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The map label for this gene is folK [H]

Identifier: 114799987

GI number: 114799987

Start: 2463467

End: 2463967

Strand: Reverse

Name: folK [H]

Synonym: HNE_2364

Alternate gene names: 114799987

Gene position: 2463967-2463467 (Counterclockwise)

Preceding gene: 114800304

Following gene: 114798731

Centisome position: 66.5

GC content: 62.28

Gene sequence:

>501_bases
ATGGCTGAAGCGGCGCTCGGTCTCGGCTCCAATCTTGGAGATCGTGAAGCGCATCTTTCCGGCGCTGTCCGCGCGCTGGA
GGCATGGGGCGGTGTTCGGGTAACGGCCATTTCCTCGCTCTGGGAAACGCCGCCCTGGGGCATTGAGGGACAGCCGCATT
TTCTCAACGCCTGCGTGCTGATTGAAACATCGCTGACGCCCATTGAGGTGCTCGATGCCTGCCTCGCAATCGAGCGGGAT
CACGGCCGGGAACGCAGCCTGCGTTGGGGCCCGCGCACGCTGGATATGGATGTTCTGTACTATGATGATGTGGAAATGGC
CGATGAGCGGCTGATCCTTCCCCATCCGCGCATGCTGCTGCGCAGCTTCGTGCTGGCGCCTCTGGCAGAAATTGCGCCGG
GCAAGGTGATCGGCGGCGCGACCATCCAGGAAAACTCTGCGCTCGTGGGGCTGGAGACAGGTATGGTCCGGATCGGGCCA
CTGAGGGGCATTGAAGAATGA

Upstream 100 bases:

>100_bases
TTCCCGCCGATCCAGAAGGTTCGGGTGGAAATCCGCAAGCCGCGCGCCCCCATCCGCCACATCGTCAACCATGTCGGCAT
TGCCATTGAGCGCGACCGCC

Downstream 100 bases:

>100_bases
TCGGGGCCAAAGAGCTGTTCGGCCTCGGTGCATTGCTGCTCACATTCATCGCCTTCTTTCCCTATATTCGCTCCATTCTG
AGGGGGCAGACGCGTCCACA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MAEAALGLGSNLGDREAHLSGAVRALEAWGGVRVTAISSLWETPPWGIEGQPHFLNACVLIETSLTPIEVLDACLAIERD
HGRERSLRWGPRTLDMDVLYYDDVEMADERLILPHPRMLLRSFVLAPLAEIAPGKVIGGATIQENSALVGLETGMVRIGP
LRGIEE

Sequences:

>Translated_166_residues
MAEAALGLGSNLGDREAHLSGAVRALEAWGGVRVTAISSLWETPPWGIEGQPHFLNACVLIETSLTPIEVLDACLAIERD
HGRERSLRWGPRTLDMDVLYYDDVEMADERLILPHPRMLLRSFVLAPLAEIAPGKVIGGATIQENSALVGLETGMVRIGP
LRGIEE
>Mature_165_residues
AEAALGLGSNLGDREAHLSGAVRALEAWGGVRVTAISSLWETPPWGIEGQPHFLNACVLIETSLTPIEVLDACLAIERDH
GRERSLRWGPRTLDMDVLYYDDVEMADERLILPHPRMLLRSFVLAPLAEIAPGKVIGGATIQENSALVGLETGMVRIGPL
RGIEE

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=42.0289855072464, Blast_Score=105, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324073, Length=134, Percent_Identity=40.2985074626866, Blast_Score=101, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18030; Mature: 17899

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAALGLGSNLGDREAHLSGAVRALEAWGGVRVTAISSLWETPPWGIEGQPHFLNACVL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCCCCEEEEEEE
IETSLTPIEVLDACLAIERDHGRERSLRWGPRTLDMDVLYYDDVEMADERLILPHPRMLL
EECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEECEEEEEECCCHHCCCEEECCCHHHHH
RSFVLAPLAEIAPGKVIGGATIQENSALVGLETGMVRIGPLRGIEE
HHHHHHHHHHHCCCCEECCCEEECCCEEEEECCCEEEECCCCCCCC
>Mature Secondary Structure 
AEAALGLGSNLGDREAHLSGAVRALEAWGGVRVTAISSLWETPPWGIEGQPHFLNACVL
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCCCCEEEEEEE
IETSLTPIEVLDACLAIERDHGRERSLRWGPRTLDMDVLYYDDVEMADERLILPHPRMLL
EECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEECEEEEEECCCHHCCCEEECCCHHHHH
RSFVLAPLAEIAPGKVIGGATIQENSALVGLETGMVRIGPLRGIEE
HHHHHHHHHHHCCCCEECCCEEECCCEEEEECCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]