| Definition | Burkholderia ambifaria AMMD chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_008390 |
| Length | 3,556,545 |
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The map label for this gene is lepA
Identifier: 115351062
GI number: 115351062
Start: 1095912
End: 1097705
Strand: Direct
Name: lepA
Synonym: Bamb_1008
Alternate gene names: 115351062
Gene position: 1095912-1097705 (Clockwise)
Preceding gene: 115351061
Following gene: 115351063
Centisome position: 30.81
GC content: 62.99
Gene sequence:
>1794_bases ATGGATCATATTCGCAATTTCTCGATCATCGCGCACATCGACCATGGCAAGTCGACACTCGCGGATCGCATCATCCAGGT ATGCGGCGGTCTCGCCGACCGTGAAATGGAGGCGCAAGTACTCGACTCGATGGATATCGAGCGCGAGCGCGGCATCACGA TCAAGGCGCAGACGGCGGCACTGTCCTATCGCGCCCGCGACGGCAAGGTCTACAACCTCAACCTGATCGATACGCCCGGG CACGTCGACTTCTCGTACGAGGTCAGCCGTTCGCTGTCCGCGTGCGAAGGCGCGCTGCTCGTGGTCGACGCGAGCCAGGG TGTCGAGGCGCAGACGGTCGCGAACTGCTACACGGCGATCGAGCTCGGCGTCGAGGTCGTGCCGGTGCTGAACAAGATCG ACCTGCCGGCCGCGAACCCCGAGAACGCGATCGAGGAGATCGAGGACGTGATCGGCATCGATGCGACCGACGCGACGCGC TGCAGCGCGAAGACGGGCCTCGGCGTCGAGGACGTGCTCGAGTCGCTGATCGCGAAGGTGCCGCCGCCGAAGGGCGATCC GGCCGCGCCGCTGCAGGCGCTCATCATCGATTCCTGGTTCGACAATTACGTCGGCGTCGTGATGCTCGTGCGCATCGTCA ACGGCACGCTGCGCCCGAAGGAAAAGATCAAGATGATGGCGACCGGCGCGCAGTATCCGGTCGAGCACGTCGGCGTGTTC ACGCCGAAGTCGCGCAATCTCGAATCGCTGTCGGCCGGGCAGGTGGGCTTCATCATCGCCGGCATCAAGGAGCTGACGGC CGCGAAGGTCGGCGACACGGTTACGCATGTGGCGAAGGCCGCCAGCGAGCCGCTGCCGGGCTTCAAGGAAGTGAAGCCGC AGGTGTTCGCGGGGCTGTATCCGGTCGAGGCGAACCAGTACGATGCGCTGCGCGAATCGCTCGAGAAGCTGAAGCTCAAC GACGCATCGCTGCAGTACGAGCCGGAAGTGTCGCAGGCGCTCGGCTTCGGTTTCCGCTGCGGCTTCCTCGGGCTGCTGCA CATGGAAATCGTGCAGGAGCGGCTTGAGCGCGAGTTCGACATGGATCTCATCACGACCGCGCCGACGGTCGTCTACGAGG TCGTGCAGAGCGATGGCTCGACGATCATGGTCGAGAACCCGGCGAAGATGCCGGAGCCCGGCCGCATCGCCGAAGTTCGC GAGCCGATCGTCACCGTGAACCTGTACATGCCGCAGGATTACGTCGGCTCCGTGATCACGCTGTGCGAGCAGAAGCGCGG CTCGCAGATCAACATGCAGTATCACGGCCGCCAGGTGCAGCTCACGTACGAGATCCCGATGGCCGAGATCGTGCTCGACT TCTTCGATCGCCTGAAGTCGGTGTCGCGCGGCTATGCGTCGATGGACTACGAGTTCAAGGAATACCGTTCGTCGGACGTC GTGAAGGTCGACATGCTGATCAACGGCGACAAGGTCGATGCACTATCGATCATCGTGCACCGGTCGCAGTCGCAGTATCG CGGTCGCGAAGTCGCCGCGAAGATGCGCGAGATCATTCCGCGCCAGATGTACGACGTGGCGATCCAGGCCGCGATCGGCG CGCACATCGTCGCCCGCGAGAACATCAAGGCACTCCGCAAGAACGTGCTCGCGAAGTGCTACGGCGGCGACATCACGCGG AAGAAGAAACTGCTCGAGAAGCAGAAAGAAGGCAAGAAGCGCATGAAGCAGGTGGGTTCGGTCGAGATCCCGCAGGAAGC GTTCCTCGCGATCTTGCGCGTCGAAGACAAATAA
Upstream 100 bases:
>100_bases GCAAAGGCCTTTTCGGCTAAAATAAGCCGTTTTTTCACCGACTTACACAAGGCGTGCTCCGCAGTCGTCGAGCGCGCCTT TTTCGCTTGATCGGCACTGA
Downstream 100 bases:
>100_bases CAGGACTGTTCCTTTTATGAATTTTGCGCTGATTCTTTTTGTGCTCGTCGTCGTGACGGGCGTAGCGTGGGTGTTGGACA AACTGGTGTTCCTGCCGCGG
Product: GTP-binding protein LepA
Products: NA
Alternate protein names: EF-4; Ribosomal back-translocase LepA
Number of amino acids: Translated: 597; Mature: 597
Protein sequence:
>597_residues MDHIRNFSIIAHIDHGKSTLADRIIQVCGGLADREMEAQVLDSMDIERERGITIKAQTAALSYRARDGKVYNLNLIDTPG HVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIELGVEVVPVLNKIDLPAANPENAIEEIEDVIGIDATDATR CSAKTGLGVEDVLESLIAKVPPPKGDPAAPLQALIIDSWFDNYVGVVMLVRIVNGTLRPKEKIKMMATGAQYPVEHVGVF TPKSRNLESLSAGQVGFIIAGIKELTAAKVGDTVTHVAKAASEPLPGFKEVKPQVFAGLYPVEANQYDALRESLEKLKLN DASLQYEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDMDLITTAPTVVYEVVQSDGSTIMVENPAKMPEPGRIAEVR EPIVTVNLYMPQDYVGSVITLCEQKRGSQINMQYHGRQVQLTYEIPMAEIVLDFFDRLKSVSRGYASMDYEFKEYRSSDV VKVDMLINGDKVDALSIIVHRSQSQYRGREVAAKMREIIPRQMYDVAIQAAIGAHIVARENIKALRKNVLAKCYGGDITR KKKLLEKQKEGKKRMKQVGSVEIPQEAFLAILRVEDK
Sequences:
>Translated_597_residues MDHIRNFSIIAHIDHGKSTLADRIIQVCGGLADREMEAQVLDSMDIERERGITIKAQTAALSYRARDGKVYNLNLIDTPG HVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIELGVEVVPVLNKIDLPAANPENAIEEIEDVIGIDATDATR CSAKTGLGVEDVLESLIAKVPPPKGDPAAPLQALIIDSWFDNYVGVVMLVRIVNGTLRPKEKIKMMATGAQYPVEHVGVF TPKSRNLESLSAGQVGFIIAGIKELTAAKVGDTVTHVAKAASEPLPGFKEVKPQVFAGLYPVEANQYDALRESLEKLKLN DASLQYEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDMDLITTAPTVVYEVVQSDGSTIMVENPAKMPEPGRIAEVR EPIVTVNLYMPQDYVGSVITLCEQKRGSQINMQYHGRQVQLTYEIPMAEIVLDFFDRLKSVSRGYASMDYEFKEYRSSDV VKVDMLINGDKVDALSIIVHRSQSQYRGREVAAKMREIIPRQMYDVAIQAAIGAHIVARENIKALRKNVLAKCYGGDITR KKKLLEKQKEGKKRMKQVGSVEIPQEAFLAILRVEDK >Mature_597_residues MDHIRNFSIIAHIDHGKSTLADRIIQVCGGLADREMEAQVLDSMDIERERGITIKAQTAALSYRARDGKVYNLNLIDTPG HVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIELGVEVVPVLNKIDLPAANPENAIEEIEDVIGIDATDATR CSAKTGLGVEDVLESLIAKVPPPKGDPAAPLQALIIDSWFDNYVGVVMLVRIVNGTLRPKEKIKMMATGAQYPVEHVGVF TPKSRNLESLSAGQVGFIIAGIKELTAAKVGDTVTHVAKAASEPLPGFKEVKPQVFAGLYPVEANQYDALRESLEKLKLN DASLQYEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDMDLITTAPTVVYEVVQSDGSTIMVENPAKMPEPGRIAEVR EPIVTVNLYMPQDYVGSVITLCEQKRGSQINMQYHGRQVQLTYEIPMAEIVLDFFDRLKSVSRGYASMDYEFKEYRSSDV VKVDMLINGDKVDALSIIVHRSQSQYRGREVAAKMREIIPRQMYDVAIQAAIGAHIVARENIKALRKNVLAKCYGGDITR KKKLLEKQKEGKKRMKQVGSVEIPQEAFLAILRVEDK
Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc
COG id: COG0481
COG function: function code M; Membrane GTPase LepA
Gene ontology:
Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily
Homologues:
Organism=Homo sapiens, GI157426893, Length=604, Percent_Identity=48.841059602649, Blast_Score=614, Evalue=1e-176, Organism=Homo sapiens, GI18390331, Length=160, Percent_Identity=38.75, Blast_Score=108, Evalue=2e-23, Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=45.1127819548872, Blast_Score=107, Evalue=3e-23, Organism=Homo sapiens, GI25306283, Length=149, Percent_Identity=46.3087248322148, Blast_Score=107, Evalue=4e-23, Organism=Homo sapiens, GI19923640, Length=149, Percent_Identity=46.3087248322148, Blast_Score=107, Evalue=4e-23, Organism=Homo