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The map label for this gene is phoR [H]

Identifier: 114800483

GI number: 114800483

Start: 3229002

End: 3230381

Strand: Reverse

Name: phoR [H]

Synonym: HNE_3058

Alternate gene names: 114800483

Gene position: 3230381-3229002 (Counterclockwise)

Preceding gene: 114798211

Following gene: 114798552

Centisome position: 87.19

GC content: 63.48

Gene sequence:

>1380_bases
ATGAGCGATGGTAGTGAAACAGAGAGTTTACAGACGCCCCGTCATTCGATGACGCGCCGGGCGAGGGATTTCGGGGTTCT
GGTCGGAACGACCGGCATTGTCATGCTGATCCTGGCGATGACCAGCTCGCTCGGGCTGATTGAGGCGTTGACCGCCATGT
TTGTTATCGGGTCGATCGCGGCGGCGTATTATGTCGGCTCGGCCAGCACGCAGGCGCCGAGCGGGCCGGTAAAAACGGTG
GAGGCAGCCGGAAGAGACAGCCTCGCCATAGCCGATTTTCTTTCGGCGCTGCCGCTTCCGGCCTTTGAAGTCAGCCATGA
TCAGCAGCGAATTACCGCATACAATGATCCTGCCGCGGCCTTTCTGCGGCTGGGCCAGCGCCGCTCGGCGCCGCCGCGCG
CGAGTGTGATTATCCGCACGCCCGCACTTTTGGCCGCAATCGAGACCTGTTTCAGCATGCCGGGGCTCGGCTCGGCCGAG
ATTGAAATGGAAATCGGGCCGGAGGAACAATGGCGCGCGCATATCCGGCCCATCCGCAGCAGCGGCAATCTGCTGGTTGT
GCTGGAAGACCTGACACCGGTGAAGCGCGCAGCGCGCGCGCGGGCGGATTTTCTGGCCAATGCGAGCCATGAACTGCGCA
CGCCGCTGACGGCTATTTCCGGTTTTATCGAAACGATGCGGGGGCCTGCGCGGGAAGACAAGGATTCCTGGGACCGGTTC
CTGGGCATCATGGCGGGCGAAAGTGAGCGGATGAGCCGGCTGATTGCTGATCTCCTCTCCCTGTCGCGGATCGAGAGCGC
CGAACATGTGCAGCCTACGGCGCGCGAGCATTTTGGCGACATCGTCATGAATTCCGTGGACGCGCTGCAACCGCTGGCGA
GCGAAAAGGGCGTGACACTGGTGATCGAGGAGCCTGCCGCGTTGCCGGCGGTAACCGCCAACCGGGATGAACTGATCCAG
GTGGTTGAGAACCTGGTGTCGAACGCCATCAAATATTCAAAGGGCGGCCACACGGTCACGATCCGGTGCGGCGTCGCGCC
AGATGGGTTTGAAGCGCGGACCGAGGCAGCTCAGGCCTGGCCGGAGAGCGAGCGGATGACCCTGCTGCAAACATCCAACC
GGATGGCCATCAGCGACCCGACCGTCTGGATGCGGGTCGAGGATCAGGGGCCGGGCATCGAGCGGGAACACCTGCCGCGC
CTGGGCGAGCGGTTTTACCGGGCCGATCAGAGCCGGGGCGGTAAGATTACCGGCACGGGCCTTGGCCTGGCCATCGTCAA
GCACATCATGGCCCACCATCGCGGCGGGATGGCGGTTGAAACCCTCATGGGGCAGGGCACGGCATTCGGGGTCTGGCTAC
CGGCTGCGCGTGAAAGTTGA

Upstream 100 bases:

>100_bases
TGCCGGCTTGGCTGGCCGGCTGGTATTGGCAGGACGCCGAGGGCGCTGTAGCCGCTAAACAGAGAACCGGAAGAAGTTTC
CGGCACAGGCGGCATTCATT

Downstream 100 bases:

>100_bases
GACCCTGAAACGGTAAAGCCCCCGGGGCGGGGGGCACCGGGGGCTTCCTTCCGTCTGGCGAGATGGAATGCGGGCGTTAG
CCTGCAATGCGCCGGACGTA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSDGSETESLQTPRHSMTRRARDFGVLVGTTGIVMLILAMTSSLGLIEALTAMFVIGSIAAAYYVGSASTQAPSGPVKTV
EAAGRDSLAIADFLSALPLPAFEVSHDQQRITAYNDPAAAFLRLGQRRSAPPRASVIIRTPALLAAIETCFSMPGLGSAE
IEMEIGPEEQWRAHIRPIRSSGNLLVVLEDLTPVKRAARARADFLANASHELRTPLTAISGFIETMRGPAREDKDSWDRF
LGIMAGESERMSRLIADLLSLSRIESAEHVQPTAREHFGDIVMNSVDALQPLASEKGVTLVIEEPAALPAVTANRDELIQ
VVENLVSNAIKYSKGGHTVTIRCGVAPDGFEARTEAAQAWPESERMTLLQTSNRMAISDPTVWMRVEDQGPGIEREHLPR
LGERFYRADQSRGGKITGTGLGLAIVKHIMAHHRGGMAVETLMGQGTAFGVWLPAARES

Sequences:

>Translated_459_residues
MSDGSETESLQTPRHSMTRRARDFGVLVGTTGIVMLILAMTSSLGLIEALTAMFVIGSIAAAYYVGSASTQAPSGPVKTV
EAAGRDSLAIADFLSALPLPAFEVSHDQQRITAYNDPAAAFLRLGQRRSAPPRASVIIRTPALLAAIETCFSMPGLGSAE
IEMEIGPEEQWRAHIRPIRSSGNLLVVLEDLTPVKRAARARADFLANASHELRTPLTAISGFIETMRGPAREDKDSWDRF
LGIMAGESERMSRLIADLLSLSRIESAEHVQPTAREHFGDIVMNSVDALQPLASEKGVTLVIEEPAALPAVTANRDELIQ
VVENLVSNAIKYSKGGHTVTIRCGVAPDGFEARTEAAQAWPESERMTLLQTSNRMAISDPTVWMRVEDQGPGIEREHLPR
LGERFYRADQSRGGKITGTGLGLAIVKHIMAHHRGGMAVETLMGQGTAFGVWLPAARES
>Mature_458_residues
SDGSETESLQTPRHSMTRRARDFGVLVGTTGIVMLILAMTSSLGLIEALTAMFVIGSIAAAYYVGSASTQAPSGPVKTVE
AAGRDSLAIADFLSALPLPAFEVSHDQQRITAYNDPAAAFLRLGQRRSAPPRASVIIRTPALLAAIETCFSMPGLGSAEI
EMEIGPEEQWRAHIRPIRSSGNLLVVLEDLTPVKRAARARADFLANASHELRTPLTAISGFIETMRGPAREDKDSWDRFL
GIMAGESERMSRLIADLLSLSRIESAEHVQPTAREHFGDIVMNSVDALQPLASEKGVTLVIEEPAALPAVTANRDELIQV
VENLVSNAIKYSKGGHTVTIRCGVAPDGFEARTEAAQAWPESERMTLLQTSNRMAISDPTVWMRVEDQGPGIEREHLPRL
GERFYRADQSRGGKITGTGLGLAIVKHIMAHHRGGMAVETLMGQGTAFGVWLPAARES

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=282, Percent_Identity=34.7517730496454, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1786783, Length=255, Percent_Identity=30.9803921568627, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI145693157, Length=262, Percent_Identity=30.5343511450382, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788713, Length=265, Percent_Identity=26.4150943396226, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788549, Length=279, Percent_Identity=25.4480286738351, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=26.3157894736842, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789808, Length=266, Percent_Identity=29.3233082706767, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49535; Mature: 49404

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDGSETESLQTPRHSMTRRARDFGVLVGTTGIVMLILAMTSSLGLIEALTAMFVIGSIA
CCCCCCCHHHCCCHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AAYYVGSASTQAPSGPVKTVEAAGRDSLAIADFLSALPLPAFEVSHDQQRITAYNDPAAA
HHHHCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCEECCCCCHHHEECCCHHHH
FLRLGQRRSAPPRASVIIRTPALLAAIETCFSMPGLGSAEIEMEIGPEEQWRAHIRPIRS
HHHHHHCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHCC
SGNLLVVLEDLTPVKRAARARADFLANASHELRTPLTAISGFIETMRGPAREDKDSWDRF
CCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LGIMAGESERMSRLIADLLSLSRIESAEHVQPTAREHFGDIVMNSVDALQPLASEKGVTL
HHHHCCCHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VIEEPAALPAVTANRDELIQVVENLVSNAIKYSKGGHTVTIRCGVAPDGFEARTEAAQAW
EEECCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCC
PESERMTLLQTSNRMAISDPTVWMRVEDQGPGIEREHLPRLGERFYRADQSRGGKITGTG
CCCCCEEEEECCCCEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECC
LGLAIVKHIMAHHRGGMAVETLMGQGTAFGVWLPAARES
HHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCCC
>Mature Secondary Structure 
SDGSETESLQTPRHSMTRRARDFGVLVGTTGIVMLILAMTSSLGLIEALTAMFVIGSIA
CCCCCCHHHCCCHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AAYYVGSASTQAPSGPVKTVEAAGRDSLAIADFLSALPLPAFEVSHDQQRITAYNDPAAA
HHHHCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCEECCCCCHHHEECCCHHHH
FLRLGQRRSAPPRASVIIRTPALLAAIETCFSMPGLGSAEIEMEIGPEEQWRAHIRPIRS
HHHHHHCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHCC
SGNLLVVLEDLTPVKRAARARADFLANASHELRTPLTAISGFIETMRGPAREDKDSWDRF
CCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LGIMAGESERMSRLIADLLSLSRIESAEHVQPTAREHFGDIVMNSVDALQPLASEKGVTL
HHHHCCCHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VIEEPAALPAVTANRDELIQVVENLVSNAIKYSKGGHTVTIRCGVAPDGFEARTEAAQAW
EEECCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCC
PESERMTLLQTSNRMAISDPTVWMRVEDQGPGIEREHLPRLGERFYRADQSRGGKITGTG
CCCCCEEEEECCCCEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECC
LGLAIVKHIMAHHRGGMAVETLMGQGTAFGVWLPAARES
HHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]