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The map label for this gene is hisM [H]

Identifier: 115351109

GI number: 115351109

Start: 1146852

End: 1147565

Strand: Direct

Name: hisM [H]

Synonym: Bamb_1055

Alternate gene names: 115351109

Gene position: 1146852-1147565 (Clockwise)

Preceding gene: 115351108

Following gene: 115351110

Centisome position: 32.25

GC content: 65.41

Gene sequence:

>714_bases
ATGATCGAGATCCTCCAGGAATTCGGCCGGGCGTTCCTTTACTGGGACGGCCAGCGCCTCTCCGGCCTTGCGGTGACGCT
GTGGCTGCTCGTCGCGTCGATTTCGCTCGGCTTCGTGTGCGCGGTGCCGCTTGCGGTCGCGCGCGTGTCGAAGAACAAGT
GGCTGTCGATGCCGGTGCGGTTCTACACGTACGTGTTCCGCGGCACGCCGCTCTACGTGCAGTTGCTGCTGATGTACACG
GGCATGTACAGCCTCGAGTTCGTGCGTTCGCACTCGCTGCTCGACGCGTTCTTCAGGAGCGGCTTCAACTGCGCGATTCT
CGCGTTCGCGCTGAATACCTGCGCGTACACGACCGAGATCTTCGCGGGCGCGATTCGCGCGATTCCGCACGGCGAGGTCG
AGGCGGCGCGTGCGTACGGGATGACGCCGTTCACGATGTACCGCCGGGTGATCCTGCCGTCGGCGCTGCGCCGCGCGCTG
CCGCTGTACAGCAACGAGGTGATCCTGATGCTGCACGCGACCACCGTGGCGTTCACGGCGACCGTGCCCGACATCCTGAA
GGTCGCGCGCGACGCCAATTCCGCGACCTACATGGCATTCCAGTCGTTCGGGATCGCCGCGCTGATCTATCTTGCGGTAT
CGTTCGCACTCGTCGCGGCATTTCGCCGGGCGGAGCGCCACTGGCTCGCGTATCTCGCGGCCGGCCGTCATTGA

Upstream 100 bases:

>100_bases
TCATCGCGGCGCTGATCTACCTCGCGATCACGACCGTCTCCAACCTCGTGCTGATCCAGCTCGAGAAGCGTTATTCCATG
GGCGTGCGCCACGCAGAACT

Downstream 100 bases:

>100_bases
TTTCACTTCGAGGAGAGCCAGTTGGCCGAGATCACTCAAACGAGCGCGTCCGCTTCCACCAAGCTTGCCGCGGTCGACAT
TCACAAGCGCTACGGCGATA

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIEILQEFGRAFLYWDGQRLSGLAVTLWLLVASISLGFVCAVPLAVARVSKNKWLSMPVRFYTYVFRGTPLYVQLLLMYT
GMYSLEFVRSHSLLDAFFRSGFNCAILAFALNTCAYTTEIFAGAIRAIPHGEVEAARAYGMTPFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAGRH

Sequences:

>Translated_237_residues
MIEILQEFGRAFLYWDGQRLSGLAVTLWLLVASISLGFVCAVPLAVARVSKNKWLSMPVRFYTYVFRGTPLYVQLLLMYT
GMYSLEFVRSHSLLDAFFRSGFNCAILAFALNTCAYTTEIFAGAIRAIPHGEVEAARAYGMTPFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAGRH
>Mature_237_residues
MIEILQEFGRAFLYWDGQRLSGLAVTLWLLVASISLGFVCAVPLAVARVSKNKWLSMPVRFYTYVFRGTPLYVQLLLMYT
GMYSLEFVRSHSLLDAFFRSGFNCAILAFALNTCAYTTEIFAGAIRAIPHGEVEAARAYGMTPFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAGRH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=232, Percent_Identity=62.9310344827586, Blast_Score=316, Evalue=1e-87,
Organism=Escherichia coli, GI1787086, Length=214, Percent_Identity=35.0467289719626, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788226, Length=196, Percent_Identity=36.734693877551, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788646, Length=198, Percent_Identity=29.7979797979798, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787030, Length=209, Percent_Identity=28.7081339712919, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786873, Length=212, Percent_Identity=27.8301886792453, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787087, Length=209, Percent_Identity=24.4019138755981, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786874, Length=210, Percent_Identity=26.1904761904762, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26509; Mature: 26509

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEILQEFGRAFLYWDGQRLSGLAVTLWLLVASISLGFVCAVPLAVARVSKNKWLSMPVR
CHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHH
FYTYVFRGTPLYVQLLLMYTGMYSLEFVRSHSLLDAFFRSGFNCAILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FAGAIRAIPHGEVEAARAYGMTPFTMYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAGRH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIEILQEFGRAFLYWDGQRLSGLAVTLWLLVASISLGFVCAVPLAVARVSKNKWLSMPVR
CHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHH
FYTYVFRGTPLYVQLLLMYTGMYSLEFVRSHSLLDAFFRSGFNCAILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FAGAIRAIPHGEVEAARAYGMTPFTMYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAGRH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]