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The map label for this gene is mcpA [H]

Identifier: 116249346

GI number: 116249346

Start: 734189

End: 736336

Strand: Direct

Name: mcpA [H]

Synonym: pRL120683

Alternate gene names: 116249346

Gene position: 734189-736336 (Clockwise)

Preceding gene: 116249345

Following gene: 116249349

Centisome position: 84.39

GC content: 63.97

Gene sequence:

>2148_bases
ATGATGTTGCATTTCTGGAATAAATTCGGCATTCGCGCACAGATCACCTCCGGCTTTGTGCCGCTGATCCTGTTGATGAG
CCTGCTCACGGTCAGCGCGATCTCGGGTATGAACGGGCTCGCCTCGATCTTCTCGTCCTATCGCGCCACGGCCGGCCAAA
GTCTCGCCATCTCGGACTACAGCGACCAGCTGAACGAGATTCAGATGTCGGCGGAAGCCTTCCGCTCCACGCCGACGCAG
GCTGTCGTCGACCGCTTCCGCGCCGGCGTGAAGGCGTTCGACGCCGATGACCCGCGCTTTGCTGGCAACAAGGACCTGCA
GTCCGGTCTTGCGGCGATCCGCCAGGACATCGCCACCTATGGCAAGGCTTTCGAAGAAATAGTTGCCCTGCAGGCCAGGC
GTGATGCCTTGATCTCCAAGGTCACCGAATTCGGCCCCTGGACCAGTATTGCGCTCAACGACGTCGTGCGCAGCGCCTGG
CGCCAGAACGATGTGCCGCTGCTGCAGATGACGGCGGCGACACTGGAGGCCTTGAACCGCAGCCTCTATTTCTCCGAACG
CTTCGTGCATTCCGATGATTTTGCCGCCTACGACACGGCGCAGGCAGCACTGGCCGAAGCGGTCACGCTCAACGAAGCCG
CCGCCAAGGCCGCGAAGAACGAGCTGCAAAAGAAGCGCCTGATGGGCGCCGGACAGCTGATGCAGAACTACACCGCCCGT
CTCGGCGACATGAAGGACGTGCTGCAGGCCTCGGGCAACATCCGCCAGACGCAGCTCAGCGTGCTCGCGCCGAAAATCTC
AGGCGGCTTCAAGGATCTGCAGGCGACTGTTACCGGTGCGCAGAAGACCCTTGATGGTTCGGTGGACGCAACGGTTGCCT
CCGCGACCAGCACGACGCTGATCATCAGCGGGCTGCTGATCGTCATTGGCCTCGTCCTTTCCTACTTCGTCGGCCGGTTG
ATTTCCTCGGCGGTGCGCAACATGGCCCAGTCCATGGAGCAGCTTGCCCGTGGTGAGGAAAGAATCGTGATAACGGGCGT
CGAACATCGCCACGAGCTGGGGGCCATGGCGCGTTCGCTGAAGGTTTTCCAGGAAACGGGGCGCGCCAAGCTGATCGCGG
AAGCCAATGCCGAACGCGCCCGCCTGGCGGCCGAAGAAGAGCGGCTCCGCCAGGAGGCCGAGCGGCTCAGCGACGCGCAG
GTGATGGAGCATGCCTTCCGCCAGATCTCAGTCGGGCTGGACGCGCTCTCGAAGGGCGACCTCACGGTCCGCGTCGGCGA
AGTCGACCATCGCTATGTCAGGATCCGGGATCATTTCAACAACTCGGTCGCGAGCCTCGAGGAGGCGGTCGACGCCGTCA
TTCGCGCGGTCGGCACCATCCGCTCCGGCCTTGCGGAAATCTCCACCGCGTCCAACGATCTCGCCCGCCGCACCGAGCAG
CAGGCAGCCTCGCTGGAGGAGACCGTCGCGGCGCTGGGTGAAGTGACCCGCGGCGTCAATGGAACGGCGGAGGGCGCAAG
CCGCGCCCAGGGAGTCGTGGCGACCGCCCGCACCAATGCGGAAAAGGGCGGCGAGATCGTTGCCCGCGCCATCGATGCGA
TGACGGAAATTCAAAATTCGTCGTCCAAGATCGGCAACATCATCAGCGTCATCGACGAGATTGCCTTCCAGACCAACCTG
CTGGCGCTGAACGCCGGCGTGGAAGCGGCGCGCGCCGGCGAGGCAGGCAAGGGCTTTGCCGTCGTCGCCCAGGAAGTCCG
TGAACTCGCCCAGCGCTCAGCCAATGCGGCAAGGGAGATCAAGCAGCTGATCTCTACCTCCTCGGCGCAGGTCAAGACCG
GCGTCCAGCTGGTGGGCGAATCCGGCCTCTCGCTCGAACAGATTGTCGAGCAGGTCACCGCCATGAATGCGACCGTGGCC
GAGATCGCTGTTGCCGCCCGCGAGCAGGCGACAAGCCTGCGCGAGGTCTCGGCTGCCGGCGACCAGATGGACAAGGTGAC
GCAGCAGAACGCCGCGATGGTCGAGGAGACCACGGCGGCCGCCCAGAGCCTGACACATGAAACCGAAAGCCTTGCCGAAT
TGCTGCGGCGGTTCAGAACGGGCAGCGGCCGGGTATCGGAACATCGCCATTACGCGATGGCATCCTGA

Upstream 100 bases:

>100_bases
AAGGAGAAGGTGCCGCGCGAAAACAACGTTCCCTTCGAACTCGTCACACCTGAGAACATTGCCACCTATCTGCCGAAGAG
CCAGTGAGCATAAGAGGACT

Downstream 100 bases:

>100_bases
CGTCCTGCCGATGCAGGCAAGAAAACGCCGCCGCCTCGAAAGGGCGGCGGTGAGCGGTCATCGGCCAGCGTCGCCTCAGT
GGCTCTCTGATGCGGGACCG

Product: putative methyl accepting chemotaxis protein

Products: NA

Alternate protein names: Methyl-accepting chemotaxis protein [H]

Number of amino acids: Translated: 715; Mature: 715

Protein sequence:

>715_residues
MMLHFWNKFGIRAQITSGFVPLILLMSLLTVSAISGMNGLASIFSSYRATAGQSLAISDYSDQLNEIQMSAEAFRSTPTQ
AVVDRFRAGVKAFDADDPRFAGNKDLQSGLAAIRQDIATYGKAFEEIVALQARRDALISKVTEFGPWTSIALNDVVRSAW
RQNDVPLLQMTAATLEALNRSLYFSERFVHSDDFAAYDTAQAALAEAVTLNEAAAKAAKNELQKKRLMGAGQLMQNYTAR
LGDMKDVLQASGNIRQTQLSVLAPKISGGFKDLQATVTGAQKTLDGSVDATVASATSTTLIISGLLIVIGLVLSYFVGRL
ISSAVRNMAQSMEQLARGEERIVITGVEHRHELGAMARSLKVFQETGRAKLIAEANAERARLAAEEERLRQEAERLSDAQ
VMEHAFRQISVGLDALSKGDLTVRVGEVDHRYVRIRDHFNNSVASLEEAVDAVIRAVGTIRSGLAEISTASNDLARRTEQ
QAASLEETVAALGEVTRGVNGTAEGASRAQGVVATARTNAEKGGEIVARAIDAMTEIQNSSSKIGNIISVIDEIAFQTNL
LALNAGVEAARAGEAGKGFAVVAQEVRELAQRSANAAREIKQLISTSSAQVKTGVQLVGESGLSLEQIVEQVTAMNATVA
EIAVAAREQATSLREVSAAGDQMDKVTQQNAAMVEETTAAAQSLTHETESLAELLRRFRTGSGRVSEHRHYAMAS

Sequences:

>Translated_715_residues
MMLHFWNKFGIRAQITSGFVPLILLMSLLTVSAISGMNGLASIFSSYRATAGQSLAISDYSDQLNEIQMSAEAFRSTPTQ
AVVDRFRAGVKAFDADDPRFAGNKDLQSGLAAIRQDIATYGKAFEEIVALQARRDALISKVTEFGPWTSIALNDVVRSAW
RQNDVPLLQMTAATLEALNRSLYFSERFVHSDDFAAYDTAQAALAEAVTLNEAAAKAAKNELQKKRLMGAGQLMQNYTAR
LGDMKDVLQASGNIRQTQLSVLAPKISGGFKDLQATVTGAQKTLDGSVDATVASATSTTLIISGLLIVIGLVLSYFVGRL
ISSAVRNMAQSMEQLARGEERIVITGVEHRHELGAMARSLKVFQETGRAKLIAEANAERARLAAEEERLRQEAERLSDAQ
VMEHAFRQISVGLDALSKGDLTVRVGEVDHRYVRIRDHFNNSVASLEEAVDAVIRAVGTIRSGLAEISTASNDLARRTEQ
QAASLEETVAALGEVTRGVNGTAEGASRAQGVVATARTNAEKGGEIVARAIDAMTEIQNSSSKIGNIISVIDEIAFQTNL
LALNAGVEAARAGEAGKGFAVVAQEVRELAQRSANAAREIKQLISTSSAQVKTGVQLVGESGLSLEQIVEQVTAMNATVA
EIAVAAREQATSLREVSAAGDQMDKVTQQNAAMVEETTAAAQSLTHETESLAELLRRFRTGSGRVSEHRHYAMAS
>Mature_715_residues
MMLHFWNKFGIRAQITSGFVPLILLMSLLTVSAISGMNGLASIFSSYRATAGQSLAISDYSDQLNEIQMSAEAFRSTPTQ
AVVDRFRAGVKAFDADDPRFAGNKDLQSGLAAIRQDIATYGKAFEEIVALQARRDALISKVTEFGPWTSIALNDVVRSAW
RQNDVPLLQMTAATLEALNRSLYFSERFVHSDDFAAYDTAQAALAEAVTLNEAAAKAAKNELQKKRLMGAGQLMQNYTAR
LGDMKDVLQASGNIRQTQLSVLAPKISGGFKDLQATVTGAQKTLDGSVDATVASATSTTLIISGLLIVIGLVLSYFVGRL
ISSAVRNMAQSMEQLARGEERIVITGVEHRHELGAMARSLKVFQETGRAKLIAEANAERARLAAEEERLRQEAERLSDAQ
VMEHAFRQISVGLDALSKGDLTVRVGEVDHRYVRIRDHFNNSVASLEEAVDAVIRAVGTIRSGLAEISTASNDLARRTEQ
QAASLEETVAALGEVTRGVNGTAEGASRAQGVVATARTNAEKGGEIVARAIDAMTEIQNSSSKIGNIISVIDEIAFQTNL
LALNAGVEAARAGEAGKGFAVVAQEVRELAQRSANAAREIKQLISTSSAQVKTGVQLVGESGLSLEQIVEQVTAMNATVA
EIAVAAREQATSLREVSAAGDQMDKVTQQNAAMVEETTAAAQSLTHETESLAELLRRFRTGSGRVSEHRHYAMAS

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein. Note=Localized at the flagellum-bearing pole of the swarmer cell [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=246, Percent_Identity=48.780487804878, Blast_Score=199, Evalue=8e-52,
Organism=Escherichia coli, GI2367378, Length=225, Percent_Identity=51.5555555555556, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1787690, Length=306, Percent_Identity=41.8300653594771, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1788195, Length=230, Percent_Identity=49.1304347826087, Blast_Score=191, Evalue=2e-49,
Organism=Escherichia coli, GI1789453, Length=244, Percent_Identity=40.1639344262295, Blast_Score=170, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 76630; Mature: 76630

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLHFWNKFGIRAQITSGFVPLILLMSLLTVSAISGMNGLASIFSSYRATAGQSLAISDY
CEEEEECCCCCEEEHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCH
SDQLNEIQMSAEAFRSTPTQAVVDRFRAGVKAFDADDPRFAGNKDLQSGLAAIRQDIATY
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GKAFEEIVALQARRDALISKVTEFGPWTSIALNDVVRSAWRQNDVPLLQMTAATLEALNR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SLYFSERFVHSDDFAAYDTAQAALAEAVTLNEAAAKAAKNELQKKRLMGAGQLMQNYTAR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDMKDVLQASGNIRQTQLSVLAPKISGGFKDLQATVTGAQKTLDGSVDATVASATSTTL
HCCHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
IISGLLIVIGLVLSYFVGRLISSAVRNMAQSMEQLARGEERIVITGVEHRHELGAMARSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
KVFQETGRAKLIAEANAERARLAAEEERLRQEAERLSDAQVMEHAFRQISVGLDALSKGD
HHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LTVRVGEVDHRYVRIRDHFNNSVASLEEAVDAVIRAVGTIRSGLAEISTASNDLARRTEQ
EEEEEECCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAASLEETVAALGEVTRGVNGTAEGASRAQGVVATARTNAEKGGEIVARAIDAMTEIQNS
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEHHCCCCCHHHHHHHHHHHHHHHHCC
SSKIGNIISVIDEIAFQTNLLALNAGVEAARAGEAGKGFAVVAQEVRELAQRSANAAREI
HHHHHHHHHHHHHHHHHHHHEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KQLISTSSAQVKTGVQLVGESGLSLEQIVEQVTAMNATVAEIAVAAREQATSLREVSAAG
HHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DQMDKVTQQNAAMVEETTAAAQSLTHETESLAELLRRFRTGSGRVSEHRHYAMAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCHHHCCC
>Mature Secondary Structure
MMLHFWNKFGIRAQITSGFVPLILLMSLLTVSAISGMNGLASIFSSYRATAGQSLAISDY
CEEEEECCCCCEEEHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCH
SDQLNEIQMSAEAFRSTPTQAVVDRFRAGVKAFDADDPRFAGNKDLQSGLAAIRQDIATY
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GKAFEEIVALQARRDALISKVTEFGPWTSIALNDVVRSAWRQNDVPLLQMTAATLEALNR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SLYFSERFVHSDDFAAYDTAQAALAEAVTLNEAAAKAAKNELQKKRLMGAGQLMQNYTAR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDMKDVLQASGNIRQTQLSVLAPKISGGFKDLQATVTGAQKTLDGSVDATVASATSTTL
HCCHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
IISGLLIVIGLVLSYFVGRLISSAVRNMAQSMEQLARGEERIVITGVEHRHELGAMARSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
KVFQETGRAKLIAEANAERARLAAEEERLRQEAERLSDAQVMEHAFRQISVGLDALSKGD
HHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LTVRVGEVDHRYVRIRDHFNNSVASLEEAVDAVIRAVGTIRSGLAEISTASNDLARRTEQ
EEEEEECCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAASLEETVAALGEVTRGVNGTAEGASRAQGVVATARTNAEKGGEIVARAIDAMTEIQNS
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEHHCCCCCHHHHHHHHHHHHHHHHCC
SSKIGNIISVIDEIAFQTNLLALNAGVEAARAGEAGKGFAVVAQEVRELAQRSANAAREI
HHHHHHHHHHHHHHHHHHHHEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KQLISTSSAQVKTGVQLVGESGLSLEQIVEQVTAMNATVAEIAVAAREQATSLREVSAAG
HHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DQMDKVTQQNAAMVEETTAAAQSLTHETESLAELLRRFRTGSGRVSEHRHYAMAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1577276; 11259647 [H]