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The map label for this gene is gcvT [H]

Identifier: 114799925

GI number: 114799925

Start: 2882197

End: 2883351

Strand: Direct

Name: gcvT [H]

Synonym: HNE_2719

Alternate gene names: 114799925

Gene position: 2882197-2883351 (Clockwise)

Preceding gene: 114797772

Following gene: 114799251

Centisome position: 77.79

GC content: 63.64

Gene sequence:

>1155_bases
ATGTCAGAGGCCTCGACTGAAAACCTGAAGCGCACGCCGCTTTTCGACTCCCACGTCAAAATGGGCGGCAAGCTCGTGGC
CTTTGCCGGCTATGAAATGCCGGTCCAGTTTGAAGGCGTGATGGCCGAACATATCTGGACACGCACGCAGGCGGGCCTGT
TTGACGTCTCGCATATGGGCCCGTGCTTCCTCACGCTGGAAGCGGGCATCGGCGGCGGCGACGCGGCCCATGCCGAGATT
TCCGCGCTCGTTGAAACGCTCGTGCCCTCCGACATCACCAGCCTCAAGCCCGGCCAGGCGCGCCTCACGGTTCTGCTGAA
CGAGGATGGCGGCATCCTCGATGATCTGATCATCACGCGACCCCTCGGCGAGGATGCGCAGGGCACGCTCTACATCGTCG
TCAATGGCGCCATGAAGGAACAGGACTGGGCAATCTTCGAGAAAGCGCTGGCCGGCAAGGCCGTGCTGACCCGCGCGGAC
GACCGCATCCTTTTCGCGCTGCAAGGCCCCAAGGCCGTCGATGTGATGGCCGACTTTTTCCCCGGCTGCGAAGAGCTGAC
CTTCATGCAGCACATGCCGTTTGAAGTGAATGGCCAGCGCTGCATCGTCTCGCGCTGCGGGTATACCGGCGAGGATGGCT
TTGAAGTTCTGATCCCGGCAGAAGCCGGCCTGCCGCTGATCGAAGAGATGTATACGGACGAGCGCGTGAAACCGATCGGC
CTTGGCGCGCGCGACTCGCTGCGCCTGGAAGCCGGGCTTTGCCTTTATGGGCATGATCTTAATCCCGAAATCTCCCCCAT
CGAGGCAGACCTTGCCTGGGTCATCCAGAAGCGCCGGCGCGAGGCGGGTAACTTCCCCGGCGCCGAACGCATCCTCCGGG
AACTGAAGGATGGCCCGGCGAAAAAGCGCGTCGGCATCCGCCCGCTGGAGCGCGCCCCGGCCCGCGAAGGCGCTGAAATC
CAGATCAATGGCGAGACCATCGGCGTTGTCACCTCCGGCGGCTTTGGCCCGACTTATGACGCGCCCGTTGCCATGGGCTA
TGTGGCCGCCGCGCATGCCGCGCCGGGCACGAAGATCGACCTTATCGTCCGCGGAAAGGCCCGGCCCGCCGAAGTGGCCG
CCCTCCCGTTCGTTCCACAAAACTATAAACGCTAG

Upstream 100 bases:

>100_bases
TGTCTTTGACGGGCGGAATCTCTCAGGCGCCCGGACAGCGGGGGCGACGGACCAAGGCAGCGCCCTCGCGCGCTGCGCCG
TCACTCTATGAAAGGGCGCC

Downstream 100 bases:

>100_bases
ACCTGCAGGGGCACGCACATGACCACCTACTACACCAAAGATCATGAATGGGTTCGCGTCGAAGGCGACACCGGCACTGT
GGGCATCACCTCCTACGCCG

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MSEASTENLKRTPLFDSHVKMGGKLVAFAGYEMPVQFEGVMAEHIWTRTQAGLFDVSHMGPCFLTLEAGIGGGDAAHAEI
SALVETLVPSDITSLKPGQARLTVLLNEDGGILDDLIITRPLGEDAQGTLYIVVNGAMKEQDWAIFEKALAGKAVLTRAD
DRILFALQGPKAVDVMADFFPGCEELTFMQHMPFEVNGQRCIVSRCGYTGEDGFEVLIPAEAGLPLIEEMYTDERVKPIG
LGARDSLRLEAGLCLYGHDLNPEISPIEADLAWVIQKRRREAGNFPGAERILRELKDGPAKKRVGIRPLERAPAREGAEI
QINGETIGVVTSGGFGPTYDAPVAMGYVAAAHAAPGTKIDLIVRGKARPAEVAALPFVPQNYKR

Sequences:

>Translated_384_residues
MSEASTENLKRTPLFDSHVKMGGKLVAFAGYEMPVQFEGVMAEHIWTRTQAGLFDVSHMGPCFLTLEAGIGGGDAAHAEI
SALVETLVPSDITSLKPGQARLTVLLNEDGGILDDLIITRPLGEDAQGTLYIVVNGAMKEQDWAIFEKALAGKAVLTRAD
DRILFALQGPKAVDVMADFFPGCEELTFMQHMPFEVNGQRCIVSRCGYTGEDGFEVLIPAEAGLPLIEEMYTDERVKPIG
LGARDSLRLEAGLCLYGHDLNPEISPIEADLAWVIQKRRREAGNFPGAERILRELKDGPAKKRVGIRPLERAPAREGAEI
QINGETIGVVTSGGFGPTYDAPVAMGYVAAAHAAPGTKIDLIVRGKARPAEVAALPFVPQNYKR
>Mature_383_residues
SEASTENLKRTPLFDSHVKMGGKLVAFAGYEMPVQFEGVMAEHIWTRTQAGLFDVSHMGPCFLTLEAGIGGGDAAHAEIS
ALVETLVPSDITSLKPGQARLTVLLNEDGGILDDLIITRPLGEDAQGTLYIVVNGAMKEQDWAIFEKALAGKAVLTRADD
RILFALQGPKAVDVMADFFPGCEELTFMQHMPFEVNGQRCIVSRCGYTGEDGFEVLIPAEAGLPLIEEMYTDERVKPIGL
GARDSLRLEAGLCLYGHDLNPEISPIEADLAWVIQKRRREAGNFPGAERILRELKDGPAKKRVGIRPLERAPAREGAEIQ
INGETIGVVTSGGFGPTYDAPVAMGYVAAAHAAPGTKIDLIVRGKARPAEVAALPFVPQNYKR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=389, Percent_Identity=42.6735218508997, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI257796258, Length=366, Percent_Identity=42.3497267759563, Blast_Score=258, Evalue=7e-69,
Organism=Homo sapiens, GI257796254, Length=384, Percent_Identity=39.3229166666667, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI257796256, Length=308, Percent_Identity=43.1818181818182, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI197927446, Length=354, Percent_Identity=24.8587570621469, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI21361378, Length=354, Percent_Identity=24.8587570621469, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI24797151, Length=356, Percent_Identity=23.0337078651685, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1789272, Length=379, Percent_Identity=31.3984168865435, Blast_Score=157, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17560118, Length=397, Percent_Identity=40.0503778337531, Blast_Score=243, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6320222, Length=401, Percent_Identity=40.1496259351621, Blast_Score=260, Evalue=2e-70,
Organism=Drosophila melanogaster, GI20129441, Length=390, Percent_Identity=43.0769230769231, Blast_Score=284, Evalue=7e-77,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41465; Mature: 41334

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEASTENLKRTPLFDSHVKMGGKLVAFAGYEMPVQFEGVMAEHIWTRTQAGLFDVSHMG
CCCCCCCCCCCCCCCHHHHHCCCEEEEEECCCCCEEECCHHHHHHHHHHCCCEEECCCCC
PCFLTLEAGIGGGDAAHAEISALVETLVPSDITSLKPGQARLTVLLNEDGGILDDLIITR
CEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEHHHEEEC
PLGEDAQGTLYIVVNGAMKEQDWAIFEKALAGKAVLTRADDRILFALQGPKAVDVMADFF
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHC
PGCEELTFMQHMPFEVNGQRCIVSRCGYTGEDGFEVLIPAEAGLPLIEEMYTDERVKPIG
CCHHHHHHHHCCCEEECCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCEEC
LGARDSLRLEAGLCLYGHDLNPEISPIEADLAWVIQKRRREAGNFPGAERILRELKDGPA
CCCCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
KKRVGIRPLERAPAREGAEIQINGETIGVVTSGGFGPTYDAPVAMGYVAAAHAAPGTKID
CCCCCCCCHHCCCCCCCCEEEECCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEE
LIVRGKARPAEVAALPFVPQNYKR
EEEECCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
SEASTENLKRTPLFDSHVKMGGKLVAFAGYEMPVQFEGVMAEHIWTRTQAGLFDVSHMG
CCCCCCCCCCCCCCHHHHHCCCEEEEEECCCCCEEECCHHHHHHHHHHCCCEEECCCCC
PCFLTLEAGIGGGDAAHAEISALVETLVPSDITSLKPGQARLTVLLNEDGGILDDLIITR
CEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEHHHEEEC
PLGEDAQGTLYIVVNGAMKEQDWAIFEKALAGKAVLTRADDRILFALQGPKAVDVMADFF
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHC
PGCEELTFMQHMPFEVNGQRCIVSRCGYTGEDGFEVLIPAEAGLPLIEEMYTDERVKPIG
CCHHHHHHHHCCCEEECCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCEEC
LGARDSLRLEAGLCLYGHDLNPEISPIEADLAWVIQKRRREAGNFPGAERILRELKDGPA
CCCCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
KKRVGIRPLERAPAREGAEIQINGETIGVVTSGGFGPTYDAPVAMGYVAAAHAAPGTKID
CCCCCCCCHHCCCCCCCCEEEECCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEE
LIVRGKARPAEVAALPFVPQNYKR
EEEECCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]