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The map label for this gene is nuoF [H]

Identifier: 114799778

GI number: 114799778

Start: 1789816

End: 1791123

Strand: Direct

Name: nuoF [H]

Synonym: HNE_1749

Alternate gene names: 114799778

Gene position: 1789816-1791123 (Clockwise)

Preceding gene: 114797708

Following gene: 114798795

Centisome position: 48.31

GC content: 61.39

Gene sequence:

>1308_bases
ATGTTGCAGGACAAGGACCGCATTTTCACAAACCTTTACGGCCTTCATTCGCCGGACCTCGAAGCTGCGAAGAAGCGCGG
CGCGTGGCATCTGACACGCGAGATGCTGGAGCAGGGGCCGGACTGGATCTGCAACCAGATCAAGGCGTCCGGCTTGCGCG
GCCGCGGCGGCGCCGGCTTCCCGACGGGCCTTAAGTGGACCTTCATGCCCAAGGAAGTGCGCGATCGCCCGCACTATCTC
GTGGTGAATGCCGACGAGTCCGAACCCGGCACCTGCAAGGACCGCGAAATCCTGCGCCACGATCCGCATCTGTTGATCGA
AGGCTGCATGGTCGCCAGCCGCGCCATGCGCGCGCACGCCTGCTACGTCTATATCCGGGGCGAATATATCAACGAGCGCC
ACGCGCTGGAGAAAGCCGTCAAGGAAGCCTATGAGGCAAAGCTGATCGGCAAGGACAATGTGAATGGCTGGGATTTCGAT
CTCTACGTCCATCACGGCGCCGGCGCCTATATCTGCGGCGAAGAAACTGCGCTGCTCGAAAGCCTTGAGGGCAAGAAGGG
CCAGCCACGCCTGAAGCCGCCATTCCCGGCGAACGCGGGCCTCTATGGCTGCCCCACCACGGTGAACAACGTTGAGTCTA
TCGCCGTTGCGCCCACCATCCTGCGGCGCGGCGCGCAATGGTTTGCCGGCTTTGGCCGCCCGAACAATGCAGGCACCAAA
CTGTTCTGCATTTCCGGCCATGTGAACACGCCGTGCAATGTCGAAGAAGAAATGTCGATCACCTTCCGTGATCTGATTGA
AACCCATTGTGGCGGCATTCGTGGCGGCTGGGAAAATCTGAAAGCGGTCATTCCGGGCGGTTCGTCGGTTCCTATGGTTC
CGGCTGAGCAGATTATGGACGCCCACATGGATTTCGACACGCTCCGGGATCTGAAATCGGGCCTGGGCACAGCGGCCGTG
ATCGTCATGGACAAGCAGACAGACCTTATCCGTGCCATCGCGCGCCTGGCTTACTTCTACAAGCATGAGAGCTGTGGCCA
GTGCACGCCGTGCCGGGAAGGCACCGGCTGGATGTGGCGCGTGCTGGAACGTATGGCACGCGGCGAGGCCGAGCATGACG
AGATCGACACGCTGCTGGATGTGACCAAACAGGTCGAAGGCCACACGATCTGCGCCCTTGGCGATGCAGCTGCCTGGCCA
ATTCAGGGCCTCATCCGCCACTTCCGCCATGAAATCGAAGACCGCATCACCCAGTACCGTCTGCCGCGCGCGATGGTGCA
GGGCGCCGTGGTCACGGCAGCAGAATAG

Upstream 100 bases:

>100_bases
GCCAGAAGCGACGGCAGAAGCTACCGGCCAGCCAGAAAAATCTGCGCCGACGAATACCGATCGCGAAGAGCCCTCCAGCA
AGGACATCAAGGAATAGGCC

Downstream 100 bases:

>100_bases
AGAAAGGCGGCACGTGAGCCTCACCCGCGCCATCCTGATCGTGTCCTGGTGCCTCTCGCTGGCTACCATTCACGCGGTCG
TGGCCTTCATTCTGGGCTAT

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLQDKDRIFTNLYGLHSPDLEAAKKRGAWHLTREMLEQGPDWICNQIKASGLRGRGGAGFPTGLKWTFMPKEVRDRPHYL
VVNADESEPGTCKDREILRHDPHLLIEGCMVASRAMRAHACYVYIRGEYINERHALEKAVKEAYEAKLIGKDNVNGWDFD
LYVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANAGLYGCPTTVNNVESIAVAPTILRRGAQWFAGFGRPNNAGTK
LFCISGHVNTPCNVEEEMSITFRDLIETHCGGIRGGWENLKAVIPGGSSVPMVPAEQIMDAHMDFDTLRDLKSGLGTAAV
IVMDKQTDLIRAIARLAYFYKHESCGQCTPCREGTGWMWRVLERMARGEAEHDEIDTLLDVTKQVEGHTICALGDAAAWP
IQGLIRHFRHEIEDRITQYRLPRAMVQGAVVTAAE

Sequences:

>Translated_435_residues
MLQDKDRIFTNLYGLHSPDLEAAKKRGAWHLTREMLEQGPDWICNQIKASGLRGRGGAGFPTGLKWTFMPKEVRDRPHYL
VVNADESEPGTCKDREILRHDPHLLIEGCMVASRAMRAHACYVYIRGEYINERHALEKAVKEAYEAKLIGKDNVNGWDFD
LYVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANAGLYGCPTTVNNVESIAVAPTILRRGAQWFAGFGRPNNAGTK
LFCISGHVNTPCNVEEEMSITFRDLIETHCGGIRGGWENLKAVIPGGSSVPMVPAEQIMDAHMDFDTLRDLKSGLGTAAV
IVMDKQTDLIRAIARLAYFYKHESCGQCTPCREGTGWMWRVLERMARGEAEHDEIDTLLDVTKQVEGHTICALGDAAAWP
IQGLIRHFRHEIEDRITQYRLPRAMVQGAVVTAAE
>Mature_435_residues
MLQDKDRIFTNLYGLHSPDLEAAKKRGAWHLTREMLEQGPDWICNQIKASGLRGRGGAGFPTGLKWTFMPKEVRDRPHYL
VVNADESEPGTCKDREILRHDPHLLIEGCMVASRAMRAHACYVYIRGEYINERHALEKAVKEAYEAKLIGKDNVNGWDFD
LYVHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANAGLYGCPTTVNNVESIAVAPTILRRGAQWFAGFGRPNNAGTK
LFCISGHVNTPCNVEEEMSITFRDLIETHCGGIRGGWENLKAVIPGGSSVPMVPAEQIMDAHMDFDTLRDLKSGLGTAAV
IVMDKQTDLIRAIARLAYFYKHESCGQCTPCREGTGWMWRVLERMARGEAEHDEIDTLLDVTKQVEGHTICALGDAAAWP
IQGLIRHFRHEIEDRITQYRLPRAMVQGAVVTAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=66.109785202864, Blast_Score=597, Evalue=1e-171,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=66.109785202864, Blast_Score=596, Evalue=1e-170,
Organism=Escherichia coli, GI1788620, Length=381, Percent_Identity=44.3569553805774, Blast_Score=334, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI17531727, Length=429, Percent_Identity=64.1025641025641, Blast_Score=592, Evalue=1e-170,
Organism=Drosophila melanogaster, GI19920794, Length=416, Percent_Identity=66.3461538461538, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI45550452, Length=418, Percent_Identity=62.6794258373206, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24653819, Length=421, Percent_Identity=48.4560570071259, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24653817, Length=421, Percent_Identity=45.1306413301663, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48447; Mature: 48447

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQDKDRIFTNLYGLHSPDLEAAKKRGAWHLTREMLEQGPDWICNQIKASGLRGRGGAGF
CCCCHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
PTGLKWTFMPKEVRDRPHYLVVNADESEPGTCKDREILRHDPHLLIEGCMVASRAMRAHA
CCCCEEEECCHHHCCCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHEE
CYVYIRGEYINERHALEKAVKEAYEAKLIGKDNVNGWDFDLYVHHGAGAYICGEETALLE
EEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANAGLYGCPTTVNNVESIAVAPTILRRGAQWFAGFGRPNNAGTK
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCCE
LFCISGHVNTPCNVEEEMSITFRDLIETHCGGIRGGWENLKAVIPGGSSVPMVPAEQIMD
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCEEECCCCCCCCCCCHHHHHH
AHMDFDTLRDLKSGLGTAAVIVMDKQTDLIRAIARLAYFYKHESCGQCTPCREGTGWMWR
HHCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VLERMARGEAEHDEIDTLLDVTKQVEGHTICALGDAAAWPIQGLIRHFRHEIEDRITQYR
HHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LPRAMVQGAVVTAAE
CCHHHHCCCEEEECC
>Mature Secondary Structure
MLQDKDRIFTNLYGLHSPDLEAAKKRGAWHLTREMLEQGPDWICNQIKASGLRGRGGAGF
CCCCHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
PTGLKWTFMPKEVRDRPHYLVVNADESEPGTCKDREILRHDPHLLIEGCMVASRAMRAHA
CCCCEEEECCHHHCCCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHEE
CYVYIRGEYINERHALEKAVKEAYEAKLIGKDNVNGWDFDLYVHHGAGAYICGEETALLE
EEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANAGLYGCPTTVNNVESIAVAPTILRRGAQWFAGFGRPNNAGTK
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCCE
LFCISGHVNTPCNVEEEMSITFRDLIETHCGGIRGGWENLKAVIPGGSSVPMVPAEQIMD
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCEEECCCCCCCCCCCHHHHHH
AHMDFDTLRDLKSGLGTAAVIVMDKQTDLIRAIARLAYFYKHESCGQCTPCREGTGWMWR
HHCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VLERMARGEAEHDEIDTLLDVTKQVEGHTICALGDAAAWPIQGLIRHFRHEIEDRITQYR
HHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LPRAMVQGAVVTAAE
CCHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]