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The map label for this gene is leuS

Identifier: 115350603

GI number: 115350603

Start: 614255

End: 616849

Strand: Direct

Name: leuS

Synonym: Bamb_0549

Alternate gene names: 115350603

Gene position: 614255-616849 (Clockwise)

Preceding gene: 115350602

Following gene: 115350604

Centisome position: 17.27

GC content: 66.2

Gene sequence:

>2595_bases
ATGCACGAGAGATACGTACCCGCCGACGTCGAAGCCGCCGCCCAGGGCGACTGGCGCGCAGCCGATGCCTACAAGACGAG
GGAAGATTCGCAGAAGCCGAAGTTCTACTGCGTGTCGATGCTGCCGTATCCGTCCGGCAAGCTGCACATGGGTCACGTGC
GCAACTACACGATCAACGACGTGATGTACCGCTATCTGCGGATGAACGGCTACAACACGCTGATGCCGATGGGCTGGGAC
GCGTTCGGGATGCCGGCCGAGAACGCCGCGATGGCGAACGGCGTGCCGCCCGCGAAGTGGACCTACGACAACATCGACTA
CATGAAGGGCCAGATGCAGTCGATGGGCCTCGCGATCGACTGGTCGCGCGAAATCGCGACGTGCAAGCCCGACTACTACA
AGTGGAACCAGTGGCTGTTCCTGAAGATGCTCGAGAAGGGCATCGCGTACAAGAAGACGGGCACCGTGAACTGGGACCCG
GTCGACCAGACCGTGCTCGCGAACGAGCAGGTGATCGACGGCCGCGGCTGGCGCTCGGGCGCGCTCGTCGAGAAGCGCGA
GATCCCGATGTACTACCTGCGGATCACGCAATACGCCGATGAACTGCTGAACGATCTCGACGGCCTCGGCTGGCCCGAGC
GCGTGAAGATCATGCAGCAGAACTGGATCGGCAAGAGCTTCGGCGTGAACTTCGGCTTCCCGTACGAACTCGACGGCGAG
AAGGCGCTCCTGCGCGTGTTCACGACGCGTGCCGACACGATCCTGGGCGTCACGTTCTGCGCGGTCGCGGCCGAGCACCC
GCTTGCCACGCGCCTCGCGCAGGGCAAGCCCGAACTGCAGGCGTTCATCGACGAATGCAAGCGCGGCGGCGTCGCCGAGG
CCGATGTCGCGACGATGGAGAAGAAGGGCGTCGCGACGGGCTTCTCGGTGTCGCACCCGCTCACGGGCGAGCCGGTCGAG
GTCTGGATCGGCAACTACGTGCTGATGAGCTATGGCGAAGGCGCGGTGATGGGCGTGCCGGGCCACGACGAGCGCGATTT
CGCATTCGCGAAGAAGTACGGCCTGCCGATCAAGCAGGTGATTGCGAGCGAAGGGCAGACGTACTCGCTGGATGCGTGGC
AGGAGTGGTACGGCGACAAGGAAACCGCGGTCTGCGTGAACAGCGGCAAGTACGACGGCCTGCGCTACGCGGATGCGGTC
GACGCGGTCGCGGCCGACCTGAAGGCCGGCGGCTACGGCGACAAGCAGGTCACGTGGCGCCTGCGCGACTGGGGCGTGTC
GCGCCAGCGCTACTGGGGCACGCCGATCCCGATCATCCACTGCCCGTCGTGCGGCGACGTGCCGGTGCCGGAGCAGGACC
TGCCGGTCGTGCTGCCGGAAGACCTCGTGCCGGACGGCTCGGGTAACCCGCTCGCGAAGTCGGAAGCGTTCCTGAACTGC
TCGTGCCCGAAGTGCGGCGCGGCCGCGAAGCGCGAGACCGACACGATGGATACCTTCGTCGATTCGTCGTGGTATTTCTC
GCGCTACACGGCGCCGGACGCCGACACGATGGTCGACGCGCGCACCGATTACTGGATGCCGATGGATCAGTACATCGGCG
GCATCGAGCACGCGATCCTGCACTTGCTGTATTCGCGCTTCTGGACCAAGGTGATGCGTGACCTCGGCCTCGTGAAGTTC
GGCGAGCCGGCGAAGAACCTGCTCACGCAGGGGATGGTGCTGAACGAGACGTTCTACCGCGAAGACGCATCCGGCAAGAA
GACCTGGTACAACCCGGCCGACGTGACGGTCACGCACGACGACAAGGGCCGCCCGGTCGGCGCGACGCTGAACACGGACG
GCCAGCCGGTCGTGCTCGGCGGCATCGAGAAGATGTCGAAGTCGAAGAACAACGGCGTCGATCCGCAGGTGCTGATCGAC
CAGTACGGCGCCGATACCGCGCGCCTGTTCACGATGTTCGCGGCGCCGCCCGAGCAGCAGCTCGAGTGGTCGGGCGCGGG
TGTCGAAGGCGCGAGCCGCTTCCTGCGCCGTGTATGGAGCTTCGGCGCGACGAATCGCGAGGCGCTCGCTACGCGCGCGG
GCTTCGACGCGGCCGCGCTCGGCGACGCCGACAAGGCGCTGCGCCGCGAAATCTACAGCGTGCTGAAGCAGGCCGATTTC
GACTACCAACGCCTGCAGTACAACACGGTCGTGTCGGCCGCGATGAAGATGCTGAACGCGATCGACGGCGCGAAGGGCGC
GACGCCCGCCGTGCTGCGCGAGACGTACGGCGTGCTGCTGCGCGTGCTGTACCCTGTCGTGCCGCACGTCACGTTCGAGC
TGTGGAAGGCGCTCGGCTACGCGGACGAATTCGGCCCGCTGCTCGACGCACCGTGGCCGAAGGTCGACGAGGCCGCGCTC
GAGCAGGCCGAGATCGAACTCGTGCTGCAGGTGAACGGCAAGGTGCGAGGCGCGCTGAAGGTCGCGAAGGACGCGAGCCG
CGAGGCGATCGAAGCCGCGGCAGTGGCCGACGAAGCGTTCGCGAAGTTCAGCGACGGCAAGCCGGCGAAGAAGATCGTCG
TCGTGCCCGGCCGCCTCGTGAACATCGTCGTCTGA

Upstream 100 bases:

>100_bases
AGAACCGTGAGCCTGCTCCCGCCGCCGGGCTGCCCGATTTCGTCCACTTCCGCGTGCCCGCCTCGTGGCGCGCTGCTTAA
AGCCTAGTCCGAACCACACC

Downstream 100 bases:

>100_bases
CGGCCATTGGCCGTCGGGCGCACACAGAAGGAGCGAAGGTGATCCGCAGATCGTTTTTGGGGCTCGTCGGCAGCGCGGTC
GCGCTGTCGGCATGCGGTTT

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 864; Mature: 864

Protein sequence:

>864_residues
MHERYVPADVEAAAQGDWRAADAYKTREDSQKPKFYCVSMLPYPSGKLHMGHVRNYTINDVMYRYLRMNGYNTLMPMGWD
AFGMPAENAAMANGVPPAKWTYDNIDYMKGQMQSMGLAIDWSREIATCKPDYYKWNQWLFLKMLEKGIAYKKTGTVNWDP
VDQTVLANEQVIDGRGWRSGALVEKREIPMYYLRITQYADELLNDLDGLGWPERVKIMQQNWIGKSFGVNFGFPYELDGE
KALLRVFTTRADTILGVTFCAVAAEHPLATRLAQGKPELQAFIDECKRGGVAEADVATMEKKGVATGFSVSHPLTGEPVE
VWIGNYVLMSYGEGAVMGVPGHDERDFAFAKKYGLPIKQVIASEGQTYSLDAWQEWYGDKETAVCVNSGKYDGLRYADAV
DAVAADLKAGGYGDKQVTWRLRDWGVSRQRYWGTPIPIIHCPSCGDVPVPEQDLPVVLPEDLVPDGSGNPLAKSEAFLNC
SCPKCGAAAKRETDTMDTFVDSSWYFSRYTAPDADTMVDARTDYWMPMDQYIGGIEHAILHLLYSRFWTKVMRDLGLVKF
GEPAKNLLTQGMVLNETFYREDASGKKTWYNPADVTVTHDDKGRPVGATLNTDGQPVVLGGIEKMSKSKNNGVDPQVLID
QYGADTARLFTMFAAPPEQQLEWSGAGVEGASRFLRRVWSFGATNREALATRAGFDAAALGDADKALRREIYSVLKQADF
DYQRLQYNTVVSAAMKMLNAIDGAKGATPAVLRETYGVLLRVLYPVVPHVTFELWKALGYADEFGPLLDAPWPKVDEAAL
EQAEIELVLQVNGKVRGALKVAKDASREAIEAAAVADEAFAKFSDGKPAKKIVVVPGRLVNIVV

Sequences:

>Translated_864_residues
MHERYVPADVEAAAQGDWRAADAYKTREDSQKPKFYCVSMLPYPSGKLHMGHVRNYTINDVMYRYLRMNGYNTLMPMGWD
AFGMPAENAAMANGVPPAKWTYDNIDYMKGQMQSMGLAIDWSREIATCKPDYYKWNQWLFLKMLEKGIAYKKTGTVNWDP
VDQTVLANEQVIDGRGWRSGALVEKREIPMYYLRITQYADELLNDLDGLGWPERVKIMQQNWIGKSFGVNFGFPYELDGE
KALLRVFTTRADTILGVTFCAVAAEHPLATRLAQGKPELQAFIDECKRGGVAEADVATMEKKGVATGFSVSHPLTGEPVE
VWIGNYVLMSYGEGAVMGVPGHDERDFAFAKKYGLPIKQVIASEGQTYSLDAWQEWYGDKETAVCVNSGKYDGLRYADAV
DAVAADLKAGGYGDKQVTWRLRDWGVSRQRYWGTPIPIIHCPSCGDVPVPEQDLPVVLPEDLVPDGSGNPLAKSEAFLNC
SCPKCGAAAKRETDTMDTFVDSSWYFSRYTAPDADTMVDARTDYWMPMDQYIGGIEHAILHLLYSRFWTKVMRDLGLVKF
GEPAKNLLTQGMVLNETFYREDASGKKTWYNPADVTVTHDDKGRPVGATLNTDGQPVVLGGIEKMSKSKNNGVDPQVLID
QYGADTARLFTMFAAPPEQQLEWSGAGVEGASRFLRRVWSFGATNREALATRAGFDAAALGDADKALRREIYSVLKQADF
DYQRLQYNTVVSAAMKMLNAIDGAKGATPAVLRETYGVLLRVLYPVVPHVTFELWKALGYADEFGPLLDAPWPKVDEAAL
EQAEIELVLQVNGKVRGALKVAKDASREAIEAAAVADEAFAKFSDGKPAKKIVVVPGRLVNIVV
>Mature_864_residues
MHERYVPADVEAAAQGDWRAADAYKTREDSQKPKFYCVSMLPYPSGKLHMGHVRNYTINDVMYRYLRMNGYNTLMPMGWD
AFGMPAENAAMANGVPPAKWTYDNIDYMKGQMQSMGLAIDWSREIATCKPDYYKWNQWLFLKMLEKGIAYKKTGTVNWDP
VDQTVLANEQVIDGRGWRSGALVEKREIPMYYLRITQYADELLNDLDGLGWPERVKIMQQNWIGKSFGVNFGFPYELDGE
KALLRVFTTRADTILGVTFCAVAAEHPLATRLAQGKPELQAFIDECKRGGVAEADVATMEKKGVATGFSVSHPLTGEPVE
VWIGNYVLMSYGEGAVMGVPGHDERDFAFAKKYGLPIKQVIASEGQTYSLDAWQEWYGDKETAVCVNSGKYDGLRYADAV
DAVAADLKAGGYGDKQVTWRLRDWGVSRQRYWGTPIPIIHCPSCGDVPVPEQDLPVVLPEDLVPDGSGNPLAKSEAFLNC
SCPKCGAAAKRETDTMDTFVDSSWYFSRYTAPDADTMVDARTDYWMPMDQYIGGIEHAILHLLYSRFWTKVMRDLGLVKF
GEPAKNLLTQGMVLNETFYREDASGKKTWYNPADVTVTHDDKGRPVGATLNTDGQPVVLGGIEKMSKSKNNGVDPQVLID
QYGADTARLFTMFAAPPEQQLEWSGAGVEGASRFLRRVWSFGATNREALATRAGFDAAALGDADKALRREIYSVLKQADF
DYQRLQYNTVVSAAMKMLNAIDGAKGATPAVLRETYGVLLRVLYPVVPHVTFELWKALGYADEFGPLLDAPWPKVDEAAL
EQAEIELVLQVNGKVRGALKVAKDASREAIEAAAVADEAFAKFSDGKPAKKIVVVPGRLVNIVV

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=865, Percent_Identity=36.9942196531792, Blast_Score=538, Evalue=1e-153,
Organism=Escherichia coli, GI1786861, Length=874, Percent_Identity=50.1144164759725, Blast_Score=865, Evalue=0.0,
Organism=Escherichia coli, GI1790708, Length=390, Percent_Identity=24.1025641025641, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997517, Length=262, Percent_Identity=40.8396946564886, Blast_Score=218, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI71997510, Length=262, Percent_Identity=40.8396946564886, Blast_Score=218, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI212645227, Length=352, Percent_Identity=29.2613636363636, Blast_Score=142, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6323414, Length=834, Percent_Identity=40.1678657074341, Blast_Score=559, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6321531, Length=401, Percent_Identity=23.6907730673317, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21355409, Length=896, Percent_Identity=35.6026785714286, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI281366294, Length=482, Percent_Identity=21.1618257261411, Blast_Score=77, Evalue=8e-14,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 95923; Mature: 95923

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHERYVPADVEAAAQGDWRAADAYKTREDSQKPKFYCVSMLPYPSGKLHMGHVRNYTIND
CCCCCCCCCCHHHCCCCCCCCCCHHCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCHHH
VMYRYLRMNGYNTLMPMGWDAFGMPAENAAMANGVPPAKWTYDNIDYMKGQMQSMGLAID
HHHHHHHHCCCCEECCCCCCCCCCCCCCCHHCCCCCCCCEECCCHHHHHHHHHHCCEEEE
WSREIATCKPDYYKWNQWLFLKMLEKGIAYKKTGTVNWDPVDQTVLANEQVIDGRGWRSG
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHCCCEEECCCCCCCC
ALVEKREIPMYYLRITQYADELLNDLDGLGWPERVKIMQQNWIGKSFGVNFGFPYELDGE
CCEECCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHCCCCCCCCEEECCH
KALLRVFTTRADTILGVTFCAVAAEHPLATRLAQGKPELQAFIDECKRGGVAEADVATME
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
KKGVATGFSVSHPLTGEPVEVWIGNYVLMSYGEGAVMGVPGHDERDFAFAKKYGLPIKQV
HCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCEEECCCCCCCCHHHHHHHCCCHHHH
IASEGQTYSLDAWQEWYGDKETAVCVNSGKYDGLRYADAVDAVAADLKAGGYGDKQVTWR
HHCCCCEEECHHHHHHCCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEE
LRDWGVSRQRYWGTPIPIIHCPSCGDVPVPEQDLPVVLPEDLVPDGSGNPLAKSEAFLNC
EHHCCCCCHHCCCCCCCEEECCCCCCCCCCCCCCCEECCHHCCCCCCCCCCCCCCCEEEC
SCPKCGAAAKRETDTMDTFVDSSWYFSRYTAPDADTMVDARTDYWMPMDQYIGGIEHAIL
CCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEECCCCCCCCHHHHHCHHHHHHH
HLLYSRFWTKVMRDLGLVKFGEPAKNLLTQGMVLNETFYREDASGKKTWYNPADVTVTHD
HHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEC
DKGRPVGATLNTDGQPVVLGGIEKMSKSKNNGVDPQVLIDQYGADTARLFTMFAAPPEQQ
CCCCEECEEECCCCCEEEEECHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHEECCCCHHH
LEWSGAGVEGASRFLRRVWSFGATNREALATRAGFDAAALGDADKALRREIYSVLKQADF
CEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHCCC
DYQRLQYNTVVSAAMKMLNAIDGAKGATPAVLRETYGVLLRVLYPVVPHVTFELWKALGY
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADEFGPLLDAPWPKVDEAALEQAEIELVLQVNGKVRGALKVAKDASREAIEAAAVADEAF
CHHHCCCCCCCCCCCCHHHHHHCCEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHH
AKFSDGKPAKKIVVVPGRLVNIVV
HHCCCCCCCCEEEECCCCEEEEEC
>Mature Secondary Structure
MHERYVPADVEAAAQGDWRAADAYKTREDSQKPKFYCVSMLPYPSGKLHMGHVRNYTIND
CCCCCCCCCCHHHCCCCCCCCCCHHCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCHHH
VMYRYLRMNGYNTLMPMGWDAFGMPAENAAMANGVPPAKWTYDNIDYMKGQMQSMGLAID
HHHHHHHHCCCCEECCCCCCCCCCCCCCCHHCCCCCCCCEECCCHHHHHHHHHHCCEEEE
WSREIATCKPDYYKWNQWLFLKMLEKGIAYKKTGTVNWDPVDQTVLANEQVIDGRGWRSG
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHCCCEEECCCCCCCC
ALVEKREIPMYYLRITQYADELLNDLDGLGWPERVKIMQQNWIGKSFGVNFGFPYELDGE
CCEECCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHCCCCCCCCEEECCH
KALLRVFTTRADTILGVTFCAVAAEHPLATRLAQGKPELQAFIDECKRGGVAEADVATME
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
KKGVATGFSVSHPLTGEPVEVWIGNYVLMSYGEGAVMGVPGHDERDFAFAKKYGLPIKQV
HCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCEEECCCCCCCCHHHHHHHCCCHHHH
IASEGQTYSLDAWQEWYGDKETAVCVNSGKYDGLRYADAVDAVAADLKAGGYGDKQVTWR
HHCCCCEEECHHHHHHCCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEE
LRDWGVSRQRYWGTPIPIIHCPSCGDVPVPEQDLPVVLPEDLVPDGSGNPLAKSEAFLNC
EHHCCCCCHHCCCCCCCEEECCCCCCCCCCCCCCCEECCHHCCCCCCCCCCCCCCCEEEC
SCPKCGAAAKRETDTMDTFVDSSWYFSRYTAPDADTMVDARTDYWMPMDQYIGGIEHAIL
CCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEECCCCCCCCHHHHHCHHHHHHH
HLLYSRFWTKVMRDLGLVKFGEPAKNLLTQGMVLNETFYREDASGKKTWYNPADVTVTHD
HHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEC
DKGRPVGATLNTDGQPVVLGGIEKMSKSKNNGVDPQVLIDQYGADTARLFTMFAAPPEQQ
CCCCEECEEECCCCCEEEEECHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHEECCCCHHH
LEWSGAGVEGASRFLRRVWSFGATNREALATRAGFDAAALGDADKALRREIYSVLKQADF
CEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHCCC
DYQRLQYNTVVSAAMKMLNAIDGAKGATPAVLRETYGVLLRVLYPVVPHVTFELWKALGY
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADEFGPLLDAPWPKVDEAALEQAEIELVLQVNGKVRGALKVAKDASREAIEAAAVADEAF
CHHHCCCCCCCCCCCCHHHHHHCCEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHH
AKFSDGKPAKKIVVVPGRLVNIVV
HHCCCCCCCCEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA