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The map label for this gene is guaB [H]

Identifier: 114800464

GI number: 114800464

Start: 1849300

End: 1850757

Strand: Direct

Name: guaB [H]

Synonym: HNE_1804

Alternate gene names: 114800464

Gene position: 1849300-1850757 (Clockwise)

Preceding gene: 114797683

Following gene: 114798023

Centisome position: 49.91

GC content: 63.1

Gene sequence:

>1458_bases
ATGAAAATCCGACAAGCGATCACCTTCGACGACGTGCTTCTGCAGCCCGGCGCGAGCGAGGTATTGCCCGCAGACGTCAA
CGTCTCAACCTTCCTGACAAAAGCTATACCGCTGAACATTCCGCTGCTTTCAGCGGCCATGGATACGGTCACAGAAGCCC
GCCTCGCCATTGCGATGGCCCAGGCCGGTGGCATCGGGGTTATTCACCGTAACCTGACCATCGAACAACAGGCCGGCGAA
GTGGCGATGGTCAAGAAGTATGAGAGCGGGGTGGTAATGAACCCCATCACGATCAGCCCGGACGCTACGCTTGGCGAGCT
TCGCGAAGTCAAGAAACGCACGGGCTTCTCCGGCATCCCGGTCGTCGAGAAAAGCGGCAAGGTGCTTGGCATTGTGACGA
ACCGCGATACGCGCTTCGCCGATGACCTCAACGAGAAGGTCGCCACCCTGATGACCCGCAATGTGGTCACGGCGCAAATG
GACATGGACCCCGCCGAAGCGCGCCGCTTGCTCCACAAACACCGGATCGAGCGCCTCGTGATTGTCGATCATGACGGCCG
CTGCCTCGGATTGCTGACCGTCAAGGACATGGACAAGGCCGCCGTGCACCCGCACGCCGCCAAGGACGCCGCCGGGCGGC
TGCGCGTTGCGGCAGCGTCCACTGTGGGCGATGCAGGCTTTGAGCGAACGATGGCGCTCATCGAGGCCGGGGCGGACGCG
ATCATCATCGACACCGCCCATGGCCACTCCATATCCGTCGCCGAAGCCGTCACCCGCGCCAAGAAGATATCCAACTCGGT
CCAGATCATCGCGGGCAACGTAGCCACCGGTGAAGCCACCAAAGCTCTGATCGACGCAGGAGCCGACGCAGTCAAAGTCG
GCATCGGCCCTGGCTCCATCTGCACAACGCGCATCGTTGCCGGCGTTGGCGTTCCTCAACTCACCGCCATTGAACAATGC
GCGACCGCCGCTCTGGCCTCCGGTGTCCCGATCATTGCAGACGGCGGCATCAAGTTCTCCGGCGACTTCGCCAAGGCGCT
CGCCGCCGGCGCGTCGACCGCCATGATGGGCTCCATGTTCGCCGGTACTGAAGAGGCGCCCGGCGAGGTGTTCCTCTACC
AGGGGCGCAGCTATAAAGCCTATCGCGGTATGGGCAGCCTCGGCGCCATGGCGCGCGGCTCGGCAGACCGCTACTTCCAG
AAAGACGCCGCCGCAGAAAAGCTCGTGCCCGAAGGCATCGAAGGGCAGGTGCCCTTCAAAGGCCCCGTCGGCGCGATCAT
TCACCAGATGGTCGGCGGCCTGCGCGCCGCGATGGGCTATGTCGGCGCCAAGGATATTGCCGAGCTTCACCAGAAGGCCG
AGTTTGTGCAGATCACCGGCGCCGGACTCAACGAAAGCCATGTCCACGACGTGATGATGACACGCGAAGCGCCGAACTAC
TCCCTGTCGAGGGGGTAG

Upstream 100 bases:

>100_bases
AGGGCGTGCCTGCATTCGAGAGATTTCCCGGCAGGTAAGCATGAGGGGACTTCACAAGCCTTCACGACTCCCTTAGTAGG
CCAAAAAGGGAGCTCCCCAC

Downstream 100 bases:

>100_bases
CCTAAACGTAAAGTCCCTTGGGTTCCCGCCACATTGCCTCAAGTGGCGGGGCACCTGGGCCAGGCTCGAACAGCTTCATC
CGTTCAAACCCATGGCTCAT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MKIRQAITFDDVLLQPGASEVLPADVNVSTFLTKAIPLNIPLLSAAMDTVTEARLAIAMAQAGGIGVIHRNLTIEQQAGE
VAMVKKYESGVVMNPITISPDATLGELREVKKRTGFSGIPVVEKSGKVLGIVTNRDTRFADDLNEKVATLMTRNVVTAQM
DMDPAEARRLLHKHRIERLVIVDHDGRCLGLLTVKDMDKAAVHPHAAKDAAGRLRVAAASTVGDAGFERTMALIEAGADA
IIIDTAHGHSISVAEAVTRAKKISNSVQIIAGNVATGEATKALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAIEQC
ATAALASGVPIIADGGIKFSGDFAKALAAGASTAMMGSMFAGTEEAPGEVFLYQGRSYKAYRGMGSLGAMARGSADRYFQ
KDAAAEKLVPEGIEGQVPFKGPVGAIIHQMVGGLRAAMGYVGAKDIAELHQKAEFVQITGAGLNESHVHDVMMTREAPNY
SLSRG

Sequences:

>Translated_485_residues
MKIRQAITFDDVLLQPGASEVLPADVNVSTFLTKAIPLNIPLLSAAMDTVTEARLAIAMAQAGGIGVIHRNLTIEQQAGE
VAMVKKYESGVVMNPITISPDATLGELREVKKRTGFSGIPVVEKSGKVLGIVTNRDTRFADDLNEKVATLMTRNVVTAQM
DMDPAEARRLLHKHRIERLVIVDHDGRCLGLLTVKDMDKAAVHPHAAKDAAGRLRVAAASTVGDAGFERTMALIEAGADA
IIIDTAHGHSISVAEAVTRAKKISNSVQIIAGNVATGEATKALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAIEQC
ATAALASGVPIIADGGIKFSGDFAKALAAGASTAMMGSMFAGTEEAPGEVFLYQGRSYKAYRGMGSLGAMARGSADRYFQ
KDAAAEKLVPEGIEGQVPFKGPVGAIIHQMVGGLRAAMGYVGAKDIAELHQKAEFVQITGAGLNESHVHDVMMTREAPNY
SLSRG
>Mature_485_residues
MKIRQAITFDDVLLQPGASEVLPADVNVSTFLTKAIPLNIPLLSAAMDTVTEARLAIAMAQAGGIGVIHRNLTIEQQAGE
VAMVKKYESGVVMNPITISPDATLGELREVKKRTGFSGIPVVEKSGKVLGIVTNRDTRFADDLNEKVATLMTRNVVTAQM
DMDPAEARRLLHKHRIERLVIVDHDGRCLGLLTVKDMDKAAVHPHAAKDAAGRLRVAAASTVGDAGFERTMALIEAGADA
IIIDTAHGHSISVAEAVTRAKKISNSVQIIAGNVATGEATKALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAIEQC
ATAALASGVPIIADGGIKFSGDFAKALAAGASTAMMGSMFAGTEEAPGEVFLYQGRSYKAYRGMGSLGAMARGSADRYFQ
KDAAAEKLVPEGIEGQVPFKGPVGAIIHQMVGGLRAAMGYVGAKDIAELHQKAEFVQITGAGLNESHVHDVMMTREAPNY
SLSRG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=455, Percent_Identity=40.2197802197802, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=40.2197802197802, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=40.2197802197802, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI34328930, Length=455, Percent_Identity=40.2197802197802, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI66933016, Length=456, Percent_Identity=39.6929824561403, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI217035152, Length=460, Percent_Identity=40, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI217035148, Length=455, Percent_Identity=39.5604395604396, Blast_Score=299, Evalue=4e-81,
Organism=Homo sapiens, GI217035150, Length=455, Percent_Identity=36.9230769230769, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI50541954, Length=270, Percent_Identity=40.3703703703704, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI50541952, Length=270, Percent_Identity=40.3703703703704, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI50541948, Length=270, Percent_Identity=40.3703703703704, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI50541956, Length=270, Percent_Identity=40.3703703703704, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI156104880, Length=262, Percent_Identity=40.0763358778626, Blast_Score=172, Evalue=5e-43,
Organism=Escherichia coli, GI1788855, Length=485, Percent_Identity=57.319587628866, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1786293, Length=245, Percent_Identity=39.5918367346939, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71994385, Length=481, Percent_Identity=36.5904365904366, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71994389, Length=426, Percent_Identity=39.2018779342723, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=39.0756302521008, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322012, Length=485, Percent_Identity=39.3814432989691, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=485, Percent_Identity=41.0309278350515, Blast_Score=329, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6323585, Length=461, Percent_Identity=40.3470715835141, Blast_Score=325, Evalue=9e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=385, Percent_Identity=37.6623376623377, Blast_Score=249, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=38.7931034482759, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24641071, Length=479, Percent_Identity=40.2922755741127, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24641073, Length=479, Percent_Identity=40.2922755741127, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI28571163, Length=437, Percent_Identity=40.9610983981693, Blast_Score=299, Evalue=4e-81,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 50666; Mature: 50666

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRQAITFDDVLLQPGASEVLPADVNVSTFLTKAIPLNIPLLSAAMDTVTEARLAIAMA
CCCCHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
QAGGIGVIHRNLTIEQQAGEVAMVKKYESGVVMNPITISPDATLGELREVKKRTGFSGIP
CCCCEEEEEECEEEECCCCCEEEEEECCCCEEECCEEECCCCCHHHHHHHHHHCCCCCCC
VVEKSGKVLGIVTNRDTRFADDLNEKVATLMTRNVVTAQMDMDPAEARRLLHKHRIERLV
EEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHCCCEEE
IVDHDGRCLGLLTVKDMDKAAVHPHAAKDAAGRLRVAAASTVGDAGFERTMALIEAGADA
EEECCCCEEEEEEECCCCHHHCCCCCHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCE
IIIDTAHGHSISVAEAVTRAKKISNSVQIIAGNVATGEATKALIDAGADAVKVGIGPGSI
EEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCH
CTTRIVAGVGVPQLTAIEQCATAALASGVPIIADGGIKFSGDFAKALAAGASTAMMGSMF
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHHHHHHHHH
AGTEEAPGEVFLYQGRSYKAYRGMGSLGAMARGSADRYFQKDAAAEKLVPEGIEGQVPFK
CCCCCCCCCEEEEECCCCHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
GPVGAIIHQMVGGLRAAMGYVGAKDIAELHQKAEFVQITGAGLNESHVHDVMMTREAPNY
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHEECCCCCC
SLSRG
CCCCC
>Mature Secondary Structure
MKIRQAITFDDVLLQPGASEVLPADVNVSTFLTKAIPLNIPLLSAAMDTVTEARLAIAMA
CCCCHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
QAGGIGVIHRNLTIEQQAGEVAMVKKYESGVVMNPITISPDATLGELREVKKRTGFSGIP
CCCCEEEEEECEEEECCCCCEEEEEECCCCEEECCEEECCCCCHHHHHHHHHHCCCCCCC
VVEKSGKVLGIVTNRDTRFADDLNEKVATLMTRNVVTAQMDMDPAEARRLLHKHRIERLV
EEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHCCCEEE
IVDHDGRCLGLLTVKDMDKAAVHPHAAKDAAGRLRVAAASTVGDAGFERTMALIEAGADA
EEECCCCEEEEEEECCCCHHHCCCCCHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCE
IIIDTAHGHSISVAEAVTRAKKISNSVQIIAGNVATGEATKALIDAGADAVKVGIGPGSI
EEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCH
CTTRIVAGVGVPQLTAIEQCATAALASGVPIIADGGIKFSGDFAKALAAGASTAMMGSMF
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHHHHHHHHH
AGTEEAPGEVFLYQGRSYKAYRGMGSLGAMARGSADRYFQKDAAAEKLVPEGIEGQVPFK
CCCCCCCCCEEEEECCCCHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
GPVGAIIHQMVGGLRAAMGYVGAKDIAELHQKAEFVQITGAGLNESHVHDVMMTREAPNY
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHEECCCCCC
SLSRG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA