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The map label for this gene is acdA [H]

Identifier: 114800388

GI number: 114800388

Start: 3073276

End: 3074391

Strand: Direct

Name: acdA [H]

Synonym: HNE_2915

Alternate gene names: 114800388

Gene position: 3073276-3074391 (Clockwise)

Preceding gene: 114799384

Following gene: 114798372

Centisome position: 82.95

GC content: 62.01

Gene sequence:

>1116_bases
ATGAATTTCGATTTTTCCGAAGACCAAAAATTTCTCGCCAATGAGGCCCGGAAGTTCCTCTCGCAGGCCTGCACGACTGC
CGAAGTCCGCAAGGTTTTGAACGATGAAAAGACCGCCTACCACAAGGAATTGTGGGGCAAGGTCGTCGAGATGGGCTGGC
TGGGCGCCGCCATCCCTGAGGAGCATGGCGGCCTTGGCCTGGGCATGCTCGAAATGTGCGTGCTGGCCGAAGAAATGGGC
CGCGCGATTGCGCCTGTGCCTTTCTCTTCCACCGCCTACTACCTGACCGAAGCGGTGAAACTCGCCGGCAATGACGGCCA
GAAGTCTGCCATCCTGCCAAAAATCGCGGCGGGTGAAGTGATCGGCGCCTATGCCGCGAGCGAAGGCCCTGGCCATCCGA
GCGCGTCCAACCTGACAACCACCTTTGACGGCAAGACCCTTTCGGGCACCAAGATCCCGGTTGCCGATGGCGATATCGCC
ACGCACGCGATTGTTCTGGCCAAGGAAGGGTCCGGCGCCTCGCTCGTCCTCGTTGACCTCTCCGGCGCGGGCGTCACCCG
CAAAGTTGTCCAGACGCTCGACCCCACACGCAGCCATGCCGAGATCACCTTCTCCGGCACGCCCGCCGAACGCCTCGGCG
GCAAGGGCGAAGGCGAAATGCTCAATGATGAGCTGCTCAACCGGGTCGCCGTCCTGTTCGCCTTCGAACAGCTGGGCGGC
GCGTCGGTCTGCCTGGAAATGGCGAACGAGTTTGCTAAGCAGCGCTACGCCTTTGGCCGCCCGATCGGTGGCAACCAGGC
GATCAAGCACAAGCTGGCCGACATGTATGTGAAGAACGAAGTCGCCCGCTCCAACTGCTACTATGGCGCCTGGGCGCTTT
CGACCGGCGCTGCCGAGCTACCGGAAGCCGCCGCTGCGGCCCGCGTTGCCGCGTCAGAAGCCTACTGGTTTGCGTCGAAG
GAAAACATCCAGACGCATGGCGGCATGGGCTTCACCTGGGAAGTCGACTGCCACCTCTTCTATCGCCGCTCCAAGCTGCT
GAACGTGCAGGCTGGTTCGCCGAAGGTCTGGAAGGAAAAGCTGGTGCGTGCACTTGAGGCCAAGAATGCGGCCTGA

Upstream 100 bases:

>100_bases
CCCTTGGGTCACGGCTTTCCGTGCGCGTAAAGCGCGCTATGCTCTCTCATCAGCGATAAACAAGACACGCCCGACCGGGC
GACTGGGAGCCTGACGCGCC

Downstream 100 bases:

>100_bases
GGCATCTGCCTCTTGCGGAGTTACCGGGCGGCAGGAGATGTCCCGCCGCCCGGATACCGGATTATTCCGTCGCAGCAGCC
GGTTCGACCGGCATGGCAAC

Product: acyl-CoA dehydrogenase family protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MNFDFSEDQKFLANEARKFLSQACTTAEVRKVLNDEKTAYHKELWGKVVEMGWLGAAIPEEHGGLGLGMLEMCVLAEEMG
RAIAPVPFSSTAYYLTEAVKLAGNDGQKSAILPKIAAGEVIGAYAASEGPGHPSASNLTTTFDGKTLSGTKIPVADGDIA
THAIVLAKEGSGASLVLVDLSGAGVTRKVVQTLDPTRSHAEITFSGTPAERLGGKGEGEMLNDELLNRVAVLFAFEQLGG
ASVCLEMANEFAKQRYAFGRPIGGNQAIKHKLADMYVKNEVARSNCYYGAWALSTGAAELPEAAAAARVAASEAYWFASK
ENIQTHGGMGFTWEVDCHLFYRRSKLLNVQAGSPKVWKEKLVRALEAKNAA

Sequences:

>Translated_371_residues
MNFDFSEDQKFLANEARKFLSQACTTAEVRKVLNDEKTAYHKELWGKVVEMGWLGAAIPEEHGGLGLGMLEMCVLAEEMG
RAIAPVPFSSTAYYLTEAVKLAGNDGQKSAILPKIAAGEVIGAYAASEGPGHPSASNLTTTFDGKTLSGTKIPVADGDIA
THAIVLAKEGSGASLVLVDLSGAGVTRKVVQTLDPTRSHAEITFSGTPAERLGGKGEGEMLNDELLNRVAVLFAFEQLGG
ASVCLEMANEFAKQRYAFGRPIGGNQAIKHKLADMYVKNEVARSNCYYGAWALSTGAAELPEAAAAARVAASEAYWFASK
ENIQTHGGMGFTWEVDCHLFYRRSKLLNVQAGSPKVWKEKLVRALEAKNAA
>Mature_371_residues
MNFDFSEDQKFLANEARKFLSQACTTAEVRKVLNDEKTAYHKELWGKVVEMGWLGAAIPEEHGGLGLGMLEMCVLAEEMG
RAIAPVPFSSTAYYLTEAVKLAGNDGQKSAILPKIAAGEVIGAYAASEGPGHPSASNLTTTFDGKTLSGTKIPVADGDIA
THAIVLAKEGSGASLVLVDLSGAGVTRKVVQTLDPTRSHAEITFSGTPAERLGGKGEGEMLNDELLNRVAVLFAFEQLGG
ASVCLEMANEFAKQRYAFGRPIGGNQAIKHKLADMYVKNEVARSNCYYGAWALSTGAAELPEAAAAARVAASEAYWFASK
ENIQTHGGMGFTWEVDCHLFYRRSKLLNVQAGSPKVWKEKLVRALEAKNAA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=386, Percent_Identity=27.979274611399, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI226958414, Length=373, Percent_Identity=28.4182305630027, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4557233, Length=332, Percent_Identity=30.421686746988, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI187960098, Length=384, Percent_Identity=25.5208333333333, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4557231, Length=384, Percent_Identity=25.5208333333333, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4501857, Length=370, Percent_Identity=26.2162162162162, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI7656849, Length=349, Percent_Identity=24.9283667621776, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI76496475, Length=377, Percent_Identity=26.525198938992, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4557235, Length=377, Percent_Identity=26.525198938992, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI21361497, Length=381, Percent_Identity=27.8215223097113, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4501859, Length=380, Percent_Identity=22.8947368421053, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=25.3926701570681, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87081958, Length=377, Percent_Identity=23.342175066313, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17570075, Length=395, Percent_Identity=26.0759493670886, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=25.5936675461741, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=378, Percent_Identity=26.1904761904762, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17569725, Length=387, Percent_Identity=28.4237726098191, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17534899, Length=387, Percent_Identity=26.6149870801034, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71985184, Length=359, Percent_Identity=27.2980501392758, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17506239, Length=382, Percent_Identity=24.3455497382199, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21356377, Length=372, Percent_Identity=28.494623655914, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24646207, Length=371, Percent_Identity=28.0323450134771, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24660351, Length=382, Percent_Identity=26.1780104712042, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI281363737, Length=341, Percent_Identity=26.6862170087977, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355753, Length=388, Percent_Identity=26.8041237113402, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24666513, Length=383, Percent_Identity=24.8041775456919, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19920834, Length=265, Percent_Identity=27.1698113207547, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 39637; Mature: 39637

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDFSEDQKFLANEARKFLSQACTTAEVRKVLNDEKTAYHKELWGKVVEMGWLGAAIPE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
EHGGLGLGMLEMCVLAEEMGRAIAPVPFSSTAYYLTEAVKLAGNDGQKSAILPKIAAGEV
CCCCCCHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHCCCH
IGAYAASEGPGHPSASNLTTTFDGKTLSGTKIPVADGDIATHAIVLAKEGSGASLVLVDL
HHHHHCCCCCCCCCCCCCEEEECCCEECCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEE
SGAGVTRKVVQTLDPTRSHAEITFSGTPAERLGGKGEGEMLNDELLNRVAVLFAFEQLGG
CCCCHHHHHHHHCCCCCCCCEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
ASVCLEMANEFAKQRYAFGRPIGGNQAIKHKLADMYVKNEVARSNCYYGAWALSTGAAEL
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHC
PEAAAAARVAASEAYWFASKENIQTHGGMGFTWEVDCHLFYRRSKLLNVQAGSPKVWKEK
HHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEEEEHHHEEEEECCCCHHHHHH
LVRALEAKNAA
HHHHHHHCCCC
>Mature Secondary Structure
MNFDFSEDQKFLANEARKFLSQACTTAEVRKVLNDEKTAYHKELWGKVVEMGWLGAAIPE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
EHGGLGLGMLEMCVLAEEMGRAIAPVPFSSTAYYLTEAVKLAGNDGQKSAILPKIAAGEV
CCCCCCHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHCCCH
IGAYAASEGPGHPSASNLTTTFDGKTLSGTKIPVADGDIATHAIVLAKEGSGASLVLVDL
HHHHHCCCCCCCCCCCCCEEEECCCEECCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEE
SGAGVTRKVVQTLDPTRSHAEITFSGTPAERLGGKGEGEMLNDELLNRVAVLFAFEQLGG
CCCCHHHHHHHHCCCCCCCCEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
ASVCLEMANEFAKQRYAFGRPIGGNQAIKHKLADMYVKNEVARSNCYYGAWALSTGAAEL
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHC
PEAAAAARVAASEAYWFASKENIQTHGGMGFTWEVDCHLFYRRSKLLNVQAGSPKVWKEK
HHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEEEEHHHEEEEECCCCHHHHHH
LVRALEAKNAA
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]