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The map label for this gene is dapE [H]

Identifier: 114799971

GI number: 114799971

Start: 613299

End: 614792

Strand: Reverse

Name: dapE [H]

Synonym: HNE_0614

Alternate gene names: 114799971

Gene position: 614792-613299 (Counterclockwise)

Preceding gene: 114798906

Following gene: 114799157

Centisome position: 16.59

GC content: 61.65

Gene sequence:

>1494_bases
ATGATCCGCAATATACTGGTTGGCCTTGGCGCCATCATCGGCATCATCATTGCCGTCGTTCTGTTCCGTACCGCGAGCTA
TGGGGCCGACCCTGTCGGTGGCCGGGTGGAGCTTCCCGCCGCGCCGGAGATTTCCTCTGAACGCGGCGCACAAAATCTCT
CCCGCGCGATCCAGTTTCGCACGATCACGATTGCGCCCGGTGATCCGCGTCCGGGTCAGGAAGGACCGTGGAACGCGCTG
CATCAGTGGCTGGAAGAAACCTATCCCGCAGCCCATGCTGCAATGCAGAAAGAACTGGTGCCGGAGACCCTCACCCTGCT
CTATACTTGGGAAGGATCTGATCCCGGATTGAAGCCGATCCTGCTGATGGCGCACCAGGATGTTGTGCCGGTGAATATCG
GCACGGAGGGAGACTGGACCGGCGGCCCGTTCGATGGCGAGATCGTTGACGGCTATGTTTATGGCCGCGGCGTGATTGAC
GACAAAGGCTCCCTCGTGGCGCTTATGGAAGCGGCTGAGGCGCTGGCCACATCAGGTTTCCAGCCGAAACGCACAATTTA
TTTCATGTTTGACCATGACGAAGAAGTTTCCGGTTCGGGCGCCGAGGCGGGCATTGCGCTCTTGAAATCGCGCGGCATCG
AGCCGGAGATGGCGCTGGATGAAGGCTTCATGATCGTCGACCCCTCCCCGCTTTCGGGCAAGGCGATGGGGTTCATCGGG
ATTGCCGAGAAAGGCTATCTGACACTGGAAATCATCGCGACGGGCGAAGGCGGGCATTCGTCCACGCCGCCGCGCGATTC
GGCAGCTGTGCGCCTGGCCCGCGCTGTGGTGGCGCTGGACGACAACCAGATGAAGGCGGATTTCTCGAAACCTCCGGTGT
CGGACCTTTTCCGCTCCGCCGCCAATGACATGCCTTTCATGCAGAAGATGGCGTTTGCCAATCTCTGGCTCTTCGAAGGC
ATGATCGACCAGCAGATGAGCGGGATTTCGGCAGGCAACGCCATGATCCGCACGACGACCGCGCCGACCATGCTGGCAGG
ATCAGCCAAGGAAAACGTACTCGCCCAGAGGGCCAGCGCCATGGTGAACTTCCGTATACACCCCAATGATACCGAAGAGG
ACGTCATGGAGCACGTGCGCGAGATGACCGCCGACATTGACGGCATCGAGATAAAGGTGGGCCAGCAGGGCATTCGCGGC
CTTGGCGCCTCGCCTGTTTCGCCGACGGACAACCTTGCCTATGCCGTGCTCGCCAGCGTGGCGGAAGCGACAGCCGGCGG
CGCGCCGGCCGCGCCGGGCCTCGTGCTGGGGGCAACCGATGCGCGCTATGCCAGCGCGATCACGCCCAACGTCTACCGCT
TTGCGCCGGCGATCATGTCGCCCGAAGACCTCACCGGTTTCCACGGCACCAATGAACGCCTTGCCGTGGAGAATATGGGA
CGGCTGGCGACAGGCTATGCGCAGATTATTCTGGCTATGGACGCGGGGGAATGA

Upstream 100 bases:

>100_bases
GAAGGTGACGGCCAAGTCATTTTTTAGCTGCGCCCTCGCTTGACGTGGCGCCGATGCCACGCAAACTGCGGCGCCAGAAG
CAGGGAGGACGGGCGACGCC

Downstream 100 bases:

>100_bases
GGGACGCCCTGACATCCCCATCTTCACCCAGCTTTACAATCTCCGTGAGCAGAAGATCGAGATCGCTGTGCTGCGTGCGG
TGATTGGTGAGGTTTATGCG

Product: hypothetical protein

Products: NA

Alternate protein names: SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MIRNILVGLGAIIGIIIAVVLFRTASYGADPVGGRVELPAAPEISSERGAQNLSRAIQFRTITIAPGDPRPGQEGPWNAL
HQWLEETYPAAHAAMQKELVPETLTLLYTWEGSDPGLKPILLMAHQDVVPVNIGTEGDWTGGPFDGEIVDGYVYGRGVID
DKGSLVALMEAAEALATSGFQPKRTIYFMFDHDEEVSGSGAEAGIALLKSRGIEPEMALDEGFMIVDPSPLSGKAMGFIG
IAEKGYLTLEIIATGEGGHSSTPPRDSAAVRLARAVVALDDNQMKADFSKPPVSDLFRSAANDMPFMQKMAFANLWLFEG
MIDQQMSGISAGNAMIRTTTAPTMLAGSAKENVLAQRASAMVNFRIHPNDTEEDVMEHVREMTADIDGIEIKVGQQGIRG
LGASPVSPTDNLAYAVLASVAEATAGGAPAAPGLVLGATDARYASAITPNVYRFAPAIMSPEDLTGFHGTNERLAVENMG
RLATGYAQIILAMDAGE

Sequences:

>Translated_497_residues
MIRNILVGLGAIIGIIIAVVLFRTASYGADPVGGRVELPAAPEISSERGAQNLSRAIQFRTITIAPGDPRPGQEGPWNAL
HQWLEETYPAAHAAMQKELVPETLTLLYTWEGSDPGLKPILLMAHQDVVPVNIGTEGDWTGGPFDGEIVDGYVYGRGVID
DKGSLVALMEAAEALATSGFQPKRTIYFMFDHDEEVSGSGAEAGIALLKSRGIEPEMALDEGFMIVDPSPLSGKAMGFIG
IAEKGYLTLEIIATGEGGHSSTPPRDSAAVRLARAVVALDDNQMKADFSKPPVSDLFRSAANDMPFMQKMAFANLWLFEG
MIDQQMSGISAGNAMIRTTTAPTMLAGSAKENVLAQRASAMVNFRIHPNDTEEDVMEHVREMTADIDGIEIKVGQQGIRG
LGASPVSPTDNLAYAVLASVAEATAGGAPAAPGLVLGATDARYASAITPNVYRFAPAIMSPEDLTGFHGTNERLAVENMG
RLATGYAQIILAMDAGE
>Mature_497_residues
MIRNILVGLGAIIGIIIAVVLFRTASYGADPVGGRVELPAAPEISSERGAQNLSRAIQFRTITIAPGDPRPGQEGPWNAL
HQWLEETYPAAHAAMQKELVPETLTLLYTWEGSDPGLKPILLMAHQDVVPVNIGTEGDWTGGPFDGEIVDGYVYGRGVID
DKGSLVALMEAAEALATSGFQPKRTIYFMFDHDEEVSGSGAEAGIALLKSRGIEPEMALDEGFMIVDPSPLSGKAMGFIG
IAEKGYLTLEIIATGEGGHSSTPPRDSAAVRLARAVVALDDNQMKADFSKPPVSDLFRSAANDMPFMQKMAFANLWLFEG
MIDQQMSGISAGNAMIRTTTAPTMLAGSAKENVLAQRASAMVNFRIHPNDTEEDVMEHVREMTADIDGIEIKVGQQGIRG
LGASPVSPTDNLAYAVLASVAEATAGGAPAAPGLVLGATDARYASAITPNVYRFAPAIMSPEDLTGFHGTNERLAVENMG
RLATGYAQIILAMDAGE

Specific function: Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bact

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. DapE subfamily [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=402, Percent_Identity=37.0646766169154, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI4501901, Length=417, Percent_Identity=27.0983213429257, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71982082, Length=428, Percent_Identity=23.5981308411215, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982085, Length=442, Percent_Identity=22.3981900452489, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322289, Length=485, Percent_Identity=31.1340206185567, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24649210, Length=355, Percent_Identity=26.7605633802817, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24649206, Length=296, Percent_Identity=28.0405405405405, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24649202, Length=169, Percent_Identity=33.7278106508876, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24649204, Length=169, Percent_Identity=33.7278106508876, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24649212, Length=170, Percent_Identity=33.5294117647059, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356353, Length=360, Percent_Identity=25, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24649208, Length=349, Percent_Identity=25.5014326647564, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR005941
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 52627; Mature: 52627

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRNILVGLGAIIGIIIAVVLFRTASYGADPVGGRVELPAAPEISSERGAQNLSRAIQFR
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHEEEEE
TITIAPGDPRPGQEGPWNALHQWLEETYPAAHAAMQKELVPETLTLLYTWEGSDPGLKPI
EEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCEE
LLMAHQDVVPVNIGTEGDWTGGPFDGEIVDGYVYGRGVIDDKGSLVALMEAAEALATSGF
EEEECCCEEEEECCCCCCCCCCCCCCCEEEEEEEECEEECCCCCEEHHHHHHHHHHHCCC
QPKRTIYFMFDHDEEVSGSGAEAGIALLKSRGIEPEMALDEGFMIVDPSPLSGKAMGFIG
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEECCCCEEEECCCCCCCCCEEEEE
IAEKGYLTLEIIATGEGGHSSTPPRDSAAVRLARAVVALDDNQMKADFSKPPVSDLFRSA
ECCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHH
ANDMPFMQKMAFANLWLFEGMIDQQMSGISAGNAMIRTTTAPTMLAGSAKENVLAQRASA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHCCCCHHHHHHHHHHCE
MVNFRIHPNDTEEDVMEHVREMTADIDGIEIKVGQQGIRGLGASPVSPTDNLAYAVLASV
EEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHH
AEATAGGAPAAPGLVLGATDARYASAITPNVYRFAPAIMSPEDLTGFHGTNERLAVENMG
HHHHCCCCCCCCCEEEECCCCHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCEEEHHHHH
RLATGYAQIILAMDAGE
HHHHCEEEEEEEEECCC
>Mature Secondary Structure
MIRNILVGLGAIIGIIIAVVLFRTASYGADPVGGRVELPAAPEISSERGAQNLSRAIQFR
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHEEEEE
TITIAPGDPRPGQEGPWNALHQWLEETYPAAHAAMQKELVPETLTLLYTWEGSDPGLKPI
EEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCEE
LLMAHQDVVPVNIGTEGDWTGGPFDGEIVDGYVYGRGVIDDKGSLVALMEAAEALATSGF
EEEECCCEEEEECCCCCCCCCCCCCCCEEEEEEEECEEECCCCCEEHHHHHHHHHHHCCC
QPKRTIYFMFDHDEEVSGSGAEAGIALLKSRGIEPEMALDEGFMIVDPSPLSGKAMGFIG
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEECCCCEEEECCCCCCCCCEEEEE
IAEKGYLTLEIIATGEGGHSSTPPRDSAAVRLARAVVALDDNQMKADFSKPPVSDLFRSA
ECCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHH
ANDMPFMQKMAFANLWLFEGMIDQQMSGISAGNAMIRTTTAPTMLAGSAKENVLAQRASA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHCCCCHHHHHHHHHHCE
MVNFRIHPNDTEEDVMEHVREMTADIDGIEIKVGQQGIRGLGASPVSPTDNLAYAVLASV
EEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHH
AEATAGGAPAAPGLVLGATDARYASAITPNVYRFAPAIMSPEDLTGFHGTNERLAVENMG
HHHHCCCCCCCCCEEEECCCCHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCEEEHHHHH
RLATGYAQIILAMDAGE
HHHHCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA