Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 115350624

GI number: 115350624

Start: 643487

End: 644551

Strand: Direct

Name: pyrC [H]

Synonym: Bamb_0570

Alternate gene names: 115350624

Gene position: 643487-644551 (Clockwise)

Preceding gene: 115350621

Following gene: 115350627

Centisome position: 18.09

GC content: 68.73

Gene sequence:

>1065_bases
ATGACTGCCTCGAACGCTTCCTCTCCGGCGACGCTCACGCTCGCCCGTCCCGACGACCTGCACCTGCACCTGCGCGACGG
CGACATGCTGGCCGCAGTGCTGCCGCATACCGCGCGCCAGTTCGCCCGCGCGATCGTCATGCCGAACCTGAAGCCGCCCG
TCACGACCACCGCGCACGCGCAGGCCTATCGCGAGCGGATCCTGGCCGCGCTGCCGGCCGGGATGTCGTTCGAGCCGTTG
ATGACGCTGTACCTGACCGACAACACGGCGCCCGACGAAATCCGCCGCGCGCGCGACAGCGGCTTCGTGCATGGCGTGAA
GCTGTATCCGGCCGGCGCGACGACGAACTCCGACCACGGCGTCAGCGATCTCGCGAAGTGCGCGAAGGCGCTCGAGGTCA
TGCAGGAAACCGGCATGCCGCTGCTCGTGCACGGCGAGGTGACCGATCCGTCGGTCGACATGTTCGATCGCGAGAAGGTG
TTCATCGATCGCGTGATGACGCCGCTGCGCCGCGATTTCCCGGGCCTGAAGGTCGTGTTCGAACACATCACGACGAAGGA
CGCGGCCGACTACGTGCGCGACGCCGACGCGGCGCCGGGCCTGCTCGGCGCGACGATCACCCCGCAGCACATGCTTTACA
GCCGCAACGCGCTGTTCGTCGGCGGGATTCGCCCGCATTACTACTGCCTGCCGGTGCTGAAGCGTGAAACGCATCGCGTC
GCGCTCGTCGAGGCCGCGACGTCGGGCAACCCGCGCTTCTTCCTCGGTACCGACAGCGCGCCGCACGCGCGCGGTGCGAA
GGAAACCGCGTGCGGCTGCGCGGGCTGCTACACGGCGCTGCACGCGCTCGAGCTGTATGCGGAAGCGTTCGACCAGGCCG
GCGCGCTCGACAAGCTGGAAAATTTCGCGAGCCGCTTCGGCGCGGATTTCTACGGGCTGCCGCACAGCACCGAAACCGTC
ACGCTGCGTCGCGAGACCTGGGAATTGCCGCGCGAGGTGTTCGCGGGCGATACGCCGGTCGTGCCGCTGCGCGCCGGCGA
GGCGATCGGCTGGAAGTTCGCGTGA

Upstream 100 bases:

>100_bases
TCCGCCGGCCGAAGGCCTCGTGTTGCGGTTTGCCGTCAGTCGGTCCGCGCACGTGCGTTCCGGCCCCGCAGATGGCCAGC
CCGTTCCTCACGACGCCTCT

Downstream 100 bases:

>100_bases
CCGGGGCGGCCGGCGCACCGCCATGTGAGGCCGGCCAGACGGCCGGCGGCGCGCGGTGCTAGAATGCGCGTCGCAAAGTA
GGCCAGGCAGTCGCGGCCTC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTASNASSPATLTLARPDDLHLHLRDGDMLAAVLPHTARQFARAIVMPNLKPPVTTTAHAQAYRERILAALPAGMSFEPL
MTLYLTDNTAPDEIRRARDSGFVHGVKLYPAGATTNSDHGVSDLAKCAKALEVMQETGMPLLVHGEVTDPSVDMFDREKV
FIDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITPQHMLYSRNALFVGGIRPHYYCLPVLKRETHRV
ALVEAATSGNPRFFLGTDSAPHARGAKETACGCAGCYTALHALELYAEAFDQAGALDKLENFASRFGADFYGLPHSTETV
TLRRETWELPREVFAGDTPVVPLRAGEAIGWKFA

Sequences:

>Translated_354_residues
MTASNASSPATLTLARPDDLHLHLRDGDMLAAVLPHTARQFARAIVMPNLKPPVTTTAHAQAYRERILAALPAGMSFEPL
MTLYLTDNTAPDEIRRARDSGFVHGVKLYPAGATTNSDHGVSDLAKCAKALEVMQETGMPLLVHGEVTDPSVDMFDREKV
FIDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITPQHMLYSRNALFVGGIRPHYYCLPVLKRETHRV
ALVEAATSGNPRFFLGTDSAPHARGAKETACGCAGCYTALHALELYAEAFDQAGALDKLENFASRFGADFYGLPHSTETV
TLRRETWELPREVFAGDTPVVPLRAGEAIGWKFA
>Mature_353_residues
TASNASSPATLTLARPDDLHLHLRDGDMLAAVLPHTARQFARAIVMPNLKPPVTTTAHAQAYRERILAALPAGMSFEPLM
TLYLTDNTAPDEIRRARDSGFVHGVKLYPAGATTNSDHGVSDLAKCAKALEVMQETGMPLLVHGEVTDPSVDMFDREKVF
IDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITPQHMLYSRNALFVGGIRPHYYCLPVLKRETHRVA
LVEAATSGNPRFFLGTDSAPHARGAKETACGCAGCYTALHALELYAEAFDQAGALDKLENFASRFGADFYGLPHSTETVT
LRRETWELPREVFAGDTPVVPLRAGEAIGWKFA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=342, Percent_Identity=55.2631578947368, Blast_Score=383, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6323452, Length=354, Percent_Identity=33.8983050847458, Blast_Score=185, Evalue=1e-47,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 38598; Mature: 38467

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASNASSPATLTLARPDDLHLHLRDGDMLAAVLPHTARQFARAIVMPNLKPPVTTTAHA
CCCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
QAYRERILAALPAGMSFEPLMTLYLTDNTAPDEIRRARDSGFVHGVKLYPAGATTNSDHG
HHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCC
VSDLAKCAKALEVMQETGMPLLVHGEVTDPSVDMFDREKVFIDRVMTPLRRDFPGLKVVF
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
EHITTKDAADYVRDADAAPGLLGATITPQHMLYSRNALFVGGIRPHYYCLPVLKRETHRV
HHHHCHHHHHHHHCCCCCCCCEECCCCCHHHHEECCEEEECCCCCCEEEEHHHHCCCCEE
ALVEAATSGNPRFFLGTDSAPHARGAKETACGCAGCYTALHALELYAEAFDQAGALDKLE
EEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
NFASRFGADFYGLPHSTETVTLRRETWELPREVFAGDTPVVPLRAGEAIGWKFA
HHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
TASNASSPATLTLARPDDLHLHLRDGDMLAAVLPHTARQFARAIVMPNLKPPVTTTAHA
CCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
QAYRERILAALPAGMSFEPLMTLYLTDNTAPDEIRRARDSGFVHGVKLYPAGATTNSDHG
HHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCC
VSDLAKCAKALEVMQETGMPLLVHGEVTDPSVDMFDREKVFIDRVMTPLRRDFPGLKVVF
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
EHITTKDAADYVRDADAAPGLLGATITPQHMLYSRNALFVGGIRPHYYCLPVLKRETHRV
HHHHCHHHHHHHHCCCCCCCCEECCCCCHHHHEECCEEEECCCCCCEEEEHHHHCCCCEE
ALVEAATSGNPRFFLGTDSAPHARGAKETACGCAGCYTALHALELYAEAFDQAGALDKLE
EEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
NFASRFGADFYGLPHSTETVTLRRETWELPREVFAGDTPVVPLRAGEAIGWKFA
HHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA