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The map label for this gene is gcvPB [H]

Identifier: 114800538

GI number: 114800538

Start: 2885095

End: 2886660

Strand: Direct

Name: gcvPB [H]

Synonym: HNE_2722

Alternate gene names: 114800538

Gene position: 2885095-2886660 (Clockwise)

Preceding gene: 114797821

Following gene: 114797279

Centisome position: 77.87

GC content: 63.92

Gene sequence:

>1566_bases
ATGAACTCCACCGGCCGCCCCACGGCGCCCACCTCCGTCTCCGCCGCCGCCATCGAGACCATTTCCGGCTCGCGCGGGCT
TCTTCAGCATGAAGATCTTCTCTTCGAGATCGGCACGCCTGAGACCACCGGCGTTGACCTGCCCAAACCCAAGGGCCTGA
AAAGCCGTCTCGGCGGCGTGGCCCGCAAGGTGGATACCGGCCTTGCCGGCCTCTCCGAGCCTCAGGCCGTGCGCCACTAT
ATGCGCCTCTCCCAGAAGAATTATGCCATCGATCTTGGCCTCTTCCCGCTGGGCAGCTGCACGATGAAACACAATCCGCG
CCTCAACGAAAAGATGGCGCGCCTGCCCGGCTTTGGCGACATTCACCCCCTCCAGCCACAGGCGACCGTTCAGGGCGCGC
TGCAGCTGATTGATGAACTCGCCACCTGGCTGAAAACGCTGACCAATATGCCGTCCGTTGCCATGAGCCCGAAAGCGGGC
GCCCATGGCGAGCTTTGCGGCCTGCTGGCCATCCGCCAGGCGCTGATCGCGCGCGGCGAGGGCGATGTGCGCAAGCGGAT
GCTGGTGCCAGAGTCCGCCCACGGAACAAACCCTGCGACCGCCGCCCAGTGTGGCTTCACGGTGGACGAGATCAAGGCCA
ACAAGCGTGGCCGCGTGGATATGGCAGACCTTAAAGCGAAGCTGGAAAAGTCCGAGGATGTTGCCGGCATCATGCTGACC
AACCCGAATACCTGCGGCCTCTTCGAAACAGACATCCGCGAGATCGCCGACCTGATCCACAAGGCTGGCGGCTATTTCTA
TTGCGACGGGGCAAACTTCAACGCCATCGTCGGCCGCGTGCGCCCCGGCGACCTTGGCGTCGATGCGATGCACATCAACC
TGCACAAGACCTTCTCCACGCCTCATGGCGGCGGCGGGCCGGGCTCTGGCCCCACGGTGTTCTCTGACGCACTGGCGCCT
TATGTGCCCGTGCCGTTCGTGACCAAGGATGATGATGGCATCTACCGTCTCGTCGAACAGGTGGACGGGGAAGCCAGCGA
GAGCTTTGGCCGCATGGTCGCCTTCCATGGCCAGATGGGCATGTTCGTGCGCGCCCTTGCCTATATCCTGAGCCATGGCG
CCGACGGCCTGAAACAGGCGGCCGAAGACGCCGTCCTCAACGCCAACTACATCCAGGCCCGCCTCAAACACGTCATGAGC
CCCGCCTTTGACGGCTATTGCATGCACGAGGCGCTCTTCTCCGACGCCTTCACCGCAGACGGCATCGAAACCATCGACAT
CGCCAAAGCCCTCATCGATGAAGGCTATCATCCGATGACGATGTATTTCCCGCTGGTGGTGCATGGCGCGATGCTGATCG
AGCCGACGGAGACCGAGTCCAAGGCCGAACTTGACCGGTTCTGCGACGCGCTGGAATCCATCGCCCGCCGCGCCGCGCAG
GGCGACGACACGCTGAAAGGCGCGCCCTACCTCGCCCCGATGCGCCGCCTGGACGAGACCCGCGCCGCGCGCAAGCCGGT
GCTGAAATGGACCGCTGAAGACACCAGCAAGGTGGCCGCCGAATAG

Upstream 100 bases:

>100_bases
ACCATCTGGGCGACGTGATCCTCGTCGCGGCGACCGAATGCACGACGGCAGATGATATTGCTGCCTACACCGACGCTCTG
AAGGAGATCATCTGATGTCC

Downstream 100 bases:

>100_bases
GCAGCACCTTCTGGCCTCACTCAGACTTCACGAGCACGGCGGCTGTCAGGAAACAGCCGCCGTCTCACAATCCGGAACAG
GGTAAGCGCCGGACGCTCGA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MNSTGRPTAPTSVSAAAIETISGSRGLLQHEDLLFEIGTPETTGVDLPKPKGLKSRLGGVARKVDTGLAGLSEPQAVRHY
MRLSQKNYAIDLGLFPLGSCTMKHNPRLNEKMARLPGFGDIHPLQPQATVQGALQLIDELATWLKTLTNMPSVAMSPKAG
AHGELCGLLAIRQALIARGEGDVRKRMLVPESAHGTNPATAAQCGFTVDEIKANKRGRVDMADLKAKLEKSEDVAGIMLT
NPNTCGLFETDIREIADLIHKAGGYFYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFSTPHGGGGPGSGPTVFSDALAP
YVPVPFVTKDDDGIYRLVEQVDGEASESFGRMVAFHGQMGMFVRALAYILSHGADGLKQAAEDAVLNANYIQARLKHVMS
PAFDGYCMHEALFSDAFTADGIETIDIAKALIDEGYHPMTMYFPLVVHGAMLIEPTETESKAELDRFCDALESIARRAAQ
GDDTLKGAPYLAPMRRLDETRAARKPVLKWTAEDTSKVAAE

Sequences:

>Translated_521_residues
MNSTGRPTAPTSVSAAAIETISGSRGLLQHEDLLFEIGTPETTGVDLPKPKGLKSRLGGVARKVDTGLAGLSEPQAVRHY
MRLSQKNYAIDLGLFPLGSCTMKHNPRLNEKMARLPGFGDIHPLQPQATVQGALQLIDELATWLKTLTNMPSVAMSPKAG
AHGELCGLLAIRQALIARGEGDVRKRMLVPESAHGTNPATAAQCGFTVDEIKANKRGRVDMADLKAKLEKSEDVAGIMLT
NPNTCGLFETDIREIADLIHKAGGYFYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFSTPHGGGGPGSGPTVFSDALAP
YVPVPFVTKDDDGIYRLVEQVDGEASESFGRMVAFHGQMGMFVRALAYILSHGADGLKQAAEDAVLNANYIQARLKHVMS
PAFDGYCMHEALFSDAFTADGIETIDIAKALIDEGYHPMTMYFPLVVHGAMLIEPTETESKAELDRFCDALESIARRAAQ
GDDTLKGAPYLAPMRRLDETRAARKPVLKWTAEDTSKVAAE
>Mature_521_residues
MNSTGRPTAPTSVSAAAIETISGSRGLLQHEDLLFEIGTPETTGVDLPKPKGLKSRLGGVARKVDTGLAGLSEPQAVRHY
MRLSQKNYAIDLGLFPLGSCTMKHNPRLNEKMARLPGFGDIHPLQPQATVQGALQLIDELATWLKTLTNMPSVAMSPKAG
AHGELCGLLAIRQALIARGEGDVRKRMLVPESAHGTNPATAAQCGFTVDEIKANKRGRVDMADLKAKLEKSEDVAGIMLT
NPNTCGLFETDIREIADLIHKAGGYFYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFSTPHGGGGPGSGPTVFSDALAP
YVPVPFVTKDDDGIYRLVEQVDGEASESFGRMVAFHGQMGMFVRALAYILSHGADGLKQAAEDAVLNANYIQARLKHVMS
PAFDGYCMHEALFSDAFTADGIETIDIAKALIDEGYHPMTMYFPLVVHGAMLIEPTETESKAELDRFCDALESIARRAAQ
GDDTLKGAPYLAPMRRLDETRAARKPVLKWTAEDTSKVAAE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=417, Percent_Identity=42.4460431654676, Blast_Score=267, Evalue=2e-71,
Organism=Escherichia coli, GI1789269, Length=434, Percent_Identity=41.4746543778802, Blast_Score=280, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17535605, Length=417, Percent_Identity=41.2470023980815, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI32564013, Length=374, Percent_Identity=41.4438502673797, Blast_Score=242, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6323843, Length=411, Percent_Identity=40.8759124087591, Blast_Score=272, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24645648, Length=417, Percent_Identity=41.2470023980815, Blast_Score=259, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 56038; Mature: 56038

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTGRPTAPTSVSAAAIETISGSRGLLQHEDLLFEIGTPETTGVDLPKPKGLKSRLGGV
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHH
ARKVDTGLAGLSEPQAVRHYMRLSQKNYAIDLGLFPLGSCTMKHNPRLNEKMARLPGFGD
HHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCC
IHPLQPQATVQGALQLIDELATWLKTLTNMPSVAMSPKAGAHGELCGLLAIRQALIARGE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
GDVRKRMLVPESAHGTNPATAAQCGFTVDEIKANKRGRVDMADLKAKLEKSEDVAGIMLT
CHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEE
NPNTCGLFETDIREIADLIHKAGGYFYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFST
CCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEEEEECC
PHGGGGPGSGPTVFSDALAPYVPVPFVTKDDDGIYRLVEQVDGEASESFGRMVAFHGQMG
CCCCCCCCCCCCHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCHHHHHHCCEEEECCHHH
MFVRALAYILSHGADGLKQAAEDAVLNANYIQARLKHVMSPAFDGYCMHEALFSDAFTAD
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
GIETIDIAKALIDEGYHPMTMYFPLVVHGAMLIEPTETESKAELDRFCDALESIARRAAQ
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHC
GDDTLKGAPYLAPMRRLDETRAARKPVLKWTAEDTSKVAAE
CCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHCCC
>Mature Secondary Structure
MNSTGRPTAPTSVSAAAIETISGSRGLLQHEDLLFEIGTPETTGVDLPKPKGLKSRLGGV
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHH
ARKVDTGLAGLSEPQAVRHYMRLSQKNYAIDLGLFPLGSCTMKHNPRLNEKMARLPGFGD
HHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCC
IHPLQPQATVQGALQLIDELATWLKTLTNMPSVAMSPKAGAHGELCGLLAIRQALIARGE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
GDVRKRMLVPESAHGTNPATAAQCGFTVDEIKANKRGRVDMADLKAKLEKSEDVAGIMLT
CHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEE
NPNTCGLFETDIREIADLIHKAGGYFYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFST
CCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEEEEECC
PHGGGGPGSGPTVFSDALAPYVPVPFVTKDDDGIYRLVEQVDGEASESFGRMVAFHGQMG
CCCCCCCCCCCCHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCHHHHHHCCEEEECCHHH
MFVRALAYILSHGADGLKQAAEDAVLNANYIQARLKHVMSPAFDGYCMHEALFSDAFTAD
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
GIETIDIAKALIDEGYHPMTMYFPLVVHGAMLIEPTETESKAELDRFCDALESIARRAAQ
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHC
GDDTLKGAPYLAPMRRLDETRAARKPVLKWTAEDTSKVAAE
CCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]