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The map label for this gene is pdhR [H]

Identifier: 116249441

GI number: 116249441

Start: 849469

End: 850230

Strand: Reverse

Name: pdhR [H]

Synonym: pRL120779

Alternate gene names: 116249441

Gene position: 850230-849469 (Counterclockwise)

Preceding gene: 116249448

Following gene: 116249440

Centisome position: 97.73

GC content: 61.42

Gene sequence:

>762_bases
GTGCGGCCGCTGACCCGGCGCACGCGGCGTCGAGAGAAAAGGACCATGATAACATTCGCCGTCGATGCCGTTTCGAACAG
GGGCGCAACGCGCTTCAGCGACATCATCTACGAGAAGATCGTGGGGATGATCGCCGACGGCAACTTTCCGGTGAACGAAC
GGCTGCCGCCGGAGACGAAGCTCGCCGCTGATTTCGGCGCATCGAGACCCGTCGTGCGCGAAGCGCTCGAACGCTTGAGA
GCCGATGGCCTGGTCGTTTCGCGCAAGGGTTCCGGTTCCTATGTCAGGCAAAGGCCGGATTCGTCGATGCTGAAAATGGT
GCCGGTCGGCTCCTTGGCCGATGTCCAGCGGTTCTTCGAATTCCGCGCCGGTCTCGAAGCCGAGGCGGCGGAGCTTGCAG
CGCGAAACTGGCAACCGGTCGACAAGGAGCGGATAACGGCAGCGCTTCTGTCGATCGAGCAATGTTTGCGCAACGGCGAG
CTTGGCGCCGAGGAGGACCAGGCTCTGCATGATGCAATTGCCATGGCGACCGGCAACCAGTTCCACATCACCCTGCGCGA
GTGGTTCAAGCCGCATTTCGCCATCGGGCATTCCGTTACGCGAAGCTTGAGCTTGAAGCGGACGCCGGAACAGATCCGCA
GCGTCCAGGATGAGCATGCGGTGATCGTCGAGGCGATCTTCGCGCACCGGGAAACCGAAGCGCATGATGCGATGAAAAGA
CACATACTGAATGCTCGCGCCCGCATGTTCCAGGGCGTTTGA

Upstream 100 bases:

>100_bases
TGCGACGTTGTGCCGCTGAAATACGGCCAGCAGGACGAAAAACGTTGAATCTGTCAGATGCTGTCGCCGCCCTGAACATC
ATGGCCGGCGACAGCCCAGG

Downstream 100 bases:

>100_bases
GCGATAATGGGAGGAGAGATGATGAAACGGGTCGCTGTGACGGGTGCTGCCGGACGTGTAGGGACGCTGCTGCGCCCGCT
TCTTCGGTCGCATTTCGAGC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MRPLTRRTRRREKRTMITFAVDAVSNRGATRFSDIIYEKIVGMIADGNFPVNERLPPETKLAADFGASRPVVREALERLR
ADGLVVSRKGSGSYVRQRPDSSMLKMVPVGSLADVQRFFEFRAGLEAEAAELAARNWQPVDKERITAALLSIEQCLRNGE
LGAEEDQALHDAIAMATGNQFHITLREWFKPHFAIGHSVTRSLSLKRTPEQIRSVQDEHAVIVEAIFAHRETEAHDAMKR
HILNARARMFQGV

Sequences:

>Translated_253_residues
MRPLTRRTRRREKRTMITFAVDAVSNRGATRFSDIIYEKIVGMIADGNFPVNERLPPETKLAADFGASRPVVREALERLR
ADGLVVSRKGSGSYVRQRPDSSMLKMVPVGSLADVQRFFEFRAGLEAEAAELAARNWQPVDKERITAALLSIEQCLRNGE
LGAEEDQALHDAIAMATGNQFHITLREWFKPHFAIGHSVTRSLSLKRTPEQIRSVQDEHAVIVEAIFAHRETEAHDAMKR
HILNARARMFQGV
>Mature_253_residues
MRPLTRRTRRREKRTMITFAVDAVSNRGATRFSDIIYEKIVGMIADGNFPVNERLPPETKLAADFGASRPVVREALERLR
ADGLVVSRKGSGSYVRQRPDSSMLKMVPVGSLADVQRFFEFRAGLEAEAAELAARNWQPVDKERITAALLSIEQCLRNGE
LGAEEDQALHDAIAMATGNQFHITLREWFKPHFAIGHSVTRSLSLKRTPEQIRSVQDEHAVIVEAIFAHRETEAHDAMKR
HILNARARMFQGV

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=230, Percent_Identity=31.7391304347826, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790032, Length=222, Percent_Identity=30.6306306306306, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790780, Length=234, Percent_Identity=30.3418803418803, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789353, Length=226, Percent_Identity=29.2035398230088, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28541; Mature: 28541

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLTRRTRRREKRTMITFAVDAVSNRGATRFSDIIYEKIVGMIADGNFPVNERLPPETK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
LAADFGASRPVVREALERLRADGLVVSRKGSGSYVRQRPDSSMLKMVPVGSLADVQRFFE
HHHHCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHCCCCCHHEECCCCCCHHHHHHHHH
FRAGLEAEAAELAARNWQPVDKERITAALLSIEQCLRNGELGAEEDQALHDAIAMATGNQ
HHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCE
FHITLREWFKPHFAIGHSVTRSLSLKRTPEQIRSVQDEHAVIVEAIFAHRETEAHDAMKR
EEEEHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
HILNARARMFQGV
HHHHHHHHHHCCC
>Mature Secondary Structure
MRPLTRRTRRREKRTMITFAVDAVSNRGATRFSDIIYEKIVGMIADGNFPVNERLPPETK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
LAADFGASRPVVREALERLRADGLVVSRKGSGSYVRQRPDSSMLKMVPVGSLADVQRFFE
HHHHCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHCCCCCHHEECCCCCCHHHHHHHHH
FRAGLEAEAAELAARNWQPVDKERITAALLSIEQCLRNGELGAEEDQALHDAIAMATGNQ
HHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCE
FHITLREWFKPHFAIGHSVTRSLSLKRTPEQIRSVQDEHAVIVEAIFAHRETEAHDAMKR
EEEEHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
HILNARARMFQGV
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]