCGCGGCACGGT
AGGCGAGGCGCCCATCACGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MWLHTGPFCIHQRLPPVSDSAVSAFIPAPLQCGRFSLTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERMIAEGVD
LIDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVREGNS
GLCAMHMLGEPQTMQVGEPDYGDVVTDVHDFLAARAQALRDAGIAPERICVDPGFGFGKAVVDDNYALLAALRDTAPARP
DGRAYPILAGMSRKSMLGAVIGGKPPMERVAASVAAALCAVGRGAAIVRVHDVAATVDALKVWNAVREAARQR

Sequences:

>Translated_313_residues
MWLHTGPFCIHQRLPPVSDSAVSAFIPAPLQCGRFSLTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERMIAEGVD
LIDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVREGNS
GLCAMHMLGEPQTMQVGEPDYGDVVTDVHDFLAARAQALRDAGIAPERICVDPGFGFGKAVVDDNYALLAALRDTAPARP
DGRAYPILAGMSRKSMLGAVIGGKPPMERVAASVAAALCAVGRGAAIVRVHDVAATVDALKVWNAVREAARQR
>Mature_313_residues
MWLHTGPFCIHQRLPPVSDSAVSAFIPAPLQCGRFSLTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERMIAEGVD
LIDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVREGNS
GLCAMHMLGEPQTMQVGEPDYGDVVTDVHDFLAARAQALRDAGIAPERICVDPGFGFGKAVVDDNYALLAALRDTAPARP
DGRAYPILAGMSRKSMLGAVIGGKPPMERVAASVAAALCAVGRGAAIVRVHDVAATVDALKVWNAVREAARQR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=279, Percent_Identity=46.5949820788531, Blast_Score=233, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6324073, Length=324, Percent_Identity=30.2469135802469, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 33186; Mature: 33186

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWLHTGPFCIHQRLPPVSDSAVSAFIPAPLQCGRFSLTFERPLVMGILNATPDSFSDGGR
CCCCCCCHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCC
FLARDDALRQAERMIAEGVDLIDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLS
EEEHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEE
IDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVREGNSGLCAMHMLGEPQTMQVGEPD
ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCCCEEECCCCC
YGDVVTDVHDFLAARAQALRDAGIAPERICVDPGFGFGKAVVDDNYALLAALRDTAPARP
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEECCCHHEEHHHHHCCCCCC
DGRAYPILAGMSRKSMLGAVIGGKPPMERVAASVAAALCAVGRGAAIVRVHDVAATVDAL
CCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHH
KVWNAVREAARQR
HHHHHHHHHHHCC
>Mature Secondary Structure
MWLHTGPFCIHQRLPPVSDSAVSAFIPAPLQCGRFSLTFERPLVMGILNATPDSFSDGGR
CCCCCCCHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCC
FLARDDALRQAERMIAEGVDLIDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLS
EEEHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEE
IDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVREGNSGLCAMHMLGEPQTMQVGEPD
ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCCCEEECCCCC
YGDVVTDVHDFLAARAQALRDAGIAPERICVDPGFGFGKAVVDDNYALLAALRDTAPARP
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEECCCHHEEHHHHHCCCCCC
DGRAYPILAGMSRKSMLGAVIGGKPPMERVAASVAAALCAVGRGAAIVRVHDVAATVDAL
CCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHH
KVWNAVREAARQR
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]