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The map label for this gene is bla [H]

Identifier: 114799804

GI number: 114799804

Start: 2923963

End: 2924784

Strand: Reverse

Name: bla [H]

Synonym: HNE_2763

Alternate gene names: 114799804

Gene position: 2924784-2923963 (Counterclockwise)

Preceding gene: 114797480

Following gene: 114798624

Centisome position: 78.94

GC content: 67.03

Gene sequence:

>822_bases
ATGCTGGCAGTCGCGGTCCTGGCGGCCTGCGCCAGCCCGGCGGCGAGCATCCCCGTGGCAGAACCCCGCCTGCTTGAGCA
GGCCCTGCTTGCCGAGGGGGTTAGCCCGGCGGATTCGGCGCTGGTGATCTATCGGCTTGAGGATGAAAAGGTCTGGGCGA
GCGGCGGCGCGCGCATTCGCGAGCGGTTTACGCCCGCCTCGACCTCGAAAATCCCCCACACCCTTCTGGCGCTGGAAACC
GGCGCCGTCACAGGGCCGGAGGAAAGCTTCGAGTGGGACGGGGAAACCCGCTTTGTCGACAGCTGGAATGAAGATCAGGA
TTTCGCGGCCGCCTTCCAGCGCTCTACCGTCTGGATCTATCAGATCGTTGTGCCCCGCATCGGCGCGGCCCGCCTCACCG
AAGGCCTTGAGGCCTTCGGCTATGGCAATGCCGACATCGGCGGGCCGGAAATGATCACCCGCTACTGGCTGGAAGGCCCG
CTCGCCATTTCGGCGACCGAGCAGGTGGAATTCCTCTCCCGCCTTGCCCGCCGCACGCTGCCCCTCTCGGCCCGCACCTA
TGATCTGGCGGTGCCGGTCATGGAAGTCGATCGCGGCGAGGGCTGGACGCTCTACGGCAAGACCGGCTGGAAAAGCGTCG
AAGGCCAGATGGACATCGGCTGGTATGTCGGCTGGGTCGAACAGTCCTCCGGCGAGGCGCCGGGCACCTACGCCTTCGCC
CTCAACATGGACATGCCCGGCGGCATGGACGAGGCCCCCAAACGCCGCGCAGCCGTGGAACGCGCGCTTCGCGCGATTGG
CGCCCTTCCGGTAGCCCAGTAA

Upstream 100 bases:

>100_bases
AGCTTCAGCCAGGATCTCGACGACGAGATCCCGTTCTGAGGAGGACTGCATGACCGCTGCTTCCGCTTCTTCGAGGACGG
GCCCGTGGGGCGCCTTGCTG

Downstream 100 bases:

>100_bases
CTTTCCGCCTAGTCCCGCTCCGGCGCGCCGAGCGGAAAATACGGCCGGAAATAGCGCGCATCGTCCACGGCGCGCGCAAA
AGATGGCCGCGCCAGAAGCC

Product: putative beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MLAVAVLAACASPAASIPVAEPRLLEQALLAEGVSPADSALVIYRLEDEKVWASGGARIRERFTPASTSKIPHTLLALET
GAVTGPEESFEWDGETRFVDSWNEDQDFAAAFQRSTVWIYQIVVPRIGAARLTEGLEAFGYGNADIGGPEMITRYWLEGP
LAISATEQVEFLSRLARRTLPLSARTYDLAVPVMEVDRGEGWTLYGKTGWKSVEGQMDIGWYVGWVEQSSGEAPGTYAFA
LNMDMPGGMDEAPKRRAAVERALRAIGALPVAQ

Sequences:

>Translated_273_residues
MLAVAVLAACASPAASIPVAEPRLLEQALLAEGVSPADSALVIYRLEDEKVWASGGARIRERFTPASTSKIPHTLLALET
GAVTGPEESFEWDGETRFVDSWNEDQDFAAAFQRSTVWIYQIVVPRIGAARLTEGLEAFGYGNADIGGPEMITRYWLEGP
LAISATEQVEFLSRLARRTLPLSARTYDLAVPVMEVDRGEGWTLYGKTGWKSVEGQMDIGWYVGWVEQSSGEAPGTYAFA
LNMDMPGGMDEAPKRRAAVERALRAIGALPVAQ
>Mature_273_residues
MLAVAVLAACASPAASIPVAEPRLLEQALLAEGVSPADSALVIYRLEDEKVWASGGARIRERFTPASTSKIPHTLLALET
GAVTGPEESFEWDGETRFVDSWNEDQDFAAAFQRSTVWIYQIVVPRIGAARLTEGLEAFGYGNADIGGPEMITRYWLEGP
LAISATEQVEFLSRLARRTLPLSARTYDLAVPVMEVDRGEGWTLYGKTGWKSVEGQMDIGWYVGWVEQSSGEAPGTYAFA
LNMDMPGGMDEAPKRRAAVERALRAIGALPVAQ

Specific function: Hydrolyzes oxacillin, first-generation cephalosporins and ceftazidime. Does not hydrolyze cefotaxime or carbapenems [H]

COG id: COG2602

COG function: function code V; Beta-lactamase class D

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-D beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR002137
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 29639; Mature: 29639

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAVAVLAACASPAASIPVAEPRLLEQALLAEGVSPADSALVIYRLEDEKVWASGGARIR
CHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCEEECCCCHHHH
ERFTPASTSKIPHTLLALETGAVTGPEESFEWDGETRFVDSWNEDQDFAAAFQRSTVWIY
HHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCEEEEE
QIVVPRIGAARLTEGLEAFGYGNADIGGPEMITRYWLEGPLAISATEQVEFLSRLARRTL
EEEHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCC
PLSARTYDLAVPVMEVDRGEGWTLYGKTGWKSVEGQMDIGWYVGWVEQSSGEAPGTYAFA
CCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCEEEEE
LNMDMPGGMDEAPKRRAAVERALRAIGALPVAQ
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLAVAVLAACASPAASIPVAEPRLLEQALLAEGVSPADSALVIYRLEDEKVWASGGARIR
CHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCEEECCCCHHHH
ERFTPASTSKIPHTLLALETGAVTGPEESFEWDGETRFVDSWNEDQDFAAAFQRSTVWIY
HHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCEEEEE
QIVVPRIGAARLTEGLEAFGYGNADIGGPEMITRYWLEGPLAISATEQVEFLSRLARRTL
EEEHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCC
PLSARTYDLAVPVMEVDRGEGWTLYGKTGWKSVEGQMDIGWYVGWVEQSSGEAPGTYAFA
CCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCEEEEE
LNMDMPGGMDEAPKRRAAVERALRAIGALPVAQ
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9087490 [H]