sapiens, GI25306287, Length=149, Percent_Identity=46.3087248322148, Blast_Score=107, Evalue=5e-23, Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=42.3611111111111, Blast_Score=105, Evalue=1e-22, Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=42.7272727272727, Blast_Score=88, Evalue=3e-17, Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=42.7272727272727, Blast_Score=88, Evalue=3e-17, Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=42.7272727272727, Blast_Score=88, Evalue=3e-17, Organism=Homo sapiens, GI217272894, Length=167, Percent_Identity=29.940119760479, Blast_Score=80, Evalue=7e-15, Organism=Homo sapiens, GI217272892, Length=167, Percent_Identity=29.940119760479, Blast_Score=80, Evalue=7e-15, Organism=Homo sapiens, GI53729339, Length=218, Percent_Identity=28.4403669724771, Blast_Score=74, Evalue=5e-13, Organism=Homo sapiens, GI53729337, Length=218, Percent_Identity=28.4403669724771, Blast_Score=74, Evalue=5e-13, Organism=Homo sapiens, GI4503475, Length=156, Percent_Identity=33.974358974359, Blast_Score=69, Evalue=1e-11, Organism=Homo sapiens, GI4503471, Length=173, Percent_Identity=31.7919075144509, Blast_Score=69, Evalue=1e-11, Organism=Escherichia coli, GI1788922, Length=594, Percent_Identity=69.6969696969697, Blast_Score=853, Evalue=0.0, Organism=Escherichia coli, GI48994988, Length=509, Percent_Identity=28.6836935166994, Blast_Score=174, Evalue=2e-44, Organism=Escherichia coli, GI1789738, Length=155, Percent_Identity=37.4193548387097, Blast_Score=93, Evalue=5e-20, Organism=Escherichia coli, GI1790835, Length=156, Percent_Identity=32.6923076923077, Blast_Score=84, Evalue=3e-17, Organism=Escherichia coli, GI1789559, Length=220, Percent_Identity=29.0909090909091, Blast_Score=65, Evalue=9e-12, Organism=Caenorhabditis elegans, GI17557151, Length=612, Percent_Identity=39.2156862745098, Blast_Score=464, Evalue=1e-131, Organism=Caenorhabditis elegans, GI17556745, Length=467, Percent_Identity=26.5524625267666, Blast_Score=120, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17533571, Length=161, Percent_Identity=34.1614906832298, Blast_Score=99, Evalue=6e-21, Organism=Caenorhabditis elegans, GI17506493, Length=156, Percent_Identity=39.7435897435897, Blast_Score=95, Evalue=1e-19, Organism=Caenorhabditis elegans, GI71988819, Length=134, Percent_Identity=38.0597014925373, Blast_Score=91, Evalue=2e-18, Organism=Caenorhabditis elegans, GI71988811, Length=134, Percent_Identity=38.0597014925373, Blast_Score=91, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17552882, Length=133, Percent_Identity=35.3383458646617, Blast_Score=83, Evalue=4e-16, Organism=Caenorhabditis elegans, GI32566303, Length=244, Percent_Identity=28.2786885245902, Blast_Score=68, Evalue=2e-11, Organism=Caenorhabditis elegans, GI25141371, Length=312, Percent_Identity=27.2435897435897, Blast_Score=67, Evalue=3e-11, Organism=Caenorhabditis elegans, GI71994658, Length=221, Percent_Identity=27.6018099547511, Blast_Score=65, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6323320, Length=602, Percent_Identity=47.1760797342193, Blast_Score=575, Evalue=1e-165, Organism=Saccharomyces cerevisiae, GI6323098, Length=160, Percent_Identity=40, Blast_Score=114, Evalue=5e-26, Organism=Saccharomyces cerevisiae, GI6324707, Length=144, Percent_Identity=42.3611111111111, Blast_Score=107, Evalue=8e-24, Organism=Saccharomyces cerevisiae, GI6320593, Length=144, Percent_Identity=42.3611111111111, Blast_Score=107, Evalue=8e-24, Organism=Saccharomyces cerevisiae, GI6322359, Length=115, Percent_Identity=42.6086956521739, Blast_Score=96, Evalue=1e-20, Organism=Saccharomyces cerevisiae, GI6324166, Length=144, Percent_Identity=38.1944444444444, Blast_Score=81, Evalue=5e-16, Organism=Saccharomyces cerevisiae, GI6325337, Length=156, Percent_Identity=31.4102564102564, Blast_Score=67, Evalue=6e-12, Organism=Saccharomyces cerevisiae, GI6319594, Length=156, Percent_Identity=31.4102564102564, Blast_Score=67, Evalue=6e-12, Organism=Saccharomyces cerevisiae, GI6324761, Length=331, Percent_Identity=25.3776435045317, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI78706572, Length=602, Percent_Identity=45.8471760797342, Blast_Score=548, Evalue=1e-156, Organism=Drosophila melanogaster, GI24582462, Length=161, Percent_Identity=37.888198757764, Blast_Score=105, Evalue=8e-23, Organism=Drosophila melanogaster, GI24585709, Length=148, Percent_Identity=38.5135135135135, Blast_Score=98, Evalue=2e-20, Organism=Drosophila melanogaster, GI24585711, Length=148, Percent_Identity=38.5135135135135, Blast_Score=98, Evalue=2e-20, Organism=Drosophila melanogaster, GI24585713, Length=148, Percent_Identity=38.5135135135135, Blast_Score=98, Evalue=2e-20, Organism=Drosophila melanogaster, GI28574573, Length=137, Percent_Identity=43.0656934306569, Blast_Score=96, Evalue=9e-20, Organism=Drosophila melanogaster, GI221458488, Length=149, Percent_Identity=38.255033557047, Blast_Score=91, Evalue=2e-18, Organism=Drosophila melanogaster, GI21357743, Length=133, Percent_Identity=34.5864661654135, Blast_Score=82, Evalue=1e-15, Organism=Drosophila melanogaster, GI28572034, Length=219, Percent_Identity=28.310502283105, Blast_Score=66, Evalue=6e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): LEPA_BURA4 (B1YVM2)
Other databases:
- EMBL: CP001025 - RefSeq: YP_001807719.1 - ProteinModelPortal: B1YVM2 - SMR: B1YVM2 - GeneID: 6176592 - GenomeReviews: CP001025_GR - KEGG: bac:BamMC406_1012 - HOGENOM: HBG286375 - OMA: YDSYRGV - ProtClustDB: PRK05433 - BioCyc: BAMB398577:BAMMC406_1012-MONOMER - GO: GO:0006412 - HAMAP: MF_00071 - InterPro: IPR009022 - InterPro: IPR006297 - InterPro: IPR013842 - InterPro: IPR000795 - InterPro: IPR005225 - InterPro: IPR000640 - InterPro: IPR004161 - InterPro: IPR009000 - Gene3D: G3DSA:3.30.70.240 - PRINTS: PR00315 - SMART: SM00838 - TIGRFAMs: TIGR01393 - TIGRFAMs: TIGR00231
Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF06421 LepA_C; SSF54980 EFG_III_V; SSF50447 Translat_factor
EC number: NA
Molecular weight: Translated: 65968; Mature: 65968
Theoretical pI: Translated: 5.36; Mature: 5.36
Prosite motif: PS00301 EFACTOR_GTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 4.2 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDHIRNFSIIAHIDHGKSTLADRIIQVCGGLADREMEAQVLDSMDIERERGITIKAQTAA CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCEEEEEHHE LSYRARDGKVYNLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAI EEEECCCCEEEEEEEECCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH ELGVEVVPVLNKIDLPAANPENAIEEIEDVIGIDATDATRCSAKTGLGVEDVLESLIAKV HHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHC PPPKGDPAAPLQALIIDSWFDNYVGVVMLVRIVNGTLRPKEKIKMMATGAQYPVEHVGVF CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHCEEE TPKSRNLESLSAGQVGFIIAGIKELTAAKVGDTVTHVAKAASEPLPGFKEVKPQVFAGLY CCCCCCCCCCCCCCHHHEEHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHCCHHHHHCCC PVEANQYDALRESLEKLKLNDASLQYEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFD CCCCCHHHHHHHHHHHHCCCCCCEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC MDLITTAPTVVYEVVQSDGSTIMVENPAKMPEPGRIAEVREPIVTVNLYMPQDYVGSVIT CHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCEEEEEEECCHHHHHHHHH LCEQKRGSQINMQYHGRQVQLTYEIPMAEIVLDFFDRLKSVSRGYASMDYEFKEYRSSDV HHHHHCCCEEEEEECCEEEEEEEECCHHHHHHHHHHHHHHHHCCHHCCCCHHHHHCCCCE VKVDMLINGDKVDALSIIVHRSQSQYRGREVAAKMREIIPRQMYDVAIQAAIGAHIVARE EEEEEEECCCCCCHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH NIKALRKNVLAKCYGGDITRKKKLLEKQKEGKKRMKQVGSVEIPQEAFLAILRVEDK HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCC >Mature Secondary Structure MDHIRNFSIIAHIDHGKSTLADRIIQVCGGLADREMEAQVLDSMDIERERGITIKAQTAA CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCEEEEEHHE LSYRARDGKVYNLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAI EEEECCCCEEEEEEEECCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH ELGVEVVPVLNKIDLPAANPENAIEEIEDVIGIDATDATRCSAKTGLGVEDVLESLIAKV HHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHC PPPKGDPAAPLQALIIDSWFDNYVGVVMLVRIVNGTLRPKEKIKMMATGAQYPVEHVGVF CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHCEEE TPKSRNLESLSAGQVGFIIAGIKELTAAKVGDTVTHVAKAASEPLPGFKEVKPQVFAGLY CCCCCCCCCCCCCCHHHEEHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHCCHHHHHCCC PVEANQYDALRESLEKLKLNDASLQYEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFD CCCCCHHHHHHHHHHHHCCCCCCEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC MDLITTAPTVVYEVVQSDGSTIMVENPAKMPEPGRIAEVREPIVTVNLYMPQDYVGSVIT CHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCEEEEEEECCHHHHHHHHH LCEQKRGSQINMQYHGRQVQLTYEIPMAEIVLDFFDRLKSVSRGYASMDYEFKEYRSSDV HHHHHCCCEEEEEECCEEEEEEEECCHHHHHHHHHHHHHHHHCCHHCCCCHHHHHCCCCE VKVDMLINGDKVDALSIIVHRSQSQYRGREVAAKMREIIPRQMYDVAIQAAIGAHIVARE EEEEEEECCCCCCHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH NIKALRKNVLAKCYGGDITRKKKLLEKQKEGKKRMKQVGSVEIPQEAFLAILRVEDK HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA