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The map label for this gene is dctA2 [H]

Identifier: 115350595

GI number: 115350595

Start: 607407

End: 608729

Strand: Direct

Name: dctA2 [H]

Synonym: Bamb_0541

Alternate gene names: 115350595

Gene position: 607407-608729 (Clockwise)

Preceding gene: 115350593

Following gene: 115350596

Centisome position: 17.08

GC content: 65.23

Gene sequence:

>1323_bases
GTGTCGAAATTCCTCAATTCGCTGTTTGGCCGGGTAGTCGTCGCATTGATACTGGGGGTCGCGCTCGGCGCGTTTTTCCC
GCATTTCGCCGAGTCGCTGCGACCGCTCGGCGACGGCTTCCTGAAGCTCATCAAGATGGTCATCGGCCCGATCGTGTTCT
GCGTCGTGGTGAGCGGGATGGCCAATGCGGGCGACCTGAAGAAGGTCGGCCGGGTCGGCCTGAAGGCCGTCATCTACTTC
GAGGTGATGACCACGCTCGCGCTCGGCATCGGGCTCGTCCTCGCGTGGCTCACGCGCCCGGGCGTCGGGATGAACATCGA
CCTGCGCTCGCTCGATGCAGCGTCGCTCTCGTCGTACGCGAAGAACGCCGAAAGCCTGAAGGACACGGCCGGCTACCTGA
TGAAGATCATCCCCGAGACCGCGATCGACGCGTTCGCGAAGGGCGACATCCTGCAGATCCTCGTGTTCGCGGTGCTGTTC
GGCTCCGCGCTGTCGCTGCTCGGCGACAAGGCGCAGCGCGTGAACAGCCTGATCGAGGAACTGTCGCACGTGTTCTTCCG
CATCATCGGCTTCATCATCAAGCTCGCGCCGCTCGGTGTGCTCGGTGCGATCGCGTTCACGACCGGCAAGTACGGCGTCT
CGTCGCTCAAGCAGCTCGGCTACCTCGTCGCGGTGTTCTACCTGAGCTGCATCGTGTTCGTCACGGTCGTGCTCGGCGTG
GTGATGCGGCTCGCGGGCTTCTCGGTGTTCAAGCTGATCCGCTACCTGCGCGAGGAACTGTCGATCGTGCTCGGCACGGC
GTCGTCGGACGCGGTGCTGCCGCAGGTGATGAGCAAGCTCGAATACATGGGCATCAAGGATTCGACGGTCGGCCTCGTGA
TCCCGACCGGCTATTCGTTCAACCTCGACGGCTTCTCGATCTACCTGACGCTCGCCGTGCTGTTCATCGCGCAGGCCACC
AACACGCCGCTGTCCACGCATGACCTGATCGTCGTGCTGCTCGTGTCGCTCGTCACGTCGAAGGGCGCGCACGGGATTCC
GGGTTCGGCGATCGTGATTCTCGCGGCGACGCTGTCGGCGATTCCCGCGATTCCGGTGCTCGGCCTCGTGCTGATCCTGC
CGGTCGACTGGTTCGTCGGCATCGCCCGCGCGCTGACCAACCTGATCGGCAACTGCGTCGCGACGGTGGTCGTCGCGGTG
TGGGAGAACGACATCGACCGGGCCCGCGCGACGCGCGTGCTGAACCGCGAGCTGCGCTACGTGGCGGTCGACGCGCAGGG
CAGCAGCGCACCGGTCGCCGGCGACCAGGCTCACGCGCTCTGA

Upstream 100 bases:

>100_bases
CCTTGACGCCACTATATCGGCTTCCTACTATCCACCATAACATCACTGGTCTTACCAGTATGAACAGACGAAACTGCAAC
CGTTGGATCGGGAGAGCGCC

Downstream 100 bases:

>100_bases
GCATCACGCGCGCGCAGCGGCTTTCCCGGCCGCTGCGCGCGATTGCATTTCCCGCGGCCGGCGCCACGACGCGCCGGCCC
ATCTCGAAAAATAGTGGAGA

Product: C4-dicarboxylate transporter DctA

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSKFLNSLFGRVVVALILGVALGAFFPHFAESLRPLGDGFLKLIKMVIGPIVFCVVVSGMANAGDLKKVGRVGLKAVIYF
EVMTTLALGIGLVLAWLTRPGVGMNIDLRSLDAASLSSYAKNAESLKDTAGYLMKIIPETAIDAFAKGDILQILVFAVLF
GSALSLLGDKAQRVNSLIEELSHVFFRIIGFIIKLAPLGVLGAIAFTTGKYGVSSLKQLGYLVAVFYLSCIVFVTVVLGV
VMRLAGFSVFKLIRYLREELSIVLGTASSDAVLPQVMSKLEYMGIKDSTVGLVIPTGYSFNLDGFSIYLTLAVLFIAQAT
NTPLSTHDLIVVLLVSLVTSKGAHGIPGSAIVILAATLSAIPAIPVLGLVLILPVDWFVGIARALTNLIGNCVATVVVAV
WENDIDRARATRVLNRELRYVAVDAQGSSAPVAGDQAHAL

Sequences:

>Translated_440_residues
MSKFLNSLFGRVVVALILGVALGAFFPHFAESLRPLGDGFLKLIKMVIGPIVFCVVVSGMANAGDLKKVGRVGLKAVIYF
EVMTTLALGIGLVLAWLTRPGVGMNIDLRSLDAASLSSYAKNAESLKDTAGYLMKIIPETAIDAFAKGDILQILVFAVLF
GSALSLLGDKAQRVNSLIEELSHVFFRIIGFIIKLAPLGVLGAIAFTTGKYGVSSLKQLGYLVAVFYLSCIVFVTVVLGV
VMRLAGFSVFKLIRYLREELSIVLGTASSDAVLPQVMSKLEYMGIKDSTVGLVIPTGYSFNLDGFSIYLTLAVLFIAQAT
NTPLSTHDLIVVLLVSLVTSKGAHGIPGSAIVILAATLSAIPAIPVLGLVLILPVDWFVGIARALTNLIGNCVATVVVAV
WENDIDRARATRVLNRELRYVAVDAQGSSAPVAGDQAHAL
>Mature_439_residues
SKFLNSLFGRVVVALILGVALGAFFPHFAESLRPLGDGFLKLIKMVIGPIVFCVVVSGMANAGDLKKVGRVGLKAVIYFE
VMTTLALGIGLVLAWLTRPGVGMNIDLRSLDAASLSSYAKNAESLKDTAGYLMKIIPETAIDAFAKGDILQILVFAVLFG
SALSLLGDKAQRVNSLIEELSHVFFRIIGFIIKLAPLGVLGAIAFTTGKYGVSSLKQLGYLVAVFYLSCIVFVTVVLGVV
MRLAGFSVFKLIRYLREELSIVLGTASSDAVLPQVMSKLEYMGIKDSTVGLVIPTGYSFNLDGFSIYLTLAVLFIAQATN
TPLSTHDLIVVLLVSLVTSKGAHGIPGSAIVILAATLSAIPAIPVLGLVLILPVDWFVGIARALTNLIGNCVATVVVAVW
ENDIDRARATRVLNRELRYVAVDAQGSSAPVAGDQAHAL

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=454, Percent_Identity=25.3303964757709, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4827012, Length=333, Percent_Identity=27.027027027027, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI21314632, Length=432, Percent_Identity=25.9259259259259, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI40254478, Length=491, Percent_Identity=24.847250509165, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI5032093, Length=426, Percent_Identity=26.056338028169, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI66773030, Length=396, Percent_Identity=26.010101010101, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI223468564, Length=301, Percent_Identity=27.2425249169435, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI223468566, Length=301, Percent_Identity=27.2425249169435, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI194239697, Length=283, Percent_Identity=28.6219081272085, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI262359914, Length=388, Percent_Identity=24.4845360824742, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI301601644, Length=199, Percent_Identity=29.1457286432161, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=51.9230769230769, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1790514, Length=423, Percent_Identity=38.5342789598109, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1788024, Length=389, Percent_Identity=23.1362467866324, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789473, Length=333, Percent_Identity=25.5255255255255, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17537407, Length=387, Percent_Identity=26.0981912144703, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193206654, Length=408, Percent_Identity=24.7549019607843, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71996953, Length=477, Percent_Identity=24.9475890985325, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193206505, Length=471, Percent_Identity=25.0530785562633, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17541374, Length=406, Percent_Identity=25.3694581280788, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71983106, Length=455, Percent_Identity=23.5164835164835, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71983099, Length=455, Percent_Identity=23.5164835164835, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24583025, Length=425, Percent_Identity=24.9411764705882, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI17137668, Length=425, Percent_Identity=24.9411764705882, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24583023, Length=425, Percent_Identity=24.9411764705882, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI281360483, Length=454, Percent_Identity=26.8722466960352, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17137666, Length=454, Percent_Identity=26.8722466960352, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281360481, Length=454, Percent_Identity=26.8722466960352, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46655; Mature: 46524

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKFLNSLFGRVVVALILGVALGAFFPHFAESLRPLGDGFLKLIKMVIGPIVFCVVVSGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC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EEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]