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The map label for this gene is ldc [H]

Identifier: 114800350

GI number: 114800350

Start: 3151052

End: 3152248

Strand: Direct

Name: ldc [H]

Synonym: HNE_2991

Alternate gene names: 114800350

Gene position: 3151052-3152248 (Clockwise)

Preceding gene: 114797590

Following gene: 114798774

Centisome position: 85.05

GC content: 62.82

Gene sequence:

>1197_bases
ATGCACACTTACGCGACCCCGTATCATATTGCTCGTGAGCAACAGCCCGAGCTGCCGACCTATTGCTTCCGTCCGGAACG
CGTGACGGCGGCTGCAAGCTGGTTCGTGGAGAAATTCCCGGCTCAGCCCTTCTATGCTGTGAAGGTGAACCCTGCCCCGC
ACGTCCTCGACGCGCTGTGGGAAGGTGGCATCCGCAGCTTTGACGCGGCATCCGAGAAGGAAATCGAGCTGATCCGCGGC
CGCTTCCCTGATGCCCGCATTGCCTTCCTGCACCCTGTGAAGCCCCGCCGCGCGATCGAGCGGGCTTACAAGCAGCATGG
CGTGCGCATCTTCGTGACCGACTCGATGGCCGAGCTGCACAAGATCCTCGACGCGACCGACTTCGCAAAGGATCTCACGA
TCCTCGTGCGTATCGCTGTCTCGAACGAAGGCTCTGCCCTGCCGCTTTCCGGCAAGTTCGGCGCGAGCGCGGCAGAAGCC
GCTGAACTTCTCAGCGTGGCCCGCCGCTATGCGGACGAGCTGGGCGTGTCGTTCCATGTTGGCAGCCAGGCGATGAAGCC
TTCGGCCTGGGCACAGGCGATGGCGGACGCCAGTCGCGTCATCATCGACGCCGGCGTGACCGTGGACATCGTGGATGTCG
GCGGCGGCTTCCCGGCGATCTATGCTGACAAGAATCCGCCCGCGATGGACGACTATGTCGCCATGGTGATGCGCTCGTTC
GAGAACATGTTTGTTCTCGAGAACGCAGACCTGTGGTGTGAGCCCGGCCGCGCGCTGGTGGCCGAAGCCGAAAGCCTTCT
GGTGGGCGTTGATCTGGCCAAGGACAACGCGATCTACATCAATGAAGGCTCCTATGGCGCGCTCTATGACGCCGTGCACG
AGAACTGGGTGTTCCCGATGCGCGCGATCTCGGGCGACGGGCGCAAGCTCGGCCGTATGGTGGAATACACCGTCTACGGA
CCGACCTGCGATTCGGCTGACATGCTTCCAGGCAAAGTCTGGTTGCCGGCCGGCCTCACCGAGGGCGACTATATCGAGAT
CGGCAACATCGGCGCCTATGGCCGTTCGATGGCCACCCGCTTCAACGGGTTTGGCGAGTCCGATGTGGCGATTGTTCAGG
ACAGCCCCTGGCCGTCGCTCTATGGCTCGGCCGAAGGCGCTGAAGTCATCTCGATCGGCTCGATGGCCACGAACTGA

Upstream 100 bases:

>100_bases
CCTGAAATTCGATGTGGCGGACATCTGGGCTAACCCGATAAGGGGGGCCCCCTGTACTAACGCCCAAAGCTGGTTTGAAG
CCCTTTGGAGGTTAGGTGTC

Downstream 100 bases:

>100_bases
ACTTCGGGAAAGCCGTAGCGTCTCAGGACGCGGGTGATCCCCTCTTCCCTTTCAGGCGGACTTGTGAGGCACGCTGTGCC
TCCCTGTCCGCCTGACTCGT

Product: decarboxylase, group IV

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MHTYATPYHIAREQQPELPTYCFRPERVTAAASWFVEKFPAQPFYAVKVNPAPHVLDALWEGGIRSFDAASEKEIELIRG
RFPDARIAFLHPVKPRRAIERAYKQHGVRIFVTDSMAELHKILDATDFAKDLTILVRIAVSNEGSALPLSGKFGASAAEA
AELLSVARRYADELGVSFHVGSQAMKPSAWAQAMADASRVIIDAGVTVDIVDVGGGFPAIYADKNPPAMDDYVAMVMRSF
ENMFVLENADLWCEPGRALVAEAESLLVGVDLAKDNAIYINEGSYGALYDAVHENWVFPMRAISGDGRKLGRMVEYTVYG
PTCDSADMLPGKVWLPAGLTEGDYIEIGNIGAYGRSMATRFNGFGESDVAIVQDSPWPSLYGSAEGAEVISIGSMATN

Sequences:

>Translated_398_residues
MHTYATPYHIAREQQPELPTYCFRPERVTAAASWFVEKFPAQPFYAVKVNPAPHVLDALWEGGIRSFDAASEKEIELIRG
RFPDARIAFLHPVKPRRAIERAYKQHGVRIFVTDSMAELHKILDATDFAKDLTILVRIAVSNEGSALPLSGKFGASAAEA
AELLSVARRYADELGVSFHVGSQAMKPSAWAQAMADASRVIIDAGVTVDIVDVGGGFPAIYADKNPPAMDDYVAMVMRSF
ENMFVLENADLWCEPGRALVAEAESLLVGVDLAKDNAIYINEGSYGALYDAVHENWVFPMRAISGDGRKLGRMVEYTVYG
PTCDSADMLPGKVWLPAGLTEGDYIEIGNIGAYGRSMATRFNGFGESDVAIVQDSPWPSLYGSAEGAEVISIGSMATN
>Mature_398_residues
MHTYATPYHIAREQQPELPTYCFRPERVTAAASWFVEKFPAQPFYAVKVNPAPHVLDALWEGGIRSFDAASEKEIELIRG
RFPDARIAFLHPVKPRRAIERAYKQHGVRIFVTDSMAELHKILDATDFAKDLTILVRIAVSNEGSALPLSGKFGASAAEA
AELLSVARRYADELGVSFHVGSQAMKPSAWAQAMADASRVIIDAGVTVDIVDVGGGFPAIYADKNPPAMDDYVAMVMRSF
ENMFVLENADLWCEPGRALVAEAESLLVGVDLAKDNAIYINEGSYGALYDAVHENWVFPMRAISGDGRKLGRMVEYTVYG
PTCDSADMLPGKVWLPAGLTEGDYIEIGNIGAYGRSMATRFNGFGESDVAIVQDSPWPSLYGSAEGAEVISIGSMATN

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=364, Percent_Identity=30.7692307692308, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI16506287, Length=355, Percent_Identity=29.5774647887324, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI22538418, Length=353, Percent_Identity=27.1954674220963, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI21361583, Length=353, Percent_Identity=27.1954674220963, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17562780, Length=372, Percent_Identity=31.1827956989247, Blast_Score=128, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6322664, Length=377, Percent_Identity=31.2997347480106, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24586472, Length=339, Percent_Identity=29.7935103244838, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24586474, Length=339, Percent_Identity=28.9085545722714, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43342; Mature: 43342

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTYATPYHIAREQQPELPTYCFRPERVTAAASWFVEKFPAQPFYAVKVNPAPHVLDALW
CCCCCCCHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHH
EGGIRSFDAASEKEIELIRGRFPDARIAFLHPVKPRRAIERAYKQHGVRIFVTDSMAELH
HCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCHHHHH
KILDATDFAKDLTILVRIAVSNEGSALPLSGKFGASAAEAAELLSVARRYADELGVSFHV
HHHHHHHHHHCEEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
GSQAMKPSAWAQAMADASRVIIDAGVTVDIVDVGGGFPAIYADKNPPAMDDYVAMVMRSF
CCCCCCCHHHHHHHHCCCEEEEECCCEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHH
ENMFVLENADLWCEPGRALVAEAESLLVGVDLAKDNAIYINEGSYGALYDAVHENWVFPM
CCEEEEECCCCEECCCCHHHHCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHCCCCCEE
RAISGDGRKLGRMVEYTVYGPTCDSADMLPGKVWLPAGLTEGDYIEIGNIGAYGRSMATR
EEECCCCHHHCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCHHHHHHH
FNGFGESDVAIVQDSPWPSLYGSAEGAEVISIGSMATN
HCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MHTYATPYHIAREQQPELPTYCFRPERVTAAASWFVEKFPAQPFYAVKVNPAPHVLDALW
CCCCCCCHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHH
EGGIRSFDAASEKEIELIRGRFPDARIAFLHPVKPRRAIERAYKQHGVRIFVTDSMAELH
HCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCHHHHH
KILDATDFAKDLTILVRIAVSNEGSALPLSGKFGASAAEAAELLSVARRYADELGVSFHV
HHHHHHHHHHCEEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
GSQAMKPSAWAQAMADASRVIIDAGVTVDIVDVGGGFPAIYADKNPPAMDDYVAMVMRSF
CCCCCCCHHHHHHHHCCCEEEEECCCEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHH
ENMFVLENADLWCEPGRALVAEAESLLVGVDLAKDNAIYINEGSYGALYDAVHENWVFPM
CCEEEEECCCCEECCCCHHHHCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHCCCCCEE
RAISGDGRKLGRMVEYTVYGPTCDSADMLPGKVWLPAGLTEGDYIEIGNIGAYGRSMATR
EEECCCCHHHCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCHHHHHHH
FNGFGESDVAIVQDSPWPSLYGSAEGAEVISIGSMATN
HCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]