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The map label for this gene is lpxC [H]

Identifier: 114800236

GI number: 114800236

Start: 382294

End: 383205

Strand: Reverse

Name: lpxC [H]

Synonym: HNE_0389

Alternate gene names: 114800236

Gene position: 383205-382294 (Counterclockwise)

Preceding gene: 114797115

Following gene: 114798667

Centisome position: 10.34

GC content: 64.8

Gene sequence:

>912_bases
ATGGGCGACATGCAACACACTCTCGCGAAAGCCGTAAGCTGCGCCGGTGTCGGCGTGCACAGCGGCGTGCGCGCCCGCCT
GAACCTGCGCCCTGCCCCTGTAAACACAGGGATTGTGTTCCTGCGCACCGATGTCCCCAAAGGCACCGGCACGGTCCTCG
CCCATGCCGAGACCGTCAGCGACACCCAGCTCGGCACCACTATCGCCAATGAACATGGCGTCTCTGTCGCGGTCGTCGAA
CACCTGCTCGCCGCCATCGCGGGCCTCGGCATCGACAACCTCATCGTTGAAATCGACGCCCAGGAAGTCCCCATCATGGA
CGGCTCCTCTTCGGTCTTCTACGAGCTGATGATGCTCGCCGGCCTCAAGGCCCAGGGCGCCCTGCGCCGCCGCATCCGCG
TGCTTGAAAAGGTTGAAGTTATTGACGGCCCCAAGCGCGCCTCGCTCTCACCGGTCGCCGATGACAGCCTCACCATGCGC
GCCCGCATCGAATATACCGACCAGACCATCGGCGTTCAGCAGATGGCCCTGCGCCTCGTCCCCGGCAGCTTTGCCCGCGA
TCTCGCCTTTGCCCGCACCTTCGGCTTCGCCCGCGATGTCGATATGCTGCGCTCCATGGGCCTTGCCCGTGGCGGCTCGC
TCGAAAACGCTGTGGTGATCGGCGACGAAGGCATCATGAACCCTGAAGGCCTGCGCGTGGAAGATGAGTTCATCCGCCAC
AAGATGCTCGACGCTGTGGGCGATTTGATGCTCGCCGGCGCGCCGATTGCCGGAGCCTATGACGCCGTCCAGCCCGGCCA
CGCGATCAACAACAAGCTGGTGCGCGCCCTGCTGGCCAATCCTTCTGCCTGGTGCTGGGAAGAAGCCGGCAAGCCCGCAG
AAGCGGCCGAAAACATCCGCGCCGCCGTTTGA

Upstream 100 bases:

>100_bases
ACAACACGCAATATCGCGTGTTTTGATGCTTTCCCCCAGCATTGCCAAATGGACTCCGAAGGCTGCGCCCCGTGCAGCCG
CAATTCAGGTGTCTGGTTTC

Downstream 100 bases:

>100_bases
TTTCAAGCGCTTGAACGGTTCAGGCCTGGCCGCTGATGCCGCCATTGGCCTGCGGGCGTTGGCCCTCCAGCTCCGCGGAC
TCGCCCTCGCCACTGCCCGA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MGDMQHTLAKAVSCAGVGVHSGVRARLNLRPAPVNTGIVFLRTDVPKGTGTVLAHAETVSDTQLGTTIANEHGVSVAVVE
HLLAAIAGLGIDNLIVEIDAQEVPIMDGSSSVFYELMMLAGLKAQGALRRRIRVLEKVEVIDGPKRASLSPVADDSLTMR
ARIEYTDQTIGVQQMALRLVPGSFARDLAFARTFGFARDVDMLRSMGLARGGSLENAVVIGDEGIMNPEGLRVEDEFIRH
KMLDAVGDLMLAGAPIAGAYDAVQPGHAINNKLVRALLANPSAWCWEEAGKPAEAAENIRAAV

Sequences:

>Translated_303_residues
MGDMQHTLAKAVSCAGVGVHSGVRARLNLRPAPVNTGIVFLRTDVPKGTGTVLAHAETVSDTQLGTTIANEHGVSVAVVE
HLLAAIAGLGIDNLIVEIDAQEVPIMDGSSSVFYELMMLAGLKAQGALRRRIRVLEKVEVIDGPKRASLSPVADDSLTMR
ARIEYTDQTIGVQQMALRLVPGSFARDLAFARTFGFARDVDMLRSMGLARGGSLENAVVIGDEGIMNPEGLRVEDEFIRH
KMLDAVGDLMLAGAPIAGAYDAVQPGHAINNKLVRALLANPSAWCWEEAGKPAEAAENIRAAV
>Mature_302_residues
GDMQHTLAKAVSCAGVGVHSGVRARLNLRPAPVNTGIVFLRTDVPKGTGTVLAHAETVSDTQLGTTIANEHGVSVAVVEH
LLAAIAGLGIDNLIVEIDAQEVPIMDGSSSVFYELMMLAGLKAQGALRRRIRVLEKVEVIDGPKRASLSPVADDSLTMRA
RIEYTDQTIGVQQMALRLVPGSFARDLAFARTFGFARDVDMLRSMGLARGGSLENAVVIGDEGIMNPEGLRVEDEFIRHK
MLDAVGDLMLAGAPIAGAYDAVQPGHAINNKLVRALLANPSAWCWEEAGKPAEAAENIRAAV

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=280, Percent_Identity=45, Blast_Score=254, Evalue=3e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32149; Mature: 32018

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDMQHTLAKAVSCAGVGVHSGVRARLNLRPAPVNTGIVFLRTDVPKGTGTVLAHAETVS
CCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCEEEEECCCC
DTQLGTTIANEHGVSVAVVEHLLAAIAGLGIDNLIVEIDAQEVPIMDGSSSVFYELMMLA
CHHHCHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHH
GLKAQGALRRRIRVLEKVEVIDGPKRASLSPVADDSLTMRARIEYTDQTIGVQQMALRLV
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCHHCHHHHHHHHC
PGSFARDLAFARTFGFARDVDMLRSMGLARGGSLENAVVIGDEGIMNPEGLRVEDEFIRH
CCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
KMLDAVGDLMLAGAPIAGAYDAVQPGHAINNKLVRALLANPSAWCWEEAGKPAEAAENIR
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHH
AAV
CCC
>Mature Secondary Structure 
GDMQHTLAKAVSCAGVGVHSGVRARLNLRPAPVNTGIVFLRTDVPKGTGTVLAHAETVS
CCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCEEEEECCCC
DTQLGTTIANEHGVSVAVVEHLLAAIAGLGIDNLIVEIDAQEVPIMDGSSSVFYELMMLA
CHHHCHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHH
GLKAQGALRRRIRVLEKVEVIDGPKRASLSPVADDSLTMRARIEYTDQTIGVQQMALRLV
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCHHCHHHHHHHHC
PGSFARDLAFARTFGFARDVDMLRSMGLARGGSLENAVVIGDEGIMNPEGLRVEDEFIRH
CCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
KMLDAVGDLMLAGAPIAGAYDAVQPGHAINNKLVRALLANPSAWCWEEAGKPAEAAENIR
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHH
AAV
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA