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The map label for this gene is serS [H]

Identifier: 115350893

GI number: 115350893

Start: 926608

End: 927909

Strand: Direct

Name: serS [H]

Synonym: Bamb_0839

Alternate gene names: 115350893

Gene position: 926608-927909 (Clockwise)

Preceding gene: 115350891

Following gene: 115350894

Centisome position: 26.05

GC content: 66.21

Gene sequence:

>1302_bases
ATGCTCGACATCCAGTTGCTGCGCAAAGACCTCGACGGCGTCGCGAAGCGCCTCGCCGATCGCGGCTACACCCTCGACGT
CGCCGCGTTTTCCGCCCTCGAAGCGGAACGCCGCGCGATCCAGACCCGTACCGAAGAGCTCCAGGCGCGCCGCAACAGCC
TGTCGAAGCAGATCGGCGCGATGAAGGGGAAGGGCGAGGACACGTCGGCCGTGATGGCCGAAGTCGGCGGCATTGGCGAC
GAGATGAAGGCGTCGGAGGCCAAGCTCGGCGAGATCCAGACGCGTCTGTCCGACCTGATGCTGGGCATGCCGAACATCGC
GCACGAAAGCGTGCCGGTCGGCAAGGACGAAGCCGACAACGTCGAGGTGCGCCGCTGGGGCACGCCGCGCGAGTTCGACT
TCGCGGTGAAGGATCACGTCGACGTCGGCACCCCGCTCGGTCTCGATTTCGAAACCGGCGCGAAGCTCGCCGGCGCACGC
TTCACGATGCTGCGCGGCTCGATCGCACGCCTGCACCGCGCGCTCGCGCAGTTCATGATCGACACGCACACGCTGCAGCA
CGGCTACACCGAGACGTACACGCCGTACATCGTCAATCCCGAGATCCTGTACGGCACGGGCCAGCTGCCGAAGTTCGCGG
ACGACATGTTCCGCGTCGAGAAGGGCGGCGGCGAGAACACGATCACGCAATACCTGATCTCGACGTCCGAGATTTCGCTG
ACGAACACCGTGCGCGAATCGATCGTCGAAGGCTCCGCGCTGCCGATCAAGCTGACCGCGCATTCGCCGTGCTTCCGCTC
GGAAGCCGGCTCGTACGGCCGCGACACGCGCGGGATGATCCGCCAGCACCAGTTCGACAAGGTCGAGATGGTGCAGGTCG
TCGCGCCCGACGCATCGTACGCGGCGCTCGACGAGATGGTCGGCCACGCGGAAGCGATCCTGCAGAAGCTCGGCCTGCCG
TACCGCGTCGTGGCGCTGTGCACCGGCGACATGGGTTTCTCTGCCGCGAAGACGTTCGACCTCGAAGTGTGGCTGCCCGC
GCAGAACACCTATCGCGAGATCTCGAGCTGCTCGAACACCGAGGCGTTCCAGGCGCGCCGGATGCAGGCGCGGTTCCGCA
ATGCGCAGGGCAAGCCGGAACTCGTGCATACGCTGAACGGCTCGGGGCTGGCCGTCGGCCGCACGCTTGTCGCGGTGCTG
GAGAACTACCAGAATGCGGATGGCTCGGTCACGGTGCCGGAAGCACTGCGTCCGTACATGGGCGGCATGGAACGTATCGA
CGCGCCTGCTCAGGTGTCGTAA

Upstream 100 bases:

>100_bases
TCAGTCGCGCGTTTGCGCCACTGTCCGTTCGGCCAATGCCGTGGCGAGCGCGCGGTGCGTTAGAATTCCCGTCTTACACA
ACGATTTCCCAAGTCCTCCC

Downstream 100 bases:

>100_bases
CGCGGGCTTCAAACCCTTCGCAAAAAATTTGCAGAAAGGGCTTGTCAGCGAGGAATCGATCGTCTTATAATCTTTTTCTC
GCGGAAACGACCAGCCGTGA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGKGEDTSAVMAEVGGIGD
EMKASEAKLGEIQTRLSDLMLGMPNIAHESVPVGKDEADNVEVRRWGTPREFDFAVKDHVDVGTPLGLDFETGAKLAGAR
FTMLRGSIARLHRALAQFMIDTHTLQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGGENTITQYLISTSEISL
TNTVRESIVEGSALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPDASYAALDEMVGHAEAILQKLGLP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEALRPYMGGMERIDAPAQVS

Sequences:

>Translated_433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGKGEDTSAVMAEVGGIGD
EMKASEAKLGEIQTRLSDLMLGMPNIAHESVPVGKDEADNVEVRRWGTPREFDFAVKDHVDVGTPLGLDFETGAKLAGAR
FTMLRGSIARLHRALAQFMIDTHTLQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGGENTITQYLISTSEISL
TNTVRESIVEGSALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPDASYAALDEMVGHAEAILQKLGLP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEALRPYMGGMERIDAPAQVS
>Mature_433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGKGEDTSAVMAEVGGIGD
EMKASEAKLGEIQTRLSDLMLGMPNIAHESVPVGKDEADNVEVRRWGTPREFDFAVKDHVDVGTPLGLDFETGAKLAGAR
FTMLRGSIARLHRALAQFMIDTHTLQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGGENTITQYLISTSEISL
TNTVRESIVEGSALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPDASYAALDEMVGHAEAILQKLGLP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEALRPYMGGMERIDAPAQVS

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=469, Percent_Identity=33.2622601279318, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI8923421, Length=420, Percent_Identity=29.0476190476191, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI225579074, Length=336, Percent_Identity=32.4404761904762, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=62.2377622377622, Blast_Score=555, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17539260, Length=335, Percent_Identity=37.0149253731343, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17542084, Length=334, Percent_Identity=31.7365269461078, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320226, Length=402, Percent_Identity=32.8358208955224, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6321799, Length=388, Percent_Identity=29.639175257732, Blast_Score=186, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24581334, Length=468, Percent_Identity=32.9059829059829, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17737985, Length=346, Percent_Identity=30.0578034682081, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47436; Mature: 47436

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGKGEDTSAVMAEVGGIGDEMKASEAKLGEIQTRLSDLMLGMPNIAHESVPVGKDEADN
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPREFDFAVKDHVDVGTPLGLDFETGAKLAGARFTMLRGSIARLHRALAQFMI
EEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DTHTLQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGGENTITQYLISTSEISL
HHHHHHCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
TNTVRESIVEGSALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPDASY
HHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHH
AALDEMVGHAEAILQKLGLPYRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHCCCCH
EAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPEALRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHHH
GGMERIDAPAQVS
CCHHHCCCCCCCC
>Mature Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGKGEDTSAVMAEVGGIGDEMKASEAKLGEIQTRLSDLMLGMPNIAHESVPVGKDEADN
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPREFDFAVKDHVDVGTPLGLDFETGAKLAGARFTMLRGSIARLHRALAQFMI
EEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DTHTLQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGGENTITQYLISTSEISL
HHHHHHCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
TNTVRESIVEGSALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPDASY
HHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHH
AALDEMVGHAEAILQKLGLPYRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHCCCCH
EAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPEALRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHHH
GGMERIDAPAQVS
CCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA