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The map label for this gene is holA

Identifier: 115350605

GI number: 115350605

Start: 617458

End: 618552

Strand: Direct

Name: holA

Synonym: Bamb_0551

Alternate gene names: 115350605

Gene position: 617458-618552 (Clockwise)

Preceding gene: 115350604

Following gene: 115350606

Centisome position: 17.36

GC content: 70.68

Gene sequence:

>1095_bases
ATGCAATTGCGACTTGATGCGCTGGAGCCGCACCTCGCGAAGGGGATGGCCGGGCTCTACACCGTCTACGGCGACGAGCC
GCTGCTCGCGCAGGAAGCGTGCGACCGCATTCGTGCGGCCGCGCGCGCGGCCGGCTTCACCGAGCGTTCGGTGCATACGG
TCGAGCGCGGCTTCGACTGGAGCGTGCTGCTCGGCGCGACGCAGGCGATGTCGCTGTTCGGCGAGCGCCAGCTGATCGAG
CTGCGCATTCCGTCGGGCAAGCCCGGCAAGGAAGGCGCCGATGCGCTGAAGACGCTCGCGGCGACTCCCAACCCCGACGC
GCTGATGCTCGTCACGTTGCCGCGCCTCGACGCGGCAACGCAGAAATCCGCATGGTTTACCGCGCTGCAGAACGGCGGCG
TCGCGCTGAAGATCGATCCGGTCGAGCGCGCGCAGCTGCCGAACTGGATCGGCCAGCGTCTGTCGATGCAGGGCCAGCGC
GTCGCGCCCGGCGACGACGGGCGGCGCGCGCTGCAGTTCATCGCGGAGCGCGTCGAGGGCAACCTGCTCGCCGCGCATCA
GGAAATCCAGAAACTCGGGCTGCTCTATCCGCAGGGCGTGCTGTCGTTCGAGCAGGTGCACGACGCGGTGCTGAATGTCG
CGCGCTACGACGTGTTCAAGCTGAACGAGGCGATGCTCGCGGGTGACGCCGCGCGGCTCGCGCGGATGATCGACGGGCTG
AAGGGCGAGGGCGAGGCGATCGTGCTCGTGATGTGGGCCGTCGTCGAGGAATTGCGCACGCTGCTGCGGATCAAGCGTGG
CACGACGGCCGGCAAGCCGCTCGCCACGCTGCTGCGCGAGAACCGCGTGTGGGGCCCGCGCGAGCGGCTGATCGGCCCCG
CGCTGAACCGCGTGTCGGAACCCGTGCTCGAAAAGGCGCTCGCGTTCGCCGCGAAACTCGACCGGCAGGTGAAGGGGCTG
TCGGCGATCACGCCGGGCCGCCGCTCGCAGGACGATCCGCCGCCCGACCCGTGGGACGGCCTGTTCCAGCTCGCGATGAC
GGTGGCGGGCGCCCGCGGCGAGCGACCGCCGCCCGCGGGTCGCGTGCGGCGTTAA

Upstream 100 bases:

>100_bases
CGTCCACTCGCTGACGCCGGCGCCGGAGGACGTGGTGCCGGGCGTCGCGCCGCGCGCGCCGCTGCCGCCGCCGCCGCTGT
AATCGCCGGCGCACGCACCG

Downstream 100 bases:

>100_bases
GCCGGGCCTTCAGCGCACGCATCGCAACCCGCTTACAATGTTTCGGTAAGCCGGCGCGGCCGGCCTGCCGCCGCGCCTCA
CGCTTCCCCACGAATTCACG

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MQLRLDALEPHLAKGMAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDWSVLLGATQAMSLFGERQLIE
LRIPSGKPGKEGADALKTLAATPNPDALMLVTLPRLDAATQKSAWFTALQNGGVALKIDPVERAQLPNWIGQRLSMQGQR
VAPGDDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPQGVLSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
KGEGEAIVLVMWAVVEELRTLLRIKRGTTAGKPLATLLRENRVWGPRERLIGPALNRVSEPVLEKALAFAAKLDRQVKGL
SAITPGRRSQDDPPPDPWDGLFQLAMTVAGARGERPPPAGRVRR

Sequences:

>Translated_364_residues
MQLRLDALEPHLAKGMAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDWSVLLGATQAMSLFGERQLIE
LRIPSGKPGKEGADALKTLAATPNPDALMLVTLPRLDAATQKSAWFTALQNGGVALKIDPVERAQLPNWIGQRLSMQGQR
VAPGDDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPQGVLSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
KGEGEAIVLVMWAVVEELRTLLRIKRGTTAGKPLATLLRENRVWGPRERLIGPALNRVSEPVLEKALAFAAKLDRQVKGL
SAITPGRRSQDDPPPDPWDGLFQLAMTVAGARGERPPPAGRVRR
>Mature_364_residues
MQLRLDALEPHLAKGMAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDWSVLLGATQAMSLFGERQLIE
LRIPSGKPGKEGADALKTLAATPNPDALMLVTLPRLDAATQKSAWFTALQNGGVALKIDPVERAQLPNWIGQRLSMQGQR
VAPGDDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPQGVLSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
KGEGEAIVLVMWAVVEELRTLLRIKRGTTAGKPLATLLRENRVWGPRERLIGPALNRVSEPVLEKALAFAAKLDRQVKGL
SAITPGRRSQDDPPPDPWDGLFQLAMTVAGARGERPPPAGRVRR

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=313, Percent_Identity=33.5463258785943, Blast_Score=157, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39694; Mature: 39694

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLDALEPHLAKGMAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDW
CCCCCCCCCHHHHHCHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCH
SVLLGATQAMSLFGERQLIELRIPSGKPGKEGADALKTLAATPNPDALMLVTLPRLDAAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHH
QKSAWFTALQNGGVALKIDPVERAQLPNWIGQRLSMQGQRVAPGDDGRRALQFIAERVEG
HHHHHHHHHCCCCEEEEECCHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPQGVLSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
KGEGEAIVLVMWAVVEELRTLLRIKRGTTAGKPLATLLRENRVWGPRERLIGPALNRVSE
CCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
PVLEKALAFAAKLDRQVKGLSAITPGRRSQDDPPPDPWDGLFQLAMTVAGARGERPPPAG
HHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
RVRR
CCCC
>Mature Secondary Structure
MQLRLDALEPHLAKGMAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDW
CCCCCCCCCHHHHHCHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCH
SVLLGATQAMSLFGERQLIELRIPSGKPGKEGADALKTLAATPNPDALMLVTLPRLDAAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHH
QKSAWFTALQNGGVALKIDPVERAQLPNWIGQRLSMQGQRVAPGDDGRRALQFIAERVEG
HHHHHHHHHCCCCEEEEECCHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPQGVLSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
KGEGEAIVLVMWAVVEELRTLLRIKRGTTAGKPLATLLRENRVWGPRERLIGPALNRVSE
CCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
PVLEKALAFAAKLDRQVKGLSAITPGRRSQDDPPPDPWDGLFQLAMTVAGARGERPPPAG
HHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
RVRR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]