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The map label for this gene is fghA [C]

Identifier: 114800056

GI number: 114800056

Start: 554085

End: 554927

Strand: Reverse

Name: fghA [C]

Synonym: HNE_0555

Alternate gene names: 114800056

Gene position: 554927-554085 (Counterclockwise)

Preceding gene: 114797153

Following gene: 114799571

Centisome position: 14.98

GC content: 61.68

Gene sequence:

>843_bases
ATGACCCTCACGCAAGTTTCTTCCTGGAAATCCTTTGGCGGCACGCTCTCCGTCCACGACCATGAAAGCGGGCTGCTTGG
CTGCACGATGCGCTTTGCCGTCTACGTGCCCCCGCAGGCAAAGGACGGCCCCGTCCCCGTGCTCTGGTATCTCTCCGGCC
TCACCTGCACCTGGGCCAATGTGATGGAAAAAGGCGGCATTCAGGAACACGCCGCCCGCCATGGGCTGATGATCATCGCG
CCCGACACCTCCCCCCGCGGCGAAGACGTGCCCAATGACGAGGCCTATGACCTCGGCCAGGGCGCAGGCTTCTACCTCAC
CGCCACGCAGGACCCCTGGGCCAAAAACTACAAGATGGACCCATACATCACCGATGAACTCCCCGACCTCATCGCCGCAA
ACTTCCCCGCAGCCGACATGAGCAGGCAAGGCATCTTCGGCCACTCGATGGGCGGCCACGGCGCCCTGACGCTGCACCTG
AAACATCCGGACACTTACAAATCCTGCTCGGCCTTCTCCCCGATCACGTCCCCGGCCCGCGTGCCCTGGGGCGAGAAAGC
CTTCACCGCCTATCTCGGCGCGCCTTCCATTGCCTGGGAACAGTATGACGCCACAGAGCTGGTGAAAGAGCGCCCCTCAA
AAGCGCTTCTCCTCATCGACACCGGCACGGCAGACAATTTCCTCGAGCCCCAGCTGAAACCGGAAATCTTCATCAAGGCA
TGCGAGAAAGACGGCCAGCGCCTCGATTACCGCCTGCGCGAAGGCTATGGCCACGACTATTACTTCATCGCCACCTTCAT
GGACGAACATATCGCCCACCATGCCAAGGCGCTGAAAGCCTAG

Upstream 100 bases:

>100_bases
CCCTCCCGGCAACCCCTCGCGCGCGCCTTCCTTGACTTGGCCGCCCCCAAAGGGCCAGAAGGCCCTTCCCCCTCACGCAG
CCAGCCTCGAGAGCGCCCCC

Downstream 100 bases:

>100_bases
ACCGCCTTCGCGTGGCGCTGCTGCGCGAGCGCGGGCGAGCGCGCATCAAAACATTGCCCCACCGTGCGCAGCATTATGCG
CGCCTCTTCGGGCACGGTGA

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTLTQVSSWKSFGGTLSVHDHESGLLGCTMRFAVYVPPQAKDGPVPVLWYLSGLTCTWANVMEKGGIQEHAARHGLMIIA
PDTSPRGEDVPNDEAYDLGQGAGFYLTATQDPWAKNYKMDPYITDELPDLIAANFPAADMSRQGIFGHSMGGHGALTLHL
KHPDTYKSCSAFSPITSPARVPWGEKAFTAYLGAPSIAWEQYDATELVKERPSKALLLIDTGTADNFLEPQLKPEIFIKA
CEKDGQRLDYRLREGYGHDYYFIATFMDEHIAHHAKALKA

Sequences:

>Translated_280_residues
MTLTQVSSWKSFGGTLSVHDHESGLLGCTMRFAVYVPPQAKDGPVPVLWYLSGLTCTWANVMEKGGIQEHAARHGLMIIA
PDTSPRGEDVPNDEAYDLGQGAGFYLTATQDPWAKNYKMDPYITDELPDLIAANFPAADMSRQGIFGHSMGGHGALTLHL
KHPDTYKSCSAFSPITSPARVPWGEKAFTAYLGAPSIAWEQYDATELVKERPSKALLLIDTGTADNFLEPQLKPEIFIKA
CEKDGQRLDYRLREGYGHDYYFIATFMDEHIAHHAKALKA
>Mature_279_residues
TLTQVSSWKSFGGTLSVHDHESGLLGCTMRFAVYVPPQAKDGPVPVLWYLSGLTCTWANVMEKGGIQEHAARHGLMIIAP
DTSPRGEDVPNDEAYDLGQGAGFYLTATQDPWAKNYKMDPYITDELPDLIAANFPAADMSRQGIFGHSMGGHGALTLHLK
HPDTYKSCSAFSPITSPARVPWGEKAFTAYLGAPSIAWEQYDATELVKERPSKALLLIDTGTADNFLEPQLKPEIFIKAC
EKDGQRLDYRLREGYGHDYYFIATFMDEHIAHHAKALKA

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=283, Percent_Identity=55.1236749116608, Blast_Score=311, Evalue=3e-85,
Organism=Escherichia coli, GI1786551, Length=269, Percent_Identity=48.6988847583643, Blast_Score=275, Evalue=2e-75,
Organism=Escherichia coli, GI1788477, Length=271, Percent_Identity=46.8634686346863, Blast_Score=245, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17510185, Length=282, Percent_Identity=48.936170212766, Blast_Score=270, Evalue=8e-73,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=40.8783783783784, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI45551932, Length=285, Percent_Identity=51.5789473684211, Blast_Score=283, Evalue=8e-77,
Organism=Drosophila melanogaster, GI24648347, Length=285, Percent_Identity=51.5789473684211, Blast_Score=282, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30923; Mature: 30792

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTQVSSWKSFGGTLSVHDHESGLLGCTMRFAVYVPPQAKDGPVPVLWYLSGLTCTWAN
CCCCCCCCHHHCCCEEEEECCCCCEEEEEEEEEEEECCCCCCCCEEEEEEECCCCHHHHH
VMEKGGIQEHAARHGLMIIAPDTSPRGEDVPNDEAYDLGQGAGFYLTATQDPWAKNYKMD
HHHHCCCHHHHHHCCEEEEECCCCCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCC
PYITDELPDLIAANFPAADMSRQGIFGHSMGGHGALTLHLKHPDTYKSCSAFSPITSPAR
CEECCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHCCCCCCCCCCCC
VPWGEKAFTAYLGAPSIAWEQYDATELVKERPSKALLLIDTGTADNFLEPQLKPEIFIKA
CCCCCHHEEEECCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHEE
CEKDGQRLDYRLREGYGHDYYFIATFMDEHIAHHAKALKA
HHCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLTQVSSWKSFGGTLSVHDHESGLLGCTMRFAVYVPPQAKDGPVPVLWYLSGLTCTWAN
CCCCCCCHHHCCCEEEEECCCCCEEEEEEEEEEEECCCCCCCCEEEEEEECCCCHHHHH
VMEKGGIQEHAARHGLMIIAPDTSPRGEDVPNDEAYDLGQGAGFYLTATQDPWAKNYKMD
HHHHCCCHHHHHHCCEEEEECCCCCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCC
PYITDELPDLIAANFPAADMSRQGIFGHSMGGHGALTLHLKHPDTYKSCSAFSPITSPAR
CEECCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHCCCCCCCCCCCC
VPWGEKAFTAYLGAPSIAWEQYDATELVKERPSKALLLIDTGTADNFLEPQLKPEIFIKA
CCCCCHHEEEECCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHEE
CEKDGQRLDYRLREGYGHDYYFIATFMDEHIAHHAKALKA
HHCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